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Carolyn J. Brown

Dr. Carolyn J. Brown, Ph.D.


Professor, Department of Medical Genetics, University of British Columbia

Dr. Carolyn Brown has a long-standing interest in the unique biology of the X chromosome.  During Ph.D. and postdoctoral studies with Dr. Huntington Willard she discovered the key gene (named XIST) involved in silencing of one X chromosome in females. Research in her lab at the University of British Columbia continues to focus on X chromosome inactivation, particularly upon how expression of the XIST RNA leads to silencing of adjacent genes through epigenetic events including DNA methylation and histone modification and replacement. As a member of the Center for Lymphoid Cancer her research interests include the role of the X chromosome and global epigenetic silencing events in lymphoma.