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John Webb, PhD

Peer-Reviewed Papers



2014

  • Wick DA, Webb JR, Nielsen JS, Martin SD, Kroeger DR, Milne K, Castellarin M,Twumasi-Boateng K, Watson PH, Holt RA, Nelson BH. Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer. Clin Cancer Res. 2014 Mar 1;20(5):1125-34. doi: 10.1158/1078-0432.CCR-13-2147.Epub 2013 Dec 9. [PubMed - 24323902]


2013

  • Webb JR, Milne K, Watson PH, Deleeuw RJ, Nelson BH, Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer. Clin Cancer Res. 2013 Nov 4. [Epub ahead of print] PMID 24190978

2011

  • Wick DA, Webb JR. A novel, broad spectrum therapeutic HPV vaccine targeting the E7 proteins of HPV16, 18, 31, 45 and 52 that elicits potent E7-specific CD8T cell immunity and regression of large, established, E7-expressing TC-1 tumors. Vaccine. 2011 Aug 2. [Epub ahead of print] [PubMed - 21816200]
  • Kader HA, Wick DA, Webb JR. Research Highlights: Do conventional treatments for HPV-positive head and neck cancers elicit immunotherapeutic type responses? Immunotherapy. 2011 Apr;3(4):469-73. [PubMed - 21463187]
  • Nelson, B.H. and Webb, JR. Tumor-specific mutations as targets for cancer immunotherapy. Experimental and Applied Immunotherapy 2011. Chapter 7 (pgs. 151-172), Springer. ISBN: 978-1-60761-979-6.

2010

  • Tran E, Nielsen JS, Wick DA, Ng AV, Johnson LD, Nesslinger NJ, McMurtrie E, Webb JR, Nelson BH.  Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines. PLoS ONE 5(12): e15625 (Dec 2010). [PubMed - 21203522]

  • Nielsen JS, Wick DA, Tran E, Nelson BH, Webb JR. An in vitro-transcribed-mRNA polyepitope construct encoding 32 distinct HLA class I-restricted epitopes from CMV, EBV, and Influenza for use as a functional control in human immune monitoring studies. J Immunol Methods. 2010 Jul 15. [Epub ahead of print] [PubMed - 20637775]

  • Webb JR, Wick DA, Nielsen JS, Tran E, Milne K, McMurtrue E, Nelson BH.  Profound elevation of CD8(+) T cells expressing the intraepithelial lymphocyte marker CD103 (alpha(E)/beta(7) Integrin) in high-grade serous ovarian cancer. Gynecol Oncol. 2010 Jun 9 [Epub ahead of print] [PubMed 20541243] Related citations

  • Wick DA, Martin SD, Nelson BH, Webb JR. Profound CD8(+) T cell immunity elicited by sequential daily immunization with exogenous antigen plus the TLR3 agonist poly(I:C). Vaccine. 2010 Nov 27. [Epub ahead of print] [PubMed - 21115055].

2009

  • Freeman JD, Warren RL, Webb JR, Nelson BH, Holt RA. Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing. Genome Res. 19(10):1817-24. Epub 2009 Jun 18. (2009). [PubMed 19541912]

2008

  • Hardy LL, Wick DA, Webb JR. Conversion of tyrosine to the inflammation-associated analog 3'-nitrotyrosine at either TCR- or MHC-contact positions can profoundly affect recognition of the MHC class I-restricted epitope of lymphocytic choriomeningitis virus glycoprotein 33 by CD8 T cells. J Immunol. 180(9):5956-62. (2008). [PubMed 18424715] 
  • Milne K, Barnes RO, Girardin A, Mawer MA, Nesslinger NJ, Ng A, Nielsen JS, Sahota R, Tran E, Webb JR, Wong MQ, Wick DA, Wray A, McMurtrie E, Kobel M, Kalloger SE, Gilks CB, Watson PH, Nelson BH. Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer. PLoS ONE. 3(10):e3409. Epub 2008 Oct 15. (2008). [PubMed 18923710]

2006

  • Goncalves RB, Leshem O, Bernards K, Webb JR, Stashenko PP, Campos-Neto A. T-cell expression cloning of Porphyromonas gingivalis genes coding for T helper-biased immune responses during infection. Infect Immun. 74(7):3958-66. (2006). [PubMed 16790769]
  • Mojibian M, Chakir H, MacFarlane AJ, Lefebvre DE, Webb JR, Touchie C, Karsh J, Crookshank JA, Scott FW. Immune reactivity to a glb1 homologue in a highly wheat-sensitive patient with type 1 diabetes and celiac disease. Diabetes Care. 29(5):1108-10. (2006). [PubMed 16644646]

2003

  • Birnboim HC, Lemay AM, Lam DK, Goldstein R, Webb JR. Cutting edge: MHC class II-restricted peptides containing the inflammation-associated marker 3-nitrotyrosine evade central tolerance and elicit a robust cell-mediated immune response. J Immunol. 171(2):528-32. (2003). [PubMed 12847213] 
  • Chakir H, Campos-Neto A, Mojibian M, Webb JR. IL-12Rbeta2-deficient mice of a genetically resistant background are susceptible to Leishmania major infection and develop a parasite-specific Th2 immune response. Microbes Infect. 5(4):241-9. (2003). [PubMed 12706437]
  • Chakir H, Lam DK, Lemay AM, Webb JR. "Bystander polarization" of CD4+ T cells: activation with high-dose IL-2 renders naive T cells responsive to IL-12 and/or IL-18 in the absence of TCR ligation. Eur J Immunol. 33(7):1788-98. (2003). [PubMed 12811838]
  • Chakir H, Wang H, Lefebvre DE, Webb J, Scott FW. T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3. J Immunol Methods. 278(1-2):157-69. (2003). [PubMed 12957404]
  • Lee SH, Zafer A, de Repentigny Y, Kothary R, Tremblay ML, Gros P, Duplay P, Webb JR, Vidal SM. Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice. J Exp Med. 197(4):515-26. (2003). [PubMed 12591908]
  • McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, Webb JR, Lansdorp PM, Lemieux M. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol. 2003 Jan;23(1):38-54. (2003). [PubMed 12482959]

2002

  • Campos-Neto A, Webb JR, Greeson K, Coler RN, Skeiky YA, Reed SG. Vaccination with plasmid DNA encoding TSA/LmSTI1 leishmanial fusion proteins confers protection against Leishmania major infection in susceptible BALB/c mice. Infect Immun. 70(6):2828-36. (2002). [PubMed 12010969]
  • Lee SH, Webb JR, Vidal SM. Innate immunity to cytomegalovirus: the Cmv1 locus and its role in natural killer cell function. Microbes Infect. 4(15):1491-503. (2002). [PubMed 12505521]
  • Skeiky YA, Coler RN, Brannon M, Stromberg E, Greeson K, Crane RT, Webb JR, Campos-Neto A, Reed SG. Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant. Vaccine. 20(27-28):3292-303. (2002). [PubMed 12213399]
  • Webb JR, Lee SH, Vidal SM. Genetic control of innate immune responses against cytomegalovirus: MCMV meets its match. Genes Immun. 3(5):250-62. (2002). [PubMed 12140743]

2001

  • Campos-Neto A, Porrozzi R, Greeson K, Coler RN, Webb JR, Seiky YA, Reed SG, Grimaldi G Jr. Protection against cutaneous leishmaniasis induced by recombinant antigens in murine and nonhuman primate models of the human disease. Infect Immun. 69(6):4103-8. (2001). [PubMed 11349082]
  • Chakir H, Lemay AM, Webb JR. Cytokine expression by murine DX5+ cells in response to IL-12, IL-18, or the combination of IL-12 and IL-18. Cell Immunol. 212(1):71-81. (2001). [PubMed 11716531]
  • Probst P, Stromberg E, Ghalib HW, Mozel M, Badaro R, Reed SG, Webb JR. Identification and characterization of T cell-stimulating antigens from Leishmania by CD4 T cell expression cloning. J Immunol. 166(1):498-505. (2001). [PubMed 11123329]

2000

  • Chakir H, Camilucci AA, Filion LG, Webb JR. Differentiation of murine NK cells into distinct subsets based on variable expression of the IL-12R beta 2 subunit. J Immunol. 165(9):4985-93. (2000). [PubMed 11046026]

1998

  • Webb JR, Campos-Neto A, Ovendale PJ, Martin TI, Stromberg EJ, Badaro R, Reed SG. Human and murine immune responses to a novel Leishmania major recombinant protein encoded by members of a multicopy gene family. Infect Immun. 66(7):3279-89. (1998). [PubMed 9632596] 
  • Webb JR, Vedvick TS, Alderson MR, Guderian JA, Jen SS, Ovendale PJ, Johnson SM, Reed SG, Skeiky YA. Molecular cloning, expression, and immunogenicity of MTB12, a novel low-molecular-weight antigen secreted by Mycobacterium tuberculosis. Infect Immun. 66(9):4208-14. (1998). [PubMed 9712769]

1997

  • Webb JR, Campos-Neto A, Skeiky YA, Reed SG. Molecular characterization of the heat-inducible LmSTI1 protein of Leishmania major. Mol Biochem Parasitol. 89(2):179-93. (1997). [PubMed 9364964]

1996

  • Webb JR, Kaufmann D, Campos-Neto A, Reed SG. Molecular cloning of a novel protein antigen of Leishmania major that elicits a potent immune response in experimental murine leishmaniasis. J Immunol. 157(11):5034-41. (1996). [PubMed 8943412]

1995

  • Joshi PB, Webb JR, Davies JE, McMaster WR. The gene encoding streptothricin acetyltransferase (sat) as a selectable marker for Leishmania expression vectors. Gene. 156(1):145-9. (1995). [PubMed 7737509]

1994

  • Webb JR, McMaster WR. Leishmania major HEXBP deletion mutants generated by double targeted gene replacement. Mol Biochem Parasitol. 63(2):231-42. (1994). [PubMed 8008021]

1993

  • Webb JR, McMaster WR. Molecular cloning and expression of a Leishmania major gene encoding a single-stranded DNA-binding protein containing nine "CCHC" zinc finger motifs. J Biol Chem. 268(19):13994-4002. (1993). [PubMed 8314766]

1991

  • Webb JR, Button LL, McMaster WR. Heterogeneity of the genes encoding the major surface glycoprotein of Leishmania donovani. Mol Biochem Parasitol. 48(2):173-84. (1991).
    [PubMed 1762629]

BOOKS (AND CHAPTERS)

1990

  • McMaster, W.R, Button, L.L., Wallis, A.E., Frommel, T., Webb, J.R., Fujikura, Y. and Reiner, N.E. . Molecular genetics of repetitive antigens and the major surface glycoprotein of Leishmania. Parasites: Molecular Biology, Drug and Vaccine Design. Wiley-Liss, Inc (1990).