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Greg Stewart

Greg


gstewart@bccrc.ca   10th floor - 675 W.10th Avenue, Vancouver, BC, V5Z1L3, Canada

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab | Greg Stewart |


Training

  • B.Sc. (Biochemistry and Microbiology), University of Victoria, 2009

Program

  •  Graduate student (Ph.D. candidate, Interdisciplinary Oncology Program), University of British Columbia

Research Interests

  • Lung cancer
  • Pathways disrupted in cancer
  • Mechanisms of therapeutic resistance
  • Non-coding RNA's - micro RNAs and pseudogenes

Publications

Papers

  • Rowbotham D, Enfield KSS, Martinez VD, Thu KL Vucic EA, Stewart GL,  Bennewith KL, Lam WL (2014) Multiple components of the VHL tumor suppressor complex are frequently affected by DNA copy number losses in pheochromocytoma. International Journal of Endocrinology 2014: 546347, 1-9.
  • Lockwood WW, Chandel SK, Stewart GL, Erdjument-Bromage H, Beverly LJ (2013). The novel ubiquitin ligase complex, SCFFbxw4, interacts with the COP9 signalosome in an f-box dependent manner, is mutated, lost and under-expressed in human cancers. PLoS ONE 8(5): e6361.
  • Gibb EA, Vucic, EA, Enfield KSS, Stewart GL, Lonergan KM, Kennett JY, Becker-Santos DD, MacAulay CE, Lam S, Brown CJ, Lam WL (2011) Human cancer long non-coding RNA transcriptomes.  PLoS ONE. 6: e25915, 1-10.

  • Gibb EA, Enfield KSS, Stewart GL, Lonergan KM, Ng RT, Zhang L, MacAulay CE, Rosin MP, Lam WL (2011)  Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions. Oral Oncology 47: 1055-61. 

  • Lockwood WW, Stack D, Morris T, Grehan D, O’Keane C, Stewart GL, Cumiskey J, Lam WL., Squire JA, Thomas DM, O’Sullivan M (2011) Cyclin E1 is amplified and over-expressed in osteosarcoma.  Journal of Molecular Diagnostics 13: 289-96.

  • Enfield KSS*, Stewart GL*, Pikor LA*, Alvarez CE, Lam S, Lam WL, Chari R (2011). MicroRNA alterations and chemotherapeutic response in lung cancer. Journal of Biomedicine and Biotechnology 2011: 474632, 1-15. (*co-first authorship)

Abstracts

  • Stewart GL, Vucic EA, Chari R, Wilson IM, Lonergan KM, Lam S, Lam WL (2010) Reversibly expressed and differentially methylated genes in airways of current and former smokers. AACR Frontiers in Cancer Prevention Research. Philadelphia, PA. Abstract No # 288.
  • Stewart GL, Vucic EA, Chari R, Wilson IM, Lonergan KM, Lam S, Lam WL (2010) Reversibly Expressed and differentially methylated genes in airways of current and former smokers. British Columbia Cancer Agency Annual Conference. Vancouver, BC. Abstract No # 30-C.
  • Stewart GL, Thu KL, Vucic EA, Kennett JY, Pikor LA, Chari R, Lam WL, Lam S (2011) Gender disparities in lung adenocarcinoma genomes. UBC Pathology Day. Vancouver, BC. Abstract #40
  • Enfield KSS, Stewart GL, Pikor LA, Alvarez CE, Lam S, Chari R, Lam WL (2011) Deregulation of specific microRNAs correlates with drug resistance in lung cancer cell lines. Bioinformatics & Oncology Retreat, Vancouver, BC.
  • Stewart GL, Thu KL, Vucic EA, Kennett JY, Pikor LA, Chari R, Lam WL, Lam S (2011) Gender related genomic differences in lung adenocarcinoma. IASLC World Conference on Lung Cancer. Amsterdam, The Netherlands. Poster No. P1.088.
  • Stewart GL, Wilson IM, Coe BP, Chari R, Thu KL, Yee J, English J, Murray N, Tsao M, Minna JD, Gazdar AF, MacAulay CE, Lam S, Lam WL, Lockwood WW (2011) Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways.IASLC World Conference on Lung Cancer. Amsterdam, The Netherlands. Oral Session No. O07.01.
  • Enfield KSS, Stewart GL, Pikor LA, Alvarez CE, Lam S, Chari R, Lam WL (2011) Deregulation of specific miRNAs correlates with systemic therapy response in non-small cell lung cancer. 14th World Conference on Lung Cancer, Amsterdam, The Netherlands. Oral presentation.
  • Stewart GL, Vucic EA, Chari R, Lam S, Lam WL (2011) The role of methylation in reversible gene expression in the airways of former smokers. ASHG Annual Meeting. Montreal, Quebec. Abstract # 22018
  • Stewart GL, Vucic EA, Chari R, Wilson IM, Lonergan KM, Lam S, Lam WL (2011) Differential methylation of reversibly expressed genes in the airways of former smokers. British Columbia Cancer Agency Annual Conference. Vancouver, BC. Abstract No # 15-B.
  • Enfield KSS, Stewart GL, Pikor LA, Alvarez CE, Lam S, Chari R, Lam WL (2011) MicroRNA deregulation is associated with inherent lung cancer cell line drug response. BC Annual Cancer Conference, Vancouver, BC
  • Gibb EA, Vucic, EA, Enfield KSS, Stewart GL, Kennet JY, Becker-Santos DD, Lonergan KM, MacAulay CE, Lam S, Brown CJ, Lam WL (2011) Human cancer long non-coding RNA transcriptomes. BC Annual Cancer Conference, Vancouver BC.
  • Stewart GL, Enfield KSS, Lam S, Lam WL (2012) DNA copy number alterations deregulate expression of mirnas in lung adenocarcinoma. AACR Non Coding RNAs and Cancer. Miami Beach, Florida; Poster A26
  • Becker-Santos DD, Gibb EA, Vucic EA, Enfield KSS, Stewart GL, MacAulay CE, Lam S, Lam WL (2012) An expression map of long non-coding RNAs in human lung and non small cell lung cancer. AACR-IASLC: The Molecular Origins of Lung Cancer, San Diego, CA.
  • Ramnarine VR, Stewart GL, Enfield KSS, Lam S, Lam WL (2012) Integrative Genomic Analysis of miRNAs in Lung Adenocarcinoma. British Columbia Pathology Day. Vancouver, BC. Abstract #50
  • Stewart GL, Enfield KSS, Lam S, Lam WL (2013) Pseudogenes as miRNA sponges in NSCLC. Interdisciplinary Oncology - Bioinformatics Retreat. Vancouver, BC. Poster #34
  • Stewart GL, Enfield KSS, Lam S, Lam WL (2013) Pseudogenes as miRNA sponges in non-small cell lung cancer. IASLC World Conference on Lung Cancer. Sydney, Australia. Oral Presentation ID 3455
  • Stewart GL, Enfield KSS, Hubaux R, Martinez V, Lam S, Lam WL (2014) Deregulation of natural antisense RNAs in non-small cell lung cancer. Interdisciplinary Oncology - Bioinformatics Retreat. Vancouver, BC. Poster #69

Invited Talks

  • Pseudogenes as miRNA sponges in non-small cell lung cancer. (2013)  International Association for the Study of Lung Cancer, World Conference on Lung Cancer. Sydney, Australia.
  • Epigenomic Landscapes of Lung Cancer Subtypes Underscore The Selection of Different Oncogenic Pathways. (2011) International Association for the Study of Lung Cancer, World Conference on Lung Cancer,. Amsterdam.The Netherlands.

Awards

  • Four Year Fellowship Award, Doctoral Award - University of British Columbia, September 2013 - 2017
  • Frederick Banting and Charles Best Canada Graduate Scholarship,Doctoral Award  - Canadian Institutes of Health Research, May 2013 - 2016

  • College for Interdisciplinary Studies Graduate Award, Recognition of academic achievement - University of British Columbia, September 2012
  • Cancer Genetics Scholar in Training Award  -- Outstanding abstract for international conference presentation, British Columbia Cancer Research Centre -- October 2010

  • Interdisciplinary Oncology Program Entrance Scholarship, University of British Columbia -- January 2010

  • Provincial Examination Scholarship, BC Ministry of Education, Richmond, BC – June 2005


Links

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab |