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Martial Guillaud, PhD

— filed under:

Senior Scientist - Imaging Unit, Integrative Oncology

Rm 6-122 ▪ 675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada

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Current Appointments

  • Senior Scientist - Imaging Unit, Integrative Oncology
  • Adjunct Professor - Department of Statistics, University of British Columbia
 
Training
  • 1989 Cellular Biology (Animal GeneticS) Msc
  • 1990 Informatics and Statistics - Technology Degree 
  • 1993 Biomedical Engineering - PhD
 

Teaching

  • Instruction in data analysis and in computers at the Joseph Fourier University (Biological Sciences) and Stendhal University (Social Sciences).
  • Instruction in Image analysis (statistics) for the French Institute National of Health and Medical Research (INSERM)
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Team

  • Jagoda Korbelic
  • Anita Carraro
  • Alan Harisson
  • Zhaoyang Chen

 

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A. Research Projects

We are interested in understand the relationship and date causality between molecular changes/perturbation and their phenotypic effects, at the nuclear, cellular, or tissular level.

     1- Oral cancer

In collaboration with Dr. Catherine  Poh and Dr. Miriam Rosin, we have been developing imaged-based technology to quantify changes occurring in oral pre-neoplasic lesions. 

     2- Cervical  Cancer

As part of two consecutive Po1 NIH grants, we have been developing, validating and testing optical and imaging technologies for the screening, detection and management of cervical pre-neoplastic lesions. These international multi-centers clinical trials are being conducting at the Vancouver General Hospital ,Vancouver, at the  MD Anderson Cancer Research Centre, and in the last year at the El Paso in Texas under the supervision of Dr. Michele Follen and Dr. Calum MacAulay.

     3- Prostate Cancer 

     4- Breast  Cancer

We have initiating a collaboration with Dr. Celia Marginean and Dr. Soufiane El Hallani from the University of Ottawa, Department of Pathology and Laboratory Medicine to investigate the potential of image cytometry and QTP as a new diagnostic test in Barrett's Eosophagus lesions

    5- Barrett's esophagus

    5. Skin Epithelium

As part of a collaborative project with Dr. Georgios Stamatas from Johnson&Johnson, Paris, we are investigating the topological and geometrical changes occurring in the early years in the infant skin epithelium using non invasive reflectance microscopy.

 

B. Technology

We have been developing a suite of algorithm for the imaging, processing and statistical classification of cytological and histological specimens. 

This suite is available for research only under recherché agreement for any academic use.

B.1 DUnit

B.2 Jclass

B.3 Asterics

B.4 Idefics Modeling Platform

 

Publications

Refereed Journals - Last 5 years

  1. Richards Montealegre J, Peckham-Gregory EC, Marquez-DO D, Dillon L, Guillaud M, Adler-Storthz K, Follen M, Scheurer ME.  Racial/Ethnic Differences in HPV 16/18 Genotypes and Integration Status Among Women with a History of Cytological Abnormalities.  Ocul. Immunol. Inflamm.  2018 Sep 20:1-8.  PMID:30234412
  2. Guillaud M, MacAulay C, Berean KW, Bullock M, Guggisberg K, Klieve H, Puttagunta L, Penner C, Kwan K, Rosin M, Poh CF.  Using quantitative tissue phenotype to asses the margins of surgical samples from a pan-Canadian Surgery Study.  Head and Neck. 2018 Jun;40(6):1263-1270.  PMID:29451953
  3. Jabalee J,Carraro A,Ng T,Prisman E,Garnis C. and Guillaud M. Identification of malignancy-associated changes in histologically normal tumor-adjacent epithelium of patients with HPV-positive oropharyngeal cancer. Anal Cell Pathol (Amst). 2018 Mar 11; 2018:1607814.  PMID:29713583
  4. Sheikhzadeh F, van Niekerk D, Ward KR, Guillaud M. Automatic labeling of molecular biomarkers of imunohistochemistry images using fully convolutional networks. PLoS One. 2018 Jan 19;13(1):e0190783.  PMID:29351281
  5. Guillaud M, Qian Y, Leung S, Carraro A, Harrison A, Hayes M, Nichol A, Keyes M. Large‑scale DNA organization is a prognostic marker of breast cancer. Medical Oncology. 2017 Dec 6;35(1):9 PMID:29214466
  6. MacAulay C, Keyes M, Hayes M, Lo A, Wang G, Guillaud M, Gleave M, Fazli L, Korbelik J, Collins C, Keyes S, Palcic B.  Quantification of large scale DNA organization for predicting prostate cancer recurrence.  Cytometry A.  2017 Dec;91(12):1164-1174 PMID:29194951
  7. Montealegre JR, Varier I, Gutierrez CM, Dillon LM, Guillaud M, Sikora AG, Follen M, Adler-Storthz K, Scheurer ME.  Racial ethnic variation in the prevalence of vaccine-preventable human papillomavirus genotypes.  Ethnicity and Health. 2017 Sep 4:1-12. PMID:28870103
  8. Bodenschatz N, Poh CF, Lam S, Lane P, Guillaud M, MacAulay CE.  Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study.  J Biomed Opt. 2017 Aug; 22(8):1-10 PMID:28823113
  9. Schlosser C, Bodenschatz N, Lam S, Lee M, McAlpine JN, Miller DM, Van Niekerk DJ, Follen M, Guillaud M, MacAulay CE, Lane PM.  Fluorescence confocal endomicroscopy of the cervix: pilot study on the potential and limiations for clinical implementation.  J biomed Opt. 2016 Dec 1l 21(12):126011. PMID: 27999860
  10. Liu KYP, MacAulay CE, Chen Z, Guillaud M, Poh CF. Novel computational image analysis to predict regional nodal disease for early-stage oral cancer. Otorhynilaryngol Head Neck Surg (2016);1(4):94-100. doi: 10.15761/OHNS.1000124
  11. Sheikhzadeh F, Ward RK, Carraro A, Chen ZY, van Niekerk D, Miller D, Ehlen T, MacAulay CE, Follen M, Lane PM, Guillaud M.  Quantification of confocal fluorescence microscopy for the detection of cervical intraepithelial neoplasia.  Biomed Eng Online.  2015 Oct 24;14(1)96 PMID: 26499452
  12. Bensaci J, Chen ZY, Mack MC, Guillaud M, Stamatas GN.  Geometrical and topological analysis of in vivo confocal microscopy images reveals dynamic maturation of epidermal structures during the first years of life.  J Biomed Optics.  2015 Sep 1;20(9):95004 PMID: 26359808
  13. El Hallani S, Guillaud M, Korbelik J, Marginean EC.  Evaluation of quantitative tissue pathology in the assessment of Barrett’s Esophagus associated dysplasia.  American Journal of Clinical Pathology.  2015 Jul; 144(1):151-64 [Epub ahead of print] PMID:26071473
  14. Ngheim VT, Davies KR, Beck JR, Follen M, MacAulay C, Guillaud M, Cantor SB.  Economic evaluation of DNA ploidy analysis vs liquid-based cytology for cervical screening.  British Journal of Cancer.  2015 June 9;112(12):1951-7 PMID:25919612
  15. Martinez V, MacAulay C.E., Guillaud M, Lam WL, Corbett K., and Rosin P. M, Targeting of chemoprevention to high-risk lesions: challenge and opportunity. Oral Oncology.  2014 Dec;50(12):1123-30  PMID:25240917
  16. Guillaud M, Buys TP, Carraro A, Korbelik J, Follen M, Scheurer M, Storthz KA, van Niekerk D, MacAulay CE.  Evaluation of HPV infection and smoking status impacts on cell proliferation in epithelial layers of cervical neoplasia.  PLoS One.  2014 Sep 11;9(9):e107088. PMID:25210770
  17. Yamal JM, Guillaud M, Atkinson EN, Follen M, MacAulay C, Cantor SB, Cox DD.  Prediction using hierarchical data: Applications for automated detection of cervical cancer.  Stat Anal Data Min.  2015 Apr 8 (2):65-74 PMID: 26617681
  18. Baik, J., Ye, Q., Zhang, L., Poh, C. Rosin, M., MacAulay, c., Guillaud, M. Automated Classification of oral premalignant lesions using image cytometry and random forests-based algorithms. Cell Oncol (Dordr). 2014 Jun;37(3):193-202 PMID:24817187
  19. Arifler D, MacAulay  C,  Follen  M, Guillaud M. Numerical Investigation of two-light scattering patterns of cervical cell nuclei to map dysplastic changes at different epithelial depths. Biomedical Optics Express, Vol. 5 Issue 2, pp.485-498 (2014) PMID: 24575343
  20. Li G, van Niekerk D, Miller D, Ehlen T, Garnis C, Follen M, Guillaud M, and MacAualy C. Molecular fixatives enables expression microarray analysis of microdissected clinical cervical specimens experimental and molecular pathology.  Experimental and Molecular Pathology.  2014 Jan 15;5(2):485-9 PMID: 24412268
  21. Arifler D, MacAaulay C, Follen M, Guillaud M. Numerical investigation of two-dimensional light scattering patterns of cervical cell nuclei to map dysplastic changes at different epithelial depths. Biomed Opt Express.  2014 Jan 15;5(2):485-98. doi: 10.1364/BOE.5.000485 PMID:24575343
  22. Contaldo M, Poh CF, Guillaud M, Lucchese A, Rullo R, Lam S, et al. Oral mucosa optical biopsy by a novel handheld fluorescent confocal microscope specifically developed: technologic improvements and future prospects. Oral Surg Oral Med Oral Pathol Oral Radiol        2013. Dec;116(6):752-758. PMID: 24237726
  23. Csikasz-Nagy A, Escudero LM, Guillaud M, Sedwards S, Baum B, Cavaliere M. Cooperation           and competition in the dynamics of tissue architecture during homeostasis and tumorigenesis'. Seminarsin cancer biology 2013. 23751796. Oral Oncol. 2013 Jun;49(6):582-90 PMID: 23751796
  24. El Hallani S, Poh, C.,MacAulay C., Follen, M., Guillaud, M., Lane, P.  Ex vivo Confocal Imaging with Contrast Agents for the Detection of Oral Potentially Malignant Lesions. Oral oncology. 2013. 23415144 PMID: 23415144