The following is a list of recent publications, grants, scholarship awards and accomplishments at the Deeley Research Centre.
Congratulations to Dr. Julie Nielsen from Brad Nelson's lab for being awarded a postdoctoral fellowship from the Lymphoma Foundation of Canada for her work with the Immune Response to Lymphoma (IROL) project!
Congratulations to Dr. Lisa Johnson from Julian Lum's lab who received a research award fromt he Canadian Urologic Oncology Association/Abbott for her project: "A Pilot Project to Examine CD4+ T Cell Responses Induced by Radiation Therapy in Men with Prostate Cancer" supervised by Dr. Paul Blood!
Congratulations to Dr. Quinn Matthews from Julian Lum's lab for being awarded a postdoctoral fellowship from the Michael Smith Foundation for Health Research for his work in "Investigating biochemical signatures of radiation resistance in human breast and prostate cancers via single cell Raman spectroscopy"!
Congratulations to Dr. Quinn Matthews, who earned a PhD in Medical Physics from the University of Victoria!
Congratulations to Dr. Sally Amos from Brad Nelson's lab for being awarded a postdoctoral fellowship from the Canadian Breast Cancer Foundation!
Tumor-specific mutations as targets for cancer immunotherapy. Experimental and Applied Immunotherapy 2011. Chapter 7 (pgs. 151-172), Springer. ISBN: 978-1-60761-979-6.
Congratulations to Dr. Michele Martin, who earned a PhD in Biology from the University of Victoria!
Thesis: T cell therapy of breast cancer
Supervisor: Dr. Brad Nelson, Deeley Research Centre
Thanks to: Team DRC, Elizabeth Chun and Dr. Steven Jones for a successful collaboration
Current position: Faculty member at UVic, where she will head her own research lab and serve as vet for the animal care unit.
An in vitro-transcribed-mRNA polyepitope construct encoding 32 distinct HLA class I-restricted epitopes from CMV, EBV, and Influenza for use as a functional control in human immune monitoring studies. J Immunol Methods. 2010 Jul 15 PMID 20637775
Project - Pre-clinical development of Pentarix: a therapeutic vaccine for HPV-associated cancers
CIHR Proof of Principle Program – Phase I = $160,000, Oct 2010 to Oct 2011
PI: John Webb
Project - CTAP III for detection of early lung cancer and monitoring treatment outcome
CIHR Proof of Principle Program - Phase I = $160,000, Sept 2010 – Aug 2011
PI: Dr. Stephen LAM (BCCA)
Co-PIs: Dr. X. Duan, Dr. M. Sadar, Dr. D. Sin
Project - Early detection of prostate cancer with antibody-nanoparticle conjugates by MRI
Prostate Cancer Canada’s Pilot = $60,000/yr, July 2010-June 2012
PI: Dr. Frank van Veggel (University of Victoria)
Co-PI: Dr. X. Duan
Project - Defining an in vivo role for autophagy in oncogenesis
CIHR Master's Award: Frederick Banting and Charles Best Canada Graduate Scholarships, $17,500/yr, Sept 2010-Aug 2011
Nesslinger N, Ng A, Tsang KY, Ferrara TA, Schlom J, Gulley JL, Nelson BH
A viral vaccine encoding PSA induces antigen spreading to a common set of self proteins in prostate cancer patients. Clin Cancer Res. 2010 PMID: 20562209
Chen R, Pan S, Duan X, Nelson BH, Sahota RA, de Rham S, Kozarek RA, McIntosh M, Brentnall TA
Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia. Mol Cancer. 2010; 9:149. PMID: 20550709
Spowart J, Lum JJ
Opening a new DOR to autophagy
EMBO Rep. 2010; 11:4-5. PMID: 20033084
Project title: Toward personalized immunotherapy: identifying tumour-specific factors that dictate the response of spontaneous mammary cancers to T cells
CIHR Operating grant of $134,386/yr, Sept 2010 – Aug 2015
PI: Brad Nelson
Profound elevation of CD8+ T cells expressing the intraepithelial lymphocytemarker CD103 (alphaE/beta7 Integrin) in high-grade serous ovarian cancer. Gynecologic Oncology. 2010 Jun 9. PMID: 20541243
Eric Tran successfully defended his Ph.D. thesis in the Dept. of Biochemistry/Microbiology at UVic on June 17. Born and raised in Ucluelet (west coast of Vancouver Island), Eric is the Deeley Research Centre's first Ph.D. student - first to start, and first to finish. Under the supervision of Brad Nelson, his thesis project spanned from interleukin-2 receptor signaling to the immunotherapy of ovarian cancer. Eric is headed to the Surgery Branch at the US National Institutes of Health in Bethesda, MD for postdoctoral training with Dr. Steven Rosenberg, an internationally recognized leader in T cell therapy of cancer. Best wishes to Eric from the entire BCCRC!