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Chad Malloff, BSc, MSc

Coordinator of Laboratory Operations, Safety Officer

camalloff@bccrc.ca   675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada 

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab | Chad Malloff


 ChadMalloff 


Training

B.Sc (Microbiology), UBC, 1997

M.Sc. (Pathology), UBC, 2002


Research Interests

  • Genetic alterations responsible for the development of cancer
  • Prostate Cancer
  • Mantle Cell Lymphoma
  • Pathogen Genomes

Identification of genes involved in cancer progression and genes involved in bacterial pathogenesis. The majority of my work has dealt with the use of Two-dimensional DNA electrophoresis to compare large genomes. Along with my supervisor I have developed a Bacterial Comparative Genomic Hybridization (BCGH) method for the identification of acquired DNA in bacterial genomes. This technique has been applied to the identification of drug resistance both at the DNA and RNA level. Adaptations of this technique are also being used to look at mutations in specific cancer linked genes as well as whole-genome scanning of alterations in lung cancer.


Publications

  • Malloff CA, Fernandez RC, Lam WL (2001) Comaprative bacterial genomic hybridization. J Mol Biol. 312: 1-5.
  • Dullaghan EM, Malloff CA, Li AH, Lam WL, Stokes RW (2002) Two-dimensional bacterial genome display: a method for the genomic analysis of mycobacteria. Microbiology 148: 3111-7.
  • Malloff CA, Fernandez RC, Dullaghan EM, Stokes RW, Lam WL (2002) Two-dimensional display of respiratory pathogen genomes of high G + C DNA content. Gene 293: 205-11.
  • Malloff CA, Dullaghan EM, I A, Stokes RW, Fernandez RC, Lam WL (2003) Two-dimensional DNA displays for comparisons of bacterial genomes. Biol. Proced. On. 53: 143-52.
  • Watson SK, DeLeeuw RJ, Ishkanian AS, Malloff CA, Lam WL (2004) Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays. BMC Genomics 5, 6: 1-8.
  • Ishkanian AS, Malloff CA, Watson SK, DeLeeuw RJ, Chi B, Coe BP, Snijders A, Albertson DG, Pinkel D, Marra MA, Ling V, MacAulay, C, Lam WL (2004) A tiling resolution DNA microarray with complete coverage of the human genome. Nature Genetics 36: 299-303.
  • Ishkanian AI*, Malloff CA*, Meng A, Ho J, Albert M, Syed, A, van der Kwast T, Milosevic M, Lam WL, Bristow RG (2009) High-resolution array CGH identifies novel regions of genomic alteration in intermediate-risk prostate cancer. Prostate 69: 1091-1100. 
  • Li AH, Waddell SJ, Hinds J, Malloff CA, Bains M, Hancock RE, Lam WL, Butcher PD, Stokes RW (2010) Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages. PLoS ONE 5: e11066, 1-14.
  • Lockwood WW, Chari R, Coe BP, Thu KL, Garnis C, Malloff CA, Campbell JM, Williams AC, Hwang D, Chang QZ, Buys TPH, Yee J, English J, MacAulay C, Tsao MS, Gazdar AF, Minna JD, Lam S, Lam WL (2010) Integrative genomic analyses identify BRF2 as a novel lineage specific oncogene in lung squamous cell carcinoma. PLoS Medicine 7(7): e1000315, 1-14.
  • Chari R, Thu KL, Wilson IM, Lockwood WW, Lonergan KM, Coe BP, Malloff CA, Gazdar AF, Lam S, Garnis C, MacAulay CE, Alvarez CE, Lam WL (2010) Integrating the multiple dimensions of genomic and epigenomic lanscapes of cancer.  Cancer and Metastasis Reviews 29:73-93.


Links

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab | Chad Malloff