Tel: 604-675-8000 ext. 7013
Research Interests:One of my major research efforts is directed toward prostate cancer (PCa) metastasis. During the past 6 years, I have developed two pairs of transplantable metastatic sublines (e.g. PCa1-met)  and their non-metastatic counterparts (e.g. PCa2) from the same patients' primary prostate cancer specimens, using our well-established subrenal capsule and orthotopic xenograft technology. The paired metastatic and non-metastatic tumor sublines are subjected to differential analyses (e.g., Serial Analysis of Gene Expression, Solexa Sequencing) in a search for up-regulated and down-regulated genes that are associated with metastasis  and as such could lead to novel predictive biomarkers and/or therapeutic targets for metastatic prostate cancer.
Another major area of my studies focuses on other applications of our transplantable tumor tissue lines at the Living Tumor Laboratory (BC Cancer Research Centre) [3,4] including evaluation of the efficacy of New Anti-Cancer Drugs in these clinically more relevant models (i.e. the patients-derived xenografts). In fact, I have been working in the field of drug research and development for more than 20 years. Particularly, I am very interested in pre-clinical anti-cancer drug development using our unique models. Through our efforts, some new anti-cancer compounds are entering different phases of clinical trials.
The Living Tumor Centre is a unique, exciting and happy place to work in. We hope that our efforts will speed up the translational research and eventually will benefit the cancer patients.
Wang Y, Xue H, Cutz JC, Bayani J, Mawji NR, Chen WG, Goetz LJ, Hayward SW, Sadar MD, Gilks CB, Gout PW, Squire JA, Cunha GR, Wang YZ(2005b) An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line. Lab Invest 85: 1392-404
Lin D, Watahiki A, Bayani J, Zhang F, Liu L, Ling V, Sadar MD, English J, Fazli L, So A, Gout PW, Gleave M, Squire JA, Wang YZ (2008) ASAP1, a gene at 8q24, is associated with prostate cancer metastasis. Cancer research 68: 4352-9
Liou LS, Zhou Y, Wang Y, Xue H, Novick C, DiDonato JA, Wang YZ (2004) A living human tumor bank using an orthotopic xenograft mouse model: Feasability and Implications of angiogenesis and proliferation. J Urol 171: 208
Watahiki A, Wang Y, Xue H, Kurita T, Sutcliffe M, Owen D, Gout P, Wang YZ (2006) Establishment and characterization of a novel pancreatic cancer tissue xenograft model. Proc Amer Assoc Cancer Res 47: Abstract #5106