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Julian J. Lum, PhD

Peer-Reviewed Papers


  •  Townsend KH, West NR, Spowart J, Lum JJ, Markers of tumor vasculature and hypoxia impact T cell infiltration and function.  (in preparation).
  • Johnson L, Nesslinger N, Chima N, Richier L, Pai H, Ludgate C, Blood P, Nelson BH, Vlahacki M, Lum JJ, Autoantibodies induced by androgen deprivation therapy and external beam radiation therapy are associated with poor outcomes in prostate cancer. (submitted Clinical Cancer Research).

  • Townsend KN, Hughson LR, Schlie K, Poon VI, Westerback A, Lum JJ,Role of hypoxia-induced autophagy in T cell function. Immuno Rev. (accepted) [PubMed -22889222]

  • Spowart JE, Townsend KN, Huwait H, Angeliso M, Esraugh S, Ries J, Gilks B, Gorksi SM, Young R, Gelmon K, Watson PW, Nelson BN, Huntsman D, Lum JJ, Autophagy levels correlate with survival in clear cell ovarian cancer.  (Journal of Pathology in press) [PubMed -22926683]

  •  Gorski SM, Ries J, Lum JJ, Targeting autophagy: The Achilles’ heel of cancer.  Autophagy. 8:8. 2012. [PubMed - 22836583]
  • Hughson LR, Poon VI, Spowart JE, Lum JJ, Implications of Therapy-Induced Selective Autophagy on Tumor Metabolism and Survival.  Int J Cell Biol. 2012:872091 2012   [PubMed - 22550492]


  • Schlie K, Spowart JE, Hughson LR, Townsend KN, Lum JJ,  When cells suffocate:  Autophagy in cancer and immune cells under low oxygen.  Int J Cell Biol. 2011:470597 

     [PubMed - 22190938]

  • Matthews Q, Jirasek A, Lum JJ, Brolo AG. Biochemical signatures of in vitro radiation response in human lung, breast and prostate tumour cells observed with Raman spectroscopy. Phys Med Biol. 56:6839-55. 2011. [PubMed - 21971286]


  • Ma XH, Piao S, Wang D, Mcafee Q, Nathanson KL, Lum JJ, Lin LZ, Amaravadi RK, Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma. Clin Canc Res. 17:3478-89.  [PubMed - 21325076]

  • Matthews Q, Brolo AG, Lum JJ, Duan X, Jirasek A.  Raman spectroscopy of single human tumour cells exposed to ionizing radiation in vitro.  Phys Med Biol. 1:19-38.[PubMed - 21119222]

  • Matthews Q, Jirasek A, Lum JJ, Duan X, Brolo AG. Variability in Raman spectra of single human tumor cells cultured in vitro: correlation with cell cycle and culture confluency. Appl Spectrosc. 8:871-87. 2010. [PubMed - 20719050]

  • Zhao FP, Mancuso A, Bui TV, Tong XM, Gruber JJ, Swider CR, Sanchez CR, Lum JJ, Sayed N, Melo JV, Perl AE, Carroll M, Tuttle SW, Thompson CB.  Imatinib Resistance Associated with BCR-ABL upregulation is dependent on HIF-1a-induced metabolic repgoramming.  Oncogene 2010 Mar 15. [Epub ahead of print] [PubMed - 20228846]
  • Spowart J, Lum JJ. Opening a new DOR to autophagy.  EMBO Rep. 2010 Jan;11(1):4-5. [PubMed - 20033084]


  • Gruber JJ, Zatechka DS, Sabin LR, Yong J, Lum JJ, Kong M, Zong WX, Zhang Z, Lau CK, Rawlings J, Cherry S, Ihle JN, Dreyfuss G, Thompson CB. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell. 138(2):328-39. (2009). [PubMed - 19632182]


  • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7(1):11-20. (2008). [PubMed - 18177721]


  • Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB. Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-deficient Tumor Growth in vivo. Cancer Res. 2007 Jul 15;67(14):6745-52. [PubMed - 1763885] 
  • Lum JJ, Bui T, Covello K, DeBerardinis RJ, Simon MC, Thompson CB. The Transcription Factor HIF-1a Plays a Critical Role in The Growth Factor-Dependent Regulation of Both Aerobic and Anaerobic Glycolysis. Genes Dev. 2007 May 1;21(9):1037-49. Epub 2007 Apr 16. [PubMed - 17437992] 
  • Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, Evan GI, Thomas-Tikhonenko A, Thompson CB.  Autophagy Promotes Tumor Cell Survival and Resistance to Apoptosis in a Mouse Model of Lymphoma.  J. Clin. Invest. 117:326-336, 2007.   [PubMed - 17235397] 


  • DeBerardinis RJ, Lum JJ, Thompson CB.  PI3K-dependent Modulation of CPT1A Expression Regulates Lipid Metabolism During Cell Growth.  J. Biol. Chem. 2006 Dec 8;281(49):37372-80. Epub 2006 Oct 9. [PubMed - 17030509] 


  • Thompson CB, Bauer DE, Lum JJ, Hatzivassiliou G, Zong WX, Zhao F, Ditsworth D, Buzzai M, Lindsten T.How Do Cancer Cells Acquire the Fuel Needed to Support Cell Growth?  Cold Spring Harb Symp Quant Biol. 70:357-62, 2005. [PubMed - 16869772] 
  • Lum JJ, Bren G, McClure R, Badley AD.  Elimination of Senescent Neutrophils by TNF-Related Apoptosis-Inducing Ligand.  J. Immunol.  2:1232-1238, 2005. [PubMed - 16002727] 
  • Lum JJ, Schnepple DJ, Badley AD.  Acquired T-cell Sensitivity to TRAIL Mediated Killing During HIV Infection is Regulated by CXCR4-gp120 Interactions.  AIDS. 11:1125-1133, 2005. [PubMed - 15990565] 
  • Lum JJ, DeBerardinis RJ, Thompson CB.  Autophagy in Metazoans:  Cell Survival in the Land of Plenty.  Nat Rev Mol Cell Biol.  2005 Jun;6(6):439-48. Review. [PubMed - 15928708] 
  • Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB.  Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis.  Cell. 2:237-248, 2005. [PubMed - 15680329]


  • Bauer DE, Harris MH, Plas DR, Lum JJ, Hammerman PS, Rathmell JC, Riley JL, Thompson CB.  Cytokine Stimulation of Aerobic Glycolysis in Hematopoietic Cells Exceeds Proliferative Demand.  FASEB J. 11:1303-1305, 2004. [PubMed - 15180958] 
  • Lum JJ, Schnepple DJ,  Nie Z, Sanchez-Dardon J, Mbisa G, Mihowich J, Hawley-Foss N, Narayan S, Kim JE, Lynch DH, Badley AD.  Differential Effects of Interleukin-7 and Interleukin-15 on NK Anti-HIV Activity.  J. Virol. 11:6033-6042, 2004. [PubMed - 15141001] 
  • Cooper CL, Phenix B, Mbisa G, Lum JJ, Parato K, Hawley N, Angel JB, Badley AD.  Antiretroviral Therapy Influences Cellular Susceptibility to Apoptosis In Vivo.  Front Biosci. 9:338-41, 2004. [PubMed - 14766370]


  • Lum JJ, Badley AD.  Resistance to Apoptosis:  Mechanism for the Development of HIV Reservoirs. Current HIV Res. 1:261-274, 2003. [PubMed - 15046251] 
  • Badley AD, Roumier T, Lum JJ, Kroemer G.  Mitochondrion mediated Apoptosis in HIV.  Trends in Pharmacological Sciences 24:298-305, 2003. [PubMed - 12823956] 
  • Lum JJ, Cohen OJ, Yao XJ, Pilon AA, Hawley-Foss N, Kim JE, Chen Z, Montpetit M, Sanchez-Dardon J, Garber G, Cohen AE, Badley AD.  Vpr Mutation R77Q is Associated with Long Term Non Progressive HIV Infection and an Impaired Ability to Induce T Cell Depletion In Vivo.   J. Clin. Invest. 111:1547-1554, 2003. [PubMed - 12750404]


  • Nie, Z, Phenix BP, Lum JJ, Alam A, Lynch DH, Beckett B, Krammer PE, Sekaly RP, Badley AD.  HIV-1 Protease Processes Procaspase 8 to Cause Mitochondrial Release of Cytochrome c, Caspase Cleavage and Nuclear Fragmentation.  Cell Death Differ. 9:1172-1184, 2002. [PubMed - 12404116] 
  • Pilon AA, Lum JJ, Sanchez-Dardon J, Phenix BN, Douglas R, Badley AD.  Induction of Apoptosis by a Non Nucleoside HIV-1 Reverse Transcriptase Inhibitor.  Antimicrob. Agents Chemother. 8:2687-2691, 2002. *shared authorship. [PubMed - 12121958]


  • Lum JJ, Pilon AA, Sanchez-Dardon J, Phenix BN, Kim JE, Mihowich J, Jamison K, Hawley-Foss N, Lynch DH, Badley AD.  Selective Induction of Cell Death in HIV Infected Macrophages and Latently Infected Memory CD4 T Cells by TRAIL/Apo2L.  J. Virol. 75:11128-11136, 2001. [PubMed - 11602752]
  • Phenix, BN, Lum JJ, Nie Z, Sanchez-Dardon J, Badley AD.  Antiapoptotic Mechanism of HIV Protease Inhibitors:  Preventing Mitochondrial Potential Loss.  Blood 98:1078-1085, 2001.  [PubMed - 11493454]
  • Hawley-Foss N, Mbisa G, Lum JJ, Pilon AA, Angel JB, Garber G, Badley AD.  Effect of Cessation of Highly Active Antiretroviral Therapy During a Discordant Response:  Implications for Scheduled Therapeutic Interruptions.  Clin. Infect. Dis. 33:344-348, 2001. [PubMed - 11438900]