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Cathie Garnis, PhD

Senior Scientist - Genetics Unit, Integrative Oncology

20100729_CGarnis 

cgarnis@bccrc.ca   Rm 10-122 ▪ 675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada


Current Appointments

Assistant Professor, Faculty of Medicine, Department of Surgery, Division of Otolaryngology, University of British Columbia

Senior Scientist, Genetics Unit, Integrative Oncology Department, BC Cancer Research Centre


Training

BSc (Cell Biology and Genetics), University of British Columbia, 2000
PhD (Pathology and Laboratory Medicine), University of British Columbia, 2005
Post-doctoral Associate, Massachusetts Institute of Technology, 2008


PLEASE NOTE: Garnis Lab activities are regularly updated at garnislab.com.


Research Interests

Our primary research interests are focused around head and neck malignancies. These are a group of biologically similar tumours originating from tissue of the upper aerodigestive tract, including the lip, oral cavity (mouth), nasal passages, paranasal sinuses, pharynx, and larynx. More than 4,300 Canadians will be diagnosed with this type of cancer this year and approximately 1,600 of them will die from it.

Currently, histopathological criteria are the gold standard for grading and classifying many tumour types. In recent years it has become clear that cancers with very similar morphologies may have drastically different underlying gene changes. Given that cancer is a disease driven by accumulated gene changes, it is imperative that we determine which of these changes are associated with specific clinical parameters. This will ultimately give us insight into mechanisms driving observed clinical behaviours (chemoresistance, metastasis, etc.) and provide us with effective biomarkers for guiding treatment strategies.

At the Garnis Lab, we are using complete molecular profiles of head and neck malignancies to better understand the gene changes involved in initiation and progression of this disease. We are looking into dysregulation of the genome and transcriptome (including small RNAs) to develop molecular stratifications for what is presently treated as a homogeneous disease. Our emphasis on early stage cases stems from the reality that pre-cancerous tissues are much more treatable than invasive tumours. DNA and RNA changes we identify in pre-malignant lesions will be further investigated as potential prognostic biomarkers and as candidates for novel targeted therapies.


Garnis Lab Members

Danielle Truong (Research Technician) - dtruong@bccrc.ca

James Lawson (Summer Student) - jlawson@bccrc.ca

Jamil Manji (Graduate Student) - jmanji@bccrc.ca

Marina Laissus (Visiting Scientist/Student) - mlaissus@bccrc.ca

Mike Gorenchtein (Graduate Student) - mgorench@bccrc.ca

Rajan Saini (Post-doctoral Fellow) - rsaini@bccrc.ca

Rebecca Towle (Graduate Student) rtowle@bccrc.ca

Sara Maclellan (Graduate Student) - smaclellan@bccrc.ca

Shevaun Hughes (Graduate Student) - shughes@bccrc.ca


Alumni

Students and Fellows

[To be updated.]

Staff

Angie Chu (Research Technician)

Razan Sheta (Research Technician)

Solene Debesson-Narce (Summer Student)


Garnis Lab Publications

Refereed Articles

Towle R, Garnis C (2012). Methylation-mediated molecular dysregulation in clinical oral malignancy, J Oncol, 170172. (link)

Gorenchtein M, Poh CF, Saini R, Garnis C (2011). MicroRNAs in an Oral Cancer Context – from Basic Biology to Clinical Utility, J Dent Res, 91(5):440-6. (link)

Lockwood WW, Chari R, Coe BP, Thu KL, Garnis C, Malloff CA, Campbell J, Williams AC, Hwang D, Zhu CQ, Buys TP, Yee J, English JC, Macaulay C, Tsao MS, Gazdar AF, Minna JD, Lam S, Lam WL. (2010) Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma. PLoS Med 7(7):e1000315. (link)

Tsui IF, Garnis C. (2010) Integrative molecular characterization of head and neck cancer cell model genomes. Head Neck 32(9):1143-60. (link)

Chari R, Thu KL, Wilson IM, Lockwood WW, Lonergan KM, Coe BP, Malloff CA, Gazdar AF, Lam S, Garnis C, Macaulay CE, Alvarez CE, Lam WL. (2010) Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer. Cancer Metastasis Rev 29(1):73-93. (link)

Tsui IF, Garnis C, Poh CF. (2009) A dynamic oral cancer field: unraveling the underlying biology and its clinical implication. American Journal of Surgical Pathology 33(11):1732-8. (link)

Garnis C, Chari R, Buys TP, Zhang L, Ng RT, Rosin MP, Lam WL. (2009) Genomic imbalances in precancerous tissues signal oral cancer risk. Molecular Cancer 8:50. (link)

Tsui IF, Poh CF, Garnis C, Rosin MP, Zhang L, Lam WL. (2009) Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias. International Journal of Cancer 125(9):2219-28. (link)

Garnis C, Lockwood WW, Vucic E, Ge Y, Girard L, Minna JD, Gazdar AF, Lam S, MacAulay C, Lam WL. (2006) High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH. International Journal of Cancer 118(6):1556-64. (link)

Baldwin C, Garnis C, Zhang L, Rosin MP, Lam WL (2006). Response to: Genomic analysis of tumors by array comparative genomic hybridization: more is better. Cancer Research 66:3955-3956. (link)

Garnis C, Davies JJ, Buys TPH, Tsao M, Lam S, MacAulay C, Lam WL. (2005) Chromosome 5p aberrations and glial cell line-derived neurotrophic factor activation are early events in lung cancer. Oncogene 24:4806-12. (link)

Garnis C, Coe BP, MacAulay C, Lam WL. (2005) High-resolution array CGH increases heterogeneity tolerance in the analysis of clinical samples. Genomics 85:790-3. (link)

Garnis C, Campbell J, Davies JJ, MacAulay C, Lam S, Lam WL. (2005) Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis. Human Molecular Genetics 14:475-82. (link)

Baldwin C, Garnis C, Zhang L, Rosin MP, Lam WL. (2005) Multiple Microalterations Detected at High Frequency in Oral Cancer. Cancer Research 65:7561-7. (link)

Garnis C, Rosin MP, Zhang L, Lam WL. (2005) Alteration of AKAP220, an upstream component of the Rb pathway, in oral carcinogenesis. International Journal of Cancer 116:813-9. (link)

Coe BP, Henderson LJ, Garnis C, Tsao-MS, Gazdar A, Minna J, Lam S, MacAulay C, Lam WL. (2005) High resolution chromosome 5p array CGH analysis of small cell lung carcinoma cell lines. Genes, Chromosomes and Cancer 42:308-313. (link)

Garnis C, Buys TPH, Lam WL. (2004) Genetic alteration and gene expression modulation during cancer progression. Molecular Cancer 3:1-23. (link)

Garnis C, Coe BP, Ishkanian A, Zhang L, Rosin MP, Lam WL. (2004) Novel regions of amplification on 8q distinct from the MYC locus and frequently altered in oral dysplasia and cancer. Genes, Chromosomes and Cancer 39:93-8. (link)

Garnis C, Coe BP, Zhang L, Rosin MP, Lam WL. (2004) Overexpression of LRP12, a gene contained within an 8q22 amplicon identified by high-resolution array CGH analysis of oral squamous cell carcinomas. Oncogene 23:2582-6. (link)

Garnis C, Campbell J, Zhang L, Rosin MP, Lam WL. (2004) OCGR array: an oral cancer genomic regional array for comparative genomic hybridization analysis. Oral Oncology 40:511-9. (link)

Garnis C, MacAulay C, Lam S, Lam WL. (2004) Genetic alteration on 8q distinct from MYC in bronchial carcinoma in situ lesions. Lung Cancer 44:403-4. (link)

Garnis C, Baldwin C, Zhang L, Rosin MP, Lam WL. (2003) Use of complete coverage array comparative genomic hybridization to define copy number alterations on chromosome 3p in oral squamous cell carcinomas. Cancer Research 63:8582-5. (link)

Siwoski A, Ishkanian A, Garnis C, Zhang L, Rosin M, Lam WL. (2002) An efficient method for the assessment of DNA quality of archival microdissected specimens. Modern Pathology 15:889-92. (link)

Book Chapters, Encyclopedia Entries, and Non-refereed Articles

Garnis, C. (2007) Diagnostic methods of lung cancer and its subtypes by comparative genomic hybridization (Patent Review). Expert Opinion on Medical Diagnostics 1(4):541-544. (link)

Buys TPH, Wilson IM, Coe BP, Lee EHL, Kennett JY, Lockwood WW, Tsui IFL, Shadeo A, Chari R, Garnis C, Lam WL. ‘Detailed comparisons of cancer genomes’ in Comparative Genomics: Fundamental and Applied Perspectives. (2007) James R. Brown (ed.), CRC Press, Taylor and Francis, LLC. Boca Raton, FLA, USA (ISBN: 9780849392160). (link)

Garnis C, Lam WL. ‘Oral Cancer’ in Encyclopedia of Cancer (2nd Edition). (2009) Manfred Schwab (ed.), Springer Press.  (ISBN: 9783540368472). (link)