Skip to content. | Skip to navigation


Personal tools

Spencer Martin

 


  spencer 

Graduate Student


Education

Contact

Tel       250-519-5700
Fax      250-519-2040

Email   smartin@bccrc.ca

 

     

Research Interests

The accumulation of mutations (or changes in the genetic code) is a hallmark of cancer.  Each tumour has a unique mutational profile.  I am interested in targeting these unique mutations for cancer immunotherapy.  I am currently working at the Michael Smith Genome Sciences Centre in Vancouver, performing whole transcriptome shotgun sequencing (WTSS) on five mouse mammary tumours.  Once I complete the bioinformatic analysis of the sequencing data, I will move to Victoria and resume work at the Deeley Centre.  

During my undergrad honors thesis project, I worked at the Deeley Centre on a method of delivering peptide vaccines that induces massive antigen-specific T cell proliferation and activation.  The technique involves long peptide antigens, the adjuvant poly(I:C), and multiple inoculations.  I will use this vaccination technique to inoculate mice with peptide antigens that correspond to the mutations identified with WTSS.  I anticipate that the vaccine will regress established tumours. 

As the price of sequencing an entire human genome approaches the $1000 mark, an era of personalized cancer vaccines may soon be clinically feasible.  This project will be an important step towards the goal of creating personalized vaccines to fight cancer. 

 

View Publications