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Ronald J. de Leeuw, PhD

Peer-Reviewed Papers

 2009

  • Iqbal J, Kucuk C, Deleeuw RJ, Srivastava G, Tam W, Geng H, Klinkebiel D, Christman JK, Patel K, Cao K, Shen L, Dybkaer K, Tsui IF, Ali H, Shimizu N, Au WY, Lam WL, Chan WC. Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia. 23(6):1139-51. Epub 2009 Feb 5. (2009). [PubMed - 19194464] 

  • Johnson NA, Leach S, Woolcock B, deLeeuw RJ, Bashashati A, Sehn LH, Connors JM, Chhanabhai M, Brooks-Wilson A, Gascoyne RD. CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure. Haematologica. 94(3):423-7. Epub 2009 Feb 11. (2009)[PubMed - 19211644]

  • van Nederveen FH, Korpershoek E, deLeeuw RJ, Verhofstad AA, Lenders JW, Dinjens WN, Lam WL, de Krijger RR. Array-comparative genomic hybridization in sporadic benign pheochromocytomas. Endocr Relat Cancer. 16(2):505-13. Epub 2009 Jan 19. (2009). [PubMed - 19153209]

2008

  • Chi B, deLeeuw RJ, Coe BP, Ng RT, MacAulay C, Lam WL. MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data. BMC Bioinformatics. 2008 May 20;9:243. (2008)[PubMed - 18492270]

  • Fadlelmola FM, Zhou M, de Leeuw RJ, Dosanjh NS, Harmer K, Huntsman D, Lam WL, Banerjee D. Sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization profiling reveals novel gains and losses of chromosomal regions in Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma cell lines. Mol Cancer. 2008 Jan 7;7:2. (2008). [PubMed - 18179710]

2007

  • Deleeuw RJ, Zettl A, Klinker E, Haralambieva E, Trottier M, Chari R, Ge Y, Gascoyne RD, Chott A, Muller-Hermelink HK, Lam WL. Whole-genome analysis and HLA genotyping of enteropathy-type T-cell lymphoma reveals 2 distinct lymphoma subtypes. Gastroenterology. 132(5):1902-11. Epub 2007 Mar 24. (2007)[PubMed - 17484883]

  • Kimm LR*, deLeeuw RJ*, Savage KJ, Rosenwald A, Campo E, Delabie J, Ott G, Muller-Hermelink HK, Jaffe ES, Rimsza LM, Weisenburger DD, Chan WC, Staudt LM, Connors JM, Gascoyne RD, Lam WL. Frequent occurrence of deletions in primary mediastinal B-cell lymphoma. Genes Chromosomes Cancer. 46(12):1090-7. (*co-first author) (2007)[PubMed - 17823928]

  • Watson SK, deLeeuw RJ, Horsman DE, Squire JA, Lam WL. Cytogenetically balanced translocations are associated with focal copy number alterations. Hum Genet. 120(6):795-805. Epub 2006 Oct 19. (2007).
    [PubMed - 17051368]

  • Wong KK*, deLeeuw RJ*, Dosanjh NS, Kimm LR, Cheng Z, Horsman DE, MacAulay C, Ng RT, Brown CJ, Eichler EE, Lam WL. A comprehensive analysis of common copy-number variations in the human genome. Am J Hum Genet. 80(1):91-104. Epub 2006 Dec 5. (*co-first author) (2007)[PubMed - 17160897] 

  • Zettl A, deLeeuw R, Haralambieva E, Mueller-Hermelink HK. Enteropathy-type T-cell lymphoma. Am J Clin Pathol. 127(5):701-6. (2007)[PubMed - 17511112]

2006

  • Aarts M, Dannenberg H, deLeeuw RJ, van Nederveen FH, Verhofstad AA, Lenders JW, Dinjens WN, Speel EJ, Lam WL, de Krijger RR. Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p. Genes Chromosomes Cancer. 45(1):83-93. (2006).   [PubMed - 16215979]

  • Lonergan KM, Chari R, Deleeuw RJ, Shadeo A, Chi B, Tsao MS, Jones S, Marra M, Ling V, Ng R, Macaulay C, Lam S, Lam WL. Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. Am J Respir Cell Mol Biol. 35(6):651-61. Epub 2006 Jun 29. (2006)[PubMed - 16809635]

  • Shah SP, Xuan X, DeLeeuw RJ, Khojasteh M, Lam WL, Ng R, Murphy KP. Integrating copy number polymorphisms into array CGH analysis using a robust HMM. Bioinformatics. 22(14):e431-9. (2006)[PubMed - 16873504]

2005

  • Prentice LM, Shadeo A, Lestou VS, Miller MA, deLeeuw RJ, Makretsov N, Turbin D, Brown LA, Macpherson N, Yorida E, Cheang MC, Bentley J, Chia S, Nielsen TO, Gilks CB, Lam W, Huntsman DG. NRG1 gene rearrangements in clinical breast cancer: identification of an adjacent novel amplicon associated with poor prognosis. Oncogene. 24(49):7281-9. (2005)[PubMed - 16027731]

  • Rubio-Moscardo F, Blesa D, Mestre C, Siebert R, Balasas T, Benito A, Rosenwald A, Climent J, Martinez JI, Schilhabel M, Karran EL, Gesk S, Esteller M, deLeeuw R, Staudt LM, Fernandez-Luna JL, Pinkel D, Dyer MJ, Martinez-Climent JA. Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes. Blood. 106(9):3214-22. Epub 2005 Jul 28. (2005).
    [PubMed - 16051735]

2004

  • Chi B, DeLeeuw RJ, Coe BP, MacAulay C, Lam WL. SeeGH--a software tool for visualization of whole genome array comparative genomic hybridization data. BMC Bioinformatics. 5:13. (2004)[PubMed - 15040819]

  • Ishkanian AS, Malloff CA, Watson SK, DeLeeuw RJ, Chi B, Coe BP, Snijders A, Albertson DG, Pinkel D, Marra MA, Ling V, MacAulay C, Lam WL. A tiling resolution DNA microarray with complete coverage of the human genome. Nat Genet. 36(3):299-303. Epub 2004 Feb 15. (2004)[PubMed - 14981516] 

  • Watson SK, deLeeuw RJ, Ishkanian AS, Malloff CA, Lam WL. Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays. BMC Genomics. 5(1):6. (2004).
    [PubMed - 14723794] 

  • de Leeuw RJ, Davies JJ, Rosenwald A, Bebb G, Gascoyne RD, Dyer MJ, Staudt LM, Martinez-Climent JA, Lam WL. Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes. Hum Mol Genet. 13(17):1827-37. Epub 2004 Jun 30. (2004)[PubMed - 15229187] 

Books (and Chapters)

2007

  • Buys TP, Wilson IM, Coe BP, Lockwood WW, Davies JJ, Chari R, DeLeeuw RJ, Shadeo A, MacAulay C, Lam WL. Key Features of BAC Array Production and Usage In DNA Microarrays (Methods Express Series, Schena M, ed), Scion Publishing, Ltd., Bloxham. pp.85-115. (2007).