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Stephen Lam, MD

slam@bccancer.bc.ca     Rm 10-111 ▪ 675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada

Stephen Lam Photo

Current Appointments

Stephen Lam MD, FRCPC is Professor of Medicine at the University of British Columbia, a Distinguished Scientist, the Leon Judah Blackmore Chair in lung cancer research and MDS-Rix endowed director of translation lung cancer research at the BC Cancer Research Center. He chairs the BC Cancer Agency Provincial Lung Tumor Group.

 

Research Interests

Dr. Lam’s research program focuses on the early detection, chemoprevention and endoscopic therapy of lung cancer.

 

Ongoing Clinical Trials

The International Lung Screen Trial is currently ongoing and recruiting participants. For more information, please visit the trial website at www.bclungscreentrial.com or contact the BC Lung Screen Trial team by phone at 604-675-8088 or by email at bclungscreening2015@gmail.com.

 

Awards and Honours

Dr. Lam was the recipient of the International Association for the Study of Lung Cancer Joseph Cullen Award for life-time scientific achievements in lung cancer prevention research, the Friesen Rygiel Award for Outstanding Canadian Academic Discovery, the Gustav Killian Medal by the World Association of Bronchology for pioneering contributions to the field early lung cancer diagnosis, as well as the Killam Research Prize in Applied Sciences and the Distinguished Achievement Award from the University of British Columbia.

 

Publications (Last 5 Years)

1.     Tammemagi M, Ritchie AJ, Atkar-Khattra S, Dougherty B, Sanghera C, Mayo JR, Yuan R, Manos D, McWilliams AM, Schmidt H, Gingras M, Pasian S, Stewart L, Tsai S, Seely JM, Burrowes P, Bhatia R, Haider EA, Boylan C, Jacobs C, van Ginneken B, Tsao MS, Lam S; Pan-Canadian Early Detection of Lung Cancer Study Group.  Predicting Malignancy Risk of Screen Detected Lung Nodules - Mean Diameter or Volume.  J Thorac Oncol. 2018 Oct 24. pii: S1556-0864(18)33187-3. doi: 10.1016/j.jtho.2018.10.006. [Epub ahead of print]

2.       Rosenberger A, Hung RJ, Christiani DC, Caporaso NE, Liu G, Bojesen SE, Le Marchand L, Haiman CA, Albanes D, Aldrich MC, Tardon A, Fernández-Tardón G, Rennert G, Field JK, Kiemeney B, Lazarus P, Haugen A, Zienolddiny S, Lam S, Schabath MB, Andrew AS, Brunnsstöm H, Goodman GE, Doherty JA, Chen C, Teare MD, Wichmann HE, Manz J, Risch A, Muley TR, Johansson M, Brennan P, Landi MT, Amos CI, Pesch B, Johnen G, Brüning T, Bickeböller H, Gomolka M.  Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners.  Int Arch Occup Environ Health. 2018 Nov;91(8):937-950.

3.       McGregor HC, Short MA, Lam S, Shaipanich T, Beaudoin EL, Zeng H. Development and in vivo test of a miniature Raman probe for early cancer detection in the peripheral lung.  J Biophotonics. 2018 Nov;11(11):e201800055. 

4.       Olson R, Liu M, Bergman A, Lam S, Hsu F, Mou B, Berrang T, Mestrovic A, Chng N, Hyde D, Matthews Q, Lund C, Glick D, Pai H, Basran P, Carolan H, Valev B, Lefresene S, Tyldesley S, Schellenberg D. Population-based phase II trial of stereotactic ablative radiotherapy (SABR) for up to 5 oligometastases: SABR-5.  BMC Cancer. 2018 Oct 4;18(1):954. doi: 10.1186/s12885-018-4859-7.

5.       Tremblay A, Myers R, Beaudoin EL, Bonifazi M, Delage A, Fortin M, Hergott CA, MacEachern PR, Shaipanich T, Shieh B, Gasparini S, Lam S. Initial Clinical Experience With a Flexible Peripheral 21-G Needle Device. J Bronchology Interv Pulmonol. 2018 Oct;25(4):346-348.

6.       Ferreiro-Iglesias A, Lesseur C, McKay J, Hung RJ, Han Y, Zong X, Christiani D, Johansson M, Xiao X, Li Y, Qian DC, Ji X, Liu G, Caporaso N, Scelo G, Zaridze D, Mukeriya A, Kontic M, Ognjanovic S, Lissowska J, Szołkowska M, Swiatkowska B, Janout V, Holcatova I, Bolca C, Savic M, Ognjanovic M, Bojesen SE, Wu X, Albanes D, Aldrich MC, Tardon A, Fernandez-Somoano A, Fernandez-Tardon G, Le Marchand L, Rennert G, Chen C, Doherty J, Goodman G, Bickeböller H, Wichmann HE, Risch A, Rosenberger A, Shen H, Dai J, Field JK, Davies M, Woll P, Teare MD, Kiemeney LA, van der Heijden EHFM, Yuan JM, Hong YC, Haugen A, Zienolddiny S, Lam S, Tsao MS, Johansson M, Grankvist K, Schabath MB, Andrew A, Duell E, Melander O, Brunnström H, Lazarus P, Arnold S, Slone S, Byun J, Kamal A, Zhu D, Landi MT, Amos CI, Brennan P. Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity.  Nat Commun. 2018 Sep 25;9(1):3927. 

7.       Ji X, Bossé Y, Landi MT, Gui J, Xiao X, Qian D, Joubert P, Lamontagne M, Li Y, Gorlov I, de Biasi M, Han Y, Gorlova O, Hung RJ, Wu X, McKay J, Zong X, Carreras-Torres R, Christiani DC, Caporaso N, Johansson M, Liu G, Bojesen SE, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Chen C, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman C, Wilkens L, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden EHFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty J, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Manz J, Muley T, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd F, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston R, McLaughlin J, Stevens V, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Artigas MS, Tobin MD, Wain LV, Gu F, Byun J, Kamal A, Zhu D, Tyndale RF, Wei WQ, Chanock S, Brennan P, Amos CI. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.  Nat Commun. 2018 Aug 13;9(1):3221.

8.       Cressman S, Ten Haaf K, Lam S, Tammemägi M. Risk-Targeted Lung Cancer Screening.  Ann Intern Med. 2018 Aug 7;169(3):199-200.

9.       Kachuri L, Saarela O, Bojesen SE, Davey Smith G, Liu G, Landi MT, Caporaso NE, Christiani DC, Johansson M, Panico S, Overvad K, Trichopoulou A, Vineis P, Scelo G, Zaridze D, Wu X, Albanes D, Diergaarde B, Lagiou P, Macfarlane GJ, Aldrich MC, Tardón A, Rennert G, Olshan AF, Weissler MC, Chen C, Goodman GE, Doherty JA, Ness AR, Bickeböller H, Wichmann HE, Risch A, Field JK, Teare MD, Kiemeney LA, van der Heijden EHFM, Carroll JC, Haugen A, Zienolddiny S, Skaug V, Wünsch-Filho V, Tajara EH, Ayoub Moysés R, Daumas Nunes F, Lam S, Eluf-Neto J, Lacko M, Peters WHM, Le Marchand L, Duell EJ, Andrew AS, Franceschi S, Schabath MB, Manjer J, Arnold S, Lazarus P, Mukeriya A, Swiatkowska B, Janout V, Holcatova I, Stojsic J, Mates D, Lissowska J, Boccia S, Lesseur C, Zong X, McKay JD, Brennan P, Amos CI, Hung RJ. Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers.  Int J Epidemiol. 2018 Jul 28. 

10.   Xu S, Tsai A, Sze MA, Vucic EA, Shaipanich T, Harris M, Guillemi S, Yang J, Sinha S, Nislow C, Montaner J, Lam W, Lam S, Sin DD, Paul Man SF, Leung JM.  Decreased microbiome diversity in the HIV small airway epithelium.  Respir Res. 2018 Jul 27;19(1):140.

11.   Xu S, Vucic EA, Shaipanich T, Lam S, Lam W, Montaner JS, Sin DD, Paul Man SF, Leung JM. Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV).  Respir Res. 2018 Jun 13;19(1):117

12.   Chen YW, Coxson HO, Coupal TM, Lam S, Munk PL, Leipsic J, Reid WD. The contribution of thoracic vertebral deformity and arthropathy to trunk pain in patients with chronic obstructive pulmonary disease (COPD).  Respir Med. 2018 Apr;137:115-122.

13.   Li Y, Xiao X, Han Y, Gorlova O, Qian D, Leighl N, Johansen JS, Barnett M, Chen C, Goodman G, Cox A, Taylor F, Woll P, Wichmann HE, Manz J, Muley T, Risch A, Rosenberger A, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Houlston R, Soler Artigas M, Grankvist K, Johansson M, Shepherd FA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Liu G, Bojesen SE, Wu X, Marchand LL, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Bertazzi PA, Pesatori AC, Christiani DC, Caporaso N, Johansson M, McKay JD, Brennan P, Hung RJ, Amos CI. Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population.  Carcinogenesis. 2018 Mar 8;39(3):336-346. 

14.   Abouei E, Lee AMD, Pahlevaninezhad H, Hohert G, Cua M, Lane P, Lam S, MacAulay C. Correction of motion artifacts in endoscopic optical coherence tomography and autofluorescence images based on azimuthal en face image registration.   J Biomed Opt. 2018 Jan;23(1):1-13. 

15.   Huang P, Park S, Yan R, Lee J, Chu LC, Lin CT, Hussien A, Rathmell J, Thomas B, Chen C, Hales R, Ettinger DS, Brock M, Hu P, Fishman EK, Gabrielson E, Lam S.  Radiology. 2018 Jan;286(1):286-295.

16.   White JD, Lin H, Jia L, Wu RS, Lam S, Li J, Dou J, Kumar N, Lin L, Lao LProceedings of the Strategy Meeting for the Development of an International Consortium for Chinese Medicine and Cancer.  Added Value of Computer-aided CT Image Features for Early Lung Cancer Diagnosis with Small Pulmonary Nodules: A Matched Case-Control Study.J Glob Oncol. 2017 Dec;3(6):814-822.

17.   Bazett M, Costa AM, Bosiljcic M, Anderson RM, Alexander MP, Wong SWY, Dhanji S, Chen JM, Pankovich J, Lam S, Sutcliffe S, Gunn H, Kalyan S, Mullins DW. Harnessing innate lung anti-cancer effector functions with a novel bacterial-derived immunotherapy.  Oncoimmunology. 2017 Nov 27;7(3):e1398875. 

18.   van Riel SJ, Ciompi F, Winkler Wille MM, Dirksen A, Lam S, Scholten ET, Rossi SE, Sverzellati N, Naqibullah M, Wittenberg R, Hovinga-de Boer MC, Snoeren M, Peters-Bax L, Mets O, Brink M, Prokop M, Schaefer-Prokop C, van Ginneken B. Malignancy risk estimation of pulmonary nodules in screening CTs: Comparison between a computer model and human observers.  PLoS One. 2017 Nov 9;12(11):e0185032.

19.   Tammemagi MC, Schmidt H, Martel S, McWilliams A, Goffin JR, Johnston MR, Nicholas G, Tremblay A, Bhatia R, Liu G, Soghrati K, Yasufuku K, Hwang DM, Laberge F, Gingras M, Pasian S, Couture C, Mayo JR, Nasute Fauerbach PV, Atkar-Khattra S, Peacock SJ, Cressman S, Ionescu D, English JC, Finley RJ, Yee J, Puksa S, Stewart L, Tsai S, Haider E, Boylan C, Cutz JC, Manos D, Xu Z, Goss GD, Seely JM, Amjadi K, Sekhon HS, Burrowes P, MacEachern P, Urbanski S, Sin DD, Tan WC, Leighl NB, Shepherd FA, Evans WK, Tsao MS, Lam S; PanCan Study Team. Participant selection for lung cancer screening by risk modelling (the Pan-Canadian Early Detection of Lung Cancer [PanCan] study): a single-arm, prospective study.  Lancet Oncol. 2017 Nov;18(11):1523-1531.

20.   Obeidat M, Nie Y, Fishbane N, Li X, Bossé Y, Joubert P, Nickle DC, Hao K, Postma DS, Timens W, Sze MA, Shannon CP, Hollander Z, Ng RT, McManus B, Miller BE, Rennard S, Spira A, Hackett TL, Lam W, Lam S, Faner R, Agusti A, Hogg JC, Sin DD, Paré PD.  Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers. Am J Respir Cell Mol Biol. 2017 Oct;57(4):411-418. 

21.   van Riel SJ, Ciompi F, Jacobs C, Winkler Wille MM, Scholten ET, Naqibullah M, Lam S, Prokop M, Schaefer-Prokop C, van Ginneken B.  Malignancy risk estimation of screen-detected nodules at baseline CT: comparison of the PanCan model, Lung-RADS and NCCN guidelines.  Eur Radiol. 2017 Oct;27(10):4019-4029.

22.   Wang T, Moon JY, Wu Y, Amos CI, Hung RJ, Tardon A, Andrew A, Chen C, Christiani DC, Albanes D, Heijden EHFMV, Duell E, Rennert G, Goodman G, Liu G, Mckay JD, Yuan JM, Field JK, Manjer J, Grankvist K, Kiemeney LA, Marchand LL, Teare MD, Schabath MB, Johansson M, Aldrich MC, Davies M, Johansson M, Tsao MS, Caporaso N, Lazarus P, Lam S, Bojesen SE, Arnold S, Wu X, Zong X, Hong YC, Ho GYF. Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium. PLoS One. 2017 Sep 28;12(9):e0185660. 

23.   Taghizadeh N, Taylor KL, MacEachern P, Koetzler R, Dickinson JA, Gillson A, Yang H, Tammemagi MC, Penz E, Pendharkar SR, Lam SC, Graham A, Culling J, Burrowes P, Bédard ELR, Tremblay A.  Tobacco use and motivation to stop smoking among long-term smokers who are ineligible for lung cancer screening. Lung Cancer. 2017 Sep;111:101-107. 

24.   Beane J, Mazzilli SA, Tassinari AM, Liu G, Zhang X, Liu H, Buncio AD, Dhillon SS, Platero SJ, Lenburg ME, Reid ME, Lam S, Spira AE.  Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression.  Clin Cancer Res. 2017 Sep 1;23(17):5091-5100.

25.   Bodenschatz N, Poh CF, Lam S, Lane P, Guillaud M, MacAulay CE. Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study.  J Biomed Opt. 2017 Aug;22(8):1-10.

26.   Lawson J, Dickman C, MacLellan S, Towle R, Jabalee J, Lam S, Garnis C. Selective secretion of microRNAs from lung cancer cells via extracellular vesicles promotes CAMK1D-mediated tube formation in endothelial cells. Oncotarget. 2017 Aug 7;8(48):83913-83924

27.   Bodenschatz N, Poh CF, Lam S, Lane P, Guillaud M, MacAulay CE.  Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study.  J Biomed Opt. 2017 Aug;22(8):1-10. 

28.   Cressman S, Peacock SJ, Tammemägi MC, Evans WK, Leighl NB, Goffin JR, Tremblay A, Liu G, Manos D, MacEachern P, Bhatia R, Puksa S, Nicholas G, McWilliams A, Mayo JR, Yee J, English JC, Pataky R, McPherson E, Atkar-Khattra S, Johnston MR, Schmidt H, Shepherd FA, Soghrati K, Amjadi K, Burrowes P, Couture C, Sekhon HS, Yasufuku K, Goss G, Ionescu DN, Hwang DM, Martel S, Sin DD, Tan WC, Urbanski S, Xu Z, Tsao MS, Lam S. The Cost-Effectiveness of High-Risk Lung Cancer Screening and Drivers of Program Efficiency.  J Thorac Oncol. 2017 Aug;12(8):1210-1222. 

29.   McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV; SpiroMeta Consortium, Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nat Genet. 2017 Jul;49(7):1126-1132.

30.   Bailey MJ, Verma N, Fradkin L, Lam S, MacAulay C, Poh C, Markey MK, Sokolov K. Detection of precancerous lesions in the oral cavity using oblique polarized reflectance spectroscopy: a clinical feasibility study.  J Biomed Opt. 2017 Jun 1;22(6):65002. 

31.   Carreras-Torres R, Johansson M, Haycock PC, Wade KH, Relton CL, Martin RM, Davey Smith G, Albanes D, Aldrich MC, Andrew A, Arnold SM, Bickeböller H, Bojesen SE, Brunnström H, Manjer J, Brüske I, Caporaso NE, Chen C, Christiani DC, Christian WJ, Doherty JA, Duell EJ, Field JK, Davies MPA, Marcus MW, Goodman GE, Grankvist K, Haugen A, Hong YC, Kiemeney LA, van der Heijden EHFM, Kraft P, Johansson MB, Lam S, Landi MT, Lazarus P, Le Marchand L, Liu G, Melander O, Park SL, Rennert G, Risch A, Haura EB, Scelo G, Zaridze D, Mukeriya A, Savić M, Lissowska J, Swiatkowska B, Janout V, Holcatova I, Mates D, Schabath MB, Shen H, Tardon A, Teare MD, Woll P, Tsao MS, Wu X, Yuan JM, Hung RJ, Amos CI, McKay J, Brennan P. Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study. PLoS One. 2017 Jun 8;12(6):e0177875. 

32.   Law FCP, Yao M, Bi HC, Lam S.  Physiologically based pharmacokinetic modeling of tea catechin mixture in rats and humans. Pharmacol Res Perspect. 2017 Apr 17;5(3):e00305.

33.   McGregor HC, Short MA, McWilliams A, Shaipanich T, Ionescu DN, Zhao J, Wang W, Chen G, Lam S, Zeng H.  Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection.  J Biophotonics. 2017 Jan;10(1):98-110.

34.   Bharmal A, Crosskill A, Lam S, Bryant H. Controlled settings for lung cancer screening: why do they matter? Considerations for referring clinicians.  Curr Oncol. 2016 Dec;23(6):371-373. 

35.   Schlosser C, Bodenschatz N, Lam S, Lee M, McAlpine JN, Miller DM, Van Niekerk DJ, Follen M, Guillaud M, MacAulay CE, Lane PM. Fluorescence confocal endomicroscopy of the cervix: pilot study on the potential and limitations for clinical implementation.J Biomed Opt. 2016 Dec 1;21(12):126011.

36.   Lam S, Mandrekar SJ, Gesthalter Y, Allen Ziegler KL, Seisler DK, Midthun DE, Mao JT, Aubry MC, McWilliams A, Sin DD, Shaipanich T, Liu G, Johnson E, Bild A, Lenburg ME, Ionescu DN, Mayo J, Yi JE, Tazelaar H, Harmsen WS, Smith J, Spira AE, Beane J, Limburg PJ, Szabo E; Cancer Prevention Network. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prev Res (Phila). 2016 Dec;9(12):906-914. 

37.   Sze MA, Xu S, Leung JM, Vucic EA, Shaipanich T, Moghadam A, Harris M, Guillemi S, Sinha S, Nislow C, Murphy D, Hague C, Leipsic J, Lam S, Lam W, Montaner JS, Sin DD, Man SF.  The bronchial epithelial cell bacterial microbiome and host response in patients infected with human immunodeficiency virus.  BMC Pulm Med. 2016 Nov 9;16(1):142.

38.   Tremblay A, Taghizadeh N, McWilliams AM, MacEachern P, Stather DR, Soghrati K, Puksa S, Goffin JR, Yasufuku K, Amjadi K, Nicholas G, Martel S, Laberge F, Johnston M, Shepherd FA, Ionescu DN, Urbanski S, Hwang D, Cutz JC, Sekhon HS, Couture C, Xu Z, Sutedja TG, Atkar-Khattra S, Tammemagi MC, Tsao MS, Lam SC; Pan-Canadian Early Lung Cancer Study Group. Low Prevalence of High-Grade Lesions Detected With Autofluorescence Bronchoscopy in the Setting of Lung Cancer Screening in the Pan-Canadian Lung Cancer Screening Study.  Chest. 2016 Nov;150(5):1015-1022. 

39.   Marshall EA, Ng KW, Kung SH, Conway EM, Martinez VD, Halvorsen EC, Rowbotham DA, Vucic EA, Plumb AW, Becker-Santos DD, Enfield KS, Kennett JY, Bennewith KL, Lockwood WW, Lam S, English JC, Abraham N, Lam WL. Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis. Mol Cancer. 2016 Oct 27;15(1):67. Review.

40.   Zafari Z, Sin DD, Postma DS, Löfdahl CG, Vonk J, Bryan S, Lam S, Tammemagi CM, Khakban R, Man SF, Tashkin D, Wise RA, Connett JE, McManus B, Ng R, Hollander Z, Sadatsafavi M. Individualized prediction of lung-function decline in chronic obstructive pulmonary disease.  CMAJ. 2016 Oct 4;188(14):1004-1011.

41.   Becker-Santos DD, Thu KL, English JC, Pikor LA, Martinez VD, Zhang M, Vucic EA, Luk MT, Carraro A, Korbelik J, Piga D, Lhomme NM, Tsay MJ, Yee J, MacAulay CE, Lam S, Lockwood WW, Robinson WP, Jurisica I, Lam WL. Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma.J Pathol. 2016 Oct;240(2):161-72. 

42.   Apperley S, Lam S. Region specific lung nodule management practice guideline. J Thorac Dis. 2016 Sep;8(9):2319-2323.

43.   Wang YW, Ma X, Zhang YA, Wang MJ, Yatabe Y, Lam S, Girard L, Chen JY, Gazdar AF. ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.  J Thorac Oncol. 2016 Sep;11(9):1469-81.

44.   Poureslami I, Kwan S, Lam S, Khan NA, FitzGerald JM. Assessing the effect of culturally specific audiovisual educational interventions on attaining self-management skills for chronic obstructive pulmonary disease in Mandarin- and Cantonese-speaking patients: a randomized controlled trial.  Int J Chron Obstruct Pulmon Dis. 2016 Aug 3;11:1811-22. 

45.   Raymakers AJN, Mayo J, Lam S, FitzGerald JM, Whitehurst DGT, Lynd LD. Cost-Effectiveness Analyses of Lung Cancer Screening Strategies Using Low-Dose Computed Tomography: a Systematic Review.  Appl Health Econ Health Policy. 2016 Aug;14(4):409-418. 

46.   Bodenschatz N, Lam S, Carraro A, Korbelik J, Miller DM, McAlpine JN, Lee M, Kienle A, MacAulay C. Diffuse optical microscopy for quantification of depth-dependent epithelial backscattering in the cervix.  J Biomed Opt. 2016 Jun 1;21(6):66001. 

47.   Tam A, Churg A, Wright JL, Zhou S, Kirby M, Coxson HO, Lam S, Man SF, Sin DD. Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease.  Am J Respir Crit Care Med. 2016 Apr 15;193(8):825-34. 

48.   Ritchie AJ, Sanghera C, Jacobs C, Zhang W, Mayo J, Schmidt H, Gingras M, Pasian S, Stewart L, Tsai S, Manos D, Seely JM, Burrowes P, Bhatia R, Atkar-Khattra S, van Ginneken B, Tammemagi M, Tsao MS, Lam S; Pan-Canadian Early Detection of Lung Cancer Study Group. Computer Vision Tool and Technician as First Reader of Lung Cancer Screening CT Scans. J Thorac Oncol. 2016 May;11(5):709-717.

49.   Murray N, Lam S. Contrasting Management of Small Cell Lung Cancer and Non-Small Cell Lung Cancer: Emerging Data for Low-Dose Computed Tomography Screening.  J Thorac Oncol. 2016 Feb;11(2):139-41. 

50.   Conway EM, Pikor LA, Kung SH, Hamilton MJ, Lam S, Lam WL, Bennewith KL. Macrophages, Inflammation, and Lung Cancer. Am J Respir Crit Care Med. 2016 Jan 15;193(2):116-30

51.   Lam S, Szabo E. Preinvasive Endobronchial Lesions: Lung Cancer Precursors and Risk Markers?  Am J Respir Crit Care Med. 2015 Dec 15;192(12):1411-3.

52.   Silkoff PE, Strambu I, Laviolette M, Singh D, FitzGerald JM, Lam S, Kelsen S, Eich A, Ludwig-Sengpiel A, Hupp GC, Backer V, Porsbjerg C, Girodet PO, Berger P, Leigh R, Kline JN, Dransfield M, Calhoun W, Hussaini A, Khatri S, Chanez P, Susulic VS, Barnathan ES, Curran M, Das AM, Brodmerkel C, Baribaud F, Loza MJ. Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study. Respir Res. 2015 Nov 17;16:142

53.   Hubaux R, Thu KL, Vucic EA, Pikor LA, Kung SH, Martinez VD, Mosslemi M, Becker-Santos DD, Gazdar AF, Lam S, Lam WL. Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.  Int J Cancer. 2015 Nov 1;137(9):2072-82.

54.   Kirby M, Ohtani K, Nickens T, Lisbona RM, Lee AM, Shaipanich T, Lane P, MacAulay C, Lam S, Coxson HO. Reproducibility of optical coherence tomography airway imaging.Biomed Opt Express. 2015 Oct 14;6(11):4365-77. 

55.   Soh J, Toyooka S, Matsuo K, Yamamoto H, Wistuba II, Lam S, Fong KM, Gazdar AF, Miyoshi S. Ethnicity affects EGFR and KRAS gene alterations of lung adenocarcinoma.  Oncol Lett. 2015 Sep;10(3):1775-1782. 

56.   Pahlevaninezhad H, Lee AM, Ritchie A, Shaipanich T, Zhang W, Ionescu DN, Hohert G, MacAulay C, Lam S, Lane P. Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature. Biomed Opt Express. 2015 Sep 30;6(10):4191-9. 

57.   Kirby M, Ohtani K, Lopez Lisbona RM, Lee AM, Zhang W, Lane P, Varfolomeva N, Hui L, Ionescu D, Coxson HO, MacAulay C, FitzGerald JM, Lam S. Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography.  Eur Respir J. 2015 Sep;46(3):859-62. 

58.   Fawzy Y, Lam S, Zeng H. Rapid multispectral endoscopic imaging system for near real-time mapping of the mucosa blood supply in the lung.  Biomed Opt Express. 2015 Jul 21;6(8):2980-90.

59.   Leung JM, Mayo J, Tan W, Tammemagi CM, Liu G, Peacock S, Shepherd FA, Goffin J, Goss G, Nicholas G, Tremblay A, Johnston M, Martel S, Laberge F, Bhatia R, Roberts H, Burrowes P, Manos D, Stewart L, Seely JM, Gingras M, Pasian S, Tsao MS, Lam S, Sin DD; Pan-Canadian Early Lung Cancer Study Group. Plasma pro-surfactant protein B and lung function decline in smokers.  Eur Respir J. 2015 Apr;45(4):1037-45. 

60.   Martinez VD, Vucic EA, Thu KL, Hubaux R, Enfield KS, Pikor LA, Becker-Santos DD, Brown CJ, Lam S, Lam WL. Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology. Sci Rep. 2015 May 27;5:10423.

61.   Martinez VD, Vucic EA, Thu KL, Pikor LA, Lam S, Lam WL. Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer.  Head Neck. 2015 May;37(5):727-34.

62.   Mayo JR, Lam S. Computed tomography and the secrets of lung nodules.  Can Assoc Radiol J. 2015 Feb;66(1):2-4.

63.   Finley RJ, Mayo JR, Grant K, Clifton JC, English J, Leo J, Lam S. Preoperative computed tomography-guided microcoil localization of small peripheral pulmonary nodules: a prospective randomized controlled trial.J Thorac Cardiovasc Surg. 2015 Jan;149(1):26-31.

64.    English C, Churg A, Lam S, Bilawich AM. Respiratory bronchiolitis with fibrosis: prevalence and progression.  Ann Am Thorac Soc. 2014 Dec;11(10):1665-6.

65.   Smoragiewicz M, Laskin J, Wilson D, Ramsden K, Yee J, Lam S, Shaipanich T, Zhai Y, Ho C. Using pet-ct to reduce futile thoracotomy rates in non-small-cell lung cancer: a population-based review. Curr Oncol. 2014 Dec;21(6):e768-74.

66.   Lamontagne M, Timens W, Hao K, Bossé Y, Laviolette M, Steiling K, Campbell JD, Couture C, Conti M, Sherwood K, Hogg JC, Brandsma CA, van den Berge M, Sandford A, Lam S, Lenburg ME, Spira A, Paré PD, Nickle D, Sin DD, Postma DS. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction.  Thorax. 2014 Nov;69(11):997-1004.

67.   Vucic EA, Thu KL, Pikor LA, Enfield KS, Yee J, English JC, MacAulay CE, Lam S, Jurisica I, Lam WL. Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology.  BMC Cancer. 2014 Oct 24;14:778.

68.   Cressman S, Lam S, Tammemagi MC, Evans WK, Leighl NB, Regier DA, Bolbocean C, Shepherd FA, Tsao MS, Manos D, Liu G, Atkar-Khattra S, Cromwell I, Johnston MR, Mayo JR, McWilliams A, Couture C, English JC, Goffin J, Hwang DM, Puksa S, Roberts H, Tremblay A, MacEachern P, Burrowes P, Bhatia R, Finley RJ, Goss GD, Nicholas G, Seely JM, Sekhon HS, Yee J, Amjadi K, Cutz JC, Ionescu DN, Yasufuku K, Martel S, Soghrati K, Sin DD, Tan WC, Urbanski S, Xu Z, Peacock SJ; Pan-Canadian Early Detection of Lung Cancer Study Team. Resource utilization and costs during the initial years of lung cancer screening with computed tomography in Canada. J Thorac Oncol. 2014 Oct;9(10):1449-58. 

69.   Kirby M, Pike D, McCormack DG, Lam S, Coxson HO, Parraga G. Longitudinal Computed Tomography and Magnetic Resonance Imaging of COPD: Thoracic Imaging Network of Canada (TINCan) Study Objectives. Chronic Obstr Pulm Dis. 2014 Sep 25;1(2):200-211.

70.   Chow KK, Short M, Lam S, McWilliams A, Zeng H. A Raman cell based on hollow core photonic crystal fiber for human breath analysis. Med Phys. 2014 Sep;41(9):092701. 

71.   Taguchi A, Taylor AD, Rodriguez J, Celiktaş M, Liu H, Ma X, Zhang Q, Wong CH, Chin A, Girard L, Behrens C, Lam WL, Lam S, Minna JD, Wistuba II, Gazdar AF, Hanash SM. A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.  Cancer Res. 2014 Sep 1;74(17):4694-705. 

72.   Wilson IM, Vucic EA, Enfield KS, Thu KL, Zhang YA, Chari R, Lockwood WW, Radulovich N, Starczynowski DT, Banáth JP, Zhang M, Pusic A, Fuller M, Lonergan KM, Rowbotham D, Yee J, English JC, Buys TP, Selamat SA, Laird-Offringa IA, Liu P, Anderson M, You M, Tsao MS, Brown CJ, Bennewith KL, MacAulay CE, Karsan A, Gazdar AF, Lam S, Lam WL. EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene. 2014 Sep 4;33(36):4464-73. 

73.   Pahlevaninezhad H, Lee AM, Shaipanich T, Raizada R, Cahill L, Hohert G, Yang VX, Lam S, MacAulay C, Lane P. A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography.  Biomed Opt Express. 2014 Aug 6;5(9):2978-87.

74.   MacLellan SA, MacAulay C, Lam S, Garnis C. Pre-profiling factors influencing serum microRNA levels.  BMC Clin Pathol. 2014 Jun 21;14:27.

75.   Lee AM, Kirby M, Ohtani K, Candido T, Shalansky R, MacAulay C, English J, Finley R, Lam S, Coxson HO, Lane P. Validation of airway wall measurements by optical coherence tomography in porcine airways.  PLoS One. 2014 Jun 20;9(6):e100145.

76.   Tammemagi MC, Lam S. Screening for lung cancer using low dose computed tomography.  BMJ. 2014 May 27;348:g2253. 

77.   Vucic EA, Chari R, Thu KL, Wilson IM, Cotton AM, Kennett JY, Zhang M, Lonergan KM, Steiling K, Brown CJ, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, Macaulay CE, Lam S, Lam WL. DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. Am J Respir Cell Mol Biol. 2014 May;50(5):912-22.