Skip to content. | Skip to navigation


Personal tools

Nelson Wong, Ph.D

Staff Scientist


nwong@bccrc.ca
Tel:  (604) 675-8000 ext. 7622
Fax: (604) 675-8183


Education

  • Ph.D. (Immunology), University of British Columbia
  • M.Sc. (Pathology), University of Western Ontario
  • B.Sc.  (Microbiology), University of Toronto

 

Research Interests

As most of the current effort of personalized medicine strives toward providing cancer treatment with molecular precision, my research interest, on the other hand, is to develop nanoparticles for the delivery of anticancer drugs with anatomical precision.  I believe the combination of these approaches will greatly diminish drug toxicities and increase treatment efficacy.  One of my current projects is to develop a formulation of molecularly targeted drug for treating a subset of triple-negative breast cancers.  I also have research projects on deciphering molecular mechanisms of drug resistance and radiosensitization.

 

Personal Interests

As for hobbies and interests, I like to play racquet sports, such as tennis and squash. I also play a little bit of guitar and I play it in a worship team at church. Moreover, I read the Bible and pray daily.

 

Patent Applications

      1. Hydrophobically derivatized hyperbranched polyglycerol for intravascular drug delivery.

          PCT application PCT/CA2015/050600 (Jun 26, 2015).

          Inventors: Khan MK, Kizhakkedathu JN, Shenoi RA, Misri R, Wong NKY, and Brooks D

 

      2. Hydrophobically derivatized hyperbranched polyglycerol with PEGylated shell for systemic drug delivery.

          U.S. Provisional Patent Application No. 62019082 (Jun 30, 2014).

          Inventors: Khan MK, Kizhakkedathu JN, Shenoi RA, Misri R, Wong NKY, and Brooks D.

 

Publications

  1. Wong NKY*, Misri R*, Shenoi RA*, Chafeeva I, Kizhakkedathu JN, and Khan MK. Design considerations for developing hyperbranched polyglyercol nanoparticles as systemic drug carriers. J. Biomed. Nanotechnol. 12(5):1089-1100, 2016. (*equal contribution)
  2. Misri R*, Wong NKY*, Shenoi RA*, Lum C, Chafeeva I, Toth K, Rustum Y, Kizhakkedathu JN, and Khan MK. Evaluation of hydrophobically derivitized hyperbranched polyglycerol with PEGylated shell as a nanocarrier of docetaxel for systemic therapy. Nanomedicine: NBM 11(7):1785-1795, 2015. (*equal contribution)
  3. Kulic I, Robertson G, Chang L, Baker JH, Lockwood WW, Mok W, Fuller M, Fournier M, Wong N, Chou V, Robinson MD, Chun HJ, Gilks B, Kempkes B, Thomson TA, Hirst M, Minchinton AI, Lam WL, Jones S, Marra M, Karsan A. Loss of the Notch effector RBPJ promotes tumorigenesis. J. Exp. Med. 212(1):37-52, 2015.
  4. Wong NKY, Fuller M, Sung S, Wong F, and Karsan A.  Heterogeneity of breast cancer stem cells as evidenced with Notch-dependent and Notch-independent populations.  Cancer Med. 1(2):105-113, 2012.
  5. Wong NKY, Lai JC, Maeshima N, and Johnson P.  CD44-mediated elongated T cell spreading requires Pyk2 activation by Src family kinases, extracellular calcium, phospholipase C and phosphatidylinositol-3 kinase.  Cell Signal. 23(5): 812-819, 2011.
  6. Wong NKY*, Lai JC*, Birkenhead D, Shaw AS, and Johnson P.  CD45 regulates CD44-mediated actin rearrangement through down-regulation of Lck activation. J Immunol.  181(10): 7033-7043, 2008. (*equal contribution)
  7. Maksumova L, Wang Y, Wong NK, Le HT, Pallen CJ, and Johnson P.  Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45.  J Biol. Chem. 282(29): 20925-20932, 2007.
  8. Li R, Wong N, Jabali MD, Johnson P.  CD44-initiated cell spreading induces Pyk2 phosphorylation, is mediated by Src family kinases, and is negatively regulated by CD45.  J. Biol. Chem.  276(31): 28767–28773, 2001.
  9. Wong NKY, He BP, Strong MJ. Characterization of neuronal intermediate filament protein expression in cervical spinal motor neurons in sporadic Amyotrophic Lateral Sclerosis (ALS).  J. Neuropathol. Exp. Neurol.  59(11): 972-982, 2000.
  10. Wong NKY and Strong MJ.  Expression of nitric oxide synthase in Amyotrophic Lateral Sclerosis.  Eur. J. Cell Biol.  77:338-343, 1998.