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Gene-ENvironment Interactions in Cancer Program


Why study gene-environment interactions?

  • Strengthen the associations between environmental factors and diseases by examining these in genetically susceptible individuals.
  • Help understand disease mechanisms by focusing on biological pathways most relevant to that disease, and environmental factors most relevant to the pathway. 
  • Determine which specific compounds in a complex mixture of chemicals (from pollution, diet, etc.) cause disease. 
  • Obtain a better estimate of the population attributable risk for genetic and environmental risk factors by accounting for their joint interactions. 
  • Use the information to design new preventive and therapeutic strategies. 
  • Offer tailored preventive advice that is based on the knowledge of the genetic profile of an individual.


Case-Control Studies:


Completed Data Collection

  • Melanoma (GEMS) - Rick Gallagher
  • Non-Hodgkin Lymphoma - John Spinelli/Angela Brooks-Wilson
  • Breast Density - Marilyn Borugian
  • Prostate Cancer - Rick Gallagher
  • Breast Cancer - John Spinelli
  • Healthy Aging - Angela Brooks-Wilson


Active Data Collection

  • Ovarian Cancer - Nhu Le
  • Multiple Myeloma/MGUS - John Spinelli
  • Melanoma - Tim Lee
  • BC Generations Project - John Spinelli