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Erin Marshall

PhD Candidate

erin2


Erin Marshall | emarshall@bccrc.ca | 604-675-8000 ext 7703 | 10th floor - 675 W.10th Avenue, Vancouver, BC, V5Z1L3, Canada
BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab | Erin Marshall |


 Training

  • B.Sc. Honours with Distinction (Queen’s University), Specialization in Biochemistry 

  • Dogwood Diploma, Archbishop Carney Regional Secondary School (Valedictorian)

  • J.M. Warren BC Cancer Research Centre Studentship (2015)                  

  • Lung Cancer Research Summer Studentship, BC Cancer Research Centre (2014)                                            

  • Clinical Respiratory Oncology Studentship, BC Cancer Research Centre (2013)

Program

  •  Interdisciplinary Oncology, Faculty of Medicine, University of British Columbia

Research Interests

  • Small RNAs in lung cancer

  • Early lung cancer development and tumour initiation

  • Common molecular mechanisms in COPD and lung cancer initiation


Media


Publications

Journal Articles (First and co-first authorships underlined).

  • Ng KW,* Marshall EA*, Bell JC, Lam WL.(2018) The emerging tumorigenic capacity of cGAS-STING. Trends in Immunology 39(1):44-54. https://doi.org/10.1016/j.it.2017.07.013 (* Co-first Authorship)

  • Ng KW, Marshall EA, Enfield KSS, Martin S, Milne K, Pewarchuk MP, Abraham A, Lam WL (2018). Somatic mutation-associated follicular helper T cell elevation in lung adenocarcinoma. Oncoimmunology, In press.

  • Enfield KSS, Martin SD, Marshall EA, Kung SHY, Gallagher P, Milne K, Chen Z, Nelson BH, Lam S, English JC, MacAulay CE, Lam WL, Guillaud M. Hyperspectral cell sociology reveals spatial tumour-immune cell interactions associated with lung cancer recurrence (2018). Journal for ImmunoTherapy of Cancer. In Press. 

  • Sage AP, Minatel BC, Marshall EA, Martinez VD, Stewart GL, Enfield KSS, Lam WL (2018) Expanding the miRAN transcriptome of human kideny and renal cell carcinoma. International Journal of Human Genomics, In press.

  • Minatel BC, Martinez VD, Ng, KW, Sage AP, Marshall EA, Anderson C, Tokar, T, Reis PP, Jurisica I, Lam WL (2019) Novel mIRNAs discovered in liver tissue display lineage-specific expession. Human Genomics 12(1), 16

  • Minatel BC*, Sage AP*, Anderson C, Hubaux R, Marshall EA, Lam WL, Martinez VD (2018). Environmental arsenic exposure: From genetic susceptibility to pathogenesis. Environment International 112:183-197. (* Co-first Authorship)

  • Sage AP, Martinez VD, Minatel BC, Pewarchuk MP, Marshall EA, MacAulay GM, Hubaux R, Pearson DD, Goodarzi AA, Dellaire G, Lam WL (2018). Genomics ad epigenetics of malignant mesothelioma. High-throughput, In press.

  • Martinez VD*, Firmino NS*, Marshall EA*, Anderson C, Wadsworth BJ, Ng KW, Lam WL, Bennewith KL. (2017) The piwi-interacting RNA transcriptome is regulated by hypoxia in human tumours. Scientific Reports 8(1):152-163. https://doi.org/10.1038/s41598-017-18462-z (* Co-first Authorship)
  • Enterina JR, Enfield KSS, Martinez VD, Ng KW, Marshall EA, Alvaro-Fuss M, Anderson C, Reis PP, Lam WL. (2017). Small non-coding RNAs at the DLK1-DIO3 locus are associated with progression of oral leukoplakia and survival of patients with head and neck cancer. Oncotarget. (Accepted)
  • Marshall EA*, Ng KW*, Kung SHY*, Conway EM, Martinez VD, Halvorsen EC, Rowbotham DA, Vucic EA, Plumb AW, Becker-Santos DD, Enfield KSS, Bennewith KL, Lockwood WW, Lam S, English JC, Abraham N, Lam WL. (2016). Emerging roles of T Helper 17 and Regulatory T Cells in lung cancer progression and metastasis. Molecular Cancer 15(1): 67, 1-15. (* Co-first Authorship)
  • Enfield KSS, Martinez VD, Marshall EA, Stewart G, Kung SHY, Enterina JR, Lam WL. (2016). Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome. Oncotarget 7(49):80957-66
  • Enterina JR,* Enfield KSS,* Anderson C, Marshall EA, Ng KW, Lam WL (2017) DLK1-DIO3 imprinted locus deregulation in development, respiratory diseases, and cancer. Expert Reviews of Respiratory Medicine 11(9):749-61. 
  • Ng KW*, Anderson C*, Marshall EA*, Minatel BC*, Enfield KSS, Saprunoff HL, Lam WL, Martinez VD (2016) Piwi-interacting RNAs in cancer: emerging functions and clinical utility. Molecular Cancer 15(1):5, 1-15 (*Co-first Authorship).
  • Marshall EA*, Ng KW*, Anderson C, Hubaux R, Thu KL, Lam WL, Martinez VD (2015) Gene expression analysis of microtubule affinity-regulating kinase 2 in non-small cell lung cancer. Genomics Data 6 (2015): 145–148. (* Co-first Authorship). 

  • Rowbotham DA, Marshall EA, Vucic EA, Kennett JY, Lam WL, Martinez VD (2014) DNA methylation changes and aging and age-related diseases. Journal of Aging Science 3(1): 1000130, 1-9.
 

Invited Talks

  • “XIST and miRNA sequestration: Insights into lncRNA-mediated gene regulation”. NCRI 2018. Glasgow, United Kingdom.

  • “Tumour evolution: Why haven’t we cured cancer already?”. Nerd Nite (2018) Vancouver, BC. https://vancouver.nerdnite.com/2018/11/02/nerd-nite-v-39-tumors-silk-and-art-in-space/

  • “Epithelial tumour suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinomas”. BC Cancer Summit (2018). Vancouver, BC

  • “Contribution of chronic obstructive pulmonary disease to a tumour-promoting microenvironment and the development of lung cancer”. Respiratory Rounds, Vancouver General Hospital. (2018) Vancouver, BC

  • “Using sex to decipher a mechanism of gene regulation”. Pathology Day 2018. Vancouver General Hospital.

  • “In depth analysis of XIST as a sex-specific miRNA sponge in NSCLC”. B.I.G. Research Day 2018. University of British Columbia 

  • “Increased T follicular helper cell infiltration in lung adenocarcinoma tertiary lymphoid organs”. International Assoication for the Study of Lung Cancer: 18th World Conference on Lung Cancer (2017). Yokohama, Japan.

  • “Gene expression deregulation in COPD patient airways is preserved in lung tumours”. BCCA Research Day 2017. BC Cancer Research Centre, Vancouver BC

  • “Women in Science: Careers in Scientific Research”. ACRSSS Career Day. Archbishop Carney Regional Secondary School, Port Coquitlam, BC  (2016)

  • "piRNA Expression is Deregulated in Hypoxia”. Tumour Hypoxia in the Genomic Era. William A. Webber Medical Student and Alumni Centre, University of British Columbia. Vancouver BC (2015)

  • "Differential expression of microRNAs in lung cancer subtypes". Lung Cancer Research Group Meeting, BC Cancer Research Centre. Vancouver BC (2014)

  • “Current Topics in Respiratory Oncology and Lung Cancer”.  Inquiry@Queen’s Conference, Queen's University. Kingston ON (2013)


Awards

  • Vanier Canada Graduate Scholarship (2018-2021)

  • Frederick Banting and Charles Best Canada Graduate Scholarship (CGS-D, Declined) (2018)

  • Roman M. Babicki fellowship in Medical Research, UBC Faculty of Medicine (2018)

  • UBC 4-year Fellowship (2018-2022)

  • UBC Pathology Top Graduate Student Poster (2018)

  • UBC B.I.G. Research Day Poster Prize (2018)

  • Frederick Banting and Charles Best Canada Graduate Scholarship (CGS-M) (2017)

  • Harry and Florence Dennison Fellowship in Medical Research (2016)

  • University of British Columbia Faculty of Medicine Graduate Award (2016)

  • Interdisciplinary Oncology Program Travel Award (2016)

  • UBC Graduate Student Travel Award (2016)

  • HackSeq "People's Choice" Project Award (2016)

  • J.M. Warren Award, First Place B.C. Cancer Studentship (2015)

  • Outstanding Presentation Award, "International Workshop: Tumor Hypoxia in the Genomic Era" (2015)

  • Lung Cancer Research Studentship, BC Cancer Research Centre (2014)

  • Clinical Respiratory Oncology Studentship, BC Cancer Research Centre (2013)

  • Queen's University Chancellor’s Scholarship (2012-2016)

  • Dean’s Honour’s List, Queen's University (2012-present)

  • Queen's University Principal’s Scholarship (2012-2014)

  • Governor General’s Academic Medal (2012)

  • HSBC BC Catholic Basketball Scholarship (2012)

  • REBGV Academic Excellence Scholarship (2012)

  • Archbishop James Carney Memorial Award (2012)

  • Passport to Education (2012)

  • The Province Newspaper “Head of the Class” Feature Story (2012)

  • Awards for Highest Grade in Principles of Mathematics 12, Chemistry 12, Biology 12, Physics 12, and History 12 (Archbishop Carney Regional Secondary School)


Abstracts

Abstracts Published at International Conferences (First and co-first authorships underlined, Selected from 48 total).

  • Marshall EA, Stewart GL, Sage AP, Lam WL, and Brown CJ (2018). XIST and miRNA sequestration: Insights into lncRNA-mediated gene regulation. NCRI UK. Glasgow, UK. Conference Date: 2018/11
  • Marshall EA, Anderson C, Ng KW, Minatel BC, Enfield KSS, Sage AP, Xu, Z, Lam WL, and Martinez VD (2018). Novel miRNAs as tissue-of-origin marker for distinguishing malignant pleural mesothelioma from lung adenocarcinoma. IASCL-AACR Joint Translational Conference. San Diego, California USA. Conference Date: 2018/01
  • Marshall EA, Vucic EA, Martinez VD, Ng RT, and Lam WL (2018). Alterations in G2/M phase associated transcriptional networks highlight lung cancer predisposition in COPD patients. IASCL-AACR Joint Translational Conference. San Diego, California USA. Conference Date: 2018/01
  • Marshall EA, Stewart GL, Sage AP, Lam WL, and Brown CJ (2018). X-inactivation specific transcript (XIST)-mediated miRNA sequestration in NSCLC. International Association for the Study of Lung Cancer: 19th World Conference on Lung Cancer. Conference Date: 2018/09
  • Marshall EA, Vucic EA, Martinez VD, Ng RT, Lam S, and Lam WL (2017). Concurrent aberrations in G2/M-phase transcriptional programs and genomic gatekeepers highlight lung cancer predisposition in COPD patients. Journal of Thoracic Oncology. International Association for the Study of Lung Cancer: 18th World Conference on Lung Cancer. Conference Date: 2017/10.
  • Marshall EA, Ng KW, Enfield KSS, Martin SD, Milne K, Kung SHY, MacAulay CE, and Lam WL (2017). Increased T follicular helper cell infiltration in lung adenocarcinoma tertiary lymphoid organs. Journal of Thoracic Oncology. International Association for the Study of Lung Cancer: 18th World Conference on Lung Cancer. Conference Date: 2017/10. Selected for invited talk
  • Marshall EA, Vucic EA, Martinez VD, Lam S, Ng RT, and Lam WL. (2017). Disruptions in G2/M-phase transcriptional programs and genomic gatekeepers suggest 2-hit model of lung cancer development in COPD patients. Canadian Cancer Research Conference. Conference Date: 2017/11
  • Marshall EA, Vucic EA, Martinez VD, Ng RT, and Lam WL (2017). Common molecular signatures in COPD and lung cancer indicate shared biology. Canary Foundation Symposium at Stanford University. Conference Date: 2017/05
  • Marshall EA, Pikor LA, Chari R, Kennett JY, Lam S, and Lam WL. (2016). Signal Regulatory Protein A (SIRPA): A key regulator of the EGFR pathway demonstrates both tumor suppressive and oncogenic properties. Journal of Thoracic Oncology. International Assoication for the Study of Lung Cancer: 17th World Conference on Lung Cancer. Conference Date: 2016/12. IOP Travel Award (2016)
  • Marshall EA, Pikor LA, Chari R, Kennett JY, Lam S, and Lam WL. (2016). SIRPA is a key regulator of the EGFR pathway and lungadenocarcinoma tumorigenesis. Cell Symposia: Hallmarks of Cancer Abstract Book. Cell Symposia: Hallmarks of Cancer. Conference Date: 2016/12. UBC Graduate Student Travel Award (2016)
  • Marshall EA, Chari R, Kennett JY, Lam S, Lam WL, and Pikor LA. (2016). Integrative genomics analysis identifies SIRPA as a key regulator of the EGFR pathway with both tumor suppressive and oncogenic properties. ASHG 2016 Abstract Book. American Society of Human Genetics Annual Meeting. Conference Date: 2016/10
Abstracts at Local and National Conferences (First and co-first authorships underlined, Selected from 29). 
  • Marshall EA, Stewart GL, Sage AP, Lam WL, and Brown CJ (2018). XIST and miRNA sequestration: Insights into lncRNA-mediated gene regulation. BC Cancer Summit. Vancouver, BC
  • Marshall EA, Martinez VD, Minatel BC, Anderson C, NG KW, Enfield KSS, Sage AP, Xu Z, and Lam WL (2018). Malignant pleural mesothelioma tissue-of-origin classifiers developed from novel miRNA sequences. BC Cancer Summit. Vancouver, BC
  • Marshall EA, Stewart GL, Sage AP, Lam WL, and Brown CJ (2018). Analysis of XIST as a sex-specific miRNA sponge in non-small cell lung cancer. Pathology Day. University of British Columbia, Vancouver BC. Poster Prize: 1st place. Selected for invited talk.
  • Marshall EA, Stewart GL, Sage AP, Lam WL, and Brown CJ (2018). In depth analysis of XIST as a sex-specific miRNA sponge in NSCLC. B.I.G. Research Day. University of British Columbia, Vancouver BC. Poster Prize: 3rd place. Selected for invited talk.
  • Marshall EA, Stewart GL, Sage AP,  Lam WL, and Brown CJ (2018). X-inactivation specific transcript (XIST)-mediated miRNA sequestration in NSCLC. BC Cancer Research Day. Vancouver BC.
  • Marshall EA, Vucic EA, Martinez VD, and Lam WL. (2017). Common molecular signatures in COPD and lung cancer indicate shared biology. BCCA Research Day
  • Marshall EA, Chari R, Kennett JY, Wistuba I, Gazdar AF, Lam S, Lam WL, and Pikor LA. (2017). Signal Regulatory Protein Alpha regulates the EGFR pathway and plays a key role in lung tumorigenesis. B.I.G. Research Day
  • Marshall EA, Chari R, Kennett JY, Lam WL, and Pikor LA. (2016). SIRPA is a key regulator of the EGFR pathway with dichotomous tumour suppressive and oncogenic function in lung adenocarcinoma. Terry Fox Research Institute BC Node Day Abstract Book. Terry Fox Research Institute BC Node Day. Conference Date: 2016/11

Links

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab |