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Alex Miranda Rodriguez, Ph D

Postdoctoral Fellow

 Alex Rodriguez


Education: 

  • BSc. Biochemistry, University of Havana, 2008
  • PhD. Biochemistry, Molecular and Cell Biology, University of Havana 2015

 

Contact: 

Email  arodriguez@bccrc.ca

Tel        250-519-5700

 

 

Research Interest

The immune system can identify and destroy tumor cells, playing a key role in the defense against cancer. However, the success of tumor immunotherapy is hindered by the ability of tumors to elicit a plethora of immunosuppressive strategies, including the capacity to dampen the tumor infiltration of lymphocytes. In support of this idea, a growing body of evidences indicates a correlation between clinical responses to immunotherapies and a pre-existing T cells infiltrated micro-environment.

 

My research is focused on describe the molecular mechanism of T cells exclusion in the tumor micro-environment of ovarian cancer. High-grade serous carcinoma (HGSC) is the most common and fatal subtype of ovarian cancer. I am undertaking my studies comparing different molecular subtypes of HGSC that were previously identified by gene expression profiling and are characterized by diverse levels of lymphocytes infiltration. The results of this investigation will shed further lights on this immune escape strategy mediated by ovarian tumor cells and may lead to the development of novel strategies to personalized treatment.