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Rebecca Wu

rwu@bccrc.ca

Tel: 604-675-8000 ext. 7013

Fax: 604-675-8183

 

  • Research Assistant
  • MSc. (Living Science), Kyoto Prefecture University (Japan), 1997;    BSc. (Food Science), Doshisha Women's University (Japan), 1995

     

      

    Research Interests:

    I am responsible for running the histology in our laboratory, including processing, embedding, sectioning and staining of cancerous and normal tissues. Our lab makes use of two special techniques:

    Immunohistochemistry (IHC) is a technique for detecting, visualizing and localizing antigens at the cellular level. We use this in a search for new, urgently needed biomarkers for improved diagnosis and prognosis of human cancers, including cancers of the prostate, ovary and lung. I routinely work on FFPE (Formalin Fixed Paraffin Embedding) cancerous tissue samples from patients that have been grown in immuno-deficient mice for research purposes.

    In situ hybridization (ISH) is a technique for detecting and visualizing RNA at the cellular level. Radiolabeled or nonradiolabeled probes are hybridized to nucleic acid targets in tissue or cell preparations. I work on the optimization of micro-RNA ISH, using the LNA-modified DNA probe (Exiqon). Our lab uses this technique to identify expression of specific microRNA in our tumor tissue lines which could be of major importance with regard to their regulation of growth and metastasis.

     Living Tumor Laboratory focuses on the development of transplantable tumor tissue lines from patients' tumors using the subrenal capsule graft site in immuno-deficient mice. Such tumor tissue lines retain important biological properties of the original cancers and as such provide useful experimental models for the patients' cancers. The above techniques are of major importance in establishing the histological and molecular similarities between the tumor lines and the original patients' cancers.

    Our lab offers histology services to research pathologists, and anyone who requires quality tissue processing, embedding, sectioning and staining.

     

     

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