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Erin Marshall

PhD Candidate


ErinLab2015 Erin2015.jpg


Erin Marshall | emarshall@bccrc.ca | 604-675-8000 ext 7703 | 10th floor - 675 W.10th Avenue, Vancouver, BC, V5Z1L3, Canada
BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab | Erin Marshall |


 Training

  • B.Sc. Honours with Distinction (Queen’s University), Specialization in Biochemistry 

  • Dogwood Diploma, Archbishop Carney Regional Secondary School (Valedictorian)

  • J.M. Warren BC Cancer Research Centre Studentship (2015)                  

  • Lung Cancer Research Summer Studentship, BC Cancer Research Centre (2014)                                            

  • Clinical Respiratory Oncology Studentship, BC Cancer Research Centre (2013)

Program

  •  Interdisciplinary Oncology, Faculty of Medicine, University of British Columbia

Research Interests

  • Small RNAs in lung cancer

  • Early lung cancer development and tumour initiation

  • Common molecular mechanisms in COPD and lung cancer initiation


Publications

Journal Articles (First and co-first authorships underlined).

  • Ng KW,* Marshall EA*, Bell JC, Lam WL.(2017) The emerging tumorigenic capacity of cGAS-STING. Trends in Immunology (In Press). https://doi.org/10.1016/j.it.2017.07.013 (* Co-first Authorship)

  • Marshall EA, Sage AP, Ng KW, Martinez VD, Firmino NS, Bennewith KL, Lam WL (2017) Small non-coding RNA transcriptome of the NCI-60 cell line panel. Scientific Data 4:170157, 1-8. doi: 10.1038/sdata.2017.157.
  • Martinez VD*, Firmino NS*, Marshall EA*, Anderson C, Wadsworth BJ, Ng KW, Lam WL, Bennewith KL. (2017) The piwi-interacting RNA transcriptome is regulated by hypoxia in human tumours. Scientific Reports (Accepted) (* Co-first Authorship)
  • Minatel BC, Sage AP, Anderson C, Hubaux R, Marshall EA, Lam WL, Martinez VD. (2017) Environmental arsenic exposure:from genetic susceptibility to pathogenesis. Environment International.
  • Enterina JR, Enfield KSS, Martinez VD, Ng KW, Marshall EA, Alvaro-Fuss M, Anderson C, Reis PP, Lam WL. (2017). Small non-coding RNAs at the DLK1-DIO3 locus are associated with progression of oral leukoplakia and survival of patients with head and neck cancer. (Submitted)
  • Marshall EA*, Ng KW*, Kung SHY*, Conway EM, Martinez VD, Halvorsen EC, Rowbotham DA, Vucic EA, Plumb AW, Becker-Santos DD, Enfield KSS, Bennewith KL, Lockwood WW, Lam S, English JC, Abraham N, Lam WL. (2016). Emerging roles of T Helper 17 and Regulatory T Cells in lung cancer progression and metastasis. Molecular Cancer. 15(1): 67, 1-15. (* Co-first Authorship)
  • Enfield KSS, Martinez VD, Marshall EA, Stewart G, Kung SHY, Enterina JR, Lam WL. (2016). Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome. Oncotarget. 7(49):80957-66
  • Enterina JR,* Enfield KSS,* Anderson C, Marshall EA, Ng KW, Lam WL (2017) DLK1-DIO3 imprinted locus deregulation in development, respiratory diseases, and cancer. Expert Reviews of Respiratory Medicine. 11(9):749-61. 
  • Ng KW*, Anderson C*, Marshall EA*, Minatel BC*, Enfield KSS, Saprunoff HL, Lam WL, Martinez VD (2016) Piwi-interacting RNAs in cancer: emerging functions and clinical utility. Molecular Cancer. 15(1):5, 1-15 (*Co-first Authorship).
  • Marshall EA*, Ng KW*, Anderson C, Hubaux R, Thu KL, Lam WL, Martinez VD (2015) Gene expression analysis of microtubule affinity-regulating kinase 2 in non-small cell lung cancer. Genomics Data. 6 (2015): 145–148. (* Co-first Authorship). 

  • Rowbotham DA, Marshall EA, Vucic EA, Kennett JY, Lam WL, Martinez VD (2014) DNA methylation changes and aging and age-related diseases. Journal of Aging Science 3(1): 1000130, 1-9.
 

Invited Talks

  • “Increased T follicular helper cell infiltration in lung adenocarcinoma tertiary lymphoid organs”. International Assoication for the Study of Lung Cancer: 18th World Conference on Lung Cancer (2017). Yokohama, Japan.

  • "Common molecular mechanism in CODP and lung cancer indicate shared biology". BCCA Research Day, BC Cancer Research Centre (2017)

  • “piRNA Expression is Deregulated in Hypoxia”. International Workshop: Tumour Hypoxia in the Genomic Era. William A. Webber Medical Student and Alumni Centre, University of British Columbia. Vancouver BC (2015)

  • Differential expression of microRNAs in lung cancer subtypes”. Lung Cancer Research Mini-Symposium, BC Cancer Research Centre. Vancouver BC (2014)

  • Adenocarcinoma and squamous cell carcinoma microRNA expression". Workshop on lung cancer origins and genetic mechanisms, BC Cancer Research Centre. Vancouver BC (2014)

  • "Differential expression of microRNAs in lung cancer subtypes". Lung Cancer Research Group Meeting, BC Cancer Research Centre. Vancouver BC (2014)

  • “Current Topics in Respiratory Oncology and Lung Cancer”.  Inquiry@Queen’s Conference, Queen's University. Kingston ON (2013).


Awards

  • CIHR CGS-M Graduate Scholarship (2017)

  • Harry and Florence Dennison Fellowship in Medical Research (2016)

  • University of British Columbia Faculty of Medicine Graduate Award (2016)

  • Interdisciplinary Oncology Program Travel Award (2016)

  • UBC Graduate Student Travel Award (2016)

  • HackSeq "People's Choice" Project Award (2016)

  • J.M. Warren Award, First Place B.C. Cancer Studentship (2015)

  • Outstanding Presentation Award, "International Workshop: Tumor Hypoxia in the Genomic Era" (2015)

  • Lung Cancer Research Studentship, BC Cancer Research Centre (2014)

  • Clinical Respiratory Oncology Studentship, BC Cancer Research Centre (2013)

  • Queen's University Chancellor’s Scholarship (2012-2016)

  • Dean’s Honour’s List, Queen's University (2012-present)

  • Queen's University Principal’s Scholarship (2012-2014)

  • Governor General’s Academic Medal (2012)

  • HSBC BC Catholic Basketball Scholarship (2012)

  • REBGV Academic Excellence Scholarship (2012)

  • Archbishop James Carney Memorial Award (2012)

  • Passport to Education (2012)

  • The Province Newspaper “Head of the Class” Feature Story (2012)

  • Awards for Highest Grade in Principles of Mathematics 12, Chemistry 12, Biology 12, Physics 12, and History 12 (Archbishop Carney Regional Secondary School

 

Abstracts

Abstracts Published at International Conferences (First and co-first authorships underlined).

  • Marshall EA, Vucic EA, Martinez VD, Ng RT, Lam S, and Lam WL. Concurrent aberrations in G2/M-phase transcriptional programs and genomic gatekeepers highlight lung cancer predisposition in COPD patients. Journal of Thoracic Oncology. International Association for the Study of Lung Cancer: 18th World Conference on Lung Cancer. Conference Date: 2017/10. 
  • Marshall EA, Ng KW, Enfield KSS, Martin SD, Milne K, Kung SHY, MacAulay CE, and Lam WL. Increased T follicular helper cell infiltration in lung adenocarcinoma tertiary lymphoid organs. Journal of Thoracic Oncology. International Association for the Study of Lung Cancer: 18th World Conference on Lung Cancer. Conference Date: 2017/10. 
  • Marshall EA, Vucic EA, Martinez VD, Lam S, Ng RT, and Lam WL. (2017).Disruptions in G2/M-phase transcriptional programs and genomic gatekeepers suggest 2-hit model of lung cancer development in COPD patients. Canadian Cancer Research Conference 
  • Marshall EA, Vucic EA, Martinez VD, Ng RT, and Lam WL (2017). Common molecular signatures in COPD and lung cancer indicate shared biology. Canary Foundation Symposium at Stanford University. Conference Date: 2017/05 
  • Ng KW, Marshall EA, Enfield KSS, and Lam WL. (2017). Antitumour B cell responses to lung adenocarcinoma are driven by T follicular helper cell infiltration in tertiary lymphoid organs. EMBO: B cells in Health and Disease.
  • Enterina JR, Enfield KSS, Martinez VD, Ng KW, Marshall EA, and Lam WL. (2017). Deregulated small non-coding RNA genes at the imprinted DLK1-DIO3 locus in Head and Neck cancer. Genome BC Annual Meeting 
  • Sage AP, Stewart GL, Enfield KSS, Marshall EA, Martinez VD, and Lam WL. (2017). Modulation of long non-coding RNA expression in metastatic lung adenocarcinoma. Canadian Cancer Research Conference 
  • Martinez VD, Marshall EA, Firmino N, Minatel BC, Bennewith KL, and Lam WL. (2017). Hypoxia-induced modifications of the small non-coding RNA transcriptome delineates risk of recurrence in early-stage lung adenocarcinoma. IASLC 18th World Conference on Lung Cancer 
  • Ng KW, Enfield KSS, Marshall EA, and Lam WL. (2017). Early presence of tertiary lymphoid organs and T follicular helper cells in lung adenocarcinoma. Crick International Cancer Conference 
  • Martinez VD, Ng KW, Marshall EA, Sage AP, Minatel BC, and Lam WL. (2017). Arsenic induces persistent alterations in lung cancer small non-coding RNA transcriptome. Workshop on Advances and Roadblocks for use of Genomics Data in Cancer Risk Assessment for Drugs and Chemicals Poster 
  • Sage AP, Stewart GL, Anderson C, Rowbotham DA, Enfield KSS, Marshall EA, Martinez VD, and Lam WL. (2017). Alternative regulation of cancer-associated genes through modulation of long non-coding RNAs. IASLC 18th World Conference on Lung Cancer 
  • Martinez VD, Ng KW, Marshall EA, Sage AP, Minatel BC, and Lam WL. (2017). Arsenic-induced alterations in the lung small non-coding RNA transcriptome targets epigenetic pathways. Canadian Cancer Research Conference 
  • Sage AP, Stewart GL, Enfield KSS, Marshall EA, Martinez VD, and Lam WL. (2017). Long non-coding RNA disruption in lung adenocarcinoma reveals novel mechanisms of metastasis. IASLC 18th World Conference on Lung Cance
  • Martinez VD, Ng KW, Marshall EA, Sage AP, Minatel BC, and Lam WL. (2017). Arsenic induces persistent alterations in lung cacner small non-coding RNA transcriptomes. Human Genomics Abstract Book. Human Genome Meeting 2017. Submitted.
  • Martinez VD, Ng KW, Marshall EA, Sage AP, Minatel BC, and Lam WL. (2017). Analysis of PIWIinteracting RNA transcriptomes reveal cancer type-specific signatures predicting lung tumour behaviour. Human Genomics Abstract Book. Human Genomics Meeting 2017. Submitted.
  • Minatel BC, Marshall EA, Ng KW, Enfield KSS, Lam S, Lam WL, and Martinez VD. (2016). Piwiinteracting RNAs display cancer-specific expression patterns that hold prognostic value in lung cancer. Journal of Thoracic Oncology. International Association for the Study of Lung Cancer: 17th World Conference on Lung Cancer. Vienna, Austria.
  • Enterina JR, Enfield KSS, Martinez VD, Marshall EA, Stewart GS, and Lam WL. (2016). Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung adenocarcinoma patient outcome. Journal of Thoracic Oncology. International Association for the Study of Lung Cancer: 17th World Conference on Lung Cancer. Vienna, Austria.
  • Enterina JR, Enfield KSS, Martinez VD, Marshall EA, Stewart GS, and Lam WL. (2016). Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung adenocarcinoma patient outcome. Cell Symposia: Hallmarks of Cancer Abstract Book. Cell Symposia: Hallmarks of Cancer. Ghent, Belgium. 
  • Marshall EA, Pikor LA, Chari R, Kennett JY, Lam S, and Lam WL. (2016). Signal Regulatory Protein A (SIRPA): A key regulator of the EGFR pathway demonstrates both tumor suppressive and oncogenic properties. Journal of Thoracic Oncology. International Assoication for the Study of Lung Cancer: 17th World Conference on Lung Cancer. Vienna, Austria.
  • Martinez VD, Vucic EA, Marshall EA, Enfield KSS, Minatel BC, Rahmati S, Abovsky M, Jurisica I, MacAulay CE, Lam S, and Lam WL. (2016). Integrated multi'omics analysis identifies common pathogenetic molecular phenotypes of lung cancer and COPD. Journal of Thoracic Oncology. International Association for the Study of Lung Cancer: 17th World Conference on Lung Cancer. Vienna, Austria.
  • Minatel BC, Martinez VD, Marshall EA, Ng KW, Enfield KSS, and Lam WL. (2016). PIWI-interacting RNAs expression networks associated with clinically-relevant tumor features and patient prognosis. Cell Symposia: Hallmarks of Cancer Abstract Book. Cell Symposia: Hallmarks of Cancer. Ghent, Belgium. 
  • Kung SHY, Enfield KSS, Rowbotham DA, Marshall EA, Holly A, Pastrello C, Minatel BC, Dellaire G, Jurisica I, and Lam WL. (2016). Combined overexpression of miR-106 paralogs regulates metastasis and is associated with poor outcome. Cell Symposia: Hallmarks of Cancer Abstract Book. Cell Symposia: Hallmarks of Cancer. Ghent, Belgium. 
  • Marshall EA, Pikor LA, Chari R, Kennett JY, Lam S, and Lam WL. (2016). SIRPA is a key regulator of the EGFR pathway and lungadenocarcinoma tumorigenesis . Cell Symposia: Hallmarks of Cancer Abstract Book. Cell Symposia: Hallmarks of Cancer. Ghent, Belgium.
  • Martinez VD, Vucic EA, Thu KL, Marshall EA, Enfield KSS, Minatel BC, Rahmati S, Abovsky M, Jurisica I, MacAulay CE, Lam S, Ng RT, and Lam WL. (2016). Integrated multi'omics analysis identifies pathogenetic molecular phenotypes of lung cancer and COPD. ASHG 2016 Abstract Book. American Society of Human Genetics Annual Meeting. Vancouver, Canada. 
  • Enfield KSS, Rowbotham DA, Rahmati S, Anderson C, Kennett JY, Marshall EA, Chari R, Becker-Santos DD, Ng, KW, MacAulay CE, Lam S, Lockwood WW, Jurisica I, and Lam WL. (2016). Alterations to the ELF3 oncogene circumvent upstream regulation in lung cancer. ASHG 2016 Abstract Book. American Society of Human Genetics Annual Meeting. Vancouver, Canada. 
  • Minatel BC, Firmino NS, Marshall EA, Bennewith KL, Lam WL, and Martinez VD. (2016). Comprehensive identification of piwi-interacting RNAs binding sites associated with hypoxia-inducible genes downregulation. ASHG 2016 Abstract Book. American Society of Human Genetics Annual Meeting. Vancouver, Canada. 
  • Enfield KSS, Rahmati S, Rowbotham DA, Fuller M, Anderson C, Kennett JY, Marshall EA, Chari R, BeckerSantos DD, Ng KW, MacAulay CE, Lam S, Lockwood WW, Karsan A, Jurisica I, and Lam WL. (2016). Frequent genetic selection of the ELF3 oncogene leads to cancer-specific reprogramming. Journal of Thoracic Oncology. International Association for the Study of Lung Cancer: 17th World Conference on Lung Cancer. Vienna, Austria.
  • Kung SHY, Enfield KSS, Rowbotham DA, Marshall EA, Suzuki M, Holly A, Pastrello C, Minatel BC, Dellaire G, Jurisica I, MacAulay C, Lam S, and Lam WL. (2016). Expression of miR-106 paralogs improves prognostic value of mesenchymal signatures but only miR-106b promotes invasiveness. Journal of Thoracic Oncology. Association for the Study of Lung Cancer: 17th World Conference on Lung Cancer. Vienna, Austria.
  • Enfield KSS, Rowbotham DA, Rahmati S, Anderson C, Kennett JY, Marshall EA, Chari R, Becker-Santos DD, Ng KW, MacAulay CE, Lam S, Lockwood WW, Jurisica I, and Lam WL. (2016). Alterations to the ELF3 oncogene circumvent upstream regulation in lung cancer. ASHG 2016 Abstract Book. American Society of Human Genetics Annual Meeting. Vancouver, Canada.  
  • Firmino NS, Marshall EA, Minatel BC, Lam WL, Bennewith KL, and Martinez VD. (2016). Hypoxia regulates piwi-interacting RNAs in human tumors. ASHG 2016 Abstract Book. American Society of Human Genetics Annual Meeting. Vancouver, Canada.  
  • Marshall EA, Chari R, Kennett JY, Lam S, Lam WL, and Pikor LA. (2016). Integrative genomics analysis identifies SIRPA as a key regulator of the EGFR pathway with both tumor suppressive and oncogenic properties. ASHG 2016 Abstract Book. American Society of Human Genetics Annual Meeting. Vancouver, Canada. 
  • Ng KW, Minatel BC, Marshall EA, Enfield KSS, Lam S, Lam WL, Martinez VD. (2016). Piwi-interacting RNAs display cancer-specific expression patterns that hold prognostic value in lung cancer. ASHG 2016 Abstract Book. American Society of Human Genetics Annual Meeting. Vancouver, Canada. 
  • Enfield KSS, Anderson C, Marshall EA, Ng KW, Minatel BC, Rowbotham DA, Chari R, Fuller M, Milne K, Becker-Santos DD, MacAulay C, Karsan A, Lam S, Lam WL. (2016). ELF3 amplification at 1q32. 1 promotes SMAD4-independent tumorigenesis. Journal of Thoracic Oncology. World Conference on Lung Cancer (11(2):S20-21)
  • Enfield KSS, Anderson C, Marshall EA, Ng KW, Minatel BC, Rowbotham DA, Chari R, Fuller M, Milne K, Becker-Santos DD, MacAulay C, Karsan A, Lam S, Lam WL. (2016). ELF3 amplification at 1q32.1 promotes SMAD4-independent tumourigenesis. AACR Conference Abstract Book. Fourth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic
Abstracts at Local and National Conferences (First and co-first authorships underlined).
  • Marshall EA, Chari R, Kennett JY, Lam WL, and Pikor LA. (2016). SIRPA is a key regulator of the EGFR pathway with dichotomous tumour suppressive and oncogenic function in lung adenocarcinoma. Terry Fox Research Institute BC Node Day Abstract Book. Terry Fox Research Institute BC Node Day. Vancouver, Canada. 
  • Martinez VD, Minatel BC, Marshall EA, Ng KW, Enfield KSS, Firmino NS, Bennewith KL, Lam S, and Lam WL. (2016). Analysis of piwi-interacting RNA transcriptomes identify cancer type-specific expression patterns and signatures predicting lung tumour behaviour. 7th Annual TFRI Scientific Meeting. 7th Annual Terry Fox Research Institute Scientific Meeting. Vancouver, Canada
  • Enfield KSS, Rowbotham DA, Anderson C, Marshall EA, Ng KW, Minatel BC, Chari R, Fuller M, BeckerSantos DD, MacAulay CE, Lam S,Lockwood WW, Karsan A, and Lam WL. (2016). ELF3 amplification circumvents dependency on upstream driver mutations in lung adenocarcinoma. 7th Annual TFRI Scientific Meeting. 7th Annual Terry Fox Research Institute Scientific Meeting. Vancouver, Canada. 

Links

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