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Darin Wick

Peer-Reviewed Papers

2014

  • Wick DA, Webb JR, Nielsen JS, Martin SD, Kroeger DR, Milne K, Castellarin M,Twumasi-Boateng K, Watson PH, Holt RA, Nelson BH. Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer. Clin Cancer Res. 2014 Mar 1;20(5):1125-34. doi: 10.1158/1078-0432.CCR-13-2147.Epub 2013 Dec 9. [PubMed - 24323902]


2013

  • Wick DA, Webb JR, Nielsen JS, Martin SD, Kroeger DR, Milne K, Castellarin M, Twumasi-Boateng K, Watson PH, Holt RA, Nelson BH. Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer. Clin Cancer Res. 2013 Dec 9. [Epub ahead of print] [PubMed - 24323902]


2011

  • Wick DA, Webb JR. A novel, broad spectrum therapeutic HPV vaccine targeting the E7 proteins of HPV16, 18, 31, 45 and 52 that elicits potent E7-specific CD8T cell immunity and regression of large, established, E7-expressing TC-1 tumors. Vaccine. 2011 Aug 2. [Epub ahead of print] [PubMed - 21816200]
  • Kader HA, Wick DA, Webb JR. Research Highlights: Do conventional treatments for HPV-positive head and neck cancers elicit immunotherapeutic type responses? Immunotherapy. 2011 Apr;3(4):469-73. [PubMed - 21463187]

 

2010

  • Tran E, Nielsen JS, Wick DA, Ng AV, Johnson LD, Nesslinger NJ, McMurtrie E, Webb JR, Nelson BH.  Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines. PLoS ONE 5(12): e15625 (Dec 2010). [PubMed - 21203522]

  • Wick DA, Martin SD, Nelson BH, Webb JR. Profound CD8(+) T cell immunity elicited by sequential daily immunization with exogenous antigen plus the TLR3 agonist poly(I:C). Vaccine. 29(5):984-93 (2010 Nov 27). [PubMed - 21115055]

  • Nielsen JS, Wick DA, Tran E, Nelson BH, Webb JR. An in vitro-transcribed-mRNA polyepitope construct encoding 32 distinct HLA class I-restricted epitopes from CMV, EBV, and Influenza for use as a functional control in human immune monitoring studies. J Immunol Methods. 2010 Jul 15. [Epub ahead of print] [PubMed - 20637775]

  • Webb JR, Wick DA, Nielsen JS, Tran E, Milne K, McMurtrue E, Nelson BH.  Profound elevation of CD8(+) T cells expressing the intraepithelial lymphocyte marker CD103 (alpha(E)/beta(7) Integrin) in high-grade serous ovarian cancer. Gynecol Oncol. 2010 Jun 9 [Epub ahead of print] [PubMed - 20541243] Related citations

 

2008

  • Hardy LL, Wick DA, Webb JR. Conversion of tyrosine to the inflammation-associated analog 3'-nitrotyrosine at either TCR- or MHC-contact positions can profoundly affect recognition of the MHC class I-restricted epitope of lymphocytic choriomeningitis virus glycoprotein 33 by CD8 T cells. J Immunol. 180(9):5956-62. (2008). [PubMed - 18424715]

  • Milne K, Barnes RO, Girardin A, Mawer MA, Nesslinger NJ, Ng A, Nielsen JS, Sahota R, Tran E, Webb JR, Wong MQ, Wick DA, Wray A, McMurtrie E, Kobel M, Kalloger SE, Gilks CB, Watson PH, Nelson BH. Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer. PLoS ONE. 3(10):e3409. Epub 2008 Oct 15. (2008)[PubMed - 18923710]