Skip to content. | Skip to navigation


Personal tools

Dr. Cheryl Helgason, Ph.D

Senior Scientist

 
Publications

Publications | Books (and Chapters) | Presentations and Symposium Proceedings | Abstracts |

In Press

1. Crea F, Clermont PL, Parolia A, Wang Y, Helgason CD. The non-coding transcriptome as a dynamic regulator of cancer metastasis. Accepted by Cancer and Metastasis Reviews, July 26, 2013.

2013

1. Watahiki A, Macfarlane RJ, Gleave ME, Crea F ,Wang Y, Helgason CD, Chi KN. Plasma miRNAs as biomarkers to identify patients with castration-resistant metastatic prostate cancer. Int. J. Mol. Sci., 2013 April 10; 14(4): 7757-7770.

2. Crea F, Clermont P-L, Mai A, Helgason CD. Histone Modifications, Stem Cells and Prostate Cancer. Current Pharmaceutical Design. July 19th E-Pub.

3. Nakamura H, Wang Y, Xue Y, Romanish MT, Mager DL, Helgason CD, Wang Y. Genistein vs. ICI 182, 780: an Ally or Enemy in Metastatic Progression of Prostate Cancer. Accepted by The Prostate, June 20, 2013.

4. Crea F, Sun L, Pikor L, Frumento P, Lam WL, Helgason CD. Mutational analysis of Polycomb genes in solid tumors identifies PHC3 amplification as a possible cancer-driving genetic alteration. British Journal of Cancer, EPub August 13, 2013. 

2012

5. Crea F, Sun L, Mai A, Chiang YT, Farrar WL, Danesi R, Helgason CD. The Emerging Role of Histone Lysine Demethylases in Prostate Cancer. (Review.) Molecular Cancer, 2012 Aug 6;11(1):52.

2011

6. Yang YH, Szabat M, Bragagnini C, Kott K, Helgason CD, Hoffman BG, Johnson JD. Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors. Diabetologia. 2011 Jan 7.


2010 

7. Antignano F, Ibaraki M, Kim C, Ruschmann J, Zhang A, Helgason CD & Krystal G. SHIP is required for dendritic cell maturation.  J Immunol March 15; 184(6): 2805-2813, 2010.

8. Fisher CL, Pineault N, Brookes C, Helgason CD, Ohta H, Bodner C, Hess JL, Humphries RK & Brock HW. Loss-of-function Additional sex combs-like1 mutations do not cause myelodysplasia or leukemia. Blood. Jan 7;115(1):38-46, 2010.

9. Fisher CL, Lee I, Bloyer S, Bozza S, Chevalier J, Dahl A, Bodner C, Helgason CD, Hess JL, Humphries RK, Brock HW. Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. Dev Biol. Jan 1;337(1):9-15, 2010.

10. Hoffman BG, Robertson G, Zavaglia B, Beach M, Cullum R, Lee S, Soukhatcheva G, Li L, Wederell ED, Thiessen N, Bilenky M, Cezard T, Tam A, Kamoh B, Birol I, Dai D, Zhao Y, Hirst M, Verchere CB, Helgason CD, Marra MA, Jones SJ, Hoodless PA. Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver. Genome Res. Aug;20(8):1037-51, 2010.

11. Kim PT, Hoffman BG, Plesner A, Helgason CD, Verchere CB, Chung SW, Warnock GL, Mui AL, Ong CJ. Differentiation of mouse embryonic stem cells into endoderm without embryoid body formation.  PLoS One. Nov 30;5(11):e14146, 2010.


2008

12. Morozova O, Morozov V, Hoffman BG, Helgason CD, Marra MA. A seriation approach for visualization-driven discovery of co-expression patterns in Serial Analysis of Gene Expression (SAGE) data. PLoS ONE. Sep 12;3(9):e3205, 2008.

13. Hoffman BG, Zavaglia B, Beach M, & Helgason CD. Expression of Groucho/TLE proteins during pancreas development. BMC Dev Biol. Sep 8;8:81, 2008.

14. Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, & Helgason CD. Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 9(6):R99, 2008.

2007

15. Lu M, Glover CH, Tien AH, Humphries RK, Piret JM, Helgason CD. Involvement of tyrosine kinase signaling in maintaining murine embryonic stem cell functionality. Exp Hematol (2007).

16. Neill L, Tien AH, Rey-Ladino J, Helgason CD. SHIP-deficient mice provide insights into the regulation of dendritic cell development and function. Exp Hematol. 35(4):627-39. (2007).

2006

17. Glover CH, Marin M, Eaves CJ, Helgason CD, Piret JM, Bryan J. Meta-analysis of differentiating mouse embryonic stem cell gene expression kinetics reveals early change of a small gene set. PLoS Comput Biol. 2(11):e158. (2006).

18. Hoffman BG, Williams KL, Tien AH, Lu V, de Algara TR, Ting JP, Helgason CD. Identification of novel genes and transcription factors involved in spleen, thymus and immunological development and function. Genes Immun. 7(2):101-12. (2006).

19. Zhang TJ, Hoffman BG, Ruiz de Algara T, Helgason CD. SAGE reveals expression of Wnt signalling pathway members during mouse prostate development. Gene Expr Patterns. 6(3):310-24. Epub 2005 Dec 27. (2006).

2005

20. Marcal N, Patel H, Dong Z, Belanger-Jasmin S, Hoffman B, Helgason CD, Dang J, Stifani S. Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation. Mol Cell Biol. 25(24):10916-29. (2005).

21. Palmqvist L, Glover CH, Hsu L, Lu M, Bossen B, Piret JM, Humphries RK, Helgason CD. Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency. Stem Cells. 23(5):663-80. (2005).

22. Siddiqui AS, Khattra J, Delaney AD, Zhao Y, Astell C, Asano J, Babakaiff R, Barber S, Beland J, Bohacec S, Brown-John M, Chand S, Charest D, Charters AM, Cullum R, Dhalla N, Featherstone R, Gerhard DS, Hoffman B, Holt RA, Hou J, Kuo BY, Lee LL, Lee S, Leung D, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu AL, Pandoh P, Riggins GJ, de Algara TR, Rupert JL, Smailus D, Stott J, Tsai M, Varhol R, Vrljicak P, Wong D, Wu MK, Xie YY, Yang G, Zhang I, Hirst M, Jones SJ, Helgason CD, Simpson EM, Hoodless PA, Marra MA. A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells. Proc Natl Acad Sci U S A. 102(51):18485-90. Epub 2005 Dec 13. (2005).

23. Tien AH, Xu L, Helgason CD. Altered immunity accompanies disease progression in a mouse model of prostate dysplasia. Cancer Res. 65(7):2947-55. (2005).

2004

24. Moody JL, Xu L, Helgason CD, Jirik FR. Anemia, thrombocytopenia, leukocytosis, extramedullary hematopoiesis, and impaired progenitor function in Pten+/-SHIP-/- mice: a novel model of myelodysplasia. Blood. 103(12):4503-10. Epub 2004 Mar 4. (2004).

2003

25. Baran CP, Tridandapani S, Helgason CD, Humphries RK, Krystal G, Marsh CB. The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. J Biol Chem. 278(40):38628-36. Epub 2003 Jul 25. (2003).

26. Crow AR, Song S, Freedman J, Helgason CD, Humphries RK, Siminovitch KA, Lazarus AH. IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity. Blood. 102(2):558-60. Epub 2003 Mar 20. (2003).

27. Helgason CD, Antonchuk J, Bodner C, Humphries RK. Homeostasis and regeneration of the hematopoietic stem cell pool are altered in SHIP-deficient mice. Blood. 102(10):3541-7. Epub 2003 Jul 10. (2003).

2002

28. Gardai S, Whitlock BB, Helgason C, Ambruso D, Fadok V, Bratton D, Henson PM. Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils. J Biol Chem. 277(7):5236-46. Epub 2001 Nov 27. (2002).

29. Pineault N, Helgason CD, Lawrence HJ, Humphries RK. Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny. Exp Hematol. 30(1):49-57. (2002).

30. Takeshita S, Namba N, Zhao JJ, Jiang Y, Genant HK, Silva MJ, Brodt MD, Helgason CD, Kalesnikoff J, Rauh MJ, Humphries RK, Krystal G, Teitelbaum SL, Ross FP. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med. 8(9):943-9. Epub 2002 Aug 5. (2002).

2001

31. Brauweiler A, Tamir I, Marschner S, Helgason CD, Cambier JC. Partially distinct molecular mechanisms mediate inhibitory FcgammaRIIB signaling in resting and activated B cells. J Immunol 167(1):204-11. (2001).

32. Cox D, Dale BM, Kashiwada M, Helgason CD, Greenberg S. A regulatory role for Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) in phagocytosis mediated by Fc gamma receptors and complement receptor 3 (alpha(M)beta(2); CD11b/CD18). J Exp Med. 193(1):61-71. (2001).

33. Latour S, Gish G, Helgason CD, Humphries RK, Pawson T, Veillette A. Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat Immunol. 2(8):681-90. (2001).

34. Wang R, Salem M, Yousef IM, Tuchweber B, Lam P, Childs SJ, Helgason CD, Ackerley C, Phillips MJ, Ling V. Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis. Proc Natl Acad Sci U S A 98(4):2011-6. (2001).

2000

35. Brauweiler A, Tamir I, Dal Porto J, Benschop RJ, Helgason CD, Humphries RK, Freed JH, Cambier JC. Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP). J Exp Med 191(9):1545-54. (2000).

36. Helgason CD, Kalberer CP, Damen JE, Chappel SM, Pineault N, Krystal G, Humphries RK. A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice. J Exp Med 191(5):781-94. (2000).

37. Huber M, Damen JE, Ware M, Hughes M, Helgason CD, Humphries RK, Krystal G. Regulation of mast cell degranulation by SHIP. In: Marone G, Lichtenstein LM, Galli SJ, editors. Mast Cells and Basophils in Physiology, Pathology and Host Defense. Academic Press. p 169-182. (2000).

38. Metzler M, Helgason CD, Dragatsis I, Zhang T, Gan L, Pineault N, Zeitlin SO, Humphries RK, Hayden MR. Huntingtin is required for normal hematopoiesis. Hum Mol Genet 9(3):387-94. (2000).

39. Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A 97(12):6687-92. (2000).

40. Tamir I, Stolpa JC, Helgason CD, Nakamura K, Bruhns P, Daeron M, Cambier JC. The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. Immunity 12(3):347-58. (2000).

1999

41. Huber M, Helgason CD, Damen JE, Scheid M, Duronio V, Liu L, Ware MD, Humphries RK, Krystal G. The role of SHIP in growth factor induced signalling. Prog Biophys Mol Biol. 71(3-4):423-34. (1999).

42. Kim CH, Hangoc G, Cooper S, Helgason CD, Yew S, Humphries RK, Krystal G, Broxmeyer HE. Altered responsiveness to chemokines due to targeted disruption of SHIP. J Clin Invest 104(12):1751-9. (1999).

43. Krystal G, Damen JE, Helgason CD, Huber M, Hughes MR, Kalesnikoff J, Lam V, Rosten P, Ware MD, Yew S, Humphries RK. SHIPs ahoy. Int J Biochem Cell Biol. 31(10):1007-10. (1999).

44. Metzler M, Chen N, Helgason CD, Graham RK, Nichol K, McCutcheon K, Nasir J, Humphries RK, Raymond LA, Hayden MR. Life without huntingtin: normal differentiation into functional neurons. J Neurochem 72(3):1009-18. (1999).

1998

45. Helgason CD, Damen JE, Rosten P, Grewal R, Sorensen P, Chappel SM, Borowski A, Jirik F, Krystal G, Humphries RK. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev 12(11):1610-20. (1998).

46. Huber M, Helgason CD, Damen JE, Liu L, Humphries RK, Krystal G. The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A 95(19):11330-5. (1998).

47. Huber M, Helgason CD, Scheid MP, Duronio V, Humphries RK, Krystal G. Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells. EMBO J 17(24):7311-9. (1998).

1997

48. Lawrence HJ, Helgason CD, Sauvageau G, Fong S, Izon DJ, Humphries RK, Largman C. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood 89(6):1922-30. (1997).

49. Miller CL, Rebel VI, Helgason CD, Lansdorp PM, Eaves CJ. Impaired steel factor responsiveness differentially affects the detection and long-term maintenance of fetal liver hematopoietic stem cells in vivo. Blood 89(4):1214-23. (1997).

1996

50. Helgason CD, Sauvageau G, Lawrence HJ, Largman C, Humphries RK. Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro. Blood 87(7):2740-9. (1996).

51. Miller CL, Rebel VI, Lemieux ME, Helgason CD, Lansdorp PM, Eaves CJ. Studies of W mutant mice provide evidence for alternate mechanisms capable of activating hematopoietic stem cells. Exp Hematol 24(2):185-94. (1996).

1995

52. Helgason CD, Atkinson EA, Pinkoski MJ, Bleackley RC. Proteinases are involved in both DNA fragmentation and membrane damage during CTL-mediated target cell killing. Exp Cell Res 218(1):50-6. (1995).

1994

53. Garner R, Helgason CD, Atkinson EA, Pinkoski MJ, Ostergaard HL, Sorensen O, Fu A, Lapchak PH, Rabinovitch A, McElhaney JE, et al.. Characterization of a granule-independent lytic mechanism used by CTL hybridomas. J Immunol 153(12):5413-21. (1994).

1993

54. Elliott JF, Miller CL, Pohajdak B, Talbot D, Helgason CD, Bleackley RC, Paetkau V. Induction of a proteoglycan core protein mRNA in mouse T lymphocytes. Mol Immunol 30(8):749-54. (1993).

55. Helgason CD, Shi L, Greenberg AH, Shi Y, Bromley P, Cotter TG, Green DR, Bleackley RC. DNA fragmentation induced by cytotoxic T lymphocytes can result in target cell death. Exp Cell Res 206(2):302-10. (1993).

1992

56. Burns K, Helgason CD, Bleackley RC, Michalak M. Calreticulin in T-lymphocytes. Identification of calreticulin in T-lymphocytes and demonstration that activation of T cells correlates with increased levels of calreticulin mRNA and protein. J Biol Chem 267(27):19039-42. (1992).

57. Fregeau CJ, Helgason CD, Bleackley RC. Two cytotoxic cell proteinase genes are differentially sensitive to sodium butyrate. Nucleic Acids Res 20(12):3113-9. (1992).

58. Helgason CD, Prendergast JA, Berke G, Bleackley RC. Peritoneal exudate lymphocyte and mixed lymphocyte culture hybridomas are cytolytic in the absence of cytotoxic cell proteinases and perforin. Eur J Immunol 22(12):3187-90. (1992).

59. McElhaney JE, Meneilly GS, Beattie BL, Helgason CD, Lee SF, Devine RD, Bleackley RC. The effect of influenza vaccination on IL2 production in healthy elderly: implications for current vaccination practices. J Gerontol 47(1):M3-8. (1992).

60. Prendergast JA, Helgason CD, Bleackley RC. Quantitative polymerase chain reaction analysis of cytotoxic cell proteinase gene transcripts in T cells. Pattern of expression is dependent on the nature of the stimulus. J Biol Chem 267(8):5090-5. (1992).

61. Prendergast JA, Helgason CD, Bleackley RC. A comparison of the flanking regions of the mouse cytotoxic cell proteinase genes. Biochim Biophys Acta 1131(2):192-8. (1992).

1990

62. Hooton JW, Miller CL, Helgason CD, Bleackley RC, Gillis S, Paetkau V. Development of precytotoxic T cells in cyclosporine-suppressed mixed lymphocyte reactions. J Immunol 144(3):816-23. (1990).

1989

63. Helgason CD, Wood JD. Changes in the amounts of amino acids associated with nerve endings (synaptosomes) during synaptogenesis. Neurochem Res 14(4):297-300. (1989).

1985

64. Roesler WJ, Helgason C, Gulka M, Khandelwal RL. Aberrations in the diurnal rhythms of plasma glucose, plasma insulin, liver glycogen, and hepatic glycogen synthase and phosphorylase activities in genetically diabetic (db/db) mice. Horm Metab Res. 17(11):572-5. (1985).

 

Books and Chapters

Publications | Books (and Chapters) | Presentations and Symposium Proceedings | Abstracts |

Edited

2013

1. Methods in Molecular Biology, Basic Cell Culture Methods, Fourth Edition. (eds. CD Helgason and CL Miller), Humana Press, 2013.

 

2004

2. Methods in Molecular Biology, Basic Cell Culture Methods, Third Edition. (eds. CD Helgason and CL Miller), Humana Press, 2004.

 

Chapters

2013

1. Clermont P-L, Crea F, Helgason CD. Thithorax Genes in Prostate Cancer. In: Prostate Cancer, (eds. Gerhard Hamilton), INTECH, pp 541-564, 2013.

 

2004

2. Helgason CD. Culture of primary adherent cells and a continuously growing non-adherent cell line Methods in Molecular Biology, Basic Cell Culture Methods, Third Edition, p.1-12 (2004).

2000

3. Huber M, Damen JE, Ware M, Hughes M, Helgason CD, Humphries RK, Krystal G. Regulation of mast cell degranulation by SHIP Mast Cells and Basophils in Physiology, Pathology and Host Defense (10): 169-182 (2000).

1999

4. Huber M, Helgason CD, Damen JE, Scheid M, Duronio V, Liu L, Ware MD, Humphries RK, Krystal G. The role of SHIP in growth factor induced signalling. Prog Biophys Mol Biol 71(3-4):423-34. (1999).

5. Huber M, Helgason CD, Damen JE, Scheid MP, Duronio V, Lam V, Humphries RK, Krystal G. The role of the SRC homology 2-containing inositol 5'-phosphatase in Fc epsilon R1-induced signaling. Curr Top Microbiol Immunol 244:29-41. (1999).

6. Huber M, Helgason CD, Damen JE, Scheid MP, Duronio V, Lam V, Humphries RK, Krystal G. The role of SHIP in FcεR1-induced signalling. In: Daeron M, Vivier E, editors. Current Topics in Microbiology and Immunology, Immunoreceptor Tyrosine-based Inhibition Motifs. Vol 244. Springer. p 29-41 (1999).

7. Krystal G, Damen JE, Helgason CD, Huber M, Hughes MR, Kalesnikoff J, Lam V, Rosten P, Ware MD, Yew S, Humphries RK. SHIPs ahoy. Int J Biochem Cell Biol 31(10):1007-10. (1999).

1998

8. Huber M, Helgason CD, Damen JE, Liu L, Ware M, Humphries RK, Krystal G. The role of SHIP in activation and apoptosis. In: ISH-EHA Program Book. p 165-169 (1998).

1995

9. Miller CL, Rebel VI, Helgason CD, Lemieux ME, Humphries RK, Lansdorp PM and Eaves CJ. Differential role of Steel factor on hematopoietic stem cells during ontogeny, in adults and after bone marrow transplantation. In: Gluckman E, Coulombel L, editors. Ontogeny of Hematopoiesis Aplastic Anemia. Joint International Workshop on Foetal and Neonatal Hematopoiesis and Mechanisms of Bone Marrow Failure. John Libbey Eurotext Limited, Montrouge, France. Vol 235. p 55-60. (1995).

 

Presentations and Symposium Proceedings         

Publications | Books (and Chapters) | Presentations and Symposium Proceedings | Abstracts |

2006

1. Helgason, CD. Progress in understanding the immunology of prostate cancer Vancouver Prostate Cancer Support Group. Vancouver, British Columbia, January 19 (2006).

2. Hoffman BG, Zavaglia B, & Helgason, CD. Cloning: Science and Issues. Britania High School – Grade 9 International Baccalaureate Progam Science class. November 22, 2006.

2005

3. Helgason CD. Stem Cell Research - Reality and Promise Disability Resource Network of BC Forum 2005.Vancouver, British Columbia. March 7-8 (2005).

4. Helgason, CD. Cell Research - Reality and Promise (Invited) Disability Resource Network of BC Forum 2005. March 7-8 (2005).

5. Hoffman BG, Williams KL, Ruiz de Algara T, Charters A, Ting JP-Y, Helgason CD. Identification of transcription factors involved in spleen, thymus, and immunological development Canadian Society for Immunology Annual Meeting: Systems Biology Approaches in Immunology Workshop. Whistler, British Columbia. April 7-10 (2005).

2004

6. Helgason CD. Update on understanding immune suppression in prostate cancer Vancouver Prostate Cancer Support Group. Vancouver, British Columbia, May 20 (2004).

7. Helgason, CD. Research Rounds: The role of regulatory T cells in a mouse model of prostate cancer (Invited) Department of Surgery, Centre of Surgical Research, UBC - VGH site. March 19 (2004).

8. Helgason, CD. The role of CD4+CD25+ regulatory T cells in prostate cancer progression 12th International Congress of Immunology. Montreal, Quebec. July 23 (2004).

9. Helgason, CD. The mouse atlas project (Invited) *omics discussion group. University of British Columbia. June 3 (2004).

2002

10. Helgason, CD. Cancer and the Immune System Vancouver Prostate Cancer Support Group. Vancouver, British Columbia. May 2 (2002).

11. Helgason, CD. Bioethics of stem cell research Invited Speaker, Trinity Western University. Langely, British Columbia, March 19 (2002).

12. Helgason, CD. Cancer and the Immune System Coquitlam Prostate Cancer Support Group. Coquitlam, British Columbia. May 7 (2002).

2000

13. Helgason CD. Cellular mechanisms contributing to autoimmunity in the SHIP knockout mouse (Invited) Department of Microbiology and Immunology, University of British Columbia, Vancouver, B.C. September 5 - 6 (2000).

14. Helgason CD. Cellular mechanisms contributing to autoimmunity in the SHIP knockout mouse (Invited) The Robart's Research Institute, University of Western Ontario, London, Ontario. November 22 -26 (2000).

15. Helgason CD. Cellular mechanisms contributing to autoimmunity in the SHIP knockout mouse (Invited) Immunology Research Group, University of Calgary, Calgary Alberta. July 6 - 8 (2000).

1999

16. Helgason CD. A role for SHIP in autoimmunity (Invited) Immunology Research Group Emerald Lake Conference. Pathogenesis and Immunotherapy in Autoimmunity. Emerald Lake, British Columbia. Sept. 30 - Oct. 3 (1999).

17. Helgason CD. Targeted disruption of SHIP: numerous consequences for hemopoiesis and immune function (Invited) Department of Medical Microbiology and Immunology. Edmonton, Alberta. Oct. 12 (1999).

 

 Abstracts

Publications | Books (and Chapters) | Presentations and Symposium Proceedings | Abstracts |

2013

1. Crea F, Helgason CD. Noncoding in RNAs in Development and Cancer. The Keystone symposium, Vancouver, Canada, January 20 – 25, 2013.

 

2. Clermont P-L, Crea F, Chiang YT, Zhang A, Helgason CD. Identification of CBX2 as Potential Drug Target in Prostate Cancer. IOP Annual Retreat, Vancouver, Canada, April 29, 2013.

 

3. Clermont P-L, Crea F, Chiang YT, Zhang A, Helgason CD. Identification of CBX2 as Potential Drug Target in Prostate Cancer. BCCRC Research Day, Vancouver, BC, May 1, 2013.

4. Crea F, Watahiki A, Quagliata L, Wang Y, Xue H, Frumento P, Farrar WL, Chi KN, Wang Y, Helgason CD. Diagnostic and prognostic features of prostate cancer non-coding transcriptome. BCCRC Research Day, Vancouver, BC, May 1, 2013.

5. Clermont P-L, Crea F, Chiang YT, Zhang A, Helgason CD. Identification of CBX2 as Potential Drug Target in Prostate Cancer. Urology Research Day, Vancouver, BC, June 18, 2013.

Crea F, Watahiki A, Quagliata L, Wang Y, Xue H, Frumento P, Farrar WL, Chi KN, Wang Y, Helgason CD. Diagnostic and prognostic features of prostate cancer non-coding transcriptome. Urology Research Day, Vancouver, BC, June 18, 2013.

2012

7. Clemont P-L, Crea F, Chiang YT, Helgason CD. Epigenetic regulation of metastasis by CBX proteins in prostate cancer. BC Cancer Agency Annual Conference, Vancouver, Canada,  November 29 – December 1, 2012.

8. Crea F, Watahiki A, Clermont P-L, Wang Y, Xue H, Farrar WL, Wang YZ, Helgason CD. The long-non coding RNA transriptome in metastatic prostate cancer. BC Cancer Agency Annual Conference, Vancouver, Canada,  November 29 – December 1, 2012.

9. Watahiki A, Macfarlane R, Gleave M,  Chi KN, Helgason CD, Wang  YZ. Plasma miRNAs distinguish metastatic castration resistant prostate cancer from localized prostate cancer and healthy control, BC Cancer Agency Annual Conference, Vancouver, BC, November 29 –December 1, 2012.

 

 

2010

10. Feng Y, Bu T, Wang Y & Helgason CD. CD83 Expression as a marker of epithelial-immune cell transition in prostate cancer. Keystone Symposia: Molecular and Cellular Biology of Immune Escape in Cancer. Keystone, Colorado, February 7-12, 2010. 

2007

11. Hoffman B, Kok D, Witzsche J, Hirst M, Robertson G, Hoodless PA, Jones S, Marra M, Helgason CD. Genome-wide analysis of Nkx2.2 binding sites using ChIP- tag sequencing (ChIP-TS) Pan American Congress in Developmental Biology. Cancun Mexico, June 16-20 (2007).

12. Tien AH, Chan JS, Helgason CD. Identification of immune modulators expressed by prostate tumor cells Canadian Society for Immunology 20th Annual Meeting. Lake Louise, Alberta. March 15-18 (2007).

13. Zavaglia B, Hoffman B, Witzsche J, Helgason CD. Analysis of the Gro/Tle Co-repressors in Pancreatic development Pan American Congress in Developmental Biology. Cancun Mexico, June 16-20 (2007).

2006

14. Tien AH, Chan JS, Helgason CD. Identification of tumor-associated molecules regulating dendritic cell development 9th International Symposium on Dendritic Cells. Edinburgh, Scotland. September 16-20 (2006).

15. Tien AH, Chan JS, Helgason CD. Identification of tumor-associated molecules modulating immune cells BC Cancer Agency Annual Cancer Care Conference. Vancouver, BC. November 22-24 (2006).

2005

16. Hoffman BC, Williams KL, Ruiz de Algara T, Charters A, Ting JP-Y, Helgason CD. Identification of transcription factors involved in spleen, thymus, and immunological development Canadian Society for Immunology 18th Annual Meeting. Whistler, British Columbia. April 7-10 (2005).

17. Hoffman BC, Williams KL, Ruiz de Algara T, Charters A, Ting JP-Y, Helgason CD. Identification of transcription factors involved in spleen, thymus, and immunological development British Columbia Cancer Agency Genomics Retreat. Vancouver, British Columbia. April 13 (2005).

18. Hoffman BG, Williams KL, Ruiz de Algara T, Charters A, Ting JP-Y, Helgason CD. Identification of transcription factors involved in spleen, thymus, and immunological development FASEB Journal. 19(4): A919 (2005).

19. Kim PTW, Hoffman BG, Morse JL, Helgason CD, Chung SW, Warnock GL, Verchere CB, Mui AL-F, Ong CJ. of islet like clusters from endoderm-derived mouse embryonic stem cells American Journal of Transplantation, Suppl. 11 (5): 521 (2005).

20. Lu M, Helgason CD. Establishing a role for c-kit in maintaining murine embryonic stem cell pluripotency 3rd Annual Meeting of the International Society for Stem Cell Research. San Francisco, California. June 23-25 (2005).

21. Piret JM, Glover C, Marin M, Chaudhry MAS, Eaves CJ, Bowen BD, Humphries RK, Helgason CD, Bryan J. Investigations of Murine Embryonic Stem Cell Maintenance by Analyses of Culture Variables and Gene Expression Profiling 19th Meeting of the European Society for Animal Cell Technology, Harrogate U.K., June 5-9 (2005).

22. Siddiqui AS, Khattra J, Delaney AD, Zhao Y, Astell C, Asano J, Babakaiff R, Barber S, Beland J, Slavita Bohacec S, Brown-John M, Chand S, Charters AM, Cullum R, Dhalla N, Featherstone R, Gerhard DS, Hoffman B, Holt R, Hou J, Kuo B Y-L, Lee LLC, Lee S, Leung D, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu A, Pandoh P, Riggins GJ, Ruiz de Algara T, Rupert JL, Smailus D, Stott J, Tsai M, Varhol R, Vrljicak P, Wong D, Wu MK, Xie Y-Y, Yang G, Zhang I, Hirst M, Jones SJM, Helgason CD, Simpson EM, Hoodless PA, Marra M. A quantitative and comprehensive atlas of gene expression in mouse Cold Spring Harbor Laboratory, New York, May 11-15 (2005).

2004

23. Berrington L, Tien A, Helgason CD. Regulation of Dendritic Cell Development and Function by Micro-Environmental Factors . 8th International Symposium on Dendritic Cells. Brugge, Belgium October 17-21 (2004).

24. Glover CH, Marin M, Helgason CD, Bryan J, Piret JM. Gene expression profiling during early differentiation of murine embryonic stem cells Stem Cell Network Annual General Meeting, Montreal, Quebec. November 3-5 (2004).

25. Glover CH, Palmqvist L, Bossen B, Hsu L, Piret JM, Humphries RK, Helgason CD. Gene Expression Profiling during Early Differentiation of Murine Embryonic Stem Cells Canadian Federation of Biological Societies. Vancouver, BC. June 16-20 (2004).

26. Helgason CD, Tien A, Xu L. . The role of CD4+CD25+ Regulatory T cells in Prostate Cancer Progression Clin. Invest. Med. Suppl. 27(4):166D (2004).

27. Hoffman B, Ruiz de Algara T, Helgason CD. SAGE analysis of pancreas development Canadian Federation of Biological Societies. Vancouver, BC. June 16-20 (2004).

28. Hoffman B, Ruiz de Algara T, Helgason CD. The Expression of Rbp-L During Pancreatic Development And In Various Pancreatic Cancer Cell Lines Society for Developmental Biology Annual Meeting. Calgary, Alberta. July 24-28, 2004. Dev Biol 271 (2): 620-621, 343 (2004).

29. Hoffman B, Ruiz de Algara T, Helgason CD. SAGE Analysis of Pancreatic Development Keystone Symposia: Signaling in vertebrate organogenesis. Sante Fe, New Mexico. Feb 27-Mar 2 (2004).

30. Marra MA, Khattra J, Varhol R, Leung D, Simpson EM, Helgason C, Jones S, Firpo M, Pera M, Eaves C, Thomson J, Riggins G, Hoodless P, Siddiqui A, Delaney A. Quantitative and comprehensive gene expression profiles in developing mouse tissues and in human embryonic stem cell lines SAGE Conference 2004. Boston, MA . Sept 30-Oct 3 (2004).

31. Rupert JL, Wu MK, Cullum R, Lee L, Charters A, Siddiqui A, Khattra J, Helgason CD, Simpson EM, Jones S, Marra M, Hoodless PA. The Atlas of Gene Expression in Mouse Development: a SAGE Project Canadian Developmental Biology Symposium. Banff, Alberta. April 1-4 (2004).

32. S. Bohacec, Y. Xie, B. Kuo, J. Khattra, A. Siddiqui, C.D. Helgason, P.A. Hoodless, S. Jones, M. Marra, E.M. Simpson. Comprehensive SAGE Atlas of Murine Gene Expression Throughout Development 18th Intenational Mouse Genome Conference. Seattle, WA. October 18-21 (2004).

33. Siddiqui AS, Delaney A, Khattra J, Hirst M, Rupert J, Astell C, Asano J, Bohacec S, Chan S, Cullum R, Hoffman B, Kuo B, Landry A, Leung D, Lee L, Moksa M, Ruiz de Algara T, Teague K, Varhol R, Wu M, Xie R, Zeng T, Zhang I, Jones S, Simpson EM, Helgason C, Hoodless P, Marra M. Uncovering transcriptional complexity in the Mouse Atlas Project: A Study of Gene Expression in Mouse Development BC Cancer Agency Annual Cancer Conference, Vancouver, British Columbia. November 25-27 (2004).

34. Siddiqui AS, Delaney A, Khattra J, Varhol R., Leung D, Simpson E, Helgason C, Hoodless P, Marra M, Jones S. Quantitative and Comprehensive Atlas of Gene Expression in Mouse Development 4th Cold Spring Harbor Laboratory/Wellcome Trust Conference on Genome Informatics. Hinxton, UK September 22-26 (2004).

35. Siddiqui AS, Khattra J, Zuyderduyn S, Simpson E, Helgason CD, Jones S, Hoodless P, Marra M. A Quantitative and Comprehensive Atlas of Gene Expression in Mouse Development Advances in Genome Biology and Technology Conference. Marco Island, Florida. February 4-7 (2004).

36. Tien A, Xu L, Helgason CD. Regulation of immune function by prostate cancer cells Canadian Federation of Biological Societies. Vancouver, BC. June 16-20 (2004).

37. Tien A, Xu L, Helgason CD. of immune responsiveness by prostate cancer cells Clin. Invest. Med. Suppl. 27(4):177D (2004).

38. Xu L, Tien A , Helgason CD. CD4+CD25+ Regulatory T cells in Prostate Cancer: Implications for development of an effective anti-tumor immune response Keystone Symposia: Regulatory/Supressor T cells. Banff, Alberta. March 10-15 (2004).

39. Xu L, Tien A, Eom G, Helgason CD. The Role of CD4+CD25+ Regulatory T (Tr) cells in Prostate Cancer Progression 10th Prout's Neck Prostate Cancer Meeting. Prout's Neck, Maine. November 4-7 (2004).

40. Zhang I, Ruiz de Algara T, Helgason CD. Identification of Genes Regulating Mouse Prostate Development Using Serial Analysis Of Gene Expression (Sage) Society for Developmental Biology Annual Meeting. Calgary, Alberta. July 24-28, 2004. Dev Biol 271 (2): 626, 367 (2004).

41. Zhang I, Ruiz de Algara, Hoffman B, Helgason CD. Identification Of Genes Regulating Branching Of Mouse Prostate Epithelium Canadian Federation of Biological Societies. Vancouver, BC. June16-20 (2004).


2003

42. Fairhurst M, Woodside SM, Thomas TE, Tien A, Berrington L, Helgason CD. A simple column free method for positive selection of functional dendritic cells from normal, knockout, and transgenic mouse strains American Association of Immunologists Annual Meeting. Denver, Colorado. FASEB J 17 (7): C199 Suppl. S. (2003).

43. Fisher C, Helgason CD, Bodner C, Humphries RK, Brock H. Targeted disruption of a mouse homologue of the Drosophila Polycomb Group gene Asx leads to bidirectional axial skeleton transformations and hematopoietic defects British Society for Cell Biology and British Society for Developmental Biology Joint Spring Meeting. Wawick, England. April 8-11 (2003).

44. Helgason CD, Xu LX, Raffard ZM, Louis SA, Lopez AM, Woodside SM, Thomas TE. Two strategies to efficiently purify functional CD4+CD25+ regulatory T cells from normal and transgenic mouse strains FASEB J 17 (7): C124 Suppl. S (2003).

45. Helgason CD, Berrington L, Raffard Z, Rey-Ladino J. Dendritic cell development, function, and homeostasis is regulated by the SH2-containing inositol-5-phosphatase SHIP Keystone Symposia: Dendritic cells: Interfaces with immunology and medicine. Keystone, Colorado, USA. March 3-8 (2003).

46. Moody JL, Helgason C, Jirik FR. Heterozygosity for the 3' inositol phosphatase Pten alters the hematopoietic abnormalities of SHIP-/- mice Exp Hematol (Suppl.1 ) 31:97 (2003).

47. Tien A, Bremner C, Rey-Ladino J, Helgason CD. Analysis of Dendritic Cell Development and Phenotype in a Mouse Model of Prostate Cancer Keystone Symposia: Basic aspects of tumor immunology. Keystone, Colorado, USA. February 17-23 (2003).

48. Tien A, Helgason CD. Primary prostate tumors secrete factors that inhibit dendritic cell differentiation BC Cancer Conference, Vancouver, BC. November 28-29 (2003).

49. Xu L, Eom G, Helgason CD. CD4+CD25+ Regulatory T cell Populations Expand with Disease Progression in a Mouse Model of Prostate Cancer. Keystone Symposia: Basic aspects of tumor immunology Keystone, Colorado, USA. February 17-23 (2003).

50. Xu L, Tien A, Eom G, Helgason CD. CD4+CD25+ Regulatory T cell Populations Expand with Disease Progression in a Mouse Model of Prostate Cancer Canadian Society for Immunology Annual Meeting. Lake Louise, Alberta. March 28-31 (2003).

51. Xu L, Tien A, Helgason CD. A CD4+CD25+ Regulatory T cell population expands with disease progression in a mouse model of prostate cancer BC Cancer Conference. Vancouver, BC. November 28-29 (2003).

52. Zhang I, Ruiz de Algara T, Hoffman B, Helgason CD. Identification of genes regulating branching of mouse prostate epithelium BC Cancer Conference, Vancouver, BC. November 28-29 (2003).

2002

53. Fairhurst MA, Louis SA, Thomas TE, Helgason CD. Efficient isolation of functional bone marrow derived dendritic cells from normal and transgenic mouse strains FASEB J 16 (5): A1229, Part 2. (2002).

54.Fisher C, Helgason C, Bodner C, Humphries K, Brock H. Targeted disruption of a mouse homolog of the drosophilia additional sex combs gene leads to bidirectional axial skeleton transformations and spermatocyte defects Dev Biol 247: p.458-459 (2002).

55. Rey-Ladino J, Bodner C, Humphries RK, Helgason CD. SHIP (SH2-containing inositol-5-phosphatase) regulated dendritic cell development and homeostasis 7th International Symposium on Dendritic Cells. Bamberg, Germany. September 19-24. (2002).

56. Takeshita S, Namba N, Zhao JJ, Jiang Y, Genant HK, Silva MJ, Brodt MD, Helgason CD, Humphries RK, Krystal G, Teitelbaum SL, Ross FP. SHIP deficient mice are severely osteoporotic due to accelerated bone resorption by pagetic-like osteoclasts J Bone and Mineral Res. 17:S211, F403 (Suppl. 1) (2002).


2001

57. Antonchuk J, Helgason CD, Takihara Y, Katoh-Fukui Y, Higashinakagawa T, Humphries RK. Functional interaction between M33 and Rae-28 polycomb group genes in hematopoiesis Blood 98:286a (2001).

58. Crow AR, Song S, Helgason CD, Humphries RK, Freedman J, Lazarus AH. Reversal of murine passive-immune thrombocytopenia by IVIG requires FcGammaRIIB expression but not the SH2-containing inositol-5-phosphatase SHIP Blood 98:286a (2001).

59. Greenberg S, Cox D, Dale BM, Kashiwada M, Helgason C, Cheney RE, Berg JS. Regulation of phagocytosis and pseudopod extension by phosphoinositides and myosin-X FASEB J 15 (5): A1039-A1039 Part 2 (2001).

60. Helgason CD, Bodner C & Humphries RK. Analysis of dendritic cell development and function in SHIP-/- mice Canadian Society of Immunology Meeting. Lake Louise, Alberta. April 6-9 (2001).

61. Helgason CD, Rosten P, Bodner C & Humphries RK. Negative regulation of hematopoiesis: Genetic interactions between SHIP and SHP-1 Conference on Signalling in Normal and Cancer Cells. Banff, Alberta. March 2-6 (2001).

2000

62. Cox D, Dale BM, Kashiwada M, Helgason CD, Greenberg S. A regulatory role for SH2 domain-containing inositol 5 Phosphatase (SHIP) in phagocytosis mediated by Fc receptors and complement receptor 3 (CD11b/CD18) Molecular Biology of the Cell 11:213A-214A, 1115 (Suppl. S) (2000).

63. Faulkes S, LeBoulch P, Helgason C & Humphries RK. Efficient site-directed DNA integration into ES and hematopoietic cells 29th Annual Scientific Meeting of the International Society for Experimental Hematology, Tampa, Florida, July 8-11, Exp Hematol 2000. (2000).

64. Helgason CD, Bodner C, Pineault N, Buske C & Humphries RK. Expanded primitive cell populations, but impaired hematopoietic differentiation, in mice bearing a targeted disruption of the SH2-containing inositol-5-phosphatase SHIP Blood 96: 537a (2000).

65. Helgason CD, Kalberer C, Bodner C, Rosten PM, Grewal R, Magil A & Humphries RK. Autoimmunity in mice lacking the SH2-containing inositol 5-phosphatase ship Regulation of Immunity. The 39th Midwinter Conference of Immunologists. Pacific Grove, CA. January 22-25 (2000).

66. Kalberer CP, Helgason CD, Rosten P, Magil A & Humphries RK. SHIP deficient mice exhibit aberrant development and function of B cells leading to autoimmunity Swiss Society for Allergology and Immunology. 50th Annual Assembly, Basel, Switzerland, April 6-7 (2000).

67. Namba N, Teitelbaum SL, Chappel JC, Brodt M, Silva MJ, Helgason CD, Krystal G, Humphries RK, Ross FP. Mice lacking the lipid phosphatase SHIP are osteoporotic, with decreased bone strength and increased osteoclast number J Bone and Mineral Research 15: S179, 1164 (Suppl. 1) (2000).

68. Pineault N, Buske C, Faulkes S, Helgason CD, Aplan PD & Humphries RK. The AML associated fusion gene NUP98-HOXD13 leads to increased myeloproliferation and decreased erythropoiesis in differentiating embryonic stem cells Blood 96: 458a (2000).

69. Pineault N, Buske C, Feuring-Buske M, Helgason CD & Humphries RK. The NUP98-HOXD13 fusion gene implicated in human leukemia induces myeloproliferation and blocks early B cell development in murine hematopoiesis 29th Annual Scientific Meeting of the International Society for Experimental Hematology, Tampa, Florida, July 8-11, Exp Hematol 28: 167 (2000).

1999

70. Helgason CD, Kalberer C, Chappel SM, Rosten PM, Grewal R, Krystal G & Humphries RK. Targeted disruption of SHIP results in elevated serum immunoglobulin levels and enhanced responsiveness to T-cell independent antigenic challenge Canadian Society of Immunology Annual Meeting. Lake Louise, March 5-8 (1999).

71. Helgason CD, Kalberer C, Rosten PM, Grewal R & Humphries RK. Immunological defects in mice lacking the SH2-containing inositol 5-phosphatase SHIP-1: Lymphoproliferation, elevated circulating immunoglobulins, and autoimmunity Exp Hematol 27: 87 (1999).

72. Kim CH, Hangoc G, Cooper S, Helgason CD, Yew S, Humphries RK, Krystal G & Broxmeyer HE. SHIP is a key regulator of chemokine-induced biological effects and signaling Exp Hematol 27: 98 (1999).

73. Miller CL, Hodge A, Humphries RK, Krystal G & Helgason CD. Enhanced IL-3 responsiveness of megakaryocyte progenitors from SHIP-/- mice Exp Hematol 27: 100 (1999).

74. Rauh MJ, Damen JE, Helgason CD, Humphries RK & Krystal G. SHIP is a positive regulator of nitric oxide production Blood 94: 208a (1999).

1998

75. Helgason CD, Damen JE, Chappel SM, Rosten PM, Grewal R, Borowski A, Jirik F, Krystal G & Humphries RK. Targeted disruption of SHIP (SH2-containing i nositol phosphatase) results in hematopoietic disturbances and early mortality Signalling in normal and cancer cells. Banff, Alberta. March 6-10 (1998).

76. Helgason CD, Damen JE, Rosten PM, Grewal R, Sorensen P, Chappel SM, Miller CL, Borowski A, Jirik F, Krystal G & Humphries RK. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened lifespan Exp Hematol 26: 815 (1998).

77. Helgason CD, Rosten PM, Parmar M & Humphries RK. Identification of a novel angiopoietin-related molecule in a subtracted cDNA library generated from HOXB3-transduced embryonic stem cell-derived hemopoietic cells Exp Hematol 26: 742 (1998).

78. Huber M, Helgason C, Damen JE, Humphries RK & Krystal G. Hyper-responsiveness in SHIP -/- mast cells: degranulation without antigen Gemeinsame Jahrestagung der Deutschen und Osterreichischen Gesellschaften fur Hamatologie und Onkologie, Frankfurt, 25-28 October (1998).

79. Huber M, Helgason C, Damen JE, Humphries RK & Krystal G. Targeted disruption of SHIP leads to enhanced mast cell responses to Steel factor Signalling in Normal and Cancer Cells, Banff, March 6-10 (1998).

80. Huber M, Helgason C, Damen JE, Scheid MP, Duronio V, Humphries RK & Krystal G. Enhanced responses to Steel factor in SHIP -/- mast cells Gemeinsame Jaharestagung der Deutschen und Osterreichischen Gesellschaften fur Hamatologie und Onkologie, Frankfurt, 25-28 October (1998)

81. Huber M, Helgason CD, Damen JE, Humphries RK & Krystal G. Enhanced responses to Steel factor in SHIP -/- mast cells Exp Hematol 26: 752 (1998).

82. Huber M, Helgason CD, Damen JE, Liu L, Humphries RK & Krystal G. The role of SHIP in activation and apoptosis Signalling in Normal and Cancer Cells, Banff, March 6-10 (1998).

83. Huber M, Helgason CD, Damen JE, Liu L, Humphries RK & Krystal G. The role of SHIP in activation and apoptosis ISE-EH Combined Haematology Congress, Amsterdam. 4-8 July (1998).

84. Huber M, Helgason CD, Damen JE, Liu L, Ware MD, Humphries RK & Krystal G. SHIP is the gatekeeper of mast cell degranulation Exp Hematol 26: 759 (1998).

85. Miller C, Helgason C, Antonchuk J, Hodge A & Eaves C. Longterm hematopoietic engraftment of sublethally irradiated adult and non-irradiated neonatal W41/W41 and W41/W42 mice Exp Hematol 26: 755 (1998).

1997

86. Helgason CD & Humphries RK. Analysis of the role of Hox homeobox genes in hematopoietic development using the in vitro differentiation of embryonic stem cells as a model 13th International Congress of Developmental Biology. Society for Developmental Biology and International Society for Developmental Biologists. Snowbird, Utah. July 5-10, Dev Biol 186: 294 (1997).

87. Helgason CD, Rosten PM, Damen JE, Liu L, Grewal R, Borowski A, Jirik F, Krystal G & Humphries RK. Targeted disruption of the gene encoding the SH2-containing inositol phosphatase, SHIP: Generation of a model to elucidate SHIP function Blood 90 (Suppl. 1): 427a (1997).

88. Helgason CD, Rosten PM, Tollmar M, Janmohamed A & Humphries RK. Identification of downstream effectors of HOXB3 function using suppression subtraction hybridization Blood 90 (Suppl. 1): 323a (1997).

89. Helgason CD, Thorsteinsdottir U & Humphries RK. Generation of a multipotential hematopoietic cell line derived from HOXA10-transduced embryonic stem cells Blood 90 (Suppl. 1): 323a (1997).

90. Pineault N, Helgason CD, Sauvageau G, Lawrence HJ & Humphries RK. Analysis of HOX gene expression in primitive hematopoietic subpopulations of murine fetal liver and adult bone marrow (Oral Presentation) ISEH 1997. Cannes, France. August 24-28 (1997).

1996

91. Humphries RK, Conneally E, Pawliuk R, Eaves CJ, Thorsteinsdottir U, Helgason C, Largman C, Lawrence J & Sauvageau G. Tracking and genetic modulation of hematopoietic stem cell behaviour Keystone Symposia on Molecular and Cellular Biology "Gene Therapy for Hematopoietic Stem Cells in Genetic Disease and Cancer". Taos, New Mexico. February 4-10 (1996).

92. Humphries RK, Pawliuk R, Conneally E, Thorsteinsdottir U, Helgason C, Eaves C, Lansdorp P, Largman C, Lawrence J & Sauvageau G. Growth potential, genetic control, and manipulation of hematopoietic stem cells 1996 Cambridge Symposia Conference "Molecular Genetic Approaches to the Treatment of Genetic Disease". Lake Tahoe, Nevada. October 25-31 (1996).

93. Humphries RK, Sauvageau G, Thorsteinsdottir U, Helgason C, Lansdorp PM, Eaves CJ, Largman C & Lawrence HJ. Expression and function of Hox homeobox genes in early hematopoiesis Keystone Symposia on Molecular and Cellular Biology "Blood and Bone Marrow Transplants". Keystone, Colorado. January 15-21 (1996).

1995

94. Helgason CD, Sauvageau G, Thorsteinsdottir U, Lawrence HJ, Largman C & Humphries RK. Overexpression of various Hox homeobox genes in embryonic stem cells reveals differential effects on hematopoietic differentiation Blood 86 (Suppl. 1): 255a (1995).

95. Humphries RK, Sauvageau G, Thorsteinsdottir U, Helgason C, Lansdorp PM, Eaves CJ, Largman C & Lawrence HJ. Expression and function of Hox homeobox genes in early hematopoiesis First Conference on Stem Cell Gene Therapy: Biology and Technology. Washington, D.C. September 29-October 1 (1995).

96. Humphries RK, Sauvageau G, Thorsteinsdottir U, Pawliuk R, Helgason C, Conneally E, Bardy P, Lansdorp P & Eaves CJ. Tracking and manipulating hematopoietic stem cells by retroviral gene transfer ASBMT First Annual Meeting, Keystone, CO, January 26-28 (1995).

97. Humphries RK, Thorsteinsdottir U, Helgason C, Lawrence HJ, Largman C, Lansdorp PM, Eaves CJ & Sauvageau G. Expression and function of Hox homeobox genes in early hematopoiesis FASEB Summer Research Conference "Hematopoietic Neoplasms: Altered State of Transcriptional Regulation". Vermont Academy, Saxtons River, Vermont. July 29-August 3 (1995).

98. Lawrence H, Helgason C, Sauvageau G, Fong S, Chisaka O, Capecchi M, Humphries RK & Largman C. Mice bearing homozygous deletions of the homeobox gene HOXA9 have defects in lymphoid and myeloid hematopoiesis International Congress of Immunology, San Francisco, CA. August (1995).

99. Lawrence HJ, Helgason CD, Sauvageau G, Fong ST, Peterson CL, Capecchi MR, Humphries RK & Largman C. Mice homozygous for a targeted disruption of the homeobox gene HOXA9 have defects in lymphoid and myeloid hematopoiesis Blood 86 (Suppl. 1): 254a (1995).

100. Miller CL, Rebel VI, Helgason CD, Humphries RK, Lansdorp PM & Eaves CJ. Steel factor is not essential for generation of murine fetal liver stem cells or for early transplant reconstitution by these cells J Hematother 4 (Suppl. 3): 219 (1995).

101. Miller CL, Rebel VI, Helgason CD, Lemieux ME, Humphries RK, Lansdorp PM & Eaves CJ. Role of steel factor during ontogeny and post bone marrow transplantation Joint International Workshop on Foetal and Neonatal Hematopoiesis & Mechanisms of Bone Marrow Failure, Paris, France, April 3-6 (1995).

102. Sauvageau G, Thorsteinsdottir U, Helgason C, Lawrence HJ, Largman C, Lansdorp PM, Eaves CJ & Humphries RK. Expression and function of Hox homeobox genes in early hematopoiesis Canadian Society for Clinical Investigation. MRC Program, Montréal, Québec. September 14 (1995).


1994

103. Helgason CD & Humphries RK. In vitro differentiation of embryonic stem cells as a model of hemopoietic differentiation J Cell Biochem (Suppl. 18b): 180 (1994).

104. Helgason CD, Sauvageau G, Largman G, Lawrence HJ & Humphries RK. In vitro differentiation of embryonic stem cells: A system to evaluate the role of specific genes in hemopoietic cell differentiation and proliferation Blood 84 (Suppl. 10): 367a (1994).

105. Miller CL, Rebel V, Lemieux M, Helgason CD, Lansdorp PM & Eaves CJ. Demonstration of discrepant properties of primitive hematopoietic cells from W41/W41 mice according to the assay used Exp Hematol 22: 754 (1994).

1991

106. Green DR, Bromley P, Bissonnette RP, Parfrey NA, Szalay M, Helgason CD, Bleackley RC, Cotter TG, ShiY. Activation-induced apoptosis in immature T-cells and T-cell hybridomas FASEB J 5(6): A1699, Part 3 (1991).

107. Helgason CD, Bleackley RC, Bromley P, Shi Y, Greenberg AH & Green DR. CTL mediated lysis and activation-induced apoptosis in T cells occur through a common pathway Annual Meeting of the Canadian Society for Immunology, Lake Louise, Alberta. March 8-12 (1991).

1990

108. Helgason CD & Bleackley RC. Antisense oligonucleotides directed against the CTL-specific serine protease CCP1 (C11) inhibit cytolytic activity Seventh Course in Oncology, Hamilton, Ontario. June 17-22 (1990).

109. Helgason CD, Bleackley RC, Bromley P, Shi Y, Greenberg AH & Green DR. CTL mediated lysis and activation-induced apoptosis in T cells occur through a common pathway Heritage Medical Research Days, Edmonton, Alberta. November 19-20 (1990).

1989

110. Helgason CD, Ehrman N, Kotkas M & Bleackley RC. Isolation of a cDNA clone expressed during the activation of cytotoxic T Cells Heritage Medical Research Days, Calgary, Alberta. November 30 - December 1 (1989).

111. Helgason CD, Ehrman N, Kotkas M & Bleackley RC. Isolation of a cDNA clone expressed during the activation of cytotoxic T cells Seventh International Congress of Immunology, Berlin, West Germany. July 30 - August 5 (1989).

1987

112. Helgason CD & Wood JD. Postnatal changes in GABA receptor binding to rat brain membranes Annual Psychiatric Research Meeting, Saskatoon, Saskatchewan. March 19-20 (1987).

113. Helgason, CD & Wood JD. GABA binding to crude synaptic membranes during brain development Canadian Federation of Biological Societies 30th Annual Meeting, Winnipeg, Manitoba. June 22-26 (1987).

1986

114. Helgason CD & Wood JD. Amino acids in whole tissue and nerve endings during brain development Seventeenth Annual Meeting of the American Society for Neurochemistry, Montreal, Quebec. March 16-21 (1986).

115. Helgason CD & Wood JD. Developmental aspects of amino acid neurotransmitters in the rat olfactory bulb and cerebral cortex Annual Psychiatric Research Meeting, Saskatoon, Saskatchewan. February 28 (1986).

  

Publications | Books (and Chapters) | Presentations and Symposium Proceedings | Abstracts |

 

Cheryl Helgason's Profile