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Objective
- To define an objective grading score for intraepithelial neoplastic lesions using quantitative nuclear morphometry.
Background
As shown in Table 1, there is poor agreement between trial site pathology and final pathology. It is desirable to have an objective grading score which has a higher degree of agreement with final pathology.
Table 1: Comparison of Trial Site Pathology (vertical axis) with Final Pathology (horizontal axis) showing poor agreement between the two
| Final Pathology |
|---|
| Norm | Hyper | Meta | Mild | Mod | Sev | CIS | Cancer |
|---|
| Trial Site Pathology | Norm | 60 | 165 | 12 | 58 | 2 | 0 | 0 | 0 |
|---|
| Hyper | 0 | 43 | 3 | 25 | 10 | 3 | 0 | 0 |
|---|
| Meta | 0 | 0 | 55 | 40 | 26 | 3 | 0 | 0 |
|---|
| Mild | 0 | 5 | 1 | 40 | 8 | 5 | 1 | 0 |
|---|
| Mod | 0 | 0 | 0 | 9 | 22 | 3 | 0 | 0 |
|---|
| Sev | 0 | 0 | 0 | 4 | 3 | 1 | 2 | 0 |
|---|
| CIS | 0 | 0 | 0 | 0 | 1 | 0 | 5 | 2 |
|---|
| Cancer | 0 | 2 | 0 | 1 | 0 | 0 | 1 | 38 |
|---|
34.8% Exact Agreement
66.0% ± 1 Category Agreement
URL: http://www.bccrc.ca/ci/lc01_objective.html
The BC Cancer Agency Research Centre is the research arm of the BC Cancer Agency (BCCA),
and is supported by the BC Cancer Foundation.
This page was last modified at 4:34pm on June 27, 2001
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