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Brenda de Carvalho Minatel

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Graduate Student

 Brenda posterBrenda Minatel2

 bminatel@bccrc.ca   675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada 

BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab | Brenda de Carvalho Minatel |


Program

  • M.Sc., Interdisciplinary Oncology, Faculty of Medicine, University of British Columbia (2016-present)


Training

  • B.Sc Biomedical Sciences (UNESP, Brazil), Specialization in Genetics (2012-2015)

  • Diploma, Anglo Matão Secondary School, Brazil 

Research Interests

  • Epigenetics in cancer development and progression

  • Small non-coding RNAs in lung and liver cancer

  • Developmental pathways reactivation


Awards

  • Second Prize for Best Speed Talk Presentation (2017) 
  • Interdisciplinary Oncology Program Travel Award (2016)
  • International Tuition Award, University of British Columbia (2016)
  • Faculty of Medicine Graduate Award, University of British Columbia (2016)
  • Best Presentation in Biological Field Award, XXVII CIC - 2nd stage (2015) 
  • Best Presentation in Biological Field Award, XXVII CIC - 1st stage (2015) 
  • BEPE-IC Fellowship, FAPESP (2015)
  • Two-year Scientific Initiation Scholarship, FAPESP (2013-2015)

Invited Talks

  • Mini-oral presentation at the IASLC World Conference on Lung Cancer. Yokohama, Japan (2017)
  • "Animal Cell Culture Bases". Theoretical and Practical Course at the 18th Biomedical National Meeting (18º ENBM). São Paulo, SP – Brazil (2015)
  • "Principles of Animal Cell Culture”. Course “Classic Study Methods in Morphology” of the B.Sc. Biomedical Sciences Program. São Paulo State University (UNESP). Botucatu, SP - Brazil (2014)

Journal Publications

  • Minatel BC*, Sage AP*, Anderson C, Hubaux R, Lam WL, Martinez VD. (November 2017). Environmental arsenic exposure: genetic and epigenetic contributions to carcinogenesis. Submitted. [*Co-first Authorship]
  • Martinez VD*, Anderson C*, Marshall EA, Ng K, Minatel BC, Sage AP, Enfield KSS, Xu Z, Lam WL. (September 2017). Discovery of 154 novel miRNAs in mesothelioma and their potential as tissue of origin markers. Submitted. [*Co-first Authorship]
  • Sage AP*, Minatel BC*, Ng K, Stewart GL, Dummer TJB, Lam WL, Martinez VD (2017) Oncogenomic disruptions in arsenic-induced carcinogenesis. Oncotarget. 8(15):25736-55. [*Co-first Authorship]
  • Ng KW*, Anderson C*, Marshall EA*, Minatel BC*, Enfield KSS, Saprunoff HL, Lam WL, Martinez VD (2016) Piwi-interacting RNAs in cancer: emerging functions and clinical utility. Molecular Cancer. 15(1):5, 1-15.  [*Co-first Authorship] 

Abstracts and Presentations

Total of 50 abstract publications.
Abstracts Published at International Conferences (Presenter underlined). [25 out of 50]
  • Minatel B.C., Martinez V.D., Sage A.P., Marshall E.A., Ng K.W., Anderson C., Becker-Santos D.D., Robinson W.P., Jurisica I., Lam W.L. (2017). Expanding the lung small RNA transcriptome: discovery of unannotated microRNAs with roles in development and tumourigenesis. IASLC WCLC. Yokohama, Japan. (Mini-oral presentation)
  • Minatel B.C., Martinez V.D., Becker-Santos D.D., Marshall E.A., Ng K.W., Sage A.P., Anderson C., Robinson W.P., Jurisica I., Lam W.L. (2017). Identification of oncofetal piRNAs in lung. Yokohama, Japan. (Poster)
  • Martinez V.D., Marshall E.A., Firmino N., Minatel B.C., Bennewith K.L., Lam W.L. (2017). The response of the small non-coding transcriptome to hypoxia delineates risk of lung adenocarcinoma recurrence. Yokohama, Japan. (Poster)
  • Martinez V.D., Ng K.W., Marshall E.A., Sage A.P., Minatel B.C., Lam W.L. (2017). Arsenic induces persistent alterations in lung cancer small non-coding RNA transcriptome. Yokohama, Japan. (Poster)
  • Minatel B.C., Martinez V.D., Marshall E.A., Ng K.W., Enfield K.S.S., Lam W.L. (2016) PIWI-interacting RNAs expression networks associated with clinically relevant tumor features and patient prognosis. Cell Symposium. Ghent, Belgium. (Poster)
  • Becker-Santos D.D., Minatel B.C., Lonergan K., Thu K.L., English J.C., Martinez V.D., Macaulay C.E., Lockwood W.W., Robinson W.P., Jurisica I., Lam S., Lam W.L. (2016) Suppression of NFIB by oncofetal miRNAs is linked to tumour aggressiveness in lung adenocarcinoma. Cell Symposium. Ghent, Belgium. (Poster)
  • Kung S.H.Y., Enfield K.S.S., Rowbotham D.A., Marshall E.A., Holly A., Pastrello C., Minatel B.C., Dellaire G., Jurisica I., Lam W.L. (2016) Combined overexpression of miR-106 paralogs regulates metastasis and is associated with poor outcome. Cell Symposium. Ghent, Belgium. (Poster)
  • Minatel B.C., Martinez V.D., Marshall E.A., Ng K.W., Enfield K.S.S., Lam S., Lam W.L. (2016) A PIWI-interacting RNAs co-expression networks as a prognostic factor in lung cancer. IASLC WCLC. Vienna, Austria. (Poster)
  • Martinez V.D., Vucic E.A., Thu K.L., Marshall E.A., Enfield K.S.S., Minatel B.C., Rahmati S., Tokar T., Abovsky M., Pastrello C., Jurisica I, Macaulay C.E., Lam S., Lam W.L. (2016) Molecular Biology Underlying COPD and Lung Cancer Converge on FOXM1 Network. IASLC WCLC. Vienna, Austria. (Poster)
  • Becker-Santos D.D., Minatel B.C., Lonergan K., Thu K.L., English J.C., Martinez V.D., Macaulay C.E., Lockwood W.W., Robinson W.P., Jurisica I., Lam S., Lam W.L. (2016) Expression of oncofetal miRNAs inactivates NFIB, a developmental transcription factor linked to tumour aggressiveness in lung adenocarcinoma. IASLC WCLC. Vienna, Austria. (Oral presentation)
  • Kung S.H.Y., Enfield K.S.S., Rowbotham D.A., Marshall E.A., Suzuki M., Holly A., Pastrello C., Minatel B.C., Dellaire G., Jurisica I., MacAulay C.E., Lam S., Lam W.L. (2016) Expression of miR-106 paralogs improves prognostic value of mesenchymal signatures but only miR-106b promotes invasiveness. IASLC WCLC. Vienna, Austria. (Poster)
  • Minatel B.C., Firmino N., Marshall E.A., Bennewith K.L., Lam W.L., Martinez V.D. (2016) Comprehensive identification of piwi-interacting RNAs binding sites associated with hypoxia-inducible genes downregulation. ASHG. Vancouver, BC. (Poster)
  • Kung S.H.Y., Enfield K.S.S., Rowbotham D.A., Pastrello C., Minatel B.C., Jurisica I., MacAulay C.E., Lam S., Lam W.L. (2016) Characterization of microRNAs upregulated in metastatic lung adenocarcinoma. ASHG. Vancouver, BC. (Poster)
  • Becker-Santos D.D., Minatel B.C., Thu K.L., English J.C., Martinez V.D., MacAulay C.E., Lockwood W.W., Lam S., Robinson W.P., Jurisica I., Lam W.L. (2016)  Developmental transcription factor NFIB is a target of oncofetal miRNAs and is linked to tumour aggressiveness in lung adenocarcinoma. ASHG. Vancouver, BC. (Oral presentation)
  • Ng K.W., Minatel B.C., Marshall E.A., Enfield K.S.S., Lam S., Lam W.L, Martinez V.D. (2016) Piwi-interacting RNAs display cancer-specific expression patterns that hold prognostic value in lung cancer. ASHG. Vancouver, BC. (Poster)
  • Firmino N., Marshall E.A., Minatel B.C., Lam W.L., Bennewith K.L., Martinez V.D. (2016) Hypoxia-regulates piwi-interacting RNAs in human tumors. ASHG. Vancouver, BC. (Poster) 
  • Martinez V.D., Vucic E.A., Thu K.L., Marshall E.A., Enfield K.S.S., Minatel B.C., Rahmati S., Abovsky M., Jurisica I., MacAulay C.E., Lam S., Ng R.T., Lam W.L. (2016) Integrated Multi'omics Analysis Identifies Pathogenetic Molecular Phenotypes of Lung Cancer and COPD. ASHG. Vancouver, BC (Poster)
  • Enfield K.S.S., Anderson C., Marshall E.A., Ng K.W., Minatel B.C., Rowbotham D.A., Chari R., Fuller M., Milne K., Becker-Santos D.D., MacAulay C.E., Karsan A., Lam S., Lam W.L. (2016) ELF3 amplification at 1q32.1 promotes SMAD4-independent tumourigenesis. AACR-IASLC International Joint Conference. San Diego, CA. (Poster)
  • Enfield K.S.S., Rowbotham D.A., Holly A., Anderson C., Ng K.W., Minatel B.C., Dellaire G., Pastrello C., Jurisica I., MacAulay C.E., Lam S., Lam W.L. (2015) miR-106a and miR-106b affect growth and metastasis of lung adenocarcinoma. AACR Non-coding RNAs and Cancer. Boston, MA. (Poster)
  • Martinucci B., Minatel B.C., Cuciello M.S., Vechetti-Junior I.J., Delella F.K. (2015) Impact of fibronectin on the expression of genes and microRNAs in LNCaP prostate cancer cells. VIII International Symposium on Extracellular Matrix. São Paulo, Brazil (Poster)
  • Minatel B.C., Martinucci B., Nunes H.C., Cuciello M.S., Vechetti-Junior I.J., Delella F.K. (2015) Influence of fibronectin and fibroblasts over the gene expression of prostate tumor cells LNCaP. VIII International Symposium on Extracellular Matrix. São Paulo, Brazil (Poster)
  • Martinucci B., Minatel B.C., Cuciello M.S., Vechetti-Junior I.J., Delella F.K. (2015) Gene and microRNAs expression characterization of human prostate cell lines. V Workshop on Male Reproductive Biology. São Paulo, Brazil (Poster)
  • Martinucci B., Minatel B.C., Souza G.R., Vechetti-Junior I.J., Delella F.K. (2014) Fibronectin regulates the expression of microRNAs 145 and 21 in prostate cancer cells. International Conference on Reproductive Biology and Toxicology. Ribeirão Preto, Brazil (Poster)
  • Delella F.K., Minatel B.C., Martinucci B., Cuciello M.S., Souza G.R. (2014) Laboratory of in vitro studies on prostate cancer and extracellular matrix components. International Conference on Reproductive Biology and Toxicology. Ribeirão Preto, Brazil (Poster)
  • Delella F.K., Moroz A., Fernandez G.G., Minatel B.C., Martinucci B., Felisbino S.L. (2013) Alterations in microRNAs expression of LNCaP cells promoted by 5 alpha reductase inhibition. IV Workshop on Male Reproductive Biology. São Paulo, Brazil (Oral presentation)
Abstracts Published at National Conferences (Presenter underlined). [9 out of 50]
  • Minatel B.C., Martinez V.D., Marshall E.A., Ng K.W., Sage A.P., Anderson C., Becker-Santos D.D., Robinson W.P., Jurisica I., Lam W.L. (2017). Discovering novel oncofetal microRNAs in the liver. Canadian Cancer Research Conference. Vancouver, BC. (Poster)
  • Martinez V.D., Ng K., Marshall E., Sage A., Minatel B., Lam W. (2017). Arsenic induces persistent alterations in lung cancer small non-coding RNA transcriptome. Human Genome Meeting. Barcelona, Spain. (Poster)
  • Martinez V.D., Ng K., Minatel B., Sage A., Marshall E., Lam W. (2017). Analysis of PIWI-interacting RNA transcriptomes reveal cancer type-specificity and signatures predicting lung tumor behavior. Human Genome Meeting. Barcelona, Spain. (Poster)
  • Enfield K.S.S., Rowbotham D.A., Anderson C., Marshall E.A., Ng K.W., Minatel B.C., Chari R., Fuller M., Becker-Santos D.D., MacAulay C.E., Lam S., Lockwood W.W., Karsan A., Lam W.L. (2016) ELF3 amplification circumvents dependency on upstream driver mutations in lung adenocarcinoma. 7th TFRI ASM. Vancouver, BC. (Poster)
  • Martinez V.D.*, Minatel B.C.*, Marshall E.A., Ng K.W., Enfield K.S.S., Firmino N., Bennewith K.L., Lam S., Lam W.L. (2016) Analysis of piwi-interacting RNA transcriptomes identify cancer type-specific expression patterns and signatures predicting lung tumor behavior. 7th TFRI ASM. Vancouver, BC.  [*Co-first Authorship]. (Poster)
  • Martinucci B., Minatel B.C., Cuciello M.S., Santos A.L.N., Vechetti-Junior I.J., Delella F.K (2016) Fibronectin induces a differential regulation of genes and microRNAs expression in LNCaP cells cultivated in 2D and 3D cell culture. XVIII Congress of the Brazilian Society for Cell Biology. São Paulo, Brazil. (Poster)
  • Cuciello M.S., Minatel B.C., Martinucci B., Caxali G.H., Medeiros M., Delella F.K. (2016) Impact of fibroblasts in gene and microRNA expression in prostate tumor cells (LNCaP). XVIII Congress of the Brazilian Society for Cell Biology. São Paulo, Brazil (Poster)
  • Cuciello M.S., Minatel B.C., Martinucci B., Souza G.R., Delella F.K. (2015) Exposure to fibronectin enhances MMP-2 and MMP-9 expression and activity. 18th ENBM. Botucatu, Brazil (Poster)
  • Minatel B.C., Delella F.K. (2013) Expression of the microRNAs 125b, 221 and 222 in prostate cancer cell lines treated with finasteride. 16th ENBM. Botucatu, Brazil (Poster)
Abstracts Published at Provincial Conferences (Presenter underlined). [5 out of 50]
  • Minatel B.C., Firmino N., Marshall E.A., Bennewith K.L., Lam W.L., Martinez V.D. (2016) Comprehensive identification of piwi-interacting RNAs binding sites associated with hypoxia-inducible genes downregulation. TFRI BC Node Research Day. Vancouver, BC. (Poster)
  • Becker-Santos D.D., Minatel B.C., Lonergan K., Thu K.L., English J.C., Martinez V.D., Macaulay C.E., Lockwood W.W., Robinson W.P., Jurisica I., Lam S., Lam W.L. (2016) Expression of oncofetal miRNAs inactivates NFIB, a developmental transcription factor linked to tumour aggressiveness in lung adenocarcinoma. TFRI BC Node Research Day. Vancouver, BC. (Poster)
  • Enfield K.S.S., Rowbotham D.A., Holly A., Anderson C., Ng K.W., Minatel B.C., Dellaire G., Pastrello C., Jurisica I., MacAulay C.E., Lam S., Lam W.L. (2015) miR-106a and miR-106b affect growth and metastasis of lung adenocarcinoma. TFRI BC Node Research Day. Vancouver, BC. (Poster) 
  • Minatel B.C., Martinucci B., Delella F.K. (2015) Influence of cellular and molecular elements of the extracellular matrix over microRNAs expression in LNCaP cells. XXVII CIC 2nd Stage. Atibaia, Brazil (Oral presentation) (Best Presentation Award)
  • Minatel B.C., Delella F.K., Martinucci B. (2014) Regulation of the oncomiRs 125b, 221 and 222 by fibronectin in LNCaP cell line. XXVI CIC 2nd Stage. Águas de Lindóia, Brazil (Poster)
Abstracts Published at Regional and Institutional Conferences (Presenter underlined). [11 out of 50]
  • Minatel B.C., Martinez V.D., Marshall E.A., Ng K.W., Sage A.P., Anderson C., Becker-Santos D.D., Robinson W.P., Lam W.L. (2017) Discovery of novel oncofetal small non-coding RNAs in the liver. BCCA Research Day. Vancouver, BC. (Oral presentation) (Second Prize Speed Talk Presentation)
  • Fuss M.A., Martinez V.D., Ng K.W., Marshall E.A., Sage A.P., Minatel B.C., Lam W.L. (2017). Chronic arsenic exposure in lung cancer induces persistent alterations in the non-coding transcriptome. BCCA Research Day. Vancouver, BC. (Poster)
  • Martinez V.D., Ng K.W., Minatel B.C., Marshall E.A., Enfield K.S.S., Lam W.L. (2017). Subtype-specific expression of piRNA hold prognostic value in non-small cell lung cancer. BCCA Research Day. Vancouver, BC. (Poster)
  • Minatel B.C., Martinez V.D., Marshall E.A., Ng K., Enfield K.S.S., Lam W.L. (2017). PIWI-interacting RNAs coexpression networks correlatewith tumor features and patient prognosis in lung cancer. B.I.G. Research Day 2017. Vancouver, BC. (Poster)
  • Cuciello M.S., Minatel B.C., Martinucci B., Souza G.R., Delella F.K. (2015) Fibronectin modify migration and the number of nucleolus in LNCaP and PC-3 cells. XXVII CIC 1st Stage. Botucatu, Brazil (Oral presentation)
  • Minatel B.C., Martinucci B., Delella F.K. (2015) Influence of cellular and molecular elements of the extracellular matrix over microRNAs expression in LNCaP cells. XXVII CIC 1st Stage. Botucatu, Brazil (Oral presentation) (Best Presentation Award)
  • Minatel B.C., Martinucci B., Delella F.K. (2015) MicroRNAs 21, 125b, 221 and 222 expression in prostate cancer cells LNCaP exposed to cellular and molecular elements of the extracellular matrix. I Cancer Cellular and Molecular Biology Course. AC Camargo Cancer Center. São Paulo, Brazil (Poster)
  • Enfield K.S.S., Anderson C., Ng K.W., Minatel B.C., Rowbotham D.A., Becker-Santos D.D., Chari R., Fuller M., MacAulay C.E., Karsan A., Lam S., Lam W.L. (2015) ELF3 is a novel lung adenocarcinoma oncogene. BCCA Research Day. Vancouver, BC. (Poster)
  • Enfield K.S.S., Ng K.W., Anderson C., Minatel B.C., Rowbotham D.A., Holly A., Dellaire G., Pastrello C., Jurisica I., MacAulay C.E., Lam S., Lam W.L. (2015) miR-106a and miR-106b are overexpressed in metastatic lung adenocarcinoma. BCCA Research Day. Vancouver, BC. (Poster)
  • Martinez V.D., Minatel B.C., Ng K.W., Anderson C., Stewart G.L., Enfield K.S.S., Vucic E.A., Lam S., Lam W.L. (2015) Cancer specific expression patterns of PIWI-interacting RNAs and predictive signatures in lung cancer patient outcome. BCCA Research Day. Vancouver, BC. (Poster)
  • Minatel B.C., Delella F.K., Martinucci B. (2014) Regulation of the oncomiRs 125b, 221 and 222 by fibronectin in LNCaP cell line. XXVI CIC 1st Stage. Botucatu, Brazil (Poster)