Skip to content. | Skip to navigation


Personal tools

Dr. Yuzhuo Wang, Ph.D, FCAHS

Distinguished Scientist

 

YZ Wang

 

 ywang@bccrc.ca
Tel: 604-675-8013
Fax: 604-675-8019
675 West 10th Avenue, Vancouver, BC, V5Z 1L3

 

 Research Role:

 

Education:

  • PDF, University of California, San Francisco (UCSF), US
  • PhD, The University of Hong Kong, Hong Kong
  • BSc. MSc, Nankai University, Tianjin, China
 

Dr. Yuzhuo Wang, Ph.D. FCAHS (王玉琢院士) has a dual appointment as a Distinguished Scientist at the BC Cancer Research Centre and Senior Research Scientist at the Vancouver Prostate Centre. He is also the Founder of the Living Tumor Laboratory (www.livingtumorlab.com) and a Professor in Department of Urologic Sciences at UBC. Dr. Wang did his Ph.D. at the University of Hong Kong, and joined Dr. Gerald R. Cunha at University of California, San Francisco (UCSF) as a postdoctoral fellow in 1997. Since then, He has authored/co-authored over 150 peer reviewed articles, many in top-tier journals such as Cancer Research, Cancer Cell, Nature Medicine, Nature, Clinical Cancer Research, and European Urology. He has published 13 book chapters and edited two books (i.e. PDX Model of Human Cancers and Tumor Dormancy). As a principal investigator, he is well funded by a number of agencies (e.g., the Canadian Institutes of Health Research).

Dr. Wang’s academic contributions can be highlighted by a number of novel hypotheses he has proposed, such as hypotheses on “prostate stem cells”, “epithelial-immune cell transition (EIT)”, “cancer-generated lactic acid is critical, immunosuppressive metabolite rather than a ‘waste product’ (which has been believed for more than 90 years)” and “tumour dormancy is a non-genetic disease”. Dr. Wang is recognized for his pioneering work in the field of prostate cancer modeling. He was the first to establish tissue recombination model of hormonal prostatic carcinogenesis. He also developed the first model of hormonal carcinogenesis in human prostatic epithelium. Moreover, he is responsible for a novel method for establishing transplantable, patient-derived xenograft models that closely resemble patients’ malignancies. Using the methodology, his group has developed over 300 transplantable patient-derived xenograft models in the Living Tumor Laboratory. Importantly such “next generation” xenograft models have been effectively applied in a number of research areas, such as (i) preclinical drug efficacy studies in anti-cancer therapeutics development, (ii) discovery and validation of potential biomarkers and/or therapeutic targets, and (iii) personalized cancer therapy.

 

Dr. Wang has received numerous awards for his academic achievements in cancer research, such as a Prostate Cancer Foundation Research Award (2007), the Translation Research Award from Roche (2009), an Overseas Chinese Scholars Award from the National Natural Science Foundation of China (2009), the Innovative Scholar Award from the International Cancer Alliance for Research and Education (ICARE), US (2010), an UBC Faculty of Medicine Distinguished Achievement Award (2011), an UBC Department of Urologic Sciences Outstanding Academic Performance Award (2013) and a Department of Urologic Sciences Research Teaching Excellence Award (2015), and an UBC Department of Urologic Sciences Outstanding Academic Performance Award (2017). Notably, he has been inducted as a Fellow of  the Canadian Academy of Health Sciences (FCAHS) (加拿大健康科学院院士) in 2018.

 

Research Interests:

Our long-term objectives are to (i) identify new biomarkers for improved diagnosis and prognosis of human cancers, including cancers of the prostate, ovary and lung, and (ii) develop novel, more effective therapies for the diseases.

 

Publications

 
 

Academic Trainees: 

 

Current:

  • Dong Lin, MD, Ph.D. Staff Scientist
  • Fang Zhang, Ph.D. Staff Scientist
  • Hongwei Cheng,MD, Ph.D. Staff Scientist
  • Hui Xue, MD, Ph.D. Staff Scientist
  • Nelson Wong, Ph.D. Staff Scientist
  • Fiona Zhang, Ph.D. Postdoctoral Fellow
  • Xinpei Ci, Ph.D. Postdoctoral Fellow
  • Stephen Choi, Ph.D. Postdoctoral Fellow
  • James Hao, Graduate Student
  • Yu Wang, Graduate Student
  • Haiqing He, Graduate Student
  • Xin (Cindy), Dong, MD. Research Pathologist
  • Peter Gout, Ph.D. Consultant
  • Ursula Steidl, MD. Lab Manager
  • Celeste Ng,  Co-op Student
  • Anna Gleave,  Co-op Student
  • Erik Venalainen, Medical Student
  • Jasmine Dai, Co-op Student

 

 

 


Back to Personnel
Back to Main Page