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Lindsay DeVorkin

Postdoctoral Fellow

Lindsay DeVorkin

Education:

  • BSc, (Biochemistry), University of British Columbia, 2008

  • PhD (Molecular Biology and Biochemistry), Simon Fraser University, 2013

 

Advisor:  Dr. Julian Lum 

 

Contact:

Tel   250-519-5716

Fax  250-519-2040

Email  lindsay.devorkin@bccancer.bc.ca

 

Research Interests

 

One promising therapeutic strategy for the treatment of advanced-stage breast cancer is to target autophagy. Autophagy is a process whereby cells digest and recycle their own contents in response to cell stress, including chemotherapies, to promote cell survival. Low oxygen levels, also known as hypoxia, are a feature of solid tumors and can stimulate autophagy to promote cancer cell survival. Hypoxia also stimulates angiogenesis, or the formation of new blood vessels, to improve the delivery of nutrients and oxygen to the tumour. Although targeting the tumour associated vasculature is a promising therapeutic avenue, autophagy has been implicated as a resistance mechanism following anti-angiogenic therapy.   My research at the DRC is focused on examining the role of autophagy in the tumour associated vasculature.  Specifically, I am undertaking studies to examine the effects of autophagy inhibition on tumour growth and metastases, and to determine whether autophagy inhibition can sensitize breast cancer cells to anti-angiogenic therapy. 

 

Publications