Figure 9: Dynamic Evolution of the tissue system breakdown [View Image]

• Tissue phenotype of a lesion describes its Structural State
• The Alterations of tumor-suppressor genes and the nuclear morphometry describe the Functional State of the tissue

The analysis of the relations between these two aspects of the same process should bring us a more integrated description of the whole dynamic process, which drives a homeostatic system to uncontrolled -but sometimes reversible- growth.

Figure 10: LOH Distribution in the HistoMorphometric Space [View Image]

• Do two different phenotypes correspond to two different genotypes?
• What can a given phenotype can tell us about the genotype?