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 Cancer Imaging 
Haishan Zeng

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Peer-Reviewed Papers

    In Press

  1. Chen, G., Chen, J., Zhuo, S., Xiong, S., Zeng, H., Jiang, X., Chen, R., Xie, S.. Nonlinear spectral imaging of human hypertrophic scar based on two-photon excited fluorescence and second-harmonic generation British J. of Dermatology (In Press).

  2. Cluff, GM, Short, MA, Lui, H, McLean, DI, Zeng, H, Korbelik, M, Chen, MX. Comparison of Connective Tissue Invaded by Lewis Lung Carcinoma to Healthy Connective Tissue by Means of Micro-Raman Spectroscopy J, of Raman Spectroscopy (In Press).

  3. 2009

  4. Han, X., Lui, H., McLean, DI, Zeng, H.. Near-infrared autofluorescence imaging of cutaneous melanins and human skin in vivo J. of Biomedical Optics, 14(2): 024017, (2009).

  5. K. Guze, M. Short, S. Sonis, N. Karimbux, J. Chan, H. Zeng. Parameters Defining The Potential Applicability Of Raman Spectroscopy As A Diagnostic Tool For Oral Disease J. of Biomedical Optics, 14 (1): 014016 (2009).
     [View Abstract - PubMed 19256704]

  6. 2008

  7. Chen, R., Huang, Z., Chen, G, Li, Y., Chen, X., Chen, J., Zeng, H.:. Kinetics and subcellular localization of 5-ALA induced PpIX in DHL cells via two-photon excitation fluorescence microscopy Intl. J. Oncology, 32:861-867, (2008).
     [View Abstract - PubMed 18360713]

  8. Fawzy, Y., Zeng, H.. Intrinsic fluorescence spectroscopy for endoscopic detection and localization of the endo-bronchial cancerous lesions J. of Biomedical Optics, 13 (6): 064022 (2008).
     [View Abstract - PubMed 19123668]

  9. Short, M., Lam, S., McWilliams, A., Zhao, J., Lui, H., Zeng, H.: . Development and preliminary results of an endoscopy Raman probe for potential inv-vivo diagnosis of lung cancers. Optics Letters, 33(7):711-713, (2008).
     [View Abstract - PubMed 18382526]

  10. Tchvialeva, L, Lee, TK, Markhvida, I, Mclean, DI, Lui, H. and Zeng, H.. Using a zone model to incorporate the influence of geometry on polychromatic speckle contrast Optical Engineering, 47(7): 074201 (2008).

  11. Zeng H, Fawzy YS, Short MA, Tercelj M, McWilliams A, Petek M, Palcic B, Zhao J, Lui H, Lam S. Combining field imaging endoscopy with point analysis spectroscopy for improving early lung cancer detection. Conf Proc IEEE Eng Med Biol Soc. 2008:1849-50. (2008).
     [View Abstract - PubMed 19163043]

  12. Zeng, H., Zhao, J., Short, M., McLean, D., Lam, S., McWilliams, A., and Lui, H.:. Raman Spectroscoy for in vivo tissue analysis and diagnosis - from insturment development to clinical applications. J. Innovative Optical Health Sciences, 1(1): 95-106 (2008).

  13. Zhao J, Lui H, McLean DI, Zeng H. Real-time raman spectroscopy for non-invasive skin cancer detection - preliminary results. Conf Proc IEEE Eng Med Biol Soc. 2008:3107-9. (2008).
     [View Abstract - PubMed 19163364]

  14. Zhao, J., Lui, H., McLean, D., Zeng, H.:. Integrated real-time raman system for clinical in vivo skin analysis. Skin Research and Tehcnology, 14: 484-492 (2008).
     [View Abstract - PubMed 18937786]

  15. 2007

  16. Chen, R., Huang, Z., Lui, H., Hamzavi, I., McLean, D.I., Xie, S., Zeng, H.. Monte Carlo simulation of cutaneous reflectance and fluorescence measurements the effect of melanin contents and localization, Journal of photochemistry and photobiology B: Biology, (2007).
     [View Abstract - PubMed 17157523]

  17. Huang, B., Chen, R., Zeng, H.. The Impact of Blood Content in Skin Tissue on Skin Spectra Spectroscopy and Spectral Analysis, 27(1):95-98, (2007).

  18. Markhvida, I, Tchvialeva, L, Lee, TK, and Zeng, H.. The Influence of Geometry on Polychromatic Speckle Contrast Journal of OSA A (2007).
     [View Abstract - PubMed 17164847]

  19. Siu, C.P.B., Zeng, H., Chiao, M.:. Magnetically actuated MEMS microlens scanner for in vivo medical imaging. Optics Express (2007).

  20. Zhao, J., Lui, H., McLean, D.I., Zeng, H.: . Automated autofluorescence background subtraction algorithm for biomedical raman spectroscopy. Applied Spectroscopy, 61(11):1225-1232 (2007).
     [View Abstract - PubMed 18028702]

  21. Zhao, J., Lui, H., McLean, D.I., Zeng, H.: . Towards instrument independent quantitative measurement of fluoresscence intensity in fiber optic spectrometer systems Applied Optics, 46(29):7132-7140 (2007).
     [View Abstract - PubMed 17932520]

  22. 2006

  23. Fawzy, Y.S., Petek, M., Tercelj, M., Zeng, H.. In-vivo assessment and evaluation of lung tissue morphologic and physiological changes from non-contact endoscopic reflectance spectroscopy for improving lung cancer detection J. of Biomedical Optics J. of Biomedical Optics, 11, 044003 (2006).
     [View Abstract - PubMed 16965160]

  24. Fawzy, Y.S., Zeng, H.. Determination of scattering volume fraction and particle size-distribution in the superficial layer of a turbid medium using diffuse reflectance spectroscopy Applied Optics, 45:3902-3912, (2006).
     [View Abstract - PubMed 16724156]

  25. Hamzavi I, Shiff N, Martinka M, Huang Z, McLean D, Zeng H, Lui H. Spectroscopic assessment of dermal melanin using blue vitiligo as an in vivo model. Photodermatol Photoimmunol Photomed. 22(1):46-51. (2006).
     [View Abstract - PubMed 16436181]

  26. Huang, Z, Zeng, H, Hamzavi, I, Alajlan, A, Tan, E, McLean, DI, Lui, H.. Cutaneous Melanin Exhibits Fluorescence Emission Under Near-Infrared Light Excitation J. of Biomedical Optics, 11: 034010, (2006).
     [View Abstract - PubMed 16822060]

  27. Lane, P.M., Gilhuly, T., Whitehead, P., Zeng, H., Poh, C., Ng, S., Williams, M., Zhang, L., Rosin, M.P., MacAulay, C.E.. Simple Device for the Direct Visualization of Oral-Cavity Tissue Fluorescence. J of Biomedical Optics, 11: 024006 (2006).
     [View Abstract - PubMed 16674196]

  28. Short, M.A., Lui, H., McLean, D.I., Zeng, H., Alajlan, A., Chen, M.X. Demonstrating Changes in Nuclei and Peritumoral Collagen within Nodular Basal Cell Carcinomas Via Confocal Micro-Raman Spectroscopy J of Biomedical Optics, 11: 034004 (2006).
     [View Abstract - PubMed 16822054]

  29. 2005

  30. Chen, R., Huang, B., Zeng, H.: . The Optical Model of Human Skin. Acta Laser Biology Sinica, 14(6):401-404, (2005).

  31. Huang Z, Lui H, McLean DI, Korbelik M, Zeng H. Raman spectroscopy in combination with background near-infrared autofluorescence enhances the in vivo assessment of malignant tissues. Photochem Photobiol. 81(5):1219-26. (2005).
     [View Abstract - PubMed 15869327]

  32. Lau DP, Huang Z, Lui H, Anderson DW, Berean K, Morrison MD, Shen L, Zeng H. Raman spectroscopy for optical diagnosis in the larynx: preliminary findings. Lasers Surg Med. 37(3):192-200. (2005).
     [View Abstract - PubMed 16127671]

  33. Tercelj M, Zeng H, Petek M, Rott T, Palcic B. Acquisition of fluorescence and reflectance spectra during routine bronchoscopy examinations using the ClearVu Elite device: pilot study. Lung Cancer. 50(1):35-42. (2005).
     [View Abstract - PubMed 16043259]

  34. 2004

  35. Hamzavi I, Jain H, McLean D, Shapiro J, Zeng H, Lui H. Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. Arch Dermatol. 140(6):677-83. (2004).
     [View Abstract - PubMed 15210457]

  36. Huang Z, Lui H, Chen XK, Alajlan A, McLean DI, Zeng H. Raman spectroscopy of in vivo cutaneous melanin. J Biomed Opt. 9(6):1198-205. (2004).
     [View Abstract - PubMed 15568940]

  37. Huang Z, Zheng W, Xie S, Chen R, Zeng H, McLean DI, Lui H. Laser-induced autofluorescence microscopy of normal and tumor human colonic tissue. Int J Oncol 24(1):59-63. (2004).
     [View Abstract - PubMed 14654941]

  38. Zeng H, Petek M, Zorman MT, McWilliams A, Palcic B, Lam S. Integrated endoscopy system for simultaneous imaging and spectroscopy for early lung cancer detection. Opt Lett. 29(6):587-9. (2004).
     [View Abstract - PubMed 15035479]

  39. Zeng, H., McWilliams, A., Lam, S.. Optical Spectroscopy and Imaging for Early Lung Cancer Detection: A Review. Photodiagnosis and Photodynamic Therapy, 1: 111-122, (2004).

  40. 2003

  41. Huang Z, McWilliams A, Lui H, McLean DI, Lam S, Zeng H. Near-infrared Raman spectroscopy for optical diagnosis of lung cancer. Int J Cancer 107(6):1047-52. (2003).
     [View Abstract - PubMed 14601068]

  42. Huang, Z., McWilliams, A., Lam, S., English, J. McLean, D.I., Lui, H. Zeng, H. Effect of Formalin Fixation on the Near-Infrared Raman Spectroscopy of Human Bronchial Tissues Intl. J. of Oncology, 23: 649-656 (2003).
     [View Abstract - PubMed 12888900]

  43. Korbelik M, Sun J, Zeng H. Ischaemia-reperfusion injury in photodynamic therapy-treated mouse tumours. Br J Cancer 88(5):760-6. (2003).
     [View Abstract - PubMed 12618887]

  44. Lau, D.P., Huang, Z., Lui, H., Man, C.S., Berean, K., Morrison, M.D., Zeng, H.. Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx - preliminary findings Lasers in Medicine and Surgery 32(3), 210-214 (2003).
     [View Abstract - PubMed 12605428]

  45. 2002

  46. Zeng H, Korbelik M, McLean DI, MacAulay C, Lui H. Monitoring photoproduct formation and photobleaching by fluorescence spectroscopy has the potential to improve PDT dosimetry with a verteporfin-like photosensitizer. Photochem Photobiol 75(4):398-405. (2002).
     [View Abstract - PubMed 12003130]

  47. 2001

  48. Bissonnette R, Zeng H, McLean DI, Korbelik M, Lui H. Oral aminolevulinic acid induces protoporphyrin IX fluorescence in psoriatic plaques and peripheral blood cells. Photochem Photobiol 74(2):339-45. (2001).
     [View Abstract - PubMed 11547574]

  49. Huang, Z., Zeng, H., Hamzavi, I., McLean, D.I., and Lui, H.. A rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements Optics Letters 26(22):1782-1784 (2001).

  50. 2000

  51. Bissonnette, R., Shapiro, J., Zeng, H., McLean, D.I., and Lui, H.: . Topical photodynamic therapy with 5-aminolaevulinic acid does not induce hair regrowth in patients with extensive alopecia areata British Journal of Dermatology 143:1032-1035 (2000).

  52. 1999

  53. Morgan, D., Wilson, Janet E., MacAulay, C., MacKinnon, N., Kenyon, J., Gerlan, P., Dong, C., Zeng, H., Whitehead, P., Thompson, C., McManus, B.. A new method for sensitive and reliable detection of heart allograft rejection: Validation in the heteroptopic abdominal rat allograft model Circulation 100:1236-1241 (1999).

  54. Zeng, H., Weiss, A., MacAulay, C., Cline, R.: . System for Fast Measurements of in vivo Fluorescence Spectra of the Gastrointestinal Tract at Multiple Wavelength Excitation Appl. Optics 38(34):7157-7158 (1999).

  55. 1998

  56. Bissonnette, R., Zeng, H., McLean, D.I., Schyeiber, W.E., MacAulay, C., Roscoe, D.L., Lui, H.: . Psoriatic plaques exhibit red autofluorescence that is due to protoporphyrin IX Journal of Investigative Dermatology, 111:586-591 (1998).

  57. Zeng, H., MacAulay, C., McLean, D., Palcic, B., Lui, H.. The Dynamics of Laser Induced Autofluorescence Decay in Human Skin Experimental Measurements and Theoretical Modeling Photochemistry and Photobiology. 68(2):227-236 (1998).

  58. Zeng, H., Weiss, A., Cline, R., and MacAulay, C. . Real time endoscopic fluorescence imaging for early cancer detection in the gastrointestinal tract. Bioimaging 6:151-165 (1998).

  59. 1997

  60. Zeng, H., MacAulay, C., McLean, D.I. and Palcic, B.. Reconstruction of in vivo skin autofluorescence spectrum from microscopic properties by Monte Carlo simulation J. Photochem. Photobiol. B: Biology 38 ( ) 234-240. (1997).

  61. 1995

  62. Zeng, H., MacAulay, C., McLean, D.I. and Palcic, B.. Spectroscopic and microscopic characteristics of human skin autofluorescence emission Photochem. Photobiol. 61(6):639-645, (1995).

  63. 1993

  64. Zeng, H., MacAulay, C., McLean, D.I. and Palcic, B.. Novel microspectrophotometer and its biomedical applications Optical Engineering, 32(8):1809-1813, (1993).

  65. Zeng, H., MacAulay, C., Palcic, B. and McLean, D.I.: . A computerized autofluorescence and diffuse reflectance spectroanalyser system for in vivo skin studies. Phys Med Biol 38(2):231-240, (1993).

  66. 1992

  67. Zeng, H., Gong, Y.M. and Zhang, Z.. Probe-hole field emission microscope system controlled by computer J. Electronics (Beijing, China, English version) 9(1), (1992).

  68. 1991

  69. Gong YM, Zeng HS: . Probe-hole field-emission microscope system controlled by computer. Chinese Physics Letters, 8(9): 446-449 (1991).

  70. Gong, Y.M. and Zeng, H.. Adsorption and desorption of oxygen on the W(100) plane Surface Science 246:169-172, (1991).

  71. 1989

  72. Zeng, H., Gong, Y.M., Zhang, Z. and Zhang, W.. Influence of the adsorbed oxygen on transition metal surfaces to electron emission studied by FEM Proceedings of the Seventh National Conference on Vacuum Electronics, Chengdu, China, January, (1989).

  73. Zeng, H., Yang, L. and Ye, Y.. Microcomputerized measurement and analysis of thermionic emission properties J. Electronics (Beijing, China), 10(2):1988; ibid. (English version) 6(2): (1989).

  74. Zeng, H., Yang, L., Ye, Y. and Guo, K.. A method for monitoring the cathode activity in actual microwave tubes Proceedings of the Seventh National Conference on Vacuum Electronics, Chengdu, China, January, (1989).

  75. 1988

  76. Yang, L., Zeng, H. and Ye, Y.. A microcomputer controlled measurement system for measuring the thermionic emission properties Shanghai Vacuum Electronics (Shanghai, China), No. 3, (1988).

  77. 1986

  78. Zeng, H., Yang, L., and Ye, Y.. Automatic measurement and analysis of the I-V characteristics of thermionic emission Proceedings of the Sixth National Conference on Vacuum Electronics, Beijing, China, Jan., (1986).

  79. 1983

  80. Zhang, Z., Jiao, J., Zeng, H., Wang, X. and Fu, W.. Field emission microscope studies of the coadsorption of Cesium and Antimony on monocrystal tungsten Proceedings of the Second National Conference on Vacuum Science, Nanjing, China, (1983).

Non Peer-Reviewed Papers

    In Press

  1. C. P. B. Siu, T. Wang, H. Zeng, M. Chiao:. Dual-axes confocal microlens for Raman spectroscopy. Proc. 22th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2009), (In Press).

  2. 2009

  3. Lucas L., Chen X. K., Smith A., Korbelik M., Zeng H., Lee P. W. K. and Hewitt K. C.:. Imaging EGFR distribution using surface-enhanced Raman spectroscopy. SPIE Proc. 7192: 719206, (2009).

  4. Tchvialeva, L., Zeng, H., Markhvida, I., McLean, L., McLean, D., Lui, H., Lee, T.K.: . Optical discrimination of surface reflection from volume backscattering in speckle contrast for skin roughness measurements SPIE Proc. 7161: 71610I, (2009).

  5. Wang, H., Huang, N., Zhao, J., Lui, H., McLean, D., Korbelik, M., Zeng, H.:. In vivo confocal Raman spectroscopy for skin diagnosis and characterization - preliminary results from mouse tumor models. SPIE Proc. 7161: 716108, (2009).

  6. 2008

  7. Short M, Lam S, McWilliams A, Zhao J, Lui H, Zeng H: . Development and Preliminary Results of an In-Vivo Raman Probe for Early Lung Cancer Detection. SPIE Proc. 6853: 68530J (2008).

  8. Zeng, H., Fawzy, Y.S., Short, M.A., Tercelj, M., McWilliams, A., Petek, M., Palcic, B., Zhao, J., Lui, H., Lam, S.: (Invited Paper). Combining Field Imaging Endoscopy with Point Analysis Spectroscopy for Improving Early Lung Cancer Detection Proc. 30th Annual International IEEE Engineering in Medicine and Biology Society (EMBS) Conference: 1849-1850, (2008).

  9. Zhao J, Huang Z., Zeng H. McLean D.I., Lui H.:. Quantitative analysis of skin chemicals using rapid near infrared Raman spectroscopy. SPIE Proc. 6842: 684209 (2008).

  10. Zhao, J., Lui, H., McLean, D.I., Zeng, H. Real-Time Raman Spectroscopy for Noninvasive Skin Cancer Detection − Preliminary Results. Proc. 30th Annual International IEEE Engineering in Medicine and Biology Society (EMBS) Conference: 3107-3109 (2008).

  11. 2007

  12. He, Q., Lui, H., Zloty, D., Cowan, B., Warshawski, L., McLean, D.I., Zeng, H.. Microscopic Fluorescence Spectral Analysis of Basal Cell Carcinomas SPIE Proc. 6534: 653414, (2007).

  13. Siu, C.P.B., Zeng, H., Chiao, M.:. Magnetically actuated scanning microlens for NIR Raman spectroscopy. Proc. 20th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2007), No. 1258, (2007).

  14. 2006

  15. Fawzy, Y.S., Petek, M., Tercelj, M., Zeng, H.. In vivo assessment and evaluation of lung cancer detection using an integrated endoscopy system for simultaneous imaging and spectroscopy. 29th Canadian Medical and Biological Engineering Conference Proceedings (2006).

  16. Han, X., Lui, H., McLean, D.I., Zeng, H.. A technique for near-infrared autofluorescence imaging of skin: preliminary results. SPIE 6078: 60780S (2006).

  17. Short, M.A., Lui, H., McLean, D.I., Zeng, H., Chen, M.X.. Preliminary Micro-Raman Images of Normal and Malignant Human Skin Cells. SPIE 6093: 60930E (2006).

  18. Tchvialeva, L., Lee, T.K., Markhvida, I., McLean, D.I., Lui, H., Zeng, H.. Geometry Influence on Polychromatic Speckle Contrast. SPIE 6341:63411V (2006).

  19. Zhao, J., Alkhayat, H., Al Robaee, A., Zeng, H., McLean, D.I., Lui, H. Multimode Spectroscopy for the in vivo Assessment of Post-Inflammatory Pigmentation-Preliminary Observations. SPIE 6078: 607809 (2006).

  20. 2005

  21. Short, M.A., Lui, H., McLean, D.I., Zeng, H., Alajlan, A., Chen, M.X.. Preliminary Observations on Differences in the Raman Spectra of Cancerous and Non-Cancerous Cells and Connective Tissue of Human Skin. SPIE 5686:126-130 (2005).

  22. 2004

  23. Huang, Z, Lui, H, McWilliams, A, Lam, S, McLean, D I, Zeng, H. Near-infrared Raman Spectroscopy Detects Lung Cancer SPIE 5630:340-343 (2004).

  24. Huang, Z., Lui, H., McLean, DI, Korbelik, M. Zeng, H.: (Invited Paper) . Combining Combining Raman Spectroscopy with Background Near-Infrared Autofluorescence and Raman Spectroscopy to Improve to Improve the Non-invasive Detection of Malignant Tumors. Proc. APBP 2004 (The Second Asian and Pacific Rim Symposium on Biophotonics, December 15-17, 2004, National Taiwan University, Taipei, Taiwan): 101-102 (2004).

  25. 2002

  26. Zeng, H., Hamzavi, I.H., Huang, Z., McLean, D.I., Lui, H.. The effect of melanin localization on skin autofluorescence and diffuse reflectance spectroscopy. Proc. BOPM 2002 (Asian Symposium on Biomedical Optics and Photomedicine, 21-23 October, 2002, Sapporo, Japan): 218 (2002).

  27. 2001

  28. Huang, Z., Zeng, H., Hamzavi, I., McLean, D.I., Lui, H.. Evaluation of variations of biomolecular constituents in human skin in vivo by near-infrared Raman spectroscopy SPIE 4597:109-114 (2001).

  29. Huang, Z., Zheng, W, Chia, T C, Diong, C H, Lim, T K, Seow, F C, Zeng, H, MacAulay, M, McLean, D, Lui, H.: . Autofluorescence diagnostic algorithm for detecting malignant colonic tissues. SPIE 4597:139-143, (2001).

  30. 2000

  31. Zeng, H., McLean, D.I., MacAulay, C. and Lui, H.: (Invited Paper) . Autofluorescence properties of skin and applications in dermatology SPIE 4224:366-373 (2000).

  32. 1999

  33. Zeng, H., MacAulay, C., Lam, S., Palcic, B.: (Invited Paper) . Light induced fluorescence endoscopy (LIFE) imaging system for early cancer detection. SPIE 3863:275-282 (1999).

  34. 1998

  35. MacAulay, C., Whitehead, P., McManus, B., Zeng, H., Wilson-McManus, J., MacKinnon, N., Morgan, D., Dong, C., Gerla, P., Kenyon, J.: . Organ transplant tissue rejection: Detection and staging by fluorescence spectroscopy SPIE 3245:38-43 (1998).

  36. Zeng, H., McLean, D., MacAulay, C., Palcic, B., Lui., H.: . Autofluorescence of basal cell carcinoma. SPIE 3245:314-317 (1998).

  37. 1997

  38. Zeng, H., Weiss, A., MacAulay, C.E., MacKinnon, N., Cline, R. and Dawson, R.. Development of a fluorescence video endoscopy imaging system for the early detection of cancer in the gastrointestinal tract SPIE 2976:291-296, (1997).

  39. 1996

  40. Zeng, H., Lui, H., McLean, D.I., MacAulay, C. and Palcic, B.. Update on fluorescence spectroscopy studies of diseased skin SPIE 2671:196-198, (1996).

  41. Zeng, H., MacAulay, C. and Palcic, B.. System for fast measurement of in vivo tissue fluorescence spectra under multiple wavelength excitation SPIE 2676:351-355, (1996).

  42. Zeng, H., Weiss, A., MacKinnon, N., Cline, R., MacAulay, C.. In vivo fluorescence spectroscopy of gastrointestinal tract under multiple wavelength excitation SPIE 2926:4-20, (1996).

  43. 1995

  44. Zeng, H., Lui, H., McLean, D.I., MacAulay, M. and Palcic, B.. Optical spectroscopy studies of diseased skin - preliminary results SPIE 2628:281-285, (1995).

  45. Zeng, H., MacAulay, C., McLean, D.I. and Palcic, B.. Miniature spectrometer and multi-spectral imager as a potential diagnostic aid in dermatology SPIE 2387:57-61, (1995).

  46. Zeng, H., MacAulay, C., McLean, D.I. and Palcic, B.. Spectroscopy and microscopy studies of skin tissue autofluorescence emission SPIE 2324:198-207, (1995).

  47. 1994

  48. Qu, J., MacAulay, C., Lam, S., Zeng, H. and Palcic, B.. Fluorescence in normal and carcinoma bronchial tissue SPIE 2134A:236-246, (1994).

  49. Zeng, H., MacAulay, C., Palcic, B. and McLean, D.I.. Monte Carlo modeling of tissue autofluorescence measurement and imaging SPIE 2135:94-104, (1994).

  50. 1993

  51. Lam, S., MacAulay, C., LeRiche, J.C., Qu, J., Krosl, G., Zeng, H., Korbelik, M., Palcic, B.. Fluorescence imaging of pre-malignant and malignant tissues with and without photosensitizers SPIE 1881:160-167, (1993).

  52. Zeng, H., MacAulay, C., Palcic, B. and McLean, D.I.. Laser-induced changes in autofluorescence of in vivo skin SPIE 1882:278-290, (1993).

  53. Zeng, H., MacAulay, C., Palcic, B. and McLean, D.I.. A computerized autofluorescence and diffuse reflectance spectroanalyser system for in vivo skin studies Phys Med Biol 38(2):231-240, (1993).

  54. Zeng, H., MacAulay, C., Palcic, B. and McLean, D.I.. Autofluorescence distribution in skin tissue revealed by microspectrophotometer measurements SPIE 1876:129-135, (1993).

  55. 1989

  56. Zeng, H., Gong, Y.M., Zhang, Z. and Zhang, W.: . Influence of the adsorbed oxygen on transition metal surfaces to electron emission studied by FEM. Seventh National Conference on Vacuum Electronics, Chengdu, China, Jan., (1989).

  57. Zeng, H., Yang, L., Ye, Y. and Guo, K.: . A method for monitoring the cathode activity in actual microwave tubes. Seventh National Conference on Vacuum Electronics, Chengdu, China, Jan., (1989).

  58. 1986

  59. Zeng, H., Yang, L., and Ye, Y.: . Automatic measurement and analysis of the I-V characteristics of thermionic emission. Sixth National Conference on Vacuum Electronics, Beijing, China, Jan., (1986).

  60. 1983

  61. Zhang, Z., Jiao, J., Zeng, H., Wang, X., and Fu, W.: . Field electron emission microscope studies of the coadsorption of Cesium and Antimony on monocrystal Tungsten. 2nd National Conferences on Vacuum Science, Nanjing, China, (1983).

Books (and Chapters)

    In Press

  1. Zeng, H.,. Characterization of Biomaterials. In: Biomaterial for MEMS, M. Chiao and J.C. Chiao (eds.), Pan Stanford Publishing (In Press).

  2. 2003

  3. Zeng, H.. Microspectrophotometer, an Instrument for Microscopic Spectral Analysis In: Science, Technology and Education of Microscopy: an Overview, A. Mendez-Vilas (ed), pp.638-642, FORMATEX, Spain, March (2003).

  4. Zeng, H. and MacAulay C.. "Fluorescence Spectroscopy and Imaging for Skin Cancer Detection and Evaluation" In: Fluorescence in Biomedicine, M. Mycek and B.W. Pogue (eds.), pp.315-360, Marcel Dekker, USA, April (2003).

  5. 2000

  6. Zeng, H. Optical Properties and Autofluorescence Characteristics of Human Skin In: Advances in Biomedical Photonics, Q. Luo (ed.), HUST Press, Wuhan, China (2000).

Presentations and Symposium Proceedings
Peer-Reviewed Papers | Non Peer-Reviewed Papers | Books (and Chapters) | Presentations and Symposium Proceedings | Abstracts | Patents

    2009

  1. C. P. B. Siu, T. Wang, H. Zeng, M. Chiao:. Dual-axes confocal microlens for raman spectroscopy, 22th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2009), Sorrento, Italy, 25 - 29 January (2009).

  2. Chen, J., Lee, A., Zhao, J., Wang, H., Lui, H., McLean, D., Zeng, H.. Spectroscopic characterization of extracted and in situ collagen and elastin based on multiphoton excitation microscopy and spectroscopy. SPIE Photonics West, San Jose, CA Jan. 24-29, (2009).

  3. Hewitt, K., Chen, M., Lucas, L., Smith, A., Korbelik, M., Zeng, H., Lee, P.W.K.: . Imaging EGFR distribution using surface enhanced Raman spectroscopy. SPIE Photonics West, San Jose, Ca, Jan 24-29 (2009).

  4. Tchvialeva, L., Zeng, H., Markhvida, I., McLean, L., McLean, D., Lui, H., Lee, T.K.: . Optical discrimination of surface reflection from volume backscattering in speckle contrast for skin roughness measurements SPIE Photonics West, San Jose, Ca, Jan. 24-29, (2009).

  5. Wang, H., Lui, H., McLean, D., Korbelik, M., Zeng, H.:. In vivo confocal Raman spectroscopy for skin diagnosis and characterization. SPIE Photonics West, San Jose, CA Jan. 24-29 (2009).

  6. Zhao, J., Lui, H., McLean, D., Zeng, H.: . Non-invasive skin cancer detection using real-time in vivo Raman spectroscopy: preliminary results. SPIE Photonics West, San Jose, CA Jan. 24-29, (2009).

  7. 2006

  8. Fawzy, Y.S., Petek, M., Tercelj, M., Zeng, H.. In vivo assessment and evaluation of lung cancer detection using an integrated endoscopy system for simultaneous imaging and spectroscopy. 29th Canadian Medical and Biological Engineering Conference, Vancouver, Canada, June 1-3, (2006).

  9. Fawzy, Y.S., Zeng, H., Zorman, M.T., Peteka, M. . In-vivo assessment and evaluation of lung tissue morphologic and physiological changes from non-contract endoscope reflectance spectroscopy for improving lung cancer detection. SPIE-Photonics West, San Jose, California Jan. 21-22 (2006).

  10. Han, X. Lui, H., McLean, D., Zeng, H. . Far-red and near-infrared fluorescence imaging system for noninvasive skin diagnosis and evaluation. SPIE-Photonics West, San Jose, California Jan. 21-22, (2006).

  11. Huang, Z., Alajian, A., Zheng, W., Zeng, H., McLean, D., Lui, H. . In vivo detection of basal cell carcinoma using Raman spectroscopy and pattern recognition techniques. SPIE-Photonics West, San Jose, California Jan 21-22, (2006).

  12. Robaee, A.A., Khayat, H., Zhao, J., Zeng, H., McLean, D.I., Lui, H.. Colorimetric monitoring of post inflammatory pigmentation: preliminary observations. 145h Annual Meeting of The Photomedicine Society, San Francisco, CA, USA, March 2, (2006).

  13. Short, M.A., Lui, Zeng, H., McLean, D., Chen, M.X.K.. Micro-Raman imaging of normal and malignant human skin cells. SPIE-Photonics West, San Jose, California Jan. 21-22 (2006).

  14. Tçhvialeva, L., Lee, T.K., Markhvida, I., McLean, D.I., Lui, H., Zeng, H.. Geometry Influence on Polychromatic Speckle Contrast. Speckle 2006 International Conference, Nimes, France, 13-15 September Abstract # 151. (2006).

  15. Zeng, H., Petek, M., Zorman, M.T., Fawzy, Y.S.. Advanced endoscopy system for simultaneous multimode imaging and non-contact spectroscopy for lung cancer detection. SPIE-Photonics West, San Jose, California Jan. 21-22 (2006).

  16. Zhao, J., Alkhayat, H., Zeng, H., Al Robaee, A., McLean, D., Lui, H.. Multimode spectroscopy for the assessment of post-inflammatory pigmentation in vivo. SPIE-Photonics West, San Jose, California Jan. 21-22, (2006).

  17. 2005

  18. Chen, X.K.M., Short, A., Zeng, H., McLean, D.I., and Lui, H.. Investigation of Skin Cancer by Raman Spectroscopy Annual March Meeting of American Physical Society, Los Angles, March (2005).

  19. Short, M., Lui, H., Zeng, H., McLean., Chen., M. . Differences in the Micro-Raman Spectra of Normal and Malignant Melanocytes. 6th World Congress on Melanoma, Vancouver Canada. Sept. 6-10, (2005).

  20. Short, M.A., Lui, H., Zeng, H., Alajlan, A., Chen, M.X.K.:. Differences in the Raman spectra of cancerous and noncancerous cells and connective tissue of human skin. SPIE Photonics West BiOS 2005, San Jose, CA., January 22-27, SPIE Abstract CD, Abstract # 5686A-24, (2005).

  21. Tchvialeva, L., Zeng, H., McLean, D., Lui, H., Lee, TK.. Skin Assessment by Speckle. 6th World Congress on Melanoma, Vancouver Canada. Sept. 6-10, Abstract # P-243 (2005).

  22. Zeng, H. (invited speaker), Huang, Z., Short, M., Alajlan, A., Chen, M.X.K., McLean, DI, Lui, H.: . Raman Spectroscopy in the Diagnosis of Skin Cancer Both ex vivo and in vivo. FACSS 2005 (the Federation of Analytical Chemistry and Spectroscopy Societies) The 32th Annual Meeting, Quebec, Quebec, Canada, October 9-13 (2005).

  23. Zeng, H., Huang, Z., Chen, MXK., Hamzavi, I., Alajlan, A., McLean, D., Zhao, J., Alkhayat, H., Lui, H. . The Unique Raman Scattering and NIR Fluorescence Properties of Melanin In Vitro and In Vivo. 6th World Congress on Melanoma, Vancouver Canada. Sept. 6-10, Abstract #201 (2005).

  24. 2004

  25. Huang, Z., Lui, H., McLean, DI, Korbelik, M. Zeng, H. (Invited Speaker). Combining Combining Raman Spectroscopy with Background Near-Infrared Autofluorescence and Raman Spectroscopy to Improve to Improve the Non-invasive Detection of Malignant Tumors. The Second Asian and Pacific Rim Symposium on Biophotonics-APBP 2004, National Taiwan University, Taipei, Taiwan, December 15-17, (2004).

  26. Huang, Z., Lui, H., McWilliams, A., Lam, S., McLean, D.I., Zeng, H.. Near-infrared spectroscopy detects lung cancer. Presented at Photonics Asia, Beijing, China, Nov. 8-12, (2004).

  27. Lau, D.P., Huang, Z., Lui, H., Anderson, D.W, Berean, K., Liang, S., Morrison, M. D., Zeng, H.. Raman Spectroscopy for Optical Diagnosis in the Larynx-Preliminary Findings. The American Laryngological Association Annual Meeting, Phoenix, AZ, April 30-May 1 (2004).

  28. Short, M.A., Chen, X.K., Zeng, H., Alajlan, A., McLean, D.I., Lui, H.:. Investigation of Skin Cancers Using MicroRaman Spectroscopy. Annual ASP (American Physical Society) March Meeting, Montreal, Quebec, March 22-26 (2004).

  29. Tercelj Zorman, M., Zeng, H., Petek, M., Rott, T., Garner, D., Palcic, B.. Fluorescence and Reflectance Spectra: A Possible Tool for Better Discriminator of Neoplastic Lesions in Fluorescence Bronchoscopy. 13th World Congress for Bronchology (WCB), Barcelona, Spain, June 20-23, (2004).

  30. Zeng, H., Huang, Z., Ajlan, A., McLean, D.I., Lui, H.. Rapid Raman spectroscopy for in vivo skin tissue characterization and evaluation. Presented at Photonics Asia, Beijing, China, Nov. 8-12, (2004).

  31. Zeng, H.,(Invited Speaker) Petek, M., Zorman, M.T., McWilliams, A., Palcic, B., Lam, S.. Integrated endoscopy system for simultaneous imaging and spectroscopy for early lung cancer detection. Presented at Photonics Asia, Beijing, China, Nov. 8-12 (2004).

  32. 2003

  33. Huang, Z., McLean, DI, Lui, H., Zeng, H.: . Changes of in vivo Raman spectra within skin by near-infrared Raman spectroscopy. SPIEs BiOS 2003 International Symposium on Biomedical Optics, Conference: Cutaneous Applications of Lasers: Dermatology and Plastic Surgery, San Jose, California, January 25-31, (2003).

  34. Lau D., Morrison M, Huang Z, Berean K, Lui H, Zeng H.:. Raman Spectroscopy for Optical Biopsy in the Larynx. American Academy of Otolaryngology - Head and Neck Surgery Foundation Combined Otolaryngological Spring Meetings (COSM), Nashville, TN, May 2-3, (2003).

  35. Zeng, H. (invited speaker), Huang, Z., McLean, D.I., Lui, H.:. Rapid Near-IR Raman Spectroscopy for in vivo Tissue Diagnosis and Evaluation. The 3rd International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2003), Wuhan, China, June 8-11 (2003).

  36. Zeng, H.(invited speaker), Petek, M., Lam, S., Palcic, B.: . An Integrated Imaging and Spectroscopy System for Early Lung Cancer Detection. ALT03 The International Conference on Advanced Laser Technologies, Cranfield University at Silsoe, Bedfordshire UK, September 19-23, (2003).

  37. 2002

  38. Hamzavi IH., Huang Z., McLean D., Zeng H., Lui H.:. In vivo Evaluation of Human Melanin by Noninvasive Raman Spectroscopy And Infrared Autofluorescence in Vitiligo. 85th Canadian Society for Chemistry (CSC) Conference, Abstract 710, Vancouver, BC, Canada, June 1-5 (2002).

  39. Hamzavi, I.H., Huang, Z., Zeng, H., Lui, H.: . In vivo evaluation of human melanin by noninvasive raman spectroscopy and infrared autofluorescence in vitiligo. P14, American Academy of Dermatology 60th Annual Meeting, New Orleans, Feb. 22-27, (2002).

  40. Hamzavi, IH., McLean, D., Huang, Z., Zeng, H., Lui, H.: . A Spectroscopic Assessment of dermal melanin using Blue Vitiligo as a Model. 85th Canadian Society for Chemistry (CSC) Conference, Abstract 708, Vancouver, BC, Canada, June 1-5, 2002. (2002).

  41. Huang Z., McLean D., Lui H., Zeng H.: . Evaluation of Raman Spectral Changes from In Vivo Skin by Near-infrared Raman Spectroscopy. 85th Canadian Society for Chemistry (CSC) Conference, Abstract 709, Vancouver, BC, Canada, June 1-5, (2002).

  42. Huang, Z., Zeng, H., Hamzavi, I., McLean, D.I., Lui, H.:. In-vivo NIR Raman spectroscopy of the skin: non-invasive evaluation of molecular constituents. SPIE BiOs 2002 Int Symposium on Biomedical Optics, San Jose, California, January 19-25, (2002).

  43. Huang, Z.; Hamzavi, I., McLean, D.I., Lui, H., Zeng., H. . Changes of in vivo Raman spectra of skin with tissue depths by near-infrared Raman spectroscopy. Opto Canada, Ottawa, Ontario, Canada, May 9-10, (2002).

  44. Lau, D., Lui, H., An, D., Huang, Z., Morrison, M., Zeng, H.: . An In Vivo Study Of Three Different Spectroscopic Techniques In The Oral Cavity In Normal Subjects. 85th Canadian Society for Chemistry (CSC) Conference, Abstract 711, Vancouver, BC, Canada, June 1-5, 2002. (2002).

  45. Lau, D., Morrison, M.D., Huang, Z., Berean, K., Lui, H., Zeng, H.:. Preliminary findings of raman spectroscopy as a means of optical diagnosis in various regions of the head and neck. The Western Section of the Triologic Society Conference, Pasadena, Ca, 1-3 Feb (2002).

  46. Lui, H., Said, S., Warshawski, L., Zloty, D., McLean, D.I., MacAulay, C., Zeng, H.:. Fluorescence visualization with blue light more accurately estimates the histopathologic margins of basal cell carcinoma as compared to clinical examination alone. SPIE BiOS 2002 Int Symposium on Biomedical Optics, San Jose, California, January 19-25, (2002).

  47. Zeng, H., Hamzavi, IH, Huang, Z., McLean, DI, Lui, H.: . Melanin Localization On Skin Autofluorescence And Diffuse Reflectance Spectroscopy. Photonics Asian, 14-18 October, Shanghai, China. (2002).

  48. Zeng, H., Hamzavi, IH, McLean, DI, Lui, H.: . The Effect Of Melanin Localization On Skin Autofluorescence And Diffuse Reflectance Spectroscopy. Asian Symposium on Biomedical Optics and Photomedicine, 21-23 October, Sapporo, Japan. (2002).

  49. Zeng, H.,(invited speaker) Korbelik, M., McLean, D.I., MacAulay, C.E., and Lui, H.:. Monitoring photoproduct and photobleaching by fluorescence spectroscopy for improving PDT dosimetry. SPIE BiOS 2002 International Symposium on Biomedical Optics, Conference: Optical Methods for Tumor Treatment and Detection: Mechanisms and Technologies in Photodynamic Therapy XI (BO26), San Jose, California, January 19-25, (2002).

  50. 2001

  51. Hamzavi, I., Jain, H., Zeng, H., Huang, Z., McLean, D., Shapiro, J., Lui, H.: . Lack of correlation between erythema and repigmentation of vitiligo during treatment with narrow band UVB phototherapy Research Day, Division of Dermatology, University of British Columbia, February 17 (2001).

  52. Huang, Z., Zeng, H., Hamzavi, I., Lui, H., McLean, D.: . Development of fiber optic NIR Raman spectroscopy system for rapid in vivo skin measurements Research Day, Division of Dermatology, University of British Columbia, February 17 (2001).

  53. Huang, Z., Zeng, H., Hamzavi, I., McLean, D.I., Lui, H.: . A rapid NIR Raman spectroscopy system for Real-Time in vivo skin measurements. Advances in Optics for Biotechnology, Medicine, and Surgery. Banff, AB, July 22-27, (2001).

  54. Lui, H., Said, S., Warshawski, L., Zloty, D., Mc.Lean, D., MacAulay, C., Zeng, H.: . Fluorescence visualization with blue light more accurately estimates the histopathologic margins of basal cell carcinoma as compared to clinical examination alone. Annual meeting of the Canadian Society of Investigative Dermatology, Halifax, Nova Scotia, Canada, September (2001).

  55. Lui, H., Said, S., Warshawski, L., Zloty, D., Mc.Lean, D., MacAulay, C., Zeng, H.: . Fluorescence visualization with blue light more accurately estimates the histopathologic margins of basal cell carcinoma as compared to clinical examination alone European Conferences on biomedical Optics, Munich, Germany, June (2001).

  56. Lui, H., Said, S., Warshawski, L., Zloty, D., McLean, D., MacAulay, C., Zeng, H.: . Fluorescence visualization with blue light more accurately estimates the histopathologic margins of basal cell carcinoma as compared to clinical examination alone Research Day, Division of Dermatology, University of British Columbia, February 17 (2001).

  57. Palcic, B., Garner, D., Lam, S., Zeng, H., Sun, X.R., Beveridge, J.: . The Role of Quantitative Sputum Cytology in a Comprehensive Approach to Prevention Invasive Lung Cancer. 14th International Congress of Cytology, Amsterdam, The Netherlands, May 27-31, (2001).

  58. Zeng, H., Korbelik, M., McLean, D., MacAulay, C., Lui, H.: . Monitoring photoproduct formation and photobleaching by fluorescence spectroscopy improves PDT dosimetry Research Day, Division of Dermatology, University of British Columbia, February 17 (2001).

  59. 2000

  60. Zeng, H. (Invited Speaker), Lui, H., McLean, D.I., MacAulay, C.: . Fluorescence spectroscopy for skin cancer detection and evaluation. Optical Society of America Biomedical Topical Meeting 2000, Miami Beach, Florida, April 2 - 5, (2000).

  61. Zeng, H. (Invited Speaker), McLean, D.I., MacAulay, C. and Lui, H.: . Autofluorescence properties of skin and applications in dermatology. SPIE's Intl. Symposium on Optics and Optoelectronic Inspection and Control: Techniques, Application and Inspection -Conference on Biomedical Photonics and Optoelectronic Imaging, Beijing, China, November 8-10, (2000).

  62. 1999

  63. Lui, H., Hobbs, L., McLean, D.I., MacAulay, C., and Zeng, H.: . Autofluorescence imaging of basal cell carcinoma. Annual Meeting of Canadian Society for Investigative Dermatology, Vancouver, July 3, (1999).

  64. 1997

  65. Zeng, H., Weiss, A., MacAulay, C., MacKinnon, N., Cline, R. and Dawson, R.: . Development of a Fluorescence Video Endoscopy Imaging System for the early detection of cancer in the gastrointestinal tract. BIOS '97: San Jose, CA. Feb. (1997).

  66. 1996

  67. Lui, H., Zeng, H., MacAulay, C., Palcic, B. and McLean, D.I.. Ratio analysis of reflectance and fluorescence spectra of diseased skin 24th Annual Meeting of American Society for Photobiology. Atlanta, GA, June 15 - 20, (1996).

  68. MacAulay, C., Weiss, A., Zeng, H., MacKinnon, N, Hunter, T., Menard, J., Cline, R.. Autofluorescence properties of gastrointestinal tract as a potential aid for early detection of GI cancer Photonics China '96, Beijing, Nov. 4 - 7, (1996).

  69. Zeng, H., Lui, H., MacAulay, C., McLean, D.I., Palcic, B.. Quantitative analysis of laser induced autofluorescence spectra of diseased skin Photonics China '96, Beijing, Nov. 4 - 7, (1996).

  70. Zeng, H., Weiss, A., MacKinnon, N, Cline, R., MacAulay, C.: . In vivo fluorescence spectroscopy of gastrointestinal tract under multiple wavelength excitation. Optical Biopsy, BIOS Europe '96, Vienna, Austria, Sept. 7-11, (1996).

  71. 1995

  72. Lui, H., Zeng, H., McLean, D.I., MacAulay, C. and Palcic, B.. Autofluorescence spectroscopy of psoriasis vulgaris: Is psoriasis a form of localized porphyria? Fourth Meeting of the Western Canadian Society for Clinical and Investigative Dermatology, Jasper, Alberta, March 24-26 (1995).

  73. Zeng, H., Lui, H., McLean, D.I., MacAulay, C. and Palcic, B.. Optical spectroscopy of diseased skin Biomedical Optics Europe'95, Barcelona, Spain, September 12-16, (1995).

  74. Zeng, H., McLean, D.I., Lui, H., MacAulay, C. and Palcic, B.. Non-invasive bedside autofluorescence spectroscopy of benign and malignant skin lesions Fourth Meeting of the Western Canadian Society for Clinical and Investigative Dermatology, Jasper, Alberta, March 24-26, (1995).

  75. 1992

  76. Zeng, H.. Skin autofluorescence morphological structure and spectral differences University of British Columbia Health Sciences Student Research Forum, October 15, (1992).

  77. Zeng, H., MacAulay, C., Palcic, B. and McLean, D.I.. A computerized autofluorescence and diffuse reflectance spectroanalyser system for in vivo skin studies The third Annual Western Canadian Society of Clinical and Investigative Dermatology, Jasper, Alberta, Feb. 21-23, (1992).

  78. 1991

  79. Zeng, H.. Optical properties of human skin University of British Columbia Health Sciences Student Research Forum, October 10, (1991).

  80. 1989

  81. Zeng, H., Gong, Y.M., Zhang, Z. and Zhang, W.. Influence of the adsorbed oxygen on transition metal surfaces to electron emission studied by FEM The Seventh National Conference on Vacuum Electronics, Chengdu, China, Jan., (1989).

  82. Zeng, H., Yang, L., Ye, Y. and Guo, K.. A method for monitoring the cathode activity in actual microwave tubes The Seventh National Conference on Vacuum Electronics, Chengdu, China, January, (1989).

  83. 1988

  84. Zeng, H.. An interface circuit for TP-805 microcomputer First National Meeting on Computer Application in Vacuum Electronics Technology, Beijing, China, Oct. (1988).

  85. Zeng, H., Zhang, Z., and Gong, Y.M.. Decarbonization of the carbonized Tungsten tip in the FEM tube The Sixth National Meeting on Refractory Metals, Dayin, China, Nov., (1988).

  86. 1986

  87. Zeng, H., Yang, L., and Ye, Y.. Automatic measurement and analysis of the I-V characteristics of thermionic emission The Sixth National Conference on Vacuum Electronics, Beijing, China, Jan., (1986).

  88. 1983

  89. Zhang, Z., Jiao, J., Zeng, H., Wang, X., and Fu, W.: . Field electron emission microscope studies of the coadsorption of Cesium and Antimony on monocrystal Tungsten. 2nd National Conferences on Vacuum Science, Nanjing, China, (1983).

Abstracts

    2005

  1. Fawzy, Y.S., Petek, M., Zorman, M.T., Zeng, H.. Early lung cancer detection using endoscopic diffuse reflectance spectroscopy. SPIE Photonics West BiOS 2005, San Jose, CA., January 22-27, SPIE Abstract CD, Abstract # 5692-26, (2005).

  2. Fawzy, Y.S., Zeng, H.. Characterization of optical scattering using discrete particle modeling approach: implication to early cancer diagnosis. SPIE Photonics West BiOS 2005, San Jose, CA., January 22-27, SPIE Abstract CD, Abstract # 5692-27 (2005).

  3. Lam, S., McWilliams, A., Zeng, H., MacAulay, C.. Endoscopic Detection of Early Lung Cancer. 11th World Conference on Lung Cancer, Barcelona, Spain, July 3-6 Abstract # P-200 (2005).

  4. Short, M.A., Lui, H., Zeng, H., Alajlan, A., Chen, M.X.K. Differences in the Raman spectra of cancerous and noncancerous cells and connective tissue of human skin SPIE Photonics West BiOS 2005, San Jose, CA., January 22-27, SPIE Abstract CD, Abstract # 5686A-24 (2005).

  5. Thiessen, D.M., Lui, H., McLean, D.I., Zeng, H.. Constructing a New Spectrometer for Measuring the Excitation-Emission Matirix of Skin Autofluorescence, The 60th Annual Congress of the Canadian Association of Physicists, Vancouver, Canada, June 5-9, 2005. Abstract # MO-P6-5, Physics in Canada, May/June p73. (2005).

  6. Zeng, H. (Invited Speaker),. Dosimetry for Photodynamic Therapy The 60th Annual Congress of the Canadian Association of Physicists, Vancouver, Canada, June 5-9, 2005. Abstract # MO-A5-3, Physics in Canada, May/June p61 (2005).

  7. 2004

  8. Alajlan, A., Zeng, H., Huang, Z., Warshawski, L., McLean, D., Zloty, D., Lui, H.. Raman spectroscopy of basal cell carcinoma and normal skin: in vivo comparison study. 32nd Annual Meeting of the American Society of Photobiology, Seattle, WA., Abstract #166, pg., 51, July 10-14 (2004).

  9. Alajlan, A., Zeng, H., Huang, Z., Warshawskil, L., McLean, D.I., Zlotyl, D., Lui, H.. Raman Spectroscopy of Basal Cell Carcinoma and Normal Skin: In Vivo Comparison Study. BC Cancer Agency Annual Cancer Conference, Abstract Book #27-1, pg. 30, Nov. 25-27 (2004).

  10. Short, M., Lui, H., Zeng, H., McLean, D.I., Alajlan, A., and Chen, M.. Differences in the MicroRaman Spectra of Cancerous and Non-Cancerous Cells and Connective Tissue of Human Skin. BC Cancer Agency Conference, Nov. 25-27 (2004).

  11. 2003

  12. Huang, Z., Lui, H., Chen, XK., Alajlan, A., McLean, D.I., and Zeng, H.:. Raman Sectroscopy of In Vivo Cutaneous Melanin BC Cancer Agency Annual Cancer Conference, Vancouver, B.C., Abstract Book pg. 22, Abstract #76, Nov. 28-29, (2003).

  13. Huang, Z., Lui, H., McLean, D.I., Korbelik, M., and Zeng, H.:. Combining Near-Infrared Autofluorescence and Raman Spectroscopies for Improving the Noninvasive In Vivo Detection of Malignant Tumors. BC Cancer Agency Annual Cancer Conference, Vancouver, B.C., Abstract Book pg. 22, Abstract # 77, Nov. 28-29, (2003).

  14. Huang, Z., McWilliams, A., Lam, S., Lui, H., Zeng, H.. Near-infrared Raman Spectroscopy for Optical Diagnosis of Lung Cancer. 10th World Conference on Lung Cancer, August 10-14, Suppl. 2, 41:S50, Abstract O-165, (2003).

  15. Huang, Z., McWilliams, A., Lui, H., McLean, D.I., Lam, S., and Zeng, H.:. Near-Infrared Raman Spectroscopy for Lung Cancer Diagnosis. BC Cancer Agency Annual Cancer Conference, Vancouver, B.C., Abstract Book pg. 28, Abstract # 98, Nov. 28-29, (2003).

  16. Zeng, H. (invited speaker), Huang, Z., McLean, DI, Lui, H.: . Raman Spectroscopy For In Vivo Skin Tissue Characterization And Evaluation. FACSS 2003 (the Federation of Analytical Chemistry and Spectroscopy Societies) The 30th Annual Meeting, Ft. Lauderdale, FL, USA, October 19-23, (2003).

  17. Zeng, H., Petek, M., Tercelj Zorman, M., McWilliams, A., Palcic, B., and Lam, S.: . Integrated Endoscopy System for Simultaneous Imaging and Spectroscopy for Early Lung Cancer Detection. BC Cancer Agency Annual Cancer Conference, Vancouver, B.C., Abstract Book pg. 28, Abstract # 99, Nov. 28-29, (2003).

  18. 2001

  19. Hamzavi, I., Huang, Z., Zeng, H., McLean, D., Lui, H.: . In Vivo Evaluation of Human Melanin by Non-Invasive Raman Spectroscopy in Vitiligo IPA 8th World Congress of Photodynamic Medicine, June 5-9, Vancouver, Canada, Abstract Book, pg. 32 (2001).

  20. Huang, Z., Hamzavi, I., Lui, H., McLean, D., Zeng, H.: . Measurements of NIR Raman Spectra of Skin In Vivo Using a Rapid Fiber Optic Raman Spectroscopy System IPA 8th World Congress of Photodynamic Medicine, June 5-9, Vancouver, Canada, Abstract Book, pg. 69 (2001).

  21. Lau, D., Huang, Z., Man, C., Berean, K., Zeng, H., Lui, H., Hamzavi, I., Morrison, M.: . Raman Spectroscopy as a Means of Optical Biopsy in Normal and Cancerous Tissue of the Nasopharynx. IPA 8th World Congress of Photodynamic Medicine, June 5-9, Vancouver, Canada, Abstract Book, pg. 42 (2001).

  22. Lui, H., Said, S., Warshawski, L., Zloty, D., Mc.Lean, D., MacAulay, C., Zeng, H.:. Fluorescence visualization with blue light more accurately estimates the histopathologic margins of basal cell carcinoma as compared to clinical examination alone European Conferences on biomedical Optics, Munich, Germany, June (2001).

  23. Lui, H., Said, S., Warshawski, L., Zloty, D., Mc.Lean, D., MacAulay, C., Zeng, H.: . Fluorescence visualization with blue light more accurately estimates the histopathologic margins of basal cell carcinoma as compared to clinical examination alone IPA 8th World Congress of Photodynamic Medicine, June 5-9, Vancouver, Canada, Abstract Book, pg. 69 (2001).

  24. Palcic, B., Garner, D., Lam, S., Zeng, H., Sun, X.R., Beveridge, J.: . The Role of Quantitative Sputum Cytology in a Comprehensive Approach to Prevention Invasive Lung Cancer 14th International Congress of Cytology, Amsterdam, The Netherlands, May 27-31 (2001).

  25. Zeng, H. (Invited Speaker), Lam, S., Lui, H., McLean, D., Weiss, A., MacAulay, C.:. Optical Spectroscopy and Imaging for Early Cancer Detection, Localization, and Evaluation CCPM Symposium 2001, Kelowna, BC, Canada, July 12 (2001).

  26. Zeng, H., Huang, Z., Hamzavi I., McLean, D., Lui, H.:. Real time in vivo Raman spectroscopy measurements of human skin European Conferences on Biomedical Optics, Munich, Germany, June (2001).

  27. Zeng, H., Korbelik, M., McLean, D., MacAulay, C., Lui, H.: . Monitoring photoproduct formation and photobleaching by fluorescence spectroscopy improves PDT dosimetry IPA 8th World Congress of Photodynamic Medicine, June 5-9, Vancouver, Canada, Abstract Book, pg. 40 (2001).

  28. 2000

  29. Zeng, H. (Invited Speaker), Lui, H., McLean, D.I., MacAulay, C.: . Fluorescence spectroscopy for skin cancer detection and evaluation. Optical Society of America Biomedical Topical Meeting 2000, Miami Beach, Florida, April 2-5 (2000).

  30. Zeng, H. (Invited Speaker), McLean, D.I., MacAulay, C. and Lui, H.: . Autofluorescence properties of skin and applications in dermatology SPIEs Intl. Symposium on Optics and Optoelectronic Inspection and Control: Techniques, Application and Inspection-Conference on Biomedical Photonics and Optoelectronic Imaging, Beijing, China, November 8-10 (2000).

  31. 1999

  32. Lui, H., Bissonnette, R., Zeng, H., and McLean, D.I.: . Photodynamic therapy of skin tumors with an LED array and verteporfin Bios 99, Intl. Biomed. Optics Symp., San Jose, Ca, Jan 22-29, Abstract 3590-09 (1999).

  33. Lui, H., Hobbs, L., McLean, D.I., MacAulay, C., and Zeng, H.: . Autofluorescence imaging of basal cell carcinoma Annual Meeting of Canadian Society for Investigative Dermatology, Vancouver, July 3 (1999).

  34. Zeng, H. (Invited Speaker), MacAulay, C., Lam, S., Palcic, B.: . Light induced fluorescence endoscopy (LIFE) imaging system for early cancer detection SPIEss Intl Symposium on Biomedical Optics-BMO 99, Wuhan, China, October 25-27, Abstract 3863-55 (1999).

  35. Zeng, H., McLean, D.I., MacAulay, C., and Lui, H.: . Autofluorescence imaging of basal cell carcinoma 6th Congress of the International Society for Skin Imaging, London, United Kingdom, July 4-6, Skin Research and Technology, 5, p.159 (1999).

  36. 1998

  37. Dong C, MacAulay C, Kenyon J, Gerla P, Morgan D, Zeng H, MacKinnon N, Wilson JE, Whitehead P, McManus BM: . A novel method for sensitive and reliable detection of cardiac allograft rejection by fluorescence spectroscopy Modern Pathology 11(1): 33A-33A JAN (1998).

  38. Dong, C., MacAulay, C., Kenyon, J.A., Gerla, P., Morgan, D., Zeng, H., MacKinnon, N., Wilson, J.E., Whitehead, P., McManus, B.M.: . A novel method for sensitive and reliable detection of cardiac allograft rejection by fluorescence spectroscopy Eighty-seventh Annual Meeting of the United States and Canadian Academy of Pathology, Boston, MA, Feb. 28 - Mar. 6. Lab. Invest. 78:33A, (1998).

  39. MacAulay, C., Whitehead, P., McManus, B., Zeng, H., Wilson-McManus, J., MacKinnon, N., Morgan, D., Dong, C., Gerla, P. and Kenyon, J.: . Organ transplant tissue rejection: Detection and staging by fluorescence spectroscopy Intl. Symp. on Biomed. Optics, San Jose, Jan. 24-30, Abstract 3245A-06, Page 4 (1998).

  40. Weiss, A.A., Zeng, H., Cline, R., MacAulay, C., MacKinnon, N.: . Use of endoscopic autofluorescence imaging in diagnosis of disease of the esophagus and stomach 1998 American Society for Gastrointestinal Endoscopy Meeting, New Orleans, LA, May 17-20, Gastrointestinal Endoscopy 47(4): 70 , Suppl. S APR (1998).

  41. Zeng, H. (Invited Speaker), Lui, H., McLean, D.I., MacAulay, C., and Palcic, B.: . Update on optical spectroscopy studies of diseased skin. 26th Annual Meeting American Society for Photobiology, Snowbird, Utah, July 11-15, Abstract StPM-E4, P. 10S (1998).

  42. Zeng, H. (Invited Speaker), Weiss, A., Cline, R., and MacAulay, C.: . Endoscopic fluorescence imaging for early cancer detection in the gastrointestinal tract. 26th Annual Meeting American Society for Photobiology, Snowbird, Utah, July 11-15, Abstract StPM-E6, P. 10S (1998).

  43. Zeng, H., McLean, D., MacAulay, C., Palcic, B., Lui., H.:. Autofluorescence of Basal Cell Carcinoma BiOS 98, Intl. Biomed. Optics Symp., San Jose, Jan 24-30, Abstract 3245D-45, Page 15 (1998).

  44. 1997

  45. Zeng, H., Bissonnette, R., McLean, D.I., Schreiber, W.E., Lui, H. and MacAulay, C.. Microscopic localization and identification of fluorophore responsible for the 635 nm peak in the autofluorescence spectrum of psoriatic skin European Laser Assoc. and Biomedical Optics Soc., San Remo, Italy, Sept. 4-8, 1997. Optical Biopsies and Microscopic Techniques II, Vol. 3197, Abstract -05. (1997).

  46. Zeng, H., Weiss, A., Cline, R., MacKinnon, N., Dawson, R., Jaggi, B. and MacAulay, C.. Development of a real time endoscopic fluorescence imaging system for the early detection of cancer in the gastrointestinal tract European Laser Assoc. and Biomedical Optics Soc., San Remo, Italy, Sept. 4-8, (Submitted). (1997).

  47. Zeng, H., Weiss, A., MacAulay, C., MacKinnon, N., Cline, R., Dawson, R.. Development of a Fluorescence Video Endoscopy Imaging System for the early detection of cancer in the Gastrointestinal tract Biomedical Optics' 97, San Jose, Feb., 2976-69:104, (1997).

  48. 1996

  49. Lui, H., Zeng, H., MacAulay, C.E., Palcic, B., McLean, D.I.. Optical spectroscopy as a potential diagnostic aid for dermatology Clinical Dermatology 2000, Vancouver, Canada, May 28-31, 584, p.176, (1996).

  50. Lui, H., Zeng, H., McLean, D.I., MacAulay, C. and Palcic, B.. In vivo fluorescence spectroscopy monitoring of BPD verteporfin concentration changes in skin tissue during photodynamic therapy of skin cancer The First Joint Meeting of the Japanese and Canadian Societies for Investigative Dermatology, May 31 - June 2, J. of Derm. Science, 12:87, Abstract 30, (1996).

  51. Zeng, H., Lui, H., McLean, D.I., MacAulay, C. and Palcic, B.. Update on fluorescence spectroscopy studies of diseased skin SPIE BiOS'96, San Jose, CA, January 27 - February 2, 2671E-42, p. 12, (1996).

  52. Zeng, H., Lui, H., McLean, D.I., MacAulay, C. and Palcic, B.. Penetration depth of topical bpd verteporfin in rabbit skin determined by microspectrophotometer measurements The First Joint Meeting of the Japanese and Canadian Societies for Investigative Dermatology, May 31 - June 2, J. of Dermatological Science 12:86, Abstract 22, (1996).

  53. Zeng, H., MacAulay, C. and Palcic, B.. System for fast measurement of in vivo tissue fluorescence spectra under multiple wavelength excitation SPIE BiOS'96, San Jose, CA, January 27 - February 2, 2676-48, p. 71, (1996).

  54. 1995

  55. Zeng, H., Lui, H., McLean, D.I., MacAulay, C. and Palcic, B.. Optical spectroscopy of diseased skin Biomedical Optics Europe'95, Barcelona, Spain September 12-16, 2628-46:145, (1995).

  56. Zeng, H., MacAulay, C., Lui, H., McLean, D.I. and Palcic, B.. Miniature spectrometer and multi-spectral imager as a potential diagnostic aid in dermatology SPIE Biomedical Optics'95, San Jose, CA, Feb. 4-10, 2387-09:17, (1995).

  57. 1994

  58. Zeng, H., MacAulay, C., McLean, D.I. and Palcic, B.. Spectroscopy and microscopy studies of skin tissue autofluorescence emission BiOS Europe'94, Lille, France, September 6-10, 2324:28, Abstract 33, (1994).

  59. Zeng, H., MacAulay, C., McLean, D.I., Lui, H. and Palcic, B.. Spectroscopic and microscopic properties of skin autofluorescence emission Clinical and Investigative Medicine 17(4):B23, Suppl. B, Abstract 138, (1994).

  60. Zeng, H., MacAulay, C., Palcic, B. and McLean, D.I.. Monte Carlo modeling of tissue autofluorescence measurement and imaging SPIE BiOS'94 Technical Abstracts, Los Angeles, CA, January 22-29, 2135-13:132, (1994).

  61. 1993

  62. Zeng, H., MacAulay, C., Palcic, B. and McLean, D.I.. Laser-induced changes in autofluorescence of in vivo skin SPIE Biomedical Optics'93, January 16-22, Los Angeles, California, Abstract 1882-29, (1993).

  63. Zeng, H., MacAulay, C., Palcic, B. and McLean, D.I.. Autofluorescence distribution in skin tissue revealed by microspectrophotometer measurements SPIE Biomedical Optics'93, Los Angeles, California, January 16-22, Abstract 1876B-24, (1993).

  64. Zeng, H., Palcic, B., MacAulay C. and McLean, D.I.. The dynamics of skin autofluorescence decay induced by continuous wave laser exposure Clinical and Investigative Medicine Suppl. 16(4), Abstract 184, (1993).

Patents

    2005

  1. Zeng, H., Lam, S., Palcic, B.: . Methods and apparatus for fluorescence and reflectance imaging and spectroscopy and for contemporaneous measurements of electromagnetic radiation with multiple measuring devices. United States Patent # 6,898,458, May 24, (2005).

  2. 2004

  3. Zeng, H., Lam, S., Palcic, B.: . Methods and apparatus for fluorescence and reflectance imaging and spectroscopy and for contemporaneous measurements of electromagnetic radiation with multiple measuring devices. United States Patent # 6,826,424, November 30, (2004).

  4. 2003

  5. MacKinnon, N., Lam, S., Zeng, H., MacAulay, C.: . Apparatus for in vivo imaging of the respiratory tract and other internal organs. United States Patent # 6,546,272, April 8 (2003).

  6. Zeng, H., Cline, R., MacAulay, C. and Jaggi, B.:. Imaging system for detecting diseased tissue using native fluorescence in the gastrointestinal and respiratory tract. European Patent # EP0792618B1, October 8, (2003).

  7. 2002

  8. Zeng, H.: . Apparatus and methods relating to high speed Raman spectroscopy. United States Patent #6,486,948, November 26, 2002. (2002).

  9. 2001

  10. Lui, H., MacAulay, C., Zeng, H., McLean, D.I., Bisonnette, R.:. Photoactivation of endogenous porphyrins for treatment of psoriasis. United States Patent # 6,269,818, August 7 (2001).

  11. Whitehead, P., MacAulay, C., MacKinnon, N., Zeng, H., Thompson, C., McManus, B.: . Methods and apparatus for detecting the rejection of transplanted tissue United States Patent # 6,201,989, March 13 (2001).

  12. 2000

  13. Lui, H., Zeng, H., MacAulay, C., Palcic, B. and McLean, D.I.: . Fluorescence scope system for dermatologic diagnosis United States Patent # 6,021,344, February 1, (2000).

  14. Zeng H., Cline, R., MacAulay, C. and Jaggi B.: . Imaging system for detecting diseased tissue using native fluorescence in the gastrointestinal and respiratory tract Japanese Patent #3022377, February 28 (2000).

  15. Zeng, H., Lui, H., MacAulay, C., Palcic, B. and McLean, D.I.: . Apparatus and method to monitor photodynamic therapy (PDT). United States Patent # 6,128,525, October 3 (2000).

  16. Zeng, H., Lui, H., MacAulay, C., Palcic, B. and McLean, D.I.: . Apparatus and methods relating to optical systems for diagnosis of skin diseases United States Patent #6,069,689, May 30 (2000).

  17. 1999

  18. Zeng, H., Lui, H., MacAulay, C., Palcic, B. and McLean, D.I.: . Spectrometer system for diagnosis of skin diseases. United States Patent #6,008,889, December 28 (1999).

  19. 1997

  20. Zeng, H., Cline, R., MacAulay, C. and Jaggi, B.:. Imaging system for detecting diseased tissue using native fluorescence in the gastrointestinal and respiratory tract. US Patent # 5,647,368, July 15 (1997).

  21. Zeng, H., Cline, R., MacAulay, C. and Jaggi, B.: . Imaging system for detecting diseased tissue using native fluorescence in the gastrointestinal and respiratory tract. European Patent # EP792618A1, September 3 (1997).


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