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Daiana Becker-Santos

 

 


 dbecker@bccrc.ca   675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada 

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam LabDaiana Becker |


Training

  • B.Sc. (Biology), Universidade Federal do Rio Grande do Norte, 2006

  • M.Sc. (Genetics), University of British Columbia, 2011 


Program

Ph.D. , Interdisciplinary Oncology, University of British Columbia


Research Interests

  • Molecular and cellular basis of cancer invasion and metastasis
  • Epithelial-to-mesenchymal transition
  • Lung and prostate cancer

Awards

  • Young Investigator Award, International Association for the Study on Lung Cancer, World Conference of Lung Cancer (2016)
  • Killam Doctoral Scholarship (2013 & 2014)
  • Vanier Canada Graduate Scholarship (2013-2016)
  • Sponsored Invited Participant - Sao Paulo Advanced School of Comparative Oncology (2012)

  • AACR Scholar in Training Award (2012)
  • Four Year Doctoral Fellowship - University of British Columbia (2012)

  • College for Interdisciplinary Studies Graduate Award - University of British Columbia (2012)
  • Most Outstanding Trainee Presentation - Terry Fox Research Institute Annual Scientific Meeting (2010)
  • Best Poster Prize - Genetics Retreat, University of British Columbia (2010)
  • University Graduate Fellowship - University of British Columbia (2008)
  • International Tuition Scholarship - University of British Columbia (2007 - 2011)
  • Best B.Sc. Thesis in Biological Sciences - Federal University of Rio Grande do Norte (2006)
  • Outstanding Graduating Student - Federal University of Rio Grande do Norte (2006)
  • Scientific Initiation Fellowship - Federal University of Rio Grande do Norte (2003) 

Publications

  • Becker-Santos DD, Thu KL, English JC, Pikor LA, Martinez VD, Zhang M, Vucic EA, Luk MT, Carraro A, Korbelik J, Piga D, Lhomme NM, Tsay MJ, Yee J, MacAulay CE, Lam S, Lockwood WW, Robinson WP, Jurisica I, Lam WL (2016) Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma. Journal of Pathology 240(2):161-72.
  • Marshall EA, Ng KW, Kung SH, Conway EM, Martinez VD, Halvorsen EC, Rowbotham DA, Vucic EA, Plumb AW, Becker-Santos DD, Enfield KS, Kennett JY, Bennewith KL, Lockwood WW, Lam S, English JC, Abraham N, Lam WL (2016) Emerging roles of T Helper 17 and Regulatory T Cells in lung cancer progression and metastasis. Molecular Cancer 15:67, 1-15.
  • Martinez VD, Vucic EA, Thu KL, Hubaux R, Enfield KSS, Pikor LA, Becker-Santos DD, Brown CJ, Lam S, Lam WL (2015) Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology. Scientific Reports. 5:10423, 1-17.
  • Hubaux R, Thu KL, Vucic EA, Pikor LA, Kung SHY, Martinez VD, Mosslemi M, Becker-Santos DD, Gazdar AF, Lam S, Lam WL (2015) Microtubule affinity-regulating kinase 2 contributes to cisplatin sensitivity through modulation of the DNA damage response in non-small cell lung cancer. International Journal of Cancer 137(9):2072-82.
  • Thu KL, Becker-Santos DD, Radulovich N, Pikor LA, Lam WL, Tsao MS (2014) SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types. Oncoscience 1 :326-35.
  • Thu KL, Radulovich N, Becker-Santos DD, Pikor LA, Pusic A, Lockwood WW, Lam WL*, Tsao MS* (2014) SOX15 is a candidate tumor suppressor in pancreatic cancer with a role in Wnt/β-catenin signaling. Oncogene. 33(3):279-88.
  • Hubaux R*, Becker-Santos DD*, Enfield KSS, Rowbotham D, Lam S, Lam WL, Martinez VD (2013) Molecular features in arsenic induced lung tumors. Molecular Cancer 12:20, 1-11. [PMID:23510327]
  • Martinez VD, Becker-Santos DD, Lam S, Lam WL (2012) How should treatment differ for lung cancers caused by arsenic exposure?  Lung Cancer Management 1: 243–46.
  • Hubaux R*, Becker-Santos DD*, Enfield K, Lam WL, Martinez VD (2012) Arsenic, asbestos and radon: Emerging players in lung tumorigenesis. Environmental Health. 11:89, 1-12. [*co-first authorship]
  • Gibb EA, Becker-Santos DD*, Enfield KSS, Guillaud M, Van Niekerk D, Matisic JP, MacAulay CE, Lam WL, (2012) Aberrant expression of long non-coding RNAs in cervical intraepithelial neoplasia. International Journal of Gynecological Cancer 22:1557-63. [*Corresponding author]
  • Becker-Santos DD, Guo Y, Ghaffari M, Vickers ED, Lehman M, Altamirano-Dimas M, Oloumi A, Furukawa J, Sharma M, Wang Y, Dedhar S, Cox ME (2012) Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models. Carcinogenesis 33: 2558-67. 
  • Hubaux R, Becker-Santos DD, Enfield KSS, Lam S, Lam WL, Martinez VD (2012) MicroRNAs as biomarkers for clinical features of lung cancer. Metabolomics 2: 108, 1-11.
  • Martinez VD, Becker-Santos DD, Vucic EA, Lam S, Lam WL (2011) Induction of human squamous cell-type carcinomas by arsenic. Journal of Skin Cancer: 454157, 1-9.
  • Martinez VD, Vucic EA, Becker-Santos DD, Gil L, Lam WL (2011) Arsenic toxicity induction of human cancers. Journal of Toxicology: 431287, 1-13.
  • Gibb EA, Vucic, EA, Enfield KSS, Stewart GL, Lonergan KM, Kennett JY, Becker-Santos DD, MacAulay CE, Lam S, Brown CJ, Lam WL (2011) Human cancer long non-coding RNA transcriptomes. PLoS ONE 6: e25915, 1-10.
  • Gavric O, Becker dos Santos D and Griffiths AJF (2007) Mutation and divergence of the phospholipase C gene in Neurospora crassa. Fungal Genetics and Biology. 44:242-249. 

Abstracts and Presentations

  • Becker-Santos DD, Thu KL, Robinson WP, Lam S, Lam WL (2013) Similarities of miRNA expression patterns in cancerous and developing lung tissues. In SPSAS - Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment.

  • Becker-Santos DD, Thu KL, Robinson WP, Lam S, Lam WL (2012) miRNA expression in human lung cancer and fetal lung: a comparative study.  In Sao Paulo Advanced School of Comparative Oncology.

  • Becker-Santos DD, Vucic EA, Lam S, Lam WL, Martinez VD (2012) Molecular events in arsenic-related lung cancer. In UICC World Cancer Congress.

  • Becker-Santos DD, Lam WL, Martinez VD (2012) Establishment of a cancer biobank network in Chile. In UICC World Cancer Congress.

  • Becker-Santos DD, Hubaux R, Vucic EA, Lam S, Lam WL, Martinez VD (2012) Molecular events in lung squamous cell carcinomas associated with arsenic exposure. In IASLC: Latin American Conference on Lung Cancer.

  • Becker-Santos DD, Gibb EA, Vucic EA, Enfield KSS, Stewart GL, MacAulay CE, Lam S, Lam WL (2012) An expression map of long non-coding RNAs in human lung and non small cell lung cancer. In AACR-IASLC: The Molecular Origins of Lung Cancer.

  • Becker-Santos DD, Vucic EA, Lam S, Lam WL, Martinez VD (2012) Genomic and epigenomic events in arsenic-related lung squamous cell carcinomas from smokers and never smokers. In AACR-IASLC: The Molecular Origins of Lung Cancer.

  • Becker-Santos DD, Martinez VD, Vucic EA,  Lam S, Lam WL (2011) Arsenic-related genomic and epigenomic alterations in lung squamous cell carcinomas. In American Society of Human Genetics Annual Meeting.

  • Enfield KS, Chari R, Becker-Santos DD, Lam S, Lam WL (2011) ELF3 is a putative oncogene frequently gained and hypomethylated in the adenocarcinoma subtype of non-small cell lung cancer. In American Society of Human Genetics Annual Meeting.

  • Becker-Santos DD, Vucic EA,  Lam S, Lam WL, Martinez VD (2011) Genomic and epigenomic alterations in arsenic-related lung squamous cell carcinomas. In American Association for Cancer Research: Frontiers in Cancer Prevention Research Meeting.

  • Thu KL, Becker Santos D, Chari R, Zhang W, MacAulay CE, Gazdar AF, Lam S,  Lam W  (2011) Lung adenocarcinoma genomes of never smokers exhibit a greater extent of genomic instability than those of smokers. In World Conference on Lung Cancer.

  • Becker Santos D, Guo Y,  Oloumi A, Cox ME and Dedhar S (2011) Integrin-linked kinase is an essential mediator of ERG-induced EMT in prostate cancer models. In Epithelial Plasticity and Epithelial to Mesenchymal Transition Keystone Symposia.

  • Becker Santos D, Guo Y,  Oloumi A, McDonald P, Cox ME and Dedhar S  (2010) ERG overexpression induces EMT in prostatic epithelial cells in an integrin-linked kinase (ILK)-dependent manner. In EMT and Cancer Progression and Treatment Meeting.

  • Becker Santos D, Guo Y,  Oloumi A, Cox ME and Dedhar S  (2009) Integrin-linked kinase is a key regulator of transformation and epithelial-to-mesenchymal transition of ERG-expressing human prostatic epithelial cells. In AACR Annual Meeting.

  • Becker Santos D and Blaha CA (2003) Thermophilic sulfate-reducing bacteria and their genes involved in oil biodegradation. In CIENTEC Annual Meeting.


Links

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam LabDaiana Becker |