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Wan L. Lam, PhD

Distinguished Scientist - Genetics Unit, Integrative Oncology   Rm 10-112 ▪ 675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada 


Heather Saprunoff: , 604-675-8111; Caitlin Clugston: , 604-675-8110

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics and Developmental Biology | Wan Lam Lab |


Current Appointments

Distinguished Scientist, Integrative Oncology, BC Cancer Agency
Deputy Head, Integrative Oncology Department, BC Cancer Agency
Professor, Pathology and Laboratory Medicine, University of British Columbia
Director, Interdisciplinary Oncology Program, University of British Columbia


BSc, MSc (Microbiology), with Kenneth L. Roy, University of Alberta
PhD (Biochemistry), with W. Ford Doolittle, Dalhousie University
MRC Post-Doctoral Fellow (Cellular and Developmental Biology), with Walter Gilbert, Harvard University
Post-Doc Res Assoc (Molecular and Cellular Biology), with Walter Gilbert, Harvard University

Research Interests

Cancer progression, Genome biology, Epigenetics, Molecular systems biology, Lung cancer, Technology development

Early events in lung cancer
COPD and lung cancer development
Environmental carcinogenesis

Tumour Genomics
Comparative lung cancer system biology in former smokers and non-smokers
Gene discovery in aggressive lung tumours (metastasis, treatment response)
Epigenetic mechanisms of cancer gene regulation
Reactivation of developmental coding and non-coding genes in cancer

Tumour Microenvironment
Hyperspectral imaging tool development (with Calum MacAulay and Martial Guillaud)
Cell sociology associations with lung cancer patient outcome
Gene expression of immune cells

Wan Lam Lab Members

2018 Lab Members: Adam Sage, Brenda Minatel, Christine Anderson, Daiana Becker, Erin Marshall, Flávia Bessi Constantino, Florian Guisier, Gavin MacAulayGreg Stewart, Heather Saprunoff, Jhon Ralph Enterina, Katey EnfieldKevin Ng, Kim Lonergan, Leigha Rock, Mateus De Camargo Barros Filho, May Zhang, Michelle PewarchukMiwa Suzuki, Sonia Kung, Spencer MartinVictor Martinez, Wan Lam

Graduate Student Alumni:
Adrian Ishkanian, Alice Kuo, Arek Siwosiki, Ashleen Shadeo, Bradley Coe, Cathie Garnis, Chad Malloff, Corrie Baldwin, David RowbothamEmma Conway, Emily Vucic, Eric Lee,  Ian Wilson,  Ivy Tsui, Jennifer Campbell, Jennifer Kennett, Jonathan Davies, Kelsie Thu, Krista Cleveland, Larissa Pikor, Laura-Jane Henderson, Mitra Mosslemi, Raj Chari, Ron DeLeeuw, Timon Buys, Varune Rohan Ramnarine, Will Lockwood  | Staff, Fellows and Research Students Alumni: Allison Pahl, Andre Soesilo, Andrea Pusic, Andrew Lam, Arjun Pradhan, Andrew Thomson, Anna Chu, Andy Lo, Baljit Kamoh, Blair Gervan, Byron Cline, Carol Cheng, Catherine Laprise, Craig Wedseltoft, David Walsh, Doug Shaw, Devon Macey, Drew Murray, Ewan Gibb, Francien van Nederveen, Giulia Del Gobbo, Greg Vatcher, Hilde Dannenberg, Ichiro Okamoto, Jacqui Whiteway, J-C Cutz, Jin Hee Kim, Julia Chae, Julia Whyte, Kelly Kasteel, Kendy Wong, Lan Wei, Lana Galac, Laura Aslan, Laura Willihnganz, Leigh Stickney, Lindsey Kimm, Lily Whitehead, Magan Trottier-Chi, Mark Siwarski, Menglin Yang, Marieke Aarts, Marie Benetti, Mark Siwoski, Marta Ungar, Meghan Pearson, Media Farshchi, Monica Alvaro Fuss, Nirpjit Dosanjh, Neil Klompas, Pamela Calderon, Phillip Wang, Philomena Kaan, Pouya Azar, Rachel Lim, Reginald Sacdalan, Roland Hubaux, Sandra Henderson, Spencer Watson, Stevan Knezevich, Tiffany Wolters, Teresa Mastracci, Shaminder Sandhu, Tiffany Chao, Timin Hadi, Tony Qin, Valerie Malla, Wendy Peng, Yong Ge

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab |

Wan Lam Lab Publications


  • Enfield KSS*, Martin SD*, Marshall EA, Kung SHY, Gallagher P, Milne K, Chen Z, Nelson BH, Lam S, English JC, MacAulay CE, Lam WL, Guillaud M (2019)  Hyperspectral cell sociology tools for the study of tumor-immune cell interactions in lung cancer. Hyperspectral cell sociology reveals tumor-immune cell interactions associated with lung cancer recurrence. Journal fo ImmunoTherapy of Cancer 7(1):13, 1-13. [PMID:30651131].


  • Huebbers CU, Verhees F, Poluschkin L, Olthof NC, Kolligs J, Siefer OG, Henfling M, Ramaekers FCS, Preuss SF, Beutner D, Seehawer J, Drebber U, Korkmaz Y, Lam WL, Vucic EA, Kremer B, Klussmann JP, Speel EM (2019) Differential mRNA expression analysis revealed deregulated AKR1C1 and AKR1C3 in OPSCC with integrated HPV16. International Journal of Cancer. [Epub ahead of print 2018 Oct 27] [PMID:30367463]

  • O'Farrell H, Harbourne B, Kurlawala Z, Inoue Y, Nagelberg AL, Martinez VD, Lu D, Oh MH, Coe BP, Thu KL, Somwar R, Lam S, Lam WL, Unni AM, Beverly L, Lockwood WW (2019) Integrative genomic analysis identifies GGA2 as a cooperative driver of EGFR mediated lung tumorigenesis. Journal of Thoracic Oncology. [Epub ahead of print 2018 Dec 19] [PMID:30578931]

  • Martinez VD*, Sage AP*, Marshall EA, Suzuki M, Goodarzi AA, Dellaire G, Lam WL (2019) Oncogenetics of lung cancer induced by environmental carcinogens. In Oncogene. Pinar Erkekoǧlu ed., InTechOpen, London. In press.

  • Ng KW, Marshall EA, Bell JC, Lam WL (2018) The emerging tumorigenic capacity of cGAS-STING. Trends in Immunology 39(1):44-54. [PMID:28830732]
  • Ng KW, Marshall EA, Enfield KSS, Martin SD, Milne K, Pewarchuk ME, Abraham N, Lam WL (2018) Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma. Oncoimmunology. 7(12):e150472,1-8. [PMID: 30524903]

  • Minatel BC*, Sage AP*, Anderson C, Hubaux R, Marshall EA, Lam WL, Martinez VD (2017) Environmental arsenic exposure: genetic and epigenetic contributions to carcinogenesis. Environment International 112:183-197. [PMID:29275244]
  • Martinez VD, Firmino N, Marshall EA, Ng KW, Wadsworth BJ, Anderson C, Lam WL, Bennewith KL (2018) Non-coding RNAs predict recurrence-free survival of patients with hypoxic tumours. Scientific Reports 8(1):152, 1-12. [PMID: 29317756]
  • Sage AP*, Martinez VD*, Minatel BC, Pewarchuk ME, MacAulay GM, Marshall EA, Hubaux R, Pearson DD, Goodarzi AA, Dellaire G, Lam WL (2018) Genomics and epigenetics of malignant mesothelioma. High Thorughput 7(3):20, 1-23. [PMID: 30060501]

  • Minatel BC*, Martinez VD*, Ng KW, Sage AP, Tokar T, Marshall EA, Anderson C, Enfield KSS, Stewart GL, Reis PP, Jurisica I, Lam WL (2018) Large-scale discovery of previously undetected microRNAs in human liver. Human Genomics. 12(1):16, 1-6. [PMID: 29587854]

  • Sage AP*, Minatel BC*, Marshall EA, Martinez VD, Stewart GL, Enfield KSS, Lam WL (2018) Expanding the miRNA transcriptome of human kidney and renal cell carcinoma. International Journal of Genomics 2018: 6972397, 1-10. [PMID: 30057905]

  • Tokar T, Pastrello C, Ramnarine VR, Zhu CQ, Craddock KJ, Pikor LA, Vucic EA, Shepherd FA, Tsao MS, Lam WL, Jurisica I  (2018) Differentially expressed microRNAs in lung adenocarcinoma invert effects of copy number aberrations of prognostic genes. Oncotarget 9(10):9137-55. [PMID: 29507679]
  • Kumaran M, Krishnan P, Cass CE, Hubaux R, Lam WL, Yasui Y, Damaraju S (2018) Breast cancer associated germline structural variants harboring small noncoding RNAs impact post-transcriptional gene regulation. Scientific Reports 8(1):7529, 1-11.[PMID: 29760470]
  • Xu S, Tsai A, Sze MA, Vucic EA, Shaipanich T, Harris M, Guillemi S, Yang J, Sinha S, Nislow C, Montaner J, Lam W, Lam S, Sin DD, Paul Man SF, Leung JM (2018) Decreased microbiome diversity in the HIV small airway epithelium. Respiratory Research 19(1):140, 1-8. [PMID: 30053882].
  • Xu S, Vucic EA, Shaipanich T, Lam S, Lam W, Montaner JS, Sin DD, Paul Man SF, Leung JM (2018) Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV). Respiratory Research 19(1):117, 1-4. [PMID: 29895291]


  • Marshall EA, Sage AP, Ng KW, Martinez VD, Firmino NS, Bennewith KL, Lam WL (2017) Small non-coding RNA transcriptome of the NCI-60 cell line panel. Scientific Data 4:170157, 1-8. [PMID: 29064465]
  • Enterina JR*, Enfield KSS*, Anderson C, Marshall EA, Ng KW, Lam WL (2017) DLK1-DIO3 imprinted locus deregulation in development, respiratory disease, and cancer. Expert Reviews of Respiratory Medicine 11(9):749-761. [PMID:28715922]
  • Becker-Santos DD, Lonergan KM, Gronostajski RM, Lam WL (2017) Nuclear Factor I/B: a master regulator of cell differentiation with paradoxical roles in cancer. EBioMedicine 22:2-9. [PMID: 28596133]
  • Kumaran M, Krishnan P, Cass C, Graham K, Mackey JR, Yasui Y, Hubaux R, Lam WL, Damaraju S (2017) Germline copy number variations are associated with breast cancer risk and prognosis. Scientific Reports 7(1):14621, 1-14. [PMID:29116104]
  • Sage AP, Minatel BC, Ng KW, Stewart GL, Dummer T, Lam WL, Martinez VD (2017) Oncogenomic disruptions in arsenic-induced carcinogenesis. Oncotarget. 8(15):25736-55 [PMID:: 28179585]
  • Thu KL, Papari-Zareei M, Stastny V, Song K, Peyton M, Martinez VD, Zhang YA, Castro IB, Varella-Garcia M, Liang H, Xing C, Kittler R, Milchgrub S, Castrillon DH, Davidson HL, Reynolds CP, Lam WL, Lea J, Gazdar AF (2017) A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas. Oncotarget. 8(31):50489-99. [PMID:28881577]
  • Obeidat M, Nie Y, Fishbane N, Bossé Y, Joubert P, Nickle DC, Hao K, Postma DS, Timens W, Sze MA, Shannon C, Hollander Z, Ng RT, McManus B, Miller BE, Rennard S, Spira A, Hackett TL, Lam W, Lam S, Hogg JC, Sin DD, Paré PD (2017) Integrative genomics of emphysema associated genes reveals potential disease biomarkers. American Journal of Respiratory Cell and Molecular Biology 57(4):411-8. [PMID:28459279]
  • Yadav S, Singh N, Shah PP, Rowbotham DA, Malik D, Srivastav A, Shankar J, Lam WL, Lockwood WW, Beverly LJ (2017) MIR155 regulation of Ubiquilin1 and Ubiquilin2: implications in cellular protection and tumorigenesis. Neoplasia 19(4):321-32. [PMID::28315615]


  • Becker-Santos DD, Thu KL, English JC, Pikor LA, Martinez VD, Zhang M, Vucic EA, Luk MT, Carraro A, Korbelik J, Piga D, Lhomme NM, Tsay MJ, Yee J, MacAulay CE, Lam S, Lockwood WW, Robinson WP, Jurisica I, Lam WL (2016) Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma. Journal of Pathology 240(2):161-72.  [PMID: 27357447]

  • Enfield KSS, Martinez VD, Marshall EA, Stewart GL, Kung SHY, Enterina JR, Lam WL (2016) Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome. Oncotarget 7(49):80957-66 [PMID:27829231]

  • Sze MA, Xu S, Leung JM, Vucic EA, Shaipanich T, Moghadam A, Harris M, Guillemi S, Sinha S, Nislow C, Murphy D, Hague C, Leipsic J, Lam S, Lam W, Montaner JS, Sin DD, Man SF (2016) The bronchial epithelial cell bacterial microbiome and host response in patients infected with human immunodeficiency virus. BMC Pulmonary Medicine 16:142, 1-10.  [PMID:27829448]

  • Marshall EA, Ng KW, Kung SH, Conway EM, Martinez VD, Halvorsen EC, Rowbotham DA, Vucic EA, Plumb AW, Becker-Santos DD, Enfield KS, Kennett JY, Bennewith KL, Lockwood WW, Lam S, English JC, Abraham N, Lam WL (2016) Emerging roles of T Helper 17 and Regulatory T Cells in lung cancer progression and metastasis. Molecular Cancer 15:67, 1-15.  [PMID:27784305]

  • Ng KW, Anderson C, Marshall EA, Minatel BC, Enfield KS, Saprunoff HL, Lam WL, Martinez VD (2016) Piwi-interacting RNAs in cancer: emerging functions and clinical utility. Molecular Cancer 15(1):5, 1-13. [PMID: 26768585]

  • Conway EM, Pikor LA, Kung SHY, Hamilton M, Lam S, Lam WL*, Bennewith KL* (2016) Macrophages, inflammation and lung cancer. American Journal of Respiratory and Critical Care Medicine 193(2):116-30. [PMID: 26583808]
  • Cinegaglia NC, Andrade SCS, Tokar T, Pinheiro M, Severino FE, Oliveira RA, Hasimoto EA, Cataneo DC, Cataneo AJM, Defaveri J, Souza CP, Marques MMC, Carvalho RF, Coutinho LL, Gross JL, Rogatto SR, Lam WL, Jurisica I, Reis PP (2015) Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma. Oncotarget. In press.. [Epub ahead of print 2016 Apr 12. doi: 10.18632/oncotarget.8713] [PMID: 27081085]
  • Martinez VD, Enfield KSS, Rowbotham DA, Lam WL (2016) An atlas of gastric PIWI-Interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence. Gastric Cancer 19(2):660-5. [PMID:25779424]
  • Crea F, Quagliata L, Michael A, Liu HH, Frumento P, Azad AA, Xue H, Pikor L, Watahiki A, Morant R, Eppenberger-Castori S, Wang Y, Parolia A, Lennox KA, Lam WL, Gleave M, Chi KN, Pandha H, Wang Y, Helgason CD (2016) Integrated analysis of the prostate cancer small-nucleolar transcriptome reveals SNORA55 as a driver of prostate cancer progression. Molecular Oncology 10(5):693-703. [PMID: 26809501]
  • Firmino N, Martinez VD, Rowbotham DA, Enfield KSS, Bennewith KL, Lam WL, (2016) HPV status alters PIWI-interacting RNA expression pattern in head and neck cancer.  Oral Oncology 55:43-8. [PMID: 26852287]
  • Clermont PL, Crea F, Chiang YT, Lin D, Zhang A, Wang JZ, Parolia A, Wu R, Xue H, Wang Y, Ding J, Thu KL, Lam WL, Shah SP, Collins CC, Wang Y, Helgason CD (2016) Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer. Clinical Epigenetics 8: 16, 1-14. [PMID: 26877821]
  • Crea F, Venalainen E, Ci X, Cheng H, Pikor L, Parolia A, Xue H, Nur Saidy NR, Lin D, Lam W, Collins C, Wang Y (2016) The role of epigenetics and long noncoding RNA MIAT in neuroendocrine prostate cancer. Epigenomics 8(5):721-31. [PMID: 27096814]
  • Sunpaweravong P, Thu KL, Lam WL, Mai S (2016) Assessment of the clinical relevance of 17q25.3 copy number and three-dimensional telomere organization in non-small lung cancer patients. Journal of Cancer Research and Clinical Oncology 142(4):749-56. [PMID: 26621152]
  • Martinez VD, Garnis C, Lam WL (2016) Oral Cancer. In Encyclopedia of Cancer. 4th Edition (Manfred Schwab ed.) Springer-Verlag Berlin Heidelberg. In press.
  • Buys T, Lam WL (2016) Malignancy Associated Changes. In Encyclopedia of Cancer. 4th Edition (Manfred Schwab ed.) Springer-Verlag Berlin Heidelberg. In press. 


  • Kulic I, Robertson G, Chang L, Baker JHE, Lockwood WW, Mok W, Fuller M, Fournier M, Chou V, Robinson MD, Chun HJ, Gilks B, Kempkes B, Thompson TA, Hirst M, Minchinton AI, Lam WL, Jones S, Marra M, Karsan A (2015) Loss of the Notch effector RBPJ promotes tumorigenesis. Journal of Experimental Medicine. 212(1):37-52. [PMID:25512468]
  • Radulovich N, Leung L, Ibrahimov E, Navab R, Sakashita S, Lockwood WW, Thu KL, Fedeshyn Y, Moffat J, Lam WL, Tsao MS (2015) Coiled-coil domain containing 68 (CCDC68) demonstrates a tumor-suppressive role in pancreatic ductal adenocarcinoma. Oncogene 34(32):4238-47. [PMID:25381825]
  • Martinez VD, Vucic EA, Thu KL, Pikor LA, Lam S, Lam WL (2015) Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms is associated with poor prognosis in head and neck cancer. Head and Neck 37(5):727-3. [PMID: 24596130]
  • Martinez VD, Vucic EA, Thu KL, Hubaux R, Enfield KSS, Pikor LA, Becker-Santos DD, Brown CJ, Lam S, Lam WL (2015) Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology. Scientific Reports 5:10423, 1-17. [PMID:26013764]
  • Hubaux R, Thu KL, Vucic EA, Pikor LA, Kung SHY, Martinez VD, Mosslemi M, Becker-Santos DD, Gazdar AF, Lam S, Lam WL (2015) Microtubule affinity-regulating kinase 2 contributes to cisplatin sensitivity through modulation of the DNA damage response in non-small cell lung cancer. International Journal of Cancer 137(9):2072-82. [PMID:25907283]
  • Marshall EA, Ng KW, Anderson C, Hubaux R, Thu KL, Lam WL, Martinez VD (2015) Gene expression analysis of microtubule affinity-regulating kinase 2 in non-small cell lung cancer. Genomics Data. 6 (2015): 145–8. [PMID: 26697357]
  • Clermont PL, Lin D, Crea F, Wu R, Xue H, Wang Y, Thu KL, Lam WL, Wang YZ, Helgason CD (2015) Polycomb-mediated silencing in neuroendocrine prostate cancer. Clinical Epigenetics 7(1):40, 1-13. [PMID:25859291]


  • Thu KL, Radulovich N, Becker-Santos DD, Pikor LA, Pusic A, Lockwood WW, Lam WL*, Tsao MS* (2014) SOX15 is a candidate tumor suppressor in pancreatic cancer with a role in Wnt/β-catenin signaling. Oncogene. 33(3):279-88. [PMID: 23318427]
  • Wilson IM*, Vucic EA*, Enfield KSS, Thu KL, Zhang Y-A, Chari R, Lockwood WW, Radulovich N, Starczynowski DT, Banáth JP, Zhang M, Pusic A, Fuller M, Lonergan KM, Rowbotham D, Yee J, English JC, Buys TPH, Selamat SA, Laird-Offinga I, Liu P, Anderson M, You M, Tsao-MS, Brown CJ, Bennewith KL, MacAulay CE, Karsan A, Gazdar AF, Lam S, Lam WL (2014) EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene33(36):4464-7. [PMID: 24096489]
  • Vucic EA*, Thu KL*, Pikor LA, Enfield KS, Yee J, English JC, MacAulay CE, Lam S, Jurisica I, Lam WL (2014). Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology. BMC Cancer. In press. [PMID:25342220]
  • Thu KL, Becker-Santos DD, Radulovich N, Pikor LA, Lam WL, Tsao MS (2014) SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types. Oncoscience 1(5) :326-35. [PMID:25594027]
  • Taguchi A, Taylor AD, Rodriguez J, Celiktas M, Liu H, Ma X, Zhang Q, Wong CH, Chin A, Girard L, Behrens C, Lam WL, Lam S, Minna JD, Wistuba II, Gazdar AF, Hanash SM (2014) A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes expanding the repertoire of potential immunotherapeutic targets. Cancer Research 74(17):4694-705. [PMID:24970476]]
  • Hubaux R, Thu KL, Lam WL (2014) Re: WNT signaling pathway in non-small cell lung cancer. JNCI-Journal of the National Cancer Institute 106 (8): dju188. [PMID:25082336]
  • Lalonde E, Ishkanian AS, Sykes J, Fraser M, Ross-Adams H, Erho N, Dunning MJ, Halim S, Lamb AD, Moon NC, Zafarana G, Warren AY, Meng X, Thoms J, Grzadkowski MR, Berlin A, Have CL, Ramnarine VR, Yao CQ, Malloff CA, Lam LL, Xie H, Harding NJ, Mak DY, Chu KC, Chong LC, Sendorek DH, P'ng C, Collins CC, Squire JA, Jurisica I, Cooper C, Eeles R, Pintilie M, Dal Pra A, Davicioni E, Lam WL, Milosevic M, Neal DE, van der Kwast T, Boutros PC, Bristow RG (2014) Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study. Lancet Oncology 15(13):1521-32. [PMID:25456371]

  • Vucic EA, Chari R, Wilson IM, Cotton AM, Thu KL, Kennett JY, Zhang M, Lonergan KM, Steiling K, Brown CJ, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, MacAulay CE, Lam S, Lam WL (2014) Aberrant DNA methylation patterns are widespread in small airways of former smokers with COPD.  American Journal of Respiratory Cell Molecular Biology 50(5):912-22. [PMID: 24298892]
  • Olthof NC, Speel EJM, Kolligs J, Haesevoets A, Henfling M, Ramaekers FCS, Preuss SF, Drebber U, Silling S, Lam WL, Vucic EA, Kremer B, Klussmann JP Huebbers CU (2014) Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression. PLoS ONE 9(2):e88718, 1-8.. [PMID: 24586376]
  • Crea F, Watahiki A, Quagliata L, Xue H, Pikor L, Parolia A, Wang Y, Lin D, Lam WL, Farrar WL, Isogai T, Morant R, Castori-Eppenberger S, Chi KN, Wang Y, Helgason CD (2014) Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. Oncotarget. 5:764-74. [PMID: 24519926]
  • Martinez VD, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL (2014) Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer. BioMed Research International 2014:159459, 1-10. [PMID: 25114896]
  • Clermont PL, Sun L, Crea F, Thu KL, Zhang A, Parolia A, Lam WL, Helgason CD (2014) Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role. British Journal of Cancer. 111(8):1663-72. [PMID:25225902]
  • Martinez VD, MacCaulay CE, Guillaud M, Lam WL, Corbett K, Rosin MP (2014) Targeting of chemoprevention to high-risk lesions: challenge and opportunity. Oral Oncology 50(12):1123-3. [PMID:25240917].
  • Berlin A, Lalonde E, Sykes J, Zafarana G, Chu KC, Ramnarine VR, Ishkanian A, Sendorek DHS, Pasic  I., Lam WL, Jurisica I, van der Kwast T, Milosevic M, Boutros PC, Bristow RG (2014) NBN gain is predictive for adverse outcome following image-guided radiotherapy for localized prostate cancer.  Oncotarget 5(22):11081-90. [PMID:25415046]
  • Rowbotham D*, Enfield KSS*, Martinez VD*, Thu KL Vucic EA, Stewart GL,  Bennewith KL, Lam WL (2014) Multiple components of the VHL tumor suppressor complex are frequently affected by DNA copy number losses in pheochromocytoma.  International Journal of Endocrinology. 2014: 546347, 1-9. [PMID:25298778]
  • Hubaux R*, Martinez VD*, Rowbotham D, Lam WL (2014) Comparative Genomic Hybridization and Array based CGH in Cancer.  In Molecular testing in cancer. George M. Yousef and Serge Jothy ed. Springer, . pp. 27-37.
  • Rowbotham DA, Marshall EA, Vucic EA, Kennett JY, LamWL, Martinez VD (2014) DNA methylation changes and aging. Journal of Aging Science 3 (1): 1000130, 1-9.


  • Martinez VD, Vucic EA, Lam S, Lam WL (2013) Emerging arsenic threat in Canada. Science 342(6158):559. [PMID: 24179203]

  • Pikor LA, Lockwood WW, Thu KL, Vucic EA, Chari R, Gazdar AF, Lam S, Lam WL (2013) Integrative analysis identifies YEATS4, a novel oncogene in NSCLC that regulates the p53 pathway. Cancer Research 73:7301-12. [PMID: 24170126]

  • Martinez VD*, Vucic EA*, Pikor LA, Thu KL, Hubaux R, Lam WL (2013) Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer. Molecular Cancer 12:124, 1-6. [PMID: 24138990]

  • Shien K, Toyooka S, Yamamoto H, Soh J, Jida M, Thu KL, Hashida S, Maki Y, Ichihara E, Asano H, Tsukuda K, Takigawa N, Kiura K, Gazdar AF, Lam WL, Miyoshi S. (2013) Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells. Cancer Research 73:3051-61 [PMID:23542356]

  • Hubaux R, Thu KL, Lam WL, Alex A (2013) In response: Do mutations of the enhancer of zeste homolog 2 gene exist in small-cell lung cancer? Journal of Thoracic Oncology 8:e103-4. [PMID: 24128723]

  • Rushlow DE, Mol BM*, Kennett JY*, Yee S*, Pajovic S, Thériault BL, Prigoda-Lee NL, Spencer C, Dimaras H, Corson TW, Pang R, Massey C, Paton K, Moll AC, Houdayer C, Raizis A, Halliday W, Lam WL, Boutros PC, Lohmann D, Dorsman JC, Gallie BL (2013) Characterization of retinoblastoma tumours without RB1 mutations: genomic, gene expression and clinical studies. Lancet Oncology 14:327-34. [PMID: 23498719]

  • Tam KW, Zhang W, Soh J, Stastny V, Chen M, Sun H, Thu KL, Rios JJ, Yang C, Marconett CN, Selamat SA, Laird-Offringa IA, Taguchi A, Hanash S, Shames D, Ma X, Zhang MQ, Lam WL, Gazdar AF, (2013) CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small cell lung cancer. Journal of Thoracic Oncology 8:1378-88 [PMID: 24077454]

  • Rodriguez-Blanco J, Schilling NS, Tokhunts R, Giambelli C, Long J, Liang-Fei D, Singh S, Black KE, Wang Z, , Galimberti F, Bejarano PA, Elliot S, Glassberg MK, Nguyen DM, Lockwood WW, Lam WL, Dmitrovsky E, Capobianco AJ, Robbins DJ (2013) The Hedgehog processing pathway is required for NSCLC growth and survival. Oncogene 32: 2335–45. [PMID: 22733134]

  • Hubaux R*, Becker-Santos DD*, Enfield KSS, Rowbotham D, Lam S, Lam WL, Martinez VD (2013) Molecular features in arsenic induced lung tumors. Molecular Cancer 12:20, 1-11. [PMID:23510327]

  • Pikor L, Thu K, Vucic E, Lam W (2013) The detection and implication of genome instability in cancer. Cancer Metastasis Review 32:341-52. [PMID:23510327]

  • Crea F, Sun L, Pikor L, Lam W, Helgason CD (2013) Mutational analysis of Polycomb genes in solid tumors identifies PHC3 amplification as a possible cancer-driving genetic alteration. British Journal of Cancer 109(6):1699-702 [PMID: 23942079]

  • Martinez VD, Thu KL, Vucic EA, Hubaux R, Adonis M, Gil L, Ling V, MacAulay C, Lam S, Lam WL (2013) Whole genome sequencing analysis identifies a distinctive mutational spectrum in an arsenic-related lung tumor. Journal of Thoracic Oncology 8:1451-5.[PMID: 24128716]
  • Hubaux R, Thu KL, Coe BP, MacAulay C, Lam S, Lam WL (2013) EZH2 promotes E2F driven SCLC tumorigenesis through modulation of apoptosis and cell cycle regulation. Journal of Thoracic Oncology 8:1102-6. [PMID: 23857401]
  • Pikor LA*, Ramnarine VR*, Lam S, Lam WL (2013) Genetic alterations defining NSCLC subtypes and their therapeutic implications. Lung Cancer 82:179-89. [PMID: 24011633]

  • Dal Pra A, Lalonde E, Sykes J, Warde F, Ishkanian A, Meng A, Maloff C, Srigley J, Joshua AM, Petrovics G, van der Kwast T, Evans A, Milosevic M, Saad F, Collins C, Squire J, Lam W, Bismar TA, Boutros PC, Bristow RG (2013) TMPRSS2-ERG status is not prognostic following prostate cancer radiotherapy: implications for fusion status and DSB repair. Clinical Cancer Research 19:5202-9. [PMID: 23918607]

  • Coe BP*, Thu KL*, Aviel-Ronen S, Vucic EA, Gazdar A, Lam S, Tsao MS, Lam WL (2013) Genomic deregulation of the Rb/E2F leads to activation of the oncogene EZH2 in small cell lung cancer. PLoS ONE 8(8):e71670, 1-8. [PMID: 23967231]

  • Ghayee HK, Bhagwandin VJ, Stastny V, Click A, Ding LH, Mizrachi D, Zou YS, Chari R, Lam WL, Bachoo RM, Smith AL, Story MD, Sidhu S, Robinson BG, Nwariaku FE, Gazdar AF, Auchus RJ, Shay JW (2013) Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor. PLoS ONE 8(6):e65624, 1-8. [PMID: 23785438]

  • Dong X, Lin D, Low C, Vucic EA, English JC, Yee J, Murray N, Lam WL, Ling V, Lam S, Gout PW, Wang Y (2013) Elevated expression of BIRC6 protein in non-small-cell lung cancers is associated with cancer recurrence and chemoresistance. Journal of Thoracic Oncololgy 8:161-70 [PMID: 23287853] 
  • Craddock K, Lam WL, Tsao-MS (2013) Adenocarcinoma of lung. "Comparative Genomic Hybridization: Protocols, Applications and Technology Trends" Methods in Molecular Biology 973:297-324. [PMID:23412798]


  • Martinez VD, Becker-Santos DD, Lam S, Lam WL (2012) How should treatment differ for lung cancers caused by arsenic exposure?  Lung Cancer Management 1: 243–246.  [PMID: In progress]
  • Vucic, EA*, Thu KL*, Robison K, Rybaczyk L, Chari R, Alvarez CE, Lam WL (2012) Translating cancer omics to outcomes.Genome Research 22:188-95. [PMID: 22301133]
  • Selamat SA, Chung BS, Girard L, Zhang W, Zhang Y, Campan M, Siegmund KD, Koss MN, Hagen JA, Lam WL, Lam S, Gazdar AF, Laird-Offringa IA (2012) Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Research 22:1197–1211. [PMID: 22613842] 
  • Hubaux R*, Becker-Santos DD*, Enfield KSS, Lam S, Lam WL, Martinez VD (2012) Arsenic, asbestos and radon: Emerging players in lung tumorigenesis. Environmental Health 11:89, 1-12. [PMID: 23173984]  
  • McKee C, Xu D, Cao Y, Kabraji S, Allen D, Kearsman V, Beech J, Smart S, Hamdy F, Ishkanian A, Sykes J, Pintile M, Milosevic M, van der Kwast T, Zafarana G, Ramnarine VR, Jurisica I, Malloff C, Lam W, Bristow RG, Muschel R (2012) Protease Nexin 1 modulates prostate adenocarcinoma by regulating the Hedgehog pathway in humans and mice.  Journal of Clinical Investigation 122: 4025-36.  [PMID: 23041623]
  • Lockwood WW*, Thu KL*, Lin L, Pikor LA, Chari R., Lam WL*, Beer DG* (2012) Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma. Clinical Cancer Research 18: 1936-46. [PMID: 22328562]
  • Lin L, Bass AJ*, Lockwood WW*, Wang Z, Silvers AL, Thomas DG, Li W, Chang AC, Orringer MB, Glover TW, Giordano TJ, Lam WL, Meyerson M, Beer DG (2012) Activation of GATA6 sustains oncogenic lineage-survival in esophageal adenocarcinoma. Proc. Natl. Acad. Sci. U.S.A. 109:4251-6. [PMID: 22375031]
  • Hubaux R*, Becker-Santos DD*, Enfield KSS, Lam S, Lam WL, Martinez VD (2011) MicroRNAs as biomarkers for clinical features of lung cancer. Metabolomics 2:108, 1-11. (doi:10.4172/2153-0769.1000108).
  • Enfield KSS, Pikor LA, Martinez VD, Lam WL (2012) Mechanistic roles of non-coding RNAs in lung cancer biology and their clinical implications. Genetic Research International 2012: 737416, 1-16.
  • Martinez VD, Vucic EA, Lam S, Lam WL (2012) Arsenic and lung cancer in never smokers: Lessons from Chile. American Journal of Respiratory and Critical Care Medicine 185: 1131-2. [PMID: 22589318]
  • Lockwood WW, Wilson IM, Coe BP, Chari R, Pikor LA, Thu KL, Yee J, English J, Murray N, Tsao MS, Minna JD, Gazdar AF, MacAulay CE., Lam S, Lam WL (2012) Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.  PLoS ONE 7(5): e37775, 1-18. [PMID: 22629454]
  • Thu KL, Vucic EA, Chari R, Zhang W, Lockwood WW, English JC, Fu R, Wang P, Feng Z, Macaulay CE, Gazdar AF, Lam S, Lam WL (2012) Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability.  PLoS ONE 7(3): e33003, 1-10. [PMID: 22412972]
  • Gibb EA*, Becker-Santos DD*, Enfield KSS, Guillaud M, Van Niekerk D, MacAulay CE, Lam WL (2012) Aberrant expression of long non-coding RNAs in cervical intraepithelial neoplasia. International Journal of Gynecological Cancer 22:1557-63. [PMID: 23095774]
  • Yao Y, Zhihao W, Wu J, Wu H, Wang J, Lam S, Lam WL, Girard L, Minna J, Gazdar AF, Zhou Q (2012) Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis.  Biochemical and Biophysical Research Communications 423: 613–19. [PMID: 22713465]
  • Li M, Lockwood W, Zielenska M, Northcott P, Ra YS, Bouffet E, Yoshimoto M, Rutka JT, Yan H, Taylor MD, Eberhart C, Hawkins CE, Lam W, Squire JA, Huang A (2012) Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor. Cancer Genetics 205: 220-31. [PMID: 22682621]
  • Locke JA, Zafarana G, Malloff CA, Lam WL, Sykes J, Pintilie M, Ramnarine VR, Meng A, Ahmed O, Jurisica I, Guns ET, van der Kwast T, Milosevic M, Bristow RG (2012) Allelic loss of the loci containing the androgen synthesis gene, StAR, is prognostic for relapse in intermediate-risk prostate cancer. Prostate 72:1295-305. [PMID: 22213075]
  • Zafarana G, Ishkanian AS, Malloff CA,, Locke JA, Sykes J, Thoms J, Lam WL, Squire JA, Yoshimoto M, Ramnarine VR, Jurisica I, Milosevic M, Pintile M, van der Kwast T, Bristow RG (2012) Copy number alterations of c-MYC and PTEN are prognostic factors for relapse following prostate cancer radiotherapy. Cancer. 118: 4053-62. [PMID: 22281794] 
  • Dasgupta S, Soudry E, Mukhopadhyay N, Shao C, Yee J, Lam S, Lam W, Zhang W, Gazdar AF, Fisher PB, Sidransky D (2012) Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression. Journal of Cellular Physiology 227: 2451-60. [PMID: 21830212]
  • Vercauteren SM, Starczynowski DT, Sung S, McNeil K, Salski C, Jensen CL, Bruyere H, Lam WL, Karsan A (2012) T cells of patients with myelodysplastic syndrome are frequently derived from the malignant clone. British Journal of Haematology 156, 402–414.
  • Locke JA, Zafarana G, Ishkanian AS, Milosevic M, Thoms J, Have CL, Malloff CA, Lam WL, Squire JA, Pintilie M, Sykes J, Ramnarine VR, Meng AX, Ahmed O, Jurisica I, van der Kwast T, Bristow RG  (2012) NKX3.1 haploinsufficiency is prognostic for prostate cancer relapse following surgery or image-guided radiotherapy. Clinical Cancer Research 18:308-16. [PMID: 22048240] 


  • Martinez VD, Becker-Santos DD, Vucic EA, Lam S, Lam WL (2011) Induction of human squamous cell-type carcinomas by arsenic. Journal of Skin Cancer 2011: 454157, 1-9.
  • Martinez VD, Vucic EA, Becker-Santos DD, Gil L, Lam WL (2011) Arsenic exposure and the induction of human cancers. Journal of Toxicology  2011:431287, 1-13..

  • Gibb EA, Vucic, EA, Enfield KSS, Stewart GL, Lonergan KM, Kennett JY, Becker-Santos DD, MacAulay CE, Lam S, Brown CJ, Lam WL (2011) Human cancer long non-coding RNA transcriptomes.  PLoS ONE 6: e25915, 1-10. [PMID: 21991387]

  • Thu KL*, Pikor LA*, Chari R, Wilson IM, MacAulay CE, Tsao-MS, Gazdar AF, Lam S, Lam WL, Lockwood WW (2011) Disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism for NFkB pathway activation in lung cancer. Journal of Thoracic Oncology 6:1521-1529. [PMID: 21795997]

  • Martinez VD, Vucic EA, Adonis M, Gil L, Lam WL (2011) Arsenic biotransformation as a cancer promoting factor by inducing DNA damage and disruption of repair mechanisms. Molecular Biology International 2011: 718974, 1-11.

  • Gibb EA, Enfield KSS, Stewart GL, Lonergan KM, Ng RT, Zhang L, MacAulay CE, Rosin MP, Lam WL (2011)  Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions. Oral Oncology 47: 1055-61.  [PMID: 21835683]
  • Starczynowski DT, Lockwood WW, Delehouzee S, Chari R, Wegrzyn J, Fuller M, Tsao-MS, Lam S, Gazdar AF, Lam WL, Karsan A (2011) TRAF6 is an amplified oncogene bridging the RAS and nuclear factor-kB cascade in lung cancer. Journal of Clinical Investigation  121: 4095-105.
  • Thu KL, Chari R, Lockwood WW, Lam S, Lam WL (2010) miR-101 DNA copy loss is a prominent subtype specific event in lung cancer. Journal of Thoracic Oncology 6:1594-1598. [PMID: 21849855]
  • Cotton AM, Lam L, Affleck JG, Wilson IM, Peñaherrera MS, McFadden DE, Kobor MS, Lam WL, Robinson WP, Brown CJ (2011) Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation. Human Genetics 130: 187-201. [PMID: 21597963]

  • Gibb EA, Brown CJ, Lam WL (2011) The functional role of long non-coding RNA in human carcinomas. Molecular Cancer 10: 38, 1-17.

  • Enfield KSS*, Stewart GL*, Pikor LA*, Alvarez CE, Lam S, Lam WL, Chari R (2011). MicroRNA gene dosage alterations and drug response in lung cancer. Journal of Biomedicine and Biotechnology 2011: 474632, 1-15.

  • Pikor LA*, Enfield KSS*, Heryet C, Lam WL (2011) DNA extraction from paraffin embedded material for genetic and epigenetic analyses.  Journal of Visualized Experiments 49: 2763.

  • Gibb EA, Enfield KSS, Tsui IFL, Chari R, Lam, S, Alvarez CE, Lam WL (2011) Deciphering squamous cell carcinoma using multi-dimensional genomic approaches. Journal of Skin Cancer 2011: 1-16.

  • Tucker T, Montpetit A; Chai D; Chan S; Chénier S; Coe BP; Delaney A; Eydoux P; Lam WL; Langlois S; Lemyre E; Marra M; Qian H; Rouleau GA; Vincent D; Michaud JL; Friedman JM (2011) Comparison of genome-wide array genomic hybridization platforms for the detection of copy number variants in idiopathic mental retardation. BMC Medical Genomics 4: 25, 1-10. 
  • Lockwood WW, Stack D, Morris T, Grehan D, O’Keane C, Stewart GL, Cumiskey J, Lam WL., Squire JA, Thomas DM, O’Sullivan M (2011) Cyclin E1 is amplified and over-expressed in osteosarcoma.  Journal of Molecular Diagnostics 13: 289-96.
  • Starczynowski DT, Morin R, McPherson A, Lam J, Chari R, Wegrzyn J, Kuchenbauer F, Hirst M, Tohyama K, Humphries RK, Lam WL, Marra M, Karsan A (2011) Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood 117:595-607.
  • Starczynowski DT, Vercauteren S, Sung S, Brooks-Wilson A, Lam WL, Karsan A (2011). Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes. Leukemia Research 35: 444-447.


  • Chari R, Thu KL, Wilson IM, Lockwood WW, Lonergan KM, Coe BP, Malloff CA, Gazdar AF, Lam S, Garnis C, MacAulay CE, Alvarez CE, Lam WL (2010) Integrating the multiple dimensions of genomic and epigenomic lanscapes of cancer.  Cancer and Metastasis Reviews 29:73-93. [PMID: 20108112]
  • Starczynowski D, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, Hirst M, Hogge D, Marra M, Wells R, Lam W, Humphries K, Karsan A (2010) Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nature Medicine 16: 49-58. [PMID: 19898489]
  • Lonergan, KM, Chari R, Coe BP, Wilson IM, Tsao MS, Ng RT, MacAulay C, Lam S, Lam WL (2010) Transcriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGE. PLoS ONE 5:e9162, 1-22. [PMID: 20161782]
  • Gazdar AF, Girard L, Lockwood W, Lam WL, Minna JD (2010) Lung cancer cell lines as tools for biomedical discovery and research.  Journal National Cancer Institute 102: 1310-21.  [PMID: 20679594]
  • Lockwood WW, Chari R, Coe BP, Thu KL, Garnis C, Malloff CA, Campbell JM, Williams AC, Hwang D, Chang QZ, Buys TPH, Yee J, English J, MacAulay C, Tsao MS, Gazdar AF, Minna JD, Lam S, Lam WL (2010) Integrative genomic analyses identify BRF2 as a novel lineage specific oncogene in lung squamous cell carcinoma. PLoS Medicine 7(7): e1000315, 1-14. [PMID: 20668658]
  • Dong X, Guan J, English JC, Flint J, Yee J, Evans K, Murray N, MacAulay C, Ng R, Gout PW, Lam WL, Laskin J, Ling V, Lam S, Wang YZ (2010) Patient-derived first generation xenografts of non-small cell lung cancers: Promising tools for predicting drug responses for personalized chemotherapy. Clinical Cancer Research 16:1442-51. [PMID: 20179238]
  • Chari R, Coe BP, Vucic EA, Lockwood WW, Lam WL (2010) An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer. BMC Systems Biology 4: 67, 1-14.  [PMID: 20478067]

  • Li AH, Waddell SJ, Hinds J, Malloff CA, Bains M, Hancock RE, Lam WL, Butcher PD, Stokes RW (2010) Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages. PLoS ONE 5: e11066, 1-14. [PMID: 20548782]

  • Vercauteren SM, Sung S, Starczynowski DT, Lam WL, Bruyere H, Horsman DE, Tsang P,Leitch H, Karsan A (2010) Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities. American Journal of Clinical Pathology 134: 119-26. [PMID: 20551276]
  • Coe BP, Chari R, MacAulay C, Lam WL (2010) FACADE: A fast and sensitive algorithm for the segmentation and calling of high resolution array CGH data. Nucleic Acids Research. 38: e157, 1-7. [PMID: 20551132]
  • Chari R, Lonergan KM, Pikor LA, Coe BP, Zhu CQ, Chan THW, MacAulay C, Tsao MS, Lam S, Ng RT, Lam WL (2010) A sequence-based approach to identify reference genes for gene expression analysis.  BMC Medical Genomics 3: 32, 1-11. [PMID: 20682026]
  • Martinez VD, Buys TPH, Adonis M, Benítez H, Gallegos I, Lam S, Lam WL, Gil L (2010) Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas. British Journal of Cancer. 103: 1277-83. [PMID: 20842114]
  • Cheung KJ, Johnson N, Affleck J, Severson T, Steidl C, Ben-Neriah S, Schein J, Morin RD, Moore R, Shah SP, Qian H, Paul J, Telenius A, Relander T, Lam WL, Savage KJ, Connors J, Brown C, Marra MA, Gascoyne RD, Horsman D. (2010) Acquired TNFRSF14 mutations in follicular lymphoma are associated with inferior prognosis.. Cancer Research. 70: 9166-74. [PMID: 20884631]
  • Thu KL, Pikor LA, Kennett JY, Alvarez CE, Lam WL (2010) Methylation analysis by DNA immunoprecipitation.  Journal of Cellular Physiology 222:522-31. [PMID: 20020444]
  • Vucic EA, Thu KL, Williams AC, Lam WL, Coe BP (2010) Copy number variations in the human genome and strategies for analysis. Methods in Molecular Biology 628: 103-17. [PMID: 20238078]


  • Thu KL, Lam WL, Coe BP (2009) The emerging role of copy number variation in cancer. Cell Science 6: 98, 1-23.
  • Soh J*, Okumura N*, Lockwood WW, Yamamoto H, Shigematsu H, Zhang W, Chari R, Shames D, Tang X, MacAulay C, Varella-Garcia M, Vooder T, Wistuba II, Lam S, Brekken R, Toyooka S, Minna JD, Lam WL, Gazdar AF (2009) Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells. PLoS ONE 4: e7464, 1-13.
  • Tsui IFL, Poh CF, Garnis C, Rosin MP, Zhang L, Lam WL (2009) Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias. International Journal of Cancer 125: 2219-2228.
  • Tsui IFL, Garnis C, Poh CF. (2009) A dynamic oral cancer field -- unraveling the underlying biology and its clinical implication. American Journal of Surgical Pathology 33: 1732-38. [Tsui’s Lam Lab publication] [PMID: 19858864]

  • Garnis C, Chari R, Buys TPH, Zhang L, Ng RT, Rosin MP, Lam WL (2009) Genomic imbalances in precancerous tissues signal oral cancer risk. Molecular Cancer 8: 50, 1-7.
  • Astanehe A, Finkbeiner MR, Hojabrpour P, To K, Fotovati A, Shadeo A, Stratford AL, Lam WL, Berquin IM, Duronio V, Dunn SE (2009) The transcriptional induction of PIK3CA in tumor cells is dependent upon the oncoprotein Y-box binding protein-1 (YB-1). Oncogene 28: 2406-2418.
  • Vucic EA, Wilson IM, Campbell JM, Lam WL (2009) Methylation analysis by DNA immunoprecipitation (MeDIP). Methods in Molecular Biology 556: 141-153.
  • van Nederveen FH, Korpershoek E, deLeeuwRJ, Verhofstad AA, Lenders JW, Dinjens WN, Lam WL, de Krijger RR (2009) Array-CGH in sporadic benign pheochromocytomas. Endocrine Related Cancers 16: 505-513.
  • Coe BP, Lockwood WW, Chari R, Lam WL (2009) Comparative Genomic Hybridization on BAC Arrays. Methods in Molecular Biology 556: 7-19.
  • Ishkanian AI*, Malloff CA*, Meng A, Ho J, Albert M, Syed, A, van der Kwast T, Milosevic M, Lam WL, Bristow RG (2009) High-resolution array CGH identifies novel regions of genomic alteration in intermediate-risk prostate cancer. Prostate 69: 1091-1100.
  • Watson SK, Woolcock BW, Fee JN, Bainbridge TC, Webber D, Kinahan TJ, Lam WL, Vielkind JR (2009) Minimum altered regions in early prostate cancer progression identified by high resolution whole genome tiling path BAC array comparative hybridization. Prostate 69: 961-975.
  • Iqbal J, Kucuk C, deLeeuw RJ, Srivastava G, Tam W, Geng H, Klinkebiel D, Christman JK, Patel K, Cao K, Shen L, Dybkaer K, Tsui IFL, Ali H, Shimizu N, Au WY, Lam WL, Chan WC. (2009) Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia 23: 1139-1151.
  • Ma S, Chan YP, Woolcock B, Wong KY, Bainbridge T, Webber D, Guan X-Y, Lam W, Vielkind J, Chan KW (2009) DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer. International Journal of Cancer 124: 2323-2332.
  • Thu KL*, Vucic EA*, Kennett JY, Heryet C, Brown CJ, Lam WL, Wilson IM (2009) Methylated DNA Immunoprecipitation. Journal of Visualized Experiments 23. pii: 935. doi: 10.3791/935.
  • Gandhi JK, Zhang J, Xie Y, Shigematsu H, Soh J, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Varella-Garcia M, Minna JD, Gazdar AF (2009) Molecular changes in lung cancers and sensitivity to tyrosine kinase inhibitors. PLoS ONE 4: e4576, 1-11.
  • Buys TPH, Aviel-Ronen S, Waddell TK, Lam WL, Tsao MS (2009) Defining genomic alteration boundaries for a combined small cell and non-small cell lung carcinoma. Journal of Thoracic Oncology 4: 227-239.
  • Kubo T, Yamamoto H, Lockwood WW, Valencia I, Fujii T, Ouchida M, Soh J, Takigawa N, Kiura K, Shimizu K, Date H, Minna JD, Lam WL, Gazdar AF, Toyooka S (2009) MET gene amplification in lung cancers untreated with gefitinib. International Journal of Cancer 124: 1778-1784.
  • Finkbeiner MR, Astanehe A, To K, Fotovati A, Davies AH, Zhao Y, Jiang H, Stratford AL, Shadeo A, Boccaccio C, Comoglio P, Mertens PR, Eirew P, Raouf A, Eaves CJ, Dunn SE (2009) Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells. Oncogene 28: 1421-1431. [Shadeo′s Lam Lab publication]
  • Cheung KJ, Shah SP, Steidl C, Johnson N, Relander T, Telenius A, Lai B, Murphy KP, Lam W, Al-Tourah AJ, Connors JM, Ng RT, Gascoyne RD, Horsman DE (2009) Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances. Blood 113: 137-148.


  • Chari R, Coe BP, Wedseltoft C, Benetti M, Wilson IM., Vucic EA., MacAulay C, Ng RT, Lam WL (2008) SIGMA2: A system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes. BMC Bioinformatics 9, 422: 1-12.
  • Lockwood WW, Chari R, Coe BP, Girard L, MacAulay C, Lam S, Gazdar AF, Minna JD, Lam WL (2008) DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers. Oncogene 27: 4615-4624.
  • Campbell JM*, Lockwood WW*, Buys TPH, Chari R, Coe BP, Lam S, Lam WL (2008) Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer. Genome 51: 1032-9.
  • Yamamoto H, Shigematsu H, Nomura M, Lockwood WW, Sato M, Okumura N, Soh J, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Date H, Lam WL, Minna JD, Gazdar AF (2008) PIK3CA mutations and gene copy number in human lung cancers. Cancer Research 68: 6913-6921.
  • Aviel-Ronen S, Coe BP, Lau SK, da Cunha Santos G, Zhu CQ, Strumpf D, Jurisica I, Lam WL, Tsao MS (2008) Genomic markers for malignant progression in pulmonary adenocarcinoma with bronchioloalveolar features. Proc. Natl. Acad. Sci. U.S.A. 105: 10155-10160.
  • Coe BP, Chari R, Lockwood WW, Lam WL (2008) Evolving strategies for global gene expression analysis of cancer. Journal of Cellular Physiology 217: 590-597.
  • Tsui IFL, Rosin MP, Zhang L, Ng RT, Lam WL (2008) Multiple aberrations of chromosome 3p detected in oral premalignant lesions. Cancer Prevention Research 1: 424-429.
  • Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A (2008) High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood. 112: 3412-3424.
  • Kennett JY, Watson SK, Saprunoff H, Heryet C, Lam WL (2008) Technical Demonstration of whole genome array comparative genomic. Journal of Visualized Experiments 18. [, doi: 10.3791/870]
  • Chi B, DeLeeuw RJ, Coe BP, Ng RT, MacAulay C, Lam WL (2008) MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data. BMC Bioinformatics 9:243, 1-9.
  • Dubrowski P, Lam W, Ling V, Lam S, MacAulay C (2008) Automated tissue m-FISH analysis workstation for identification of clonally related cells. Proc. SPIE 6859: 68591T, 1-12 (

  • Vucic EA, Brown CJ, Lam WL (2008) Epigenomics of cancer progression. Pharmacogenomics 9: 215-234.
  • Lee EHL*, Chari R*, Lam A, Ng RT, Yee J, English J, Evans KG, MacAulay C, Lam S, Lam WL (2008) Disruption of the non-canonical WNT pathway in lung squamous cell carcinoma. Clinical Medicine: Oncology 2: 169-179.
  • Li AH, Lam WL, Stokes RW (2008) Characterization of genes differentially expressed within macrophages by virulent and attenuated Mycobacterium tuberculosis identifies candidate genes involved in intracellular growth. Microbiology 154: 2291-2303.
  • Li AH, Lam WL, Stokes RW (2008) Bacterial artificial chromosome fingerprint arrays for the differentiation of transcriptomic differences in mycobacteria. Journal of Microbiological Methods 75: 416-424.
  • Gao K, Lockwood WW, Li J, Lam WL, Li G (2008) Gene candidates for acquired irinotecan resistance in melanoma cells. International Journal of Oncology 32:1343-1349.
  • Wang J-C, Coe BP, Lomax B, MacLeod PM, Parslow MI, Schein JE, Lam WL, Eydoux P (2008) Inverted duplication with terminal deletion of 5p with no cat-like. American Journal of Medical Genetics A. 146: 1173-1179.
  • Coe BP, Macaulay C, Lam WL, Ylstra B, Carvalho B, Meijer GA (2008) Comment re: A comparison of DNA copy number profiling platforms. Cancer Research 68: 4010.
  • Shadeo A, Chari R, Lonergan KM, Pusic A, Miller D, Ehlen T, Van Niekerk D, Matisic J, Richards-Kortum R, Follen M, Guillaud M, Lam WL*, MacAulay C* (2008) Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia. BMC Genomics 9: 64, 1-14.
  • Rosin MP, Poh CF, Elwood JM, Williams PM, Gallagher R, MacAulay C, Lam W, Auluck A, Zhang L, Hislop TG (2008) New hope for an oral cancer solution: Together we can make a difference. J Canadian Dental Association 74:261-266.
  • Fadlelmola FM, Zhou M, deLeeuw RJ, Dosanjh N, Harmer K, Huntsman D, Lam WL, Banerjee D (2008) Sub megabase resolution tiling (SMRT) array-based profiling reveals novel gains and losses of chromosomal regions in Hodgkin lymphoma and anaplastic large cell lymphoma cell lines. Molecular Cancer 7:2, 1-13.
  • Garnis C, Lam WL (2008) Oral Cancer. In Encyclopedia of Cancer. Second Edition (Manfred Schwab ed.) Springer. pp. 2183-2184.
  • Buys TPH, Lam WL (2008) Malignancy Associated Changes. In Encyclopedia of Cancer. Second Edition (Manfred Schwab ed.) Springer. pp. 1748-1749.
  • Tucker CA, Kapanen AI, Chikh G, Hoffman BG, Kyle AH, Wilson IM, Masin D, Gascoyne RD, Bally M, Klasa RJ (2008) Silencing Bcl-2 in models of mantle cell lymphoma correlates with a loss in Cyclin D1a expression but not CyclinD1b and is associated with decreases in NFkappaB, p53, bax and p27 levels. Molecular Cancer Therapeutics 7:749-58. [Wilson’s Lam Lab publication]


  • Buys TPH, Wilson IM, Coe BP, Lee EHL, Kennett JY, Lockwood WW, Tsui IFL, Shadeo A, Chari R, Garnis C, Lam WL (2007) Detailed comparisons of cancer genomes. In Comparative Genomics: Fundamental and Applied Perspectives. James R. Brown (ed.) CRC Press, Taylor and Francis Publisher. pp.245-259.
  • Kuo A, Wilson IM, Vucic E, Lee E, Davies JJ, MacAulay C, Brown C, Lam W (2007) Comparative cancer epigenomics. In Comparative Genomics: Fundamental and Applied Perspectives. James R. Brown (ed.) CRC Press, Taylor and Francis Publisher. pp. 261-279.
  • Buys TP, Wilson IM, Coe BP, Lockwood WW, Davies JJ, Chari R, DeLeeuw RJ, Shadeo A, MacAulay C, Lam WL. (2007) ″Key Features of BAC Array Production and Usage″• In DNA Microarrays (Methods Express Series, Schena M, ed), Scion Publishing, Ltd., Bloxham. pp.85-115.
  • Mastracci TL, Boulos F, Andrulis IL, Lam WL (2007) Genomics and premalignant breast lesions: clues to the development and progression of lobular breast cancer. Breast Cancer Research 9:215, 1-9.
  • Tsui IFL, Chari R, Buys TPH, Lam WL (2007) Public databases and software for the pathway analysis of cancer genomes. Cancer Informatics 3: 389-407.
  • Kimm L*, DeLeeuw RJ*, Savage K, Rosenwald A, Campo E, Delabie J, Muller-Hermelink HK, Jaffe ES, Rimsza LM, Weisenburger DD, Chan WC, Staudt LM, Connors JM, Gascoyne RD, Lam WL (2007) Frequent occurrence of deletions in primary mediastinal B-cell lymphoma. Genes Chromosomes Cancer 46:1090-7.
  • Buys TPH, Chari R, Lee EHL, Zhang M, MacAulay C, Lam S, Lam WL, Ling V (2007) Genetic changes in the evolution of multi-drug resistance for cultured human ovarian cancer cells. Genes Chromosome Cancer 46:1069-79.
  • Chari R, Lonergan KM, MacAulay C, Ng R, Lam WL*, Lam S* (2007) Effect of active smoking on the bronchial epithelium transcriptome. BMC Genomics 8: 297, 1-13.
  • Shah SP, Lam WL, Ng RT, Murphy KP (2007) Modeling recurrent DNA copy number alterations in array CGH data. Bioinformatics 23: i450-i458.
  • Stratford AL, Habibi G, Astanehe A, Jiang H, Hu K, Park E, Shadeo A, Buys TP, Lam W, Pugh T, Marra M, Nielsen TO, Klinge U, Mertens PR, Aparicio S, Dunn SE (2007) Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer providing a potential target for therapy. Breast Cancer Research 9:R61, 1-14.
  • Robinson WP , Slee J, Smith N, Murch A, Watson S, Lam WL, McFadden DE (2007) Placental mesenchymal dysplasia associated with fetal overgrowth and mosaic deletion of the maternal copy of 11p15.5. American J Medical Genetics A 143:1752-9.
  • Wong KK, DeLeeuw RJ, Brown CJ, Lam WL (2007) Reply to: Copy number variations and human disease. American Journal of Human Genetics 81:415.
  • DeLeeuw RJ, Wong KK, Ng RT, Brown CJ, Lam WL (2007) Reply to: Numbers of CNVs and false negative rates will be underestimated if we do not account for the dependence between repeated experiments. American Journal of Human Genetics 81:420-1.
  • DeLeeuw RJ*, Zettl A*, Haralambieva E, Trottier M, Chari R, Ge Y, Gascoyne RD, Chott A, Muller-Hermelink H-K, Lam WL (2007) Whole genome analysis of enteropathy-type T-cell lymphoma reveals two distinct genetic signatures. Gastroenterology 132:1902-11.
  • Coe BP, Ylstra B, Carvalho B, Meijer GA, MacAulay C, Lam WL (2007) Resolving the resolution of array CGH. Genomics 89:647-53.
  • Shadeo A, Chari R, Vatcher G, Campbell J, Lonergan KM, Matisic J, Van NieKirk D, Ehlen T, Miller D, Follen M, Lam WL, MacAulay C (2007) Comprehensive serial analysis of gene expression of the cervical epithelium transcriptome. BMC Genomics 8: 142, 1-11.
  • Wong KK*, DeLeeuw RJ*, Dosanjh NS, Kimm LR, Cheng Z, Horsman DH, MacAulay C, Ng R, Brown CJ, Eichler EE, Lam WL (2007) A Comprehensive Analysis of Common Copy-Number Variations in the Human Genome. American Journal of Human Genetics 80: 91-104.
  • Kneller JM, Ehlen T, Matisic JP, Miller D, Van Niekerk D, Lam WL, Marra M, Richards-Kortum R, Follen M, MacAulay C, Jones SJM (2007) Using LongSAGE to establish biomarkers of cervical cancer amenable to optical contrast agent labeling. Biomarker Insights 2: 447-461.
  • Thiberville C, Guillaud M, Lockwood WW, Lam WL, Follen M, MacAulay C (2007) Multi-scale systems biology applied to cervical inter-epithelial neoplasia. Gynaecologic Oncology 107: S72-82.
  • Renault N, Dyack S, Dobson MJ, Costa T, Lam WL, Greer WL (2007) Heritable skewed X-chromosome inactivation leads to haemophilia A expression in heterozygous females. European Journal of Human Genetics 15: 628-37.
  • Bretherick KL, Metzger DL, Chanione JP, Panagiotopoulos C, Watson SK, Lam WL, Fluker MR, Brown CJ, Robinson WP (2007) Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure. American Journal of Medical Genetics A 143: 945-951.
  • Watson SK, DeLeeuw RJ, Horsman DE, Squire JA, Lam WL (2007) Cytogenetically balanced translocations are associated with focal copy number alterations. Human Genetics 120: 795-805.
  • Lockwood WW, Coe BP, Williams AC, MacAulay C, Lam WL (2007) Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell lines. International Journal of Cancer 120: 436-43.
  • Chari R*, Lockwood WW*, Lam WL (2006) Bioinformatic applications for array comparative genomic hybridization data analysis and visualization. Cancer Informatics 2: 48-58.


  • Chari R, Lockwood WW, Coe BP, Chu A, Macey D, Thomson A, Davies JJ, MacAulay C, Lam WL (2006) SIGMA: a system for integrative genomic microarray analysis of cancer genomes. BMC Genomics 7, 324: 1-28.
  • Aviel-Ronen S, Zhu CQ, Coe BP, Liu N, Watson SK, Lam WL, Tsao MS (2006) Large Fragment Bst DNA Polymerase for Whole Genome Amplification of DNA from Formalin-Fixed Paraffin-Embedded Tissues. BMC Genomics 7, 312: 1-10.
  • Lonergan KM, Chari R, Deleeuw RJ, Shadeo A, Chi B, Tsao MS, Jones S, Marra M, Ling V, Ng R, MacAulay C, Lam S, Lam WL (2006) Identification of Novel Lung Genes in Bronchial Epithelium by Serial Analysis of Gene Expression. American Journal of Respiratory Cell Molecular Biology 35: 651-61.
  • Mastracci TL, Shadeo A, Colby SM, Tuck AB, O´Malley FP, Bull SB, Lam WL, Andrulis IL (2006) Genomic alterations in lobular neoplasia: A microarray comparative genomic hybridization signature for early neoplastic proliferationin the breast. Genes Chromosomes Cancer 45: 1007-17.
  • Shah SP, Xuan X, Deleeuw RJ, Khojasteh M, Lam WL, Ng R, Murphy KP (2006) Integrating copy number polymorphisms into array CGH analysis using a robust HMM. Bioinformatics 22: e431-9.
  • Coe BP*, Lockwood WW*, Girard L, Chari R, MacAulay C, Lam S, Gazdar AF, Minna JD, Lam WL (2006) Differential regulation of cell cycle pathways in small cell and non-small cell lung cancer. British Journal of Cancer 94:1927-35.
  • Baldwin C, Garnis C, Zhang L, Rosin MP, Lam WL (2006). Response to: Genomic analysis of tumors by array comparative genomic hybridization: more is better. Cancer Research 66: 3955-3956.
  • Wilson IM, Davies JJ, Brown CJ, Weber M, Alveraz CE, MacAulay C, Schübeler D, Lam WL (2006) Epigenomics: mapping the methylome. Cell Cycle 5:155-8.
  • Shadeo A, Lam WL (2006) Comprehensive copy number profiles of breast cancer cell model genomes. Breast Cancer Research 8: R9, 1-14.
  • Lewis CM, Herbert BS, Bu D, Halloway S, Beck A, Shadeo A, Zhang C, Ashfaq R, Shay JW, Euhus DM (2006) Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier. Breast Cancer Res Treat. 99:103-15. [Shadeo´s Lam Lab publication]
  • Garnis C, Lockwood WW, Vucic E, Ge Y, Girard L, Minna JD, Gazdar AF, Lam S, MacAulay C, Lam WL (2006) Comparing canonical non-small cell lung squamous and adenocarcinoma model genomes. International Journal of Cancer 118: 1556-64.
  • Lockwood WW*, Chari R*, Chi B, Lam WL (2006) Recent advances in array comparative genomic hybridization technologies and their applications in human genetics. European Journal of Human Genetics 14:139-48.
  • Coe BP, Lee EHL, Chi B, Girard L, Minna JD, Gazdar AF, Lam S, MacAulay C, Lam WL (2006) Tiling genomic array profiling of small cell lung cancer cell lines identifies highly frequent copy number gains of MAD1L1. Genes Chromosomes Cancer 45: 11-19.
  • Khojasteh M, Coe B, Shah S, Ward RK, Lam WL, MacAulay C (2006) A novel algorithm for the analysis of array CGH data. Institute of Electrical and Electronics Engineers (IEEE) International Conference on Acoustics, Speech, and Signal Processing (ICASSP). Volume 2, 1020-23.
  • Aarts M, Dannenberg H, Deleeuw RJ, van Nederveen FH, Verhofstad AA, Lenders JW, Dinjens WN, Speel EJ, Lam WL, de Krijger RR (2006) Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p. Genes Chromosomes Cancer 45: 83-93.


  • Weber M, Davies JJ, Wittig D, Haase M, Lam WL, Schübeler D (2005) Chromosome-wide and promoter-specific analyses reveal sites of differential DNA methylation in normal and transformed human cells. Nature Genetics 37: 853-62.
  • Baldwin C, Garnis C, Zhang L, Rosin MP, Lam WL (2005) Multiple microalterations detected at high frequency in oral cancer. Cancer Research 65: 7561-7.
  • Garnis C, Davies JJ, Buys TPH, Tsao M, Lam S, MacAulay C, Lam WL (2005) Chromosome 5p Aberrations and Glial Cell Line-Derived Neurotrophic Factor Activation Are Early Events In Lung Cancer. Oncogene 24: 4806-12.
  • Garnis C, Campbell J, Davies JJ, Lam S, MacAulay C, Lam WL. (2005) disruption of multiple developmental genes on chromosome 1p in lung tumorigenesis. Human Molecular Genetic 14: 475-82.
  • Khojasteh M, Lam WL, Ward RK, MacAulay C (2005) A stepwise framework for the normalization of Array CGH data. BMC Bioinformatics 6: 274, 1-15.
  • Prentice LM, Shadeo A, Lestou VS, Miller M, deLeeuw RJ, Makretsov N, Turbin D, Brown LA, Cheang MCU, Macpherson N, Yorida E, Bentley J, Chia S, Nielsen TO, C. Gilks B, Lam W, Huntsman DG (2005) NRG1 gene rearrangements in clinical breast cancer: identification of an adjacent novel amplicon associated with poor prognosis. Oncogene 24: 7281-89.
  • Zhang L, Williams M, Poh CF, Laronde D, Epstein JB, Durham S, Nakamura H, Berean K, Hovan A, Le ND, Greg Hislop G, Priddy R, Hay J, Lam WL, Rosin MP (2005) Toluidine blue staining identifies primary oral premalignant lesions with high molecular risk of progression. Cancer Research 65: 8017-21.
  • Rubio-Moscardo F, Blesa D, Mestre C, Siebert R, Balasas T, Benito A, Rosenwald A, Climent J, Martinez JI, Schilhabel M, Karran EL, Gesk S, Esteller M, deLeeuw R, Staudt LM, Fernandez-Luna JL, Pinkel D, Dyer MJ, Martinez-Climent JA (2005) Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes. Blood 106: 3214-22. [deLeeuw´s Lam Lab publication]
  • Davies JJ, Wilson I, Lam WL (2005) Array technologies and their applications to cancer genomes. Chromosome Research 13: 237-48.
  • Garnis C, Coe BP, MacAulay C, Lam WL (2005) High-resolution array CGH increases heterogeneity tolerance in the analysis of clinical samples. Genomics 85:790-3.
  • Garnis C, Zhang L, Rosin MP, Lam WL (2005) Alteration of AKAP220 an upstream component of the Rb pathway in oral carcinogenesis. International Journal of Cancer 116: 813-9.
  • Henderson LJ, Coe BP, Lee E, Girard L, Gazdar AF, Minna JD, Lam S, MacAulay C, Lam WL (2005) Genomic and gene expression profiling of minute alterations of chromosome arm 1p in small cell lung carcinoma cells. British Journal of Cancer 92: 1553-60.
  • Knezevich S, Ludkovski O, Salski C, Lestou V, Chhanabhai M, Lam W, Klasa R, Connors JM, Dyer MJS, Gascoyne RD, Horsman DE (2005) Concurrent translocation of BCL2 and MYC with a single immunoglobulin locus in high-grade B-cell lymphomas. Leukemia 19: 659-63.
  • Coe BP, Henderson LJ, Garnis C, Tsao-MS, Gazdar A, Minna J, Lam S, MacAulay C, Lam WL (2005) High resolution chromosome 5p array CGH analysis of small cell lung carcinoma cell lines. Genes Chromosomes Cancer 42: 308-13.
  • Lim G, Karaskova J, Beheshti B, Vukovic B, Bayani J, Selvarajah S, Watson SK, Lam WL, Zielenska M, Squire JA (2005) An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma. Genes Chromosomes Cancer 42: 392-403.


  • Ishkanian AS, Malloff CA, Watson SK, DeLeeuw RJ, Chi B, Coe BP, Snijders A, Albertson DG, Pinkel D, Marra MA, Ling V, MacAulay, C, Lam WL (2004) A tiling resolution DNA microarray with complete coverage of the human genome. Nature Genetics 36: 299-303.
  • DeLeeuw RJ, Davies JJ, Bebb G, Gascoyne RD, Staudt LM, Martinez-Climent JA, Lam WL (2004) Whole genome array CGH profiling of mantle cell lymphoma model genomes. Human Molecular Genetics 13: 1827-37.
  • Garnis C, Buys TPH, Lam WL (2004) Genetic alteration and gene expression modulation during cancer progress. Molecular Cancer 3, 9: 1-23.
  • Garnis C, Coe BP, Zhang L, Rosin MP, Lam WL (2004) Overexpression of LRP12, a gene contained within an 8q22 amplicon identified by high resolution array CGH analysis of oral squamous cell carcinomas. Oncogene 23: 2582-86.
  • Krzywinski M, Bosdet I, Smailus D, Chiu R, Mathewson C, Wye N, Barber S, Brown-John M, Chan S, Chand S, Cloutier A, Girn N, Lee D, Masson A, Mayo M, Olson T, Pandoh P, Prabhu AL, Schoenmakers E, Tsai M, Albertson D, Lam W, Choy CO, Osoegawa K, Zhao S, de Jong PJ, Schein J, Jones S, Marra MA (2004) A set of BAC clones spanning the human genome. Nucleic Acids Research 32: 3651-60.
  • Chi B, DeLeeuw R, Coe B, MacAulay C, Lam WL (2004) SeeGH -- A software tool for the visualization of whole genome array CGH data. BMC Bioinformatics 5, 13: 1-6.
  • Garnis C, MacAulay C, Lam S, Lam W (2004) Genetic alteration on 8q distinct from MYC in bronchial carcinoma In situ lesions. Lung Cancer 44: 403-4.
  • Henderson LJ, Okamoto I, LestouVS, Ludkovski O, Robichaud M, Chhanabhai M, Gascoyne RD, KlasaR, ConnorsJM, Marra MA, Horsman DE, Lam WL (2004) Delineation of a Minimal Region of Deletion at 6q16.3 in Follicular Lymphoma and Construction of a Bacterial Artificial Chromosome Contig Spanning a 6-megabase Region of 6q16-q21. Genes Chromosomes Cancer 40: 60-65.
  • Garnis C, Coe BP, Ishkanian A, Zhang L, Rosin MP, Lam WL (2004) Novel regions of amplification on 8q distinct from the MYC locus and frequently altered in oral dysplasia and cancer. Genes Chromosomes Cancer 39: 93-8.
  • Watson SK, DeLeeuw RJ, Ishkanian AS, Malloff CA, Lam WL (2004) Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays. BMC Genomics 5, 6: 1-8.
  • MacAulay C, Lonergan K, Chi B, Zuyderduyn S, Shein J, Tsao M, LeRiche J, Jones S, Marra M, Lam S, Lam WL (2004) Serial analysis of gene expression profiles of developmental stages in non-small cell lung carcinoma. Chest 125 (5 Suppl):97S.
  • Garnis C, Coe B, Henderson LJ, Ishkanian A, Watson S, Marra M, Minna J, Lam S, MacAulay C, Lam W (2004) Construction and optimization of chromosome arm-specific comparative genomic hybridization arrays for identifying genetic alterations in preinvasive lung cancers. Chest 125 (5 Suppl):104S-5S.
  • Garnis C, Campbell J, Zhang L, Rosin MP, Lam WL (2004) OCGR Array, an oral cancer genomic regional array for comparative genomic hybridization analysis. Oral Oncology 40:511-9.
  • Neufeld JD, Yu Z, Lam W, Mohn WW (2004) SARST, Serial Analysis of Ribosomal Sequence Tags. In Molecular Microbial Ecology Manual, 2nd Ed. Kluwer, The Netherlands.
  • Neufeld JD, Yu Z, Lam W, Mohn WW (2004) Serial Analysis of Ribosomal Sequence Tags (SARST): a high-throughput method for profiling complex microbial communities. Enviromental Microbiology 6: 131-44.


  • Garnis C, Baldwin C, Zhang L, Rosin MP, Lam WL (2003) Use of Complete Coverage Array CGH to Define Copy Number Alterations on Chromosome 3p in Oral Squamous Cell Carcinomas. Cancer Research 63: 8582-5.
  • Rosin MP, Lam WL, Zhang L (2003) Correspondence to: 3p14 and 9p21 loss is a simple tool for predicting second oral malignancy at previously treated oral cancer sites. Cancer Research 63: 5167-9.
  • Sokolov K, Aaron J, Hsu B, Nida D, Gillenwater A, Follen M, MacAulay C, Adler-Storthz K, Korgel B, Descour M, Pasqualini R, Arap W, Lam W, Richards-Kortum R (2003) Optical systems for in vivo molecular imaging of cancer. Technol Cancer Res Treat 2: 491-504.
  • Malloff CA, Dullaghan EM, I A, Stokes RW, Fernandez RC, Lam WL (2003) Two-dimensional DNA displays for comparisons of bacterial genomes. Biol. Proced. On. 53: 143-52.
  • Lestou VS, Ludkovski O′ Connors JM, Gascoyne RD, Lam WL, Horsman DE (2003) Characterization of the recurrent translocation t(1;1)(p36.3;q21.1-2) in non-Hodgkin′s lymphoma by multicolor banding and FISH analysis. Genes Chromosomes and Cancer 36: 375-81.


  • Rosin MP, Lam WL, Poh C, Le ND, Li RJ, Zeng T, Priddy R, Zhang L (2002) 3p14 and 9p21 loss is a simple tool for predicting second oral malignancy at previously treated oral cancer sites. Cancer Research 62: 6447-50.
  • Lestou VS, Robichaud M, Chudoba I, O′Connell J, Maguire J, Sorensen PHB, Lam W, Horsman D (2002) Cryptic t(X;18) and ins(6;18) in a monophasic intraneural synovial sarcoma as characterized by mFISH and locus specific FISH analysis. Genes Chromosomes Cancer 138: 153-6.
  • Siwoski A, Ishkanian A, Garnis C, Zhang, L, Rosin MP, Lam, WL (2002) An Efficient method for the assessment of DNA quality of archival microdissected specimens. Modern Pathology 15: 889-92.
  • Malloff CA, Fernandez RC, Dullaghan EM, Stokes RW, Lam WL (2002) Two-dimensional display of respiratory pathogen genomes of high G + C DNA content. Gene 293: 205-11.
  • Oloumi A, Lam W, Banath JP, Olive PL (2002) Identification of genes differentially expressed in V79 cells grown as multicell spheroids. Int J Radiat Biol 78: 483-92.
  • Dullaghan EM, Malloff CA, Li AH, Lam WL, Stokes RW (2002) Two-dimensional bacterial genome display: a method for the genomic analysis of mycobacteria. Microbiology 148: 3111-7.
  • Zhang L, Epstein JB , Poh CF, Berean K, Lam WL, Rosin MP (2002) Comparison of HPV infection, p53 mutation and allelic losses in oral squamous cell carcinomas from transplant and non-transplant recipients. J Oral Path Med 31:134-41.


  • Malloff CA, Fernandez RC, Lam WL (2001) Comaprative bacterial genomic hybridization. J Mol Biol 312: 1-5.
  • Zhang L, Cheung KJ, Lam WL, Cheng, X, Poh C, Priddy R, Epstein JB, Le ND, Rosin MP (2001) Increased genetic damage in oral leukoplakia from high-risk sites: potential impact on staging and clinical management. Cancer 91: 2148-55.
  • Zhang L, Poh C, Lam WL, Epstein JB, Cheng X, Zhang X, Priddy R, Lovas J, Le ND, Rosin MP (2001) Impact of localized treatment in reducing risk of progression of oral dysplasia: molecular evidence of incomplete resection. Oral Oncology 37: 505-12.
  • Poh CF, Zhang L, Lam WL, Zhang X, An D, Chau C, Priddy R, Epstein J, Rosin MP (2001) A high frequency of allelic loss in oral verrucous lesions may explain malignant risk. Laboratory Investigation 81: 629-34.

2000 and earlier

  • Rosin, MP, Cheng X, Poh C, Lam WL, Huang Y, Lovas J, Berean K, Epstein JB, Priddy R, Le ND and Zhang, L (2000) Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clinical Cancer Research 6: 357-62.
  • Bochar DA, Brown JR, Doolittle WF, Klenk H-P, Lam WL, Schenk ME, Stauffacher CV and Rodwell VW (1997) HMG-CoA reductase of Sulfolobus solfataricus: DNA sequence, phylogeny, expression in Escherichia coli of the hmgA gene, and purification and kinetic characterization of the gene product. Journal of Bacteriology 179: 3632-8.
  • Lam WL, Lee TS, Gilbert W (1996) Active transposition in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 93: 10870-5.
  • Lam WL, Seo P, Robison K, Virk S, Gilbert W (1996) Discovery of amphibian Tc1-like transposon families. Journal of Molecular Biology. 257: 359-66.
  • Lam WL and Doolittle WF (1992) Mevinolin resistant mutations identify a promoter and the gene for a eukaryotic-like 3-hydroxy-3-methylglutaryl coenzyme A reductase in the archaebacterium Haloferax volcanii. Journal of Biological Chemistry 267: 5829-34.
  • Doolittle WF, Lam WL, Schalkwyk LC, Charlebois RL, Cline SW and Cohen A (1992) Progress in developing the genetics of the archaebacteria. Biochem. Journal (Biochem. Soc. Symp.) 58: 73-8.
  • Lam WL, Logan SM and Doolittle WF (1992) Genes for tryptophan biosynthesis in the halophilic archaebacterium Haloferax volcanii: the trpDFEG cluster. Journal of Bacteriology 174: 1694-7.
  • Cohen A, Lam WL, Charlebois RL, Doolittle WF and Schalkwyk LC (1992) Localizing genes on the map of the genome of Haloferax volcanii, one of the Archaea. Proc. Natl. Acad. Sci. U.S.A. 89: 1602-6.
  • Doolittle WF, Lam WL and Schalkwyk LC (1991) Evolution and basic features of gene and genome structure. Symp. Soc. Gen. Microbiol. 47: 1-16.
  • Cline SW, Lam WL, Doolittle WF (1991) Transformation of Haloferax volcanii. In Protocols for Archaebacterial Research, Fleischmann EM, Place AR, Robb FT & Schreier (ed.), Center of Marine Biotech, Univ. of Maryland System. pp. 3.2.1-6
  • Cline SW, Lam WL, Doolittle WF (1991) Transformation of Halobacterium halobium. In Protocols for Archaebacterial Research, Fleischmann EM, Place AR., Robb FT & Schreier (ed.), Center of Marine Biotech., U. of Maryland Sys. pp. 3.1.1-5
  • Lam WL, Cohen A, Tsouluhas D, Doolittle WF (1990) Genes for tryptophan biosynthesis in the archaebacterium Haloferax (Halobacterium) volcanii.  Proc. Natl. Acad. Sci. U.S.A. 87: 6614-8.
  • Doolittle WF, Charlebois RL, Schalkwyk L, Lam WL, Conover RK, Tsouluhas D, Cline SW, Hofman JD and Cohen A (1990) Physical mapping and gene transfer methods for Halobacterium volcanii. In Proc. FEMS Workshop on Halophilic Bacteria, F. Rodriguez-Valera (ed.), Plenum.
  • Lam WL, Charlebois RL, Doolittle WF (1989) Progress in the molecular biology of the archaebacteria. UCLA Symp. Mol. Cell. Biol. 122: 265-72.
  • Charlebois RL, Hofman JD, Schalkwyk LC, Lam WL, Doolittle WF (1989) Genome mapping in halobacteria.  Canadian J. Microbiology 35, 21-9.
  • Lam WL, Doolittle WF (1989) Shuttle vectors for the archaebacterium Halobacterium volcanii. Proc. Natl. Acad. Sci. U.S.A. 86: 5478-82.
  • Cline SW, Lam WL, Charlebois RL, Schalkwyk LC, Doolittle WF (1989) Transformation methods for halophilic archaebacteria. Canadian J. Microbiology 35: 148-52.
  • Lam WL, Doolittle WF (1988) Isolation of a mevinolin resistance marker for genetic transfer in halophilic archaebacteria. Genome 30: 31.
  • Charlebois RL, Lam WL, Cline SW, Doolittle WF (1987) Characterization of pHV2 from Halobacterium volcanii and its use in demonstrating transformation of an archaebacterium.  Proc. Natl. Acad. Sci. U.S.A. 84: 8530-4.


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