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Emily A. Vucic, PhD

Post-doctoral research associate

Emily Vucic 


evucic@bccrc.ca   675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada 

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab | Emily Vucic |


Previous Training

  • PhD (Pathology and Laboratory Medicine), University of British Columbia, September 2014

  • BSc (Cell Biology and Genetics), University of British Columbia, April 2007

  • Associate's Degree (Applied Chemistry and Biotechnology), Camosun College, April 2003


Research Interests

I am very interested in understanding how and why cancer develops in environments of chronic inflammation. Chronic inflammation is associated with an increased risk of cancer in many organs, including the lung in the context of chronic obstructive pulmonary disease (COPD). My thesis research focused on developing and applying an integrative multi-omics approach to deciphering the biology driving lung cancer in the context of COPD and smoking. My goal is to extend the scope of this work to understand how chronic exposure to damaging agents such as inflammation and reactive oxidative species alters metabolic and epigenetic systems to promote tumour development in the lung and other organs.


Scholarships & Awards

  • 2015 AJRCMB Award for Most Outstanding Paper by a Junior Investigator, American Thoracic Society (2015)
  • Lloyd Skarsgard Research Excellence Prize for Best BC Cancer Agency Graduate Student (2014)
  • Terry Fox Research Institute Trainee Travel Award, 5th Annual Scientific Meeting (2014)
  • Four Year Doctoral Fellowship, University of British Columbia (2010-2014)
  • Canada Graduate Scholarships, Frederick Banting and Charles Best Doctoral Award, Canadian Institutes of Health Research (2010 - 2013)
  • Young Investigator Award, International Association for the Study of Lung Cancer, World Congress of Lung Cancer (2011)
  • Travel Award, Canadian Student Health Research Forum, Canadian Institutes of Health Research (2011)
  • Travel Award, Faculty of Medicine, Dean's Office, University of British Columbia (2011)
  • Outstanding abstract for International Conference Presentation, Cancer Genetics Scholar in Training Award, BCCRC (2010)
  • Tuition Award for Academic Excellence, Department of Pathology and Laboratory Medicine, University of British Columbia (2009)
  • Tuition Award for Academic Excellence, Department of Pathology and Laboratory Medicine, University of British Columbia (2009) 
  • Outstanding Presentation Award, Mini-Symposium on Molecular Dysregulation in Epithelial Cancers  (2009)
  • Outstanding Presentation Award, Mini Symposium on Genetic Engineering of Cell Models, Vancouver, BC (2009)
  • Betty Rice Award, Lung Cancer Research, Vancouver, BC (2008) 
  • Graduate Student Excellence Award, Tom Brown Award for Cancer Research, Vancouver, BC (2008) 
  • Dr. Don Rix Best Student Abstract Award, World Microarray Congress,  Vancouver, BC (2008) 
  • Scholar-in-Training Award supported by AstraZeneca, AACR Frontiers in Cancer Prevention Research Conference, Philadelphia, PA (2007) 

Publications

  • Martinez VD, Vucic EA, Thu KL, Hubaux R, Enfield KSS, Pikor LA, Becker-Santos DD, Brown CJ, Lam S, Lam WL (2015) Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology. Scientific Reports. 5:10423, 1-17. [PMID:26013764]
  • Hubaux R, Thu KL, Vucic EA, Pikor LA, Kung SHY, Martinez VD, Mosslemi M, Becker-Santos DD, Gazdar AF, Lam S, Lam WL (2015) Microtubule affinity-regulating kinase 2 contributes to cisplatin sensitivity through modulation of the DNA damage response in non-small cell lung cancer. International Journal of Cancer. In press. [PMID:25907283]
  • Martinez VD*, Vucic EA*, Thu KL, Pikor LA, Lam S, Lam WL (2015) Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms is associated with poor prognosis in head and neck cancer. Head and Neck 37(5):727-3. [PMID: 24596130] *co-first authors
  • Vucic EA†*,Thu KL*, Pikor LA, Enfield KSS, Yee, J, English JC, Macaulay CE, Lam S, Lam WL. Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology. BMC Cancer, 2014. In press. *co-first authors, corresponding author
  • Vucic EA, Chari R, Wilson IM, Cotton AM, Thu KL, Kennett JY, Zhang M, Lonergan KM, Steiling K, Brown CJ, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, MacAulay CE, Lam S, Lam WL. DNA methylation is globally disrupted and associated with expression changes in COPD small airways. American Journal of Respiratory Cell Molecular Biology, 2014:50(5):912-22. [PMID: 24298892] corresponding author

  • Wilson IM*, Vucic EA*, Enfield KSS, Thu KL, Zhang Y-A, Chari R, Lockwood WW, Radulovich N, Starczynowski DT, Banáth JP, Zhang M, Pusic A, Fuller M, Lonergan KM, Rowbotham D, Yee J, English JC, Buys TPH, Selamat SA, Laird-Offinga I, Liu P, Anderson M, You M, Tsao-MS, Brown CJ, Bennewith KL, MacAulay CE, Karsan A, Gazdar AF, Lam S, Lam WL. EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene2014:Sep 4;33(36):4464-73. [PMID: 24096489] *co-first authors
  • Martinez VD*, Vucic EA*, Thu KL, Pikor LA, Lam S, Lam WL. Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms is associated with poor prognosis in head and neck cancer. Head and Neck. In press. [PMID: 24596130] *co-first authors
  • Rowbotham DA, Marshall EA, Vucic EA, Kennett JY, LamWL, Martinez VD. Epigenetic Changes and Aging. Journal of Aging Science, 2014. In press.

  • Martinez VD, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL. Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer. BioMed Research International 2014:159459, 1-10. [PMID: 25114896]
  • Rowbotham D*, Enfield KSS*, Martinez VD*, Thu KL Vucic EA, Stewart GL,  Bennewith KL, Lam WL. Multiple components of the VHL tumor suppressor complex are frequently affected by DNA copy number losses in pheochromocytoma. International Journal of Endocrinology. In press.
  • Olthof NC, Speel EJM, Kolligs J, Haesevoets A, Henfling M, Ramaekers FCS, Preuss SF, Drebber U, Silling S, Lam WL, Vucic EA, Kremer B, Klussmann JP, Huebbers CU. Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression. PLoS ONE, 2014:9(2):e88718, 1-8. [PMID: 24586376]
  • Martinez VD, Vucic EA, Lam S, Lam WL. Emerging arsenic threat in Canada. Science, 2013:342(6158):559. [PMID: 24179203]
  • Martinez VD*, Vucic EA*, Pikor LA, Thu KL, Hubaux R, Lam WL. Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer. Molecular Cancer, 2013:12:124, 1-6. [PMID: 24138990] *co-first authors
  • Pikor LA, Lockwood WW, Thu KL, Vucic EA, Chari R, Gazdar AF, Lam S, Lam WL. Integrative analysis identifies YEATS4, a novel oncogene in NSCLC that regulates the p53 pathway. Cancer Research, 2013:73:7301-12. [PMID: 24170126]
  • Pikor L, Thu K, Vucic E, Lam W. The detection and implication of genome instability in cancer. Cancer Metastasis Review, 2013:32:341-52. [PMID:23510327]
  • Martinez VD, Thu KL, Vucic EA, Hubaux R, Adonis M, Gil L, Ling V, MacAulay C, Lam S, Lam WL. Whole genome sequencing analysis identifies a distinctive mutational spectrum in an arsenic-related lung tumor. Journal of Thoracic Oncology, 2013:8:1451-5.[PMID: 24128716]
  • Coe BP*, Thu KL*, Aviel-Ronen S, Vucic EA, Gazdar A, Lam S, Tsao MS, Lam WL. Genomic deregulation of the Rb/E2F leads to activation of the oncogene EZH2 in small cell lung cancer. PLoS ONE, 2013:8(8):e71670, 1-8. [PMID: 23967231]
  • Dong X, Lin D, Low C, Vucic EA, English JC, Yee J, Murray N, Lam WL, Ling V, Lam S, Gout PW, Wang Y. Elevated expression of BIRC6 protein in non-small-cell lung cancers is associated with cancer recurrence and chemoresistance. Journal of Thoracic Oncololgy, 2013:8:161-70. [PMID: 23287853]
  • Vucic EA*, Thu KL*, Robison K, Rybaczyk L, Chari R, Alvarez CE, Lam WL. Translating cancer omics to outcomes.Genome Research, 2012:22:188-95. [PMID: 22301133]. *co-first authors, corresponding author
  • Thu KL, Vucic EA, Chari R, Zhang W, Lockwood WW, English JC, Fu R, Wang P, Feng Z, Macaulay CE, Gazdar AF, Lam S, Lam WL. Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability.  PLoS ONE, 2012:7(3): e33003, 1-10. [PMID: 22412972]
  • Martinez VD, Vucic EA, Lam S, Lam WL. Arsenic and lung cancer in never smokers: Lessons from Chile. American Journal of Respiratory and Critical Care Medicine, 2012:185: 1131-2. [PMID: 22589318]
  • Martinez VD, Vucic EA, Adonis M, Gil L, Lam WL. Arsenic biotransformation as a cancer promoting factor by inducing DNA damage and disruption of repair mechanisms. Molecular Biology International, 2011:718974, 1-11.
  • Gibb EA, Vucic, EA, Enfield KSS, Stewart GL, Lonergan KM, Kennett JY, Becker-Santos DD, MacAulay CE, Lam S, Brown CJ, Lam WL. Human cancer long non-coding RNA transcriptomes. PLoS ONE, 2011:6:e25915,1-10. [PMID: 21991387]
  • Martinez VD, Vucic EA, Becker-Santos DD, Gil L, Lam WL. Arsenic exposure and the induction of human cancers. Journal of Toxicology2011:431287,1-13.
  • Martinez VD, Becker-Santos DD, Vucic EA, Lam S, Lam WL. Induction of human squamous cell-type carcinomas by arsenic. Journal of Skin Cancer2011: 454157,1-9.
  • Chari R, Coe BP, Vucic EA, Lockwood WW, Lam WL. An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer. BMC Systems Biology, 2010:4: 67, 1-14. [PMID: 20478067]
  • Vucic EA, Thu KL, Williams AC, Lam WL, Coe BP. Copy number variations in the human genome and strategies for analysis. Methods in Molecular Biology, 2010:628:103-17. [PMID: 20238078] corresponding author
  • Thu KL*, Vucic EA*, Kennett JY, Heryet C, Brown CJ, Lam WL, Wilson IM. Methylated DNA Immunoprecipitation. Journal of Visualized Experiments, 2009:23. pii: 935. doi: 10.3791/935. [PMID:19241501] *co-first author
  • Vucic EA, Wilson IM, Campbell JM, Lam WL. Methylation analysis by DNA immunoprecipitation (MeDIP). Methods in Molecular Biology, 2009:556:141-53. corresponding author
  • Vucic EA, Brown CJ, Lam WL. Epigenomics of cancer progression. Pharmacogenomics, 2008:9: 215-34. [PMID:18370850] corresponding author
  • Chari R, Coe BP, Wedseltoft C, Benetti M, Wilson IM., Vucic EA., MacAulay C, Ng RT, Lam WL. SIGMA2: A system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes. BMC Bioinformatics, 2008:9, 422: 1-12. [PMID:18840289]
  • Kuo A, Wilson IM, Vucic E, Lee E, Davies JJ, MacAulay C, Brown C, Lam WL. Comparative cancer epigenomics. In Comparative Genomics: Fundamental and Applied Perspectives. (2008) James R. Brown (ed.) CRC Press, Taylor & Francis Publisher. 261-79.
  • Garnis C, Lockwood WW, Vucic E, Ge Y, Girard L, Minna JD, Gazdar AF, Lam S, MacAulay C, Lam WL. High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH. International Journal of Cancer, 2006:118: 1556-64. [PMID:16187286] 

Selected Invited Talks and Lectures

  • "Analytical approaches for integrating multi-’omics data",450K Workshop Series, Vancouver, BC (April, 2014)

  • Invited “Rising Star” speaker at Institute for Heart and Lung Health Leaders Breakfast Forum: “Exemplary Rising Stars for Better Heart + Lung Health”, Vancouver, BC (December 2013)

  • “Genome-wide disruption of DNA methylation patterns associated with gene expression changes in COPD small airways" Pacific Northwest Epithelial Biology Meeting, Vancouver, BC (December 2013)

  • “A multi-platform approach to biomarker discovery in lung cancers in never smokers” BC Cancer Agency Lung Tumour Team—3 year progress, Canary Foundation Annual Conference, Stanford University, Palo Alto, CA (July 2013)

  • “Aberrant DNA methylation patterns are widespread in small airways of former smokers with chronic obstructive pulmonary disease (COPD)” American Thoracic Society International Conference in Philadelphia, PA (May 2013)

  • “DNA Methylation changes in COPD and COPD-related lung cancer”, Vancouver General Hospital Respiratory Clinical Lecture Series, Vancouver, BC (March 2013)

  • "Contribution of DNA methylation to the development of lung cancer in smokers with chronic obstructive pulmonary disease", International Association for the Study of Lung Cancer, 14th World Conference on Lung Cancer, Amsterdam, NL (July 2011)

  • "DNA methylation analysis of small airways from COPD patients with and without lung cancer", British Columbia Lung Tumour Group meeting, Vancouver, BC (January 2011)

  • "Global DNA methylation analysis of bronchial epithelial cells from patients with asthma, COPD with and without lung cancer”, American Thoracic Society International Conference, New Orleans, LA (May 2010)

  • Press conference, “Identifying molecular mechanisms of lung cancer development in former smokers”, American Association of Cancer Research, Frontiers in Cancer Prevention conference, Washington, DC (November 2008)

  •  “Global methylation analysis of oligodendroglioma”, Vancouver General Hospital, Department of Neuropathology Grand Rounds, Vancouver, BC (November 2008)


Abstracts and Presentations

1.    Vucic EA, Thu KL, Martinez VD, Pastrello C, Yee J, Jurisica I, Lam S, Lam WL. (2014) Lung tumors and non-malignant airways from patients with chronic lung inflammatory disease bear distinct genetic and epigenetic disruptions corresponding to metabolic processes involved in senescence and methylation. Metabolism, Diet and Disease 2014: Cancer and Metabolism. Washington, DC

2.    Vucic EA, Martinez VD, Thu KL, Pikor LA, Lam S, Lam WL. (2014) Genetic and Epigenetic Contribution to Chronic Obstructive Pulmonary Disease Related Lung Cancer. Keystone Symposia on Molecular and Cellular Biology: Cancer Epigenetics. Santa Fe, NM

3.    Vucic EA, Martinez VD, Thu KL, Pikor LA, Enfield KSS, Yee J, Lam S, Lam WL. (2014) Distinct genetic and epigenetic disruptions in lung tumours and small airways of patients with chronic obstructive pulmonary disease and lung cancer. The Terry Fox Research Institute 5th Annual Scientific Meeting. Montreal, QC

4.    Vucic EA, Chari R, Wilson IM, Thu KL, Kennett JY, Steiling K, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, MacAulay CE, Lam S, Lam WL. (2013) Aberrant DNA methylation patterns are widespread in small airways of former smokers with chronic obstructive pulmonary disease (COPD). 2013 American Thoracic Society Annual Conference Philadelphia, PA

5.    Vucic EA, Pikor LA, Thu KL, Ramnarine VR, Enfield KSS, Macaulay CE, Lam S, Lam WL. (2012) Contribution of smoking to miRNA deregulation in lung tumours. Mechanisms & Models of Cancer, Cold Spring Harbor Laboratory Meetings, Mechanisms & Models of Cancer Program and Abstracts, pg 44. Cold Spring Harbor, NY

6.    Pikor L, Thu KM, Vucic EA, Lam S, Lam WL. (2012) miRNAs display subtype specific patterns of aberrant expression in lung adenocarcinoma & squamous cell carcinoma.  Mechanisms & Models of Cancer, Cold Spring Harbor Laboratory Meetings, Mechanisms & Models of Cancer Program and Abstracts, pg 35. Cold Spring Harbor, NY

7.    Thu KL, Mosslemi M, Pikor LA, Vucic EA, Zhang W, Selamat SA, Laird-Offringa IA, Gazdar AF, Lam S, MacAulay CA, Lam WL. (2012) Pathway profiles of lung adenocarcinoma in smokers and never smokers.  Mechanisms & Models of Cancer, Cold Spring Harbor Laboratory Meetings, Mechanisms & Models of Cancer Program and Abstracts, pg 42. Cold Spring Harbor, NY

8.    Becker-Santos DD, Vucic EA, Lam S, Lam WL, Martinez VD. (2012) Molecular Events in Arsenic-Related Lung Cancer. World Cancer Congress, Montreal, QC.  Abstract# 2012WCC-2637

9.    Becker-Santos DD, Vucic EA, Lam S, Lam WL, Martinez VD. (2011) Genomic and epigenomic events in arsenic-related lung squamous cell carcinomas from smokers and never smokers. AACR-IASLC meeting

10.  Vucic EA, Thu KL, Chari R, Sin D, Lam S, Lam WL. (2011) Epigenetics of lung cancer development in smokers with Chronic Obstructive Pulmonary Disease.  Canadian Institute of Health Research (CIHR), 24th annual Canadian Student Health Research Forum (CSHRF), Winnipeg, MB.

11.  Vucic EA, Thu KL, Kennett JY, Chari R, Coxson H, Sin D, Lam S, Lam WL. (2011) Contribution of DNA methylation in the development of lung cancer in smokers with Chronic Obstructive Pulmonary Disease.  International Association for the Study of Lung Cancer (IASLC), 14th World Conference on Lung Cancer, Amsterdam, The Netherlands. Abstract #1445

12.  Wilson I, Vucic EA, Enfield KSS, Chari R, Zhang YA, Radulovich N, Starczynowski D, Banath J, Zhang M, Pusic A, Fuller M, Lonergan K, Buys T, Yee J, Laird-Offringa IA, Liu P, Tsao MS, Anderson M, You M, Bennewith K, Karsan A, MacAulay CE, Lam S, Gazdar AF, Lam WL. (2011) EYA4 is a frequently inactivated tumour suppressor gene within the 6q lung cancer susceptibility locus. International Association for the Study of Lung Cancer (IASLC), 14th World Conference on Lung Cancer, Amsterdam, The Netherlands.

13.  Stewart GL, Thu K, Vucic EA, Kennett JY, Pikor LA, Chari R, Lam WL, Lam S. (2011) Gender related genomic differences in lung adenocarcinoma. International Association for the Study of Lung Cancer (IASLC), 14th World Conference on Lung Cancer, Amsterdam, The Netherlands.

14.  Vucic EA, Wilson IM, Chari R, Siwoski M, Lonergan KM, Lam S, Lam WL. (2010) DNA methylation analysis of airway epithelia from former smokers with COPD, with and without lung cancer.  British Columbia Cancer Agency Annual Conference.  Vancouver, BC.

15.  Enfield KSS, Wilson IM, Vucic EA, Chari R, Zhang YA, You M, MacAulay CA, Lam SL, Gazdar AF, Lam WL. (2010) EYA4 is a putative lung tumor suppressor on 6q23-25 with a role in DNA repair and apoptosis. British Columbia Cancer Agency Annual Conference.  Vancouver, BC.

16.  Stewart GL, Vucic EA, Chari R, Wilson IM, Lonergan KM, Lam S, Lam WL. (2010) Reversibly Expressed and Differentially Methylated Genes in Airways of Current and Former Smokers. British Columbia Cancer Agency Annual Conference. Vancouver, BC.

17.  Stewart GL, Vucic EA, Chari R, Wilson IM, Lonergan KM, Lam S, Lam WL. (2010) Reversibly Expressed and Differentially Methylated Genes in Airways of Current and Former Smokers.  American Association for Cancer Research: Frontiers in Cancer Prevention Research, Frontiers in Cancer Prevention 2010 Program and Proceedings, p72-73.  Philadelphia, PA.

18.  Vucic EA, Wilson IM, Chari R, Kennett JY, Lonergan KM, Lam S, Lam WL. (2010) Global DNA Methylation Analysis of Bronchial Epithelia of Former Smokers with COPD, with and without Lung Cancer.  American Association for Cancer Research: Frontiers in Cancer Prevention Research, Frontiers in Cancer Prevention 2010 Program and Proceedings, p74.  Philadelphia, PA

19.  Enfield KSS, Wilson IM, Vucic EA, Chair R, Zhang YA, You M, MacAulay C, Gazdar AF, Lam S, Lam WL. (2010) EYA4 is a risk- and survival-associated TSG that is deleted and hypermethylated in the earliest stages of NSCLC. American Association for Cancer Research: Frontiers in Cancer Prevention Research, Frontiers in Cancer Prevention 2010 Program and Proceedings, p76-77.  Philadelphia, PA

20.  Vucic EA, Wilson IM, Chari R, Sin D, Coxson H, Lam WL, Lam S. (2010) Global DNA Methylation Analysis of Bronchial Epithelial Cells from Patients with Asthma, COPD with and without lung cancer.  American Thoracic Society Annual Conference, ATS 2010 International Conference Final Program, p 316.  New Orleans, LA.

21.  Pikor L, Lockwood WW, Vucic EA, Chari R, Lam S, Lam WL. (2010) Amplification of GAS41, an oncogene in lung cancer. American Association for Cancer Research Annual Conference. Washington, DC.

22.  Wilson IM, Enfield KSS, Vucic EA, Chari R, Zhang YA, You M, MacAulay CA, Lam SL, Gazdar AF, Lam WL. (2010) A novel lung tumor suppressor implicated in somatic and familial cancers. American Association for Cancer Research Annual Conference. Washington, DC.

23.  Wilson IM, Vucic E, Buys T, Chari R, Lam S, Lam WL. (2009) Identification of a novel lung cancer tumour suppressor in a risk-associated region. ComBio 2009, Australian Society for Biochemistry and Molecular Biology. Christchurch, New Zealand.

24.  Vucic EA, Lockwood WW, Garnis C. (2009) Copy Number Variation with Gene Expression Changes Specific to Normal Lung Tissue and Tumors of Lung Cancer Patients. Mini Symposium on Genetic Engineering of Cell Models, British Columbia Cancer Research Centre, 2009. Vancouver, BC.

25.  Vucic EA, Lockwood WW, Garnis C. (2009) Knock Down of Glioma-Amplified Sequence 41 (GAS41) in a Lung Adenocarcinoma Cell Line. Mini Symposium on Genetic Engineering of Cell Models, British Columbia Cancer Research Centre, 2009. Vancouver, BC.

26.  Vucic EA, Buys T, Chari R, Brown CJ, MacAulay C, Lam WL. (2009) Methylation as a mechanism of multidrug resistance in ovarian carcinoma. Annual Conference, Department of Pathology & Laboratory Medicine, 2009 Pathology Day Program and Abstracts, 2009 Pathology Day Abstract Book, pg 40. Vancouver, BC.

27.  Vucic EA, Wilson IM, Coe BP, Chari R, Lam S, Lam WL. (2009) The role of DNA methylation in development of lung cancer in former smokers. Annual Conference, Department of Pathology & Laboratory Medicine, 2009 Pathology Day Program and Abstracts, 2009 Pathology Day Abstract Book, pg 39. Vancouver, BC.

28.  Vucic EA, Wilson IM, Coe BP, Chari R, Lockwood WW, Lam S, Lam WL. (2008) Identifying molecular mechanisms of lung cancer development in former smokers. 2008 British Columbia Cancer Research Association Conference. Vancouver, BC.

29.  Vucic EA, Wilson IM, Coe BP, Chari R, Lockwood WW, Lam S, Lam WL. (2008) Contribution of DNA Methylation in Development of Lung Cancer in Former Smokers. American Association for Cancer Research: Frontiers in Cancer Prevention Research, pg 77. Washington, DC.

30.  Vucic EA, Wilson IM, Lam S, Lam WL. (2008) Discovery of tumor suppressor genes in non-small cell lung cancer by integrative genome wide epigenetic and genetic analysis. World Microarray Congress.  Vancouver, BC.

31.  Wilson IM, Vucic E, Lam SL, Lam WL. (2008) A multi-dimensional approach to tumor suppressor gene discovery in non-small cell lung cancer. Annual Conference, Department of Pathology & Laboratory Medicine, 2008 Pathology Day Program and Abstracts, 2008 Pathology Day Abstract Book, pg 47.   Vancouver, BC.

32.  Vucic E, Chari R, Buys T, Wilson IM, Brown CJ, MacAulay C, Lam WL. (2008) Multidimensional approach to delineate epigenetic and genetic contribution to multidrug resistance in ovarian carcinoma. Annual Conference, Department of Pathology & Laboratory Medicine, 2008 Pathology Day Program and Abstracts, 2008 Pathology Day Abstract Book, pg 72.  Vancouver, BC.

33.  Vucic EA, Wilson IM, Lam S, Lam WL. (2008) Parallel epigenetic and genetic approach to discovery of tumor suppressor genes in non-small cell lung cancer.  Marie Curie Genomic Architecture in Relation to Disease. Cellular Oncology, 2008; 30 (3): pg 278.  Madrid, Spain

34.  Kennet JY, Chari R, Vucic EA, Lam WL, Shadeo A. (2008) Two-hit mechanism of deregulation of gene control in breast cancer. Canadian Breast Cancer Research Alliance Reasons for Hope, poster #64.  Vancouver, BC.

35.  Chari R, Shadeo A, Vucic EA, Kennett JY, Lam WL. (2008) Multi-dimensional genetic, epigenetic and gene expression analysis of breast cancer. Canadian Breast Cancer Research Alliance Reasons for Hope, poster #58.  Vancouver, BC.

36.  Vucic EA, Chari R, Buys T, Brown CJ, MacAulay C, Lam WL. (2008) A multi-dimensional approach to delineate mechanisms of multidrug resistance in ovarian carcinoma.  American Association for Cancer Research Annual Conference.  San Diego, CA.

37.  Wilson IM, Vucic E, MacAulay C, Lam SL, Lam WL. (2007) Epigenomic analysis of bronchial epithelial cells in smokers at risk of developing lung cancer. American Association for Cancer Research: Frontiers in Cancer Prevention Research, pg 100.  Philadelphia, PA.

38.  Vucic E, Wilson I, Lam S, Lam WL. (2007) Whole Genome Survey for Epigenetic Changes in Response to EGCG Treatment in Lung Cancer Cells.   American Association for Cancer Research: Frontiers in Cancer Prevention Research, pg 118.  Philadelphia, PA.

39.  Vucic E, Chari R, Buys T, Brown CJ., MacAulay C, Lam WL. (2007) Multi-dimensional Analysis of Multidrug Resistance in Ovarian Carcinoma.  2007 British Columbia Cancer Conference Proceedings. Vancouver, BC.

40.  Vucic E, Lockwood WW, Wilson I, Chari R, Coe BP, MacAulay C, Lam S, Lam WL. (2007) Integrative Whole Genome Genetic and Epigenetic Analysis of Lung Tumor Genomes. American Society of Human Genetics 57th Annual Meeting. San Diego, CA.

41.  Vucic EA, Chari R, Buys T, Brown CJ, MacAulay C, Lam WL. (2007) Epigenetic and genetic contribution to vincristine resistance in ovarian carcinoma. World Microarray Congress 2007. Vancouver, BC.

42.  Lockwood WW, Vucic E, Wilson I, Chari R, Coe BP, MacAulay C, Lam S, Lam WL. (2007) Novel Genetic and Epigenetic Features of Lung Tumor Genomes.  World Microarray Congress 2007. Vancouver, BC.

43.  Vucic EA, Lockwood WW, Chari R, Coe BP, MacAulay C, Lam S, Lam WL (2007).  High resolution analysis of copy number amplifications in cancer genomes. Human Genome Organization (HUGO) 12th Human Genome Meeting Proceedings, pg 54. Montreal, QC.

44.  Vucic EA, Chari R, Campbell J, Brown C, MacAulay C, Lam WL. (2007) Comprehensive Whole Genome and Epigenome Integrated Analysis of Drug Resistance in Ovarian Cancer. Annual Conference, Department of Pathology & Laboratory Medicine, 2007 Pathology Day Program and Abstracts, 2007 Pathology Day Abstract Book, p 50. Vancouver, BC.

45.  Wilson IM, Davies JJ, Buys TPH, Chari R, Lockwood WW, Vucic E, Lam WL. (2007) DNA Methylation Landscape Comparisons of Non-Small Cell Lung Cancers. Annual Conference, Department of Pathology & Laboratory Medicine, 2007 Pathology Day Program and Abstracts, 2007 Pathology Day Abstract Book, p 11. Vancouver, BC.

46.  Vucic E, Chari R, Buys T, Brown CJ, MacAulay C, Lam WL. (2007)  Integrative Genetic and Epigenetic Analysis of Multi Drug Resistance in Ovarian Carcinoma. TechMed British Columbia, Vancouver, BC.

47.  Vucic E, Chari R, Buys TPH, Lam WL. (2007) Drug resistance in ovarian cancer: Genome and Epigenome Integrated Analysis. University of British Columbia Multidisciplinary Undergraduate Research Conference (MURC), MURC Abstracts p16. Vancouver, BC.

48.  Vucic E, Davies J, Wilson I, Lam W. (2006) Whole genome and epigenomic progression profile of 5-azacytidine treated non small cell lung carcinoma cell line, HCC15. Annual Conference, Department of Pathology & Laboratory Medicine, 2006 Pathology Day Program and Abstracts, pg 63. Vancouver, BC.

49.  Vucic E, Chari R, Davies J, Buys TPH, Wilson I, MacAulay C, Lam WL. (2006) Comprehensive whole genome and epigenome integrated analysis of drug resistance in ovarian cancer Genome British Columbia Annual Conference. Vancouver, BC.

50.  Swartz J, Chen W-K, Vucic E, Lam W, McBride K, Alvarez C. (2006) Genome-wide analysis of DNA methylation patterns in human childhood diseases National Conference on Undergraduate Research (NCUR). Columbus, OH.

51.  Chen W-K, Swartz J, Vucic E, Lam W, McBride K, Alvarez C. (2006) Identification of Genome-wide Methylation Patterns in Human Childhood Diseases. National Conference on Undergraduate Research (NCUR). Columbus, OH.

52.  Wilson IM, Davies JJ, Vucic E, Lockwood WW, MacAulay C, Lam S, Lam WL. (2006) Whole-Genome Integration of Copy Number and DNA Methylation Data in Lung Squamous Cell Carcinoma. 2006 British Columbia Cancer Conference Proceedings, pg 57. Vancouver, BC.

53.  Vucic E, Wilson IM, Buys TPH, Chari R, MacAulay C, Lam S, Lam WL. (2006) Integrative genomic and epigenomic analysis defines DNA alterations in lung adenocarcinoma.  2006 British Columbia Cancer Conference Proceedings, pg 53. Vancouver, BC.

54.  Garnis C, Vucic E, Baldwin C, Zhang L, Rosin MP, Lam WL. (2005) Monitoring genomic changes that parallel oral cancer progression. 96th Annual American Association of Cancer Research Conference Proceedings, pg 208. Anaheim, CA.

55.  Vucic E, Garnis C, Davies J, MacAulay C, Lam S, Lam WL. (2004) Whole genome display of lung squamous cell lines Canadian Federation of Biological Societies (CFBS) 47th Annual Meeting: Northern Lights Summer Conference Proceedings, pg 67.  Vancouver, BC.

56.  Garnis C, Davies JJ, Vucic E, MacAulay C, Lam S, Lam WL. (2004) Novel genetic alterations in early stage lung cancer. 54th American Society of Human Genetics Annual Meeting Proceedings, pg 366.  Toronto, ON. 

57.  Davies JJ, Garnis C, Vucic E, Baldwin C, deLeeuw R.J, Watson SK, MacAulay C, Lam WL. (2004) Whole genome array CGH identifies micro-genetic alterations in cancer. 54th American Society of Human Genetics Annual Meeting Proceedings, pg 489.  Toronto, ON.

58.  Garnis C, Davies J, Vucic E, Coe B, Ge Y, Gazdar A, Ramirez R, Shay J, Minna J, MacAulay C, Lam S, Lam W. (2004) Whole genome sub-megabase resolution tiling (SMRT) array comparative genomic hybridization (CGH) analysis of lung cancer and immortalized cell lines. 2004 Winter Lung Cancer SPORE meeting Proceedings, pg 14.  Baltimore, MD.

  


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