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Ivy Tsui

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Graduate Student

itsui@bccrc.ca   675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada 

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab |


 Ivy 


Training

BSc (Honours Biochemistry & Molecular Biology), UBC, 2005


Program

Ph.D. program, Pathology and Laboratory Medicine, UBC


Research Interests

Squamous cell carcinoma (SCC) is the most common human cancer throughout the body. For SCC in the oral cavity, patients suffer from a 5-year survival rate of 40-50%, a figure that has not improved significantly for the past 30 years. For oral SCC, premalignant changes become visible before SCC develops, offering the chance for early intervention to prevent progression to cancer. However, only 30% of oral premalignant lesions (OPLs) will progress to invasive carcinomas, imposing a dilemma of prioritizing treatment since lesions that progress to cancer can appear similar morphologically to those that never progress or even regress. It is now known that genetic alterations accumulate as cancer cell evolves, but the distinction of causal genetic events from random genomic instability that accumulate with time is an imperative question. My goal is to understand the early biological changes in the premalignant stages in order to rationally design prevention and treatment strategies.  


Publications

  • Tsui IFL and Garnis C. (2009) Integrative molecular characterization of head and neck cancer cell model genomes. Head Neck. [Published ahead-of-print 15 December 2009; DOI: 10.1002/hed.21311]
  • Tsui IFL, Garnis C, Poh CF. (2009) A dynamic oral cancer field --unraveling the underlying biology and its clinical implication. American Journal of Surgical Pathology. 33: 1732-8
  • Tsui IFL, Poh CF, Garnis C, Rosin MP, Zhang L, Lam WL. (2009) Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias. International Journal of Cancer. 125: 2219-28
  • Tsui IFL, Rosin MP, Zhang L, Ng RL, Lam WL. (2008)  Multiple aberrations of chromosome 3p detected in oral premalignant lesions.  Cancer Prevention Research. 1: 424-9.
  • Tsui IFL, Chari R, Buys THP, Lam WL. (2007) Public databases and software for the pathway analysis of cancer genomes. Cancer Informatics. 3: 389-407.
  • Iqbal J, Kucuk C, deLeeuw RJ, Srivastava G, Tam W, Geng H, Klinkebiel D, Christman JK, Patel K, Cao K, Shen L, Dybkaer K, Tsui IFL, Ali H, Shimizu N, Au W, Lam WL, Chan WC. (2009) Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia. 23: 1139-51. 
  • Buys TPH, Wilson IM, Coe BP, Lee EHL, Kennett JY, Lockwood WW, Tsui IFL, Shadeo A, Chari R, Garnis C, Lam WL (2007) Detailed comparisons of cancer genomes.  In  Comparative Genomics: Fundamental and Applied Perspectives. James R. Brown (ed.) CRC Press, Taylor & Francis Publisher. P. .245-261.
 

Awards and Scholarships

  • Scholar-in-Training Award, American Association for Cancer Research Frontiers in Basic Cancer Research 2009
  • Senior Graduate Studentship, Michael Smith Foundation for Health Research, 2008-2011
  • Dr. Don Rix Best Student Abstract Award, World Microarray Congress 2008
  • Outstanding Poster Presentation, University of British Columbia Pathology Day 2008
  • Doctoral Research Award, Canadian Institute of Health Research (CIHR), 2007-2010
  • Fellow, Biovision.Nxt, Unicef, France, 2007
  • Aflac Scholar-in-Training Award, American Association for Cancer Research Frontiers in Cancer Prevention Research 2007
  • CIHR National Research Poster Award Honorary Mention Recognition, Canadian Institute of Health, 2007
  • Roman M. Babicki Fellowship in Medical Research, University of British Columbia, 2006-2007
  • Next Generation Award Silver Medal, BioContact Symposium 2006
  • Scholar-in-Training Award, American Association for Cancer Research Frontiers in Cancer Prevention Research 2006
  • Travel Award 2007, University of British Columbia
  • Best Scientific Poster, University of Pittsburgh 11th Annual Advancing Practice, Instruction, and Innovation Through Informatics Conference 2006

    Links

    | BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab |