• In collaboration with Dr. Adi Gazdar

Materials and Methods

• Blood and bronchial biopsies tested
• Sites examined
  • Rb, 3p25, 3p23-24, 9p, 3p21
  • 5q, 3p14.2, 3p14.3, p53
• Microdissection of 7 micron bronchial biopsy sections adjacent to section on which histopathological assessment was done

Figure 5: Correlation of LOH Index with Pathology Grade More than 3 Sites Informative: Rb, 3p25, 3p23-24, 9p, 3p21, 5q, 3p14.2, 3p14.3, p53 [View Image]

Correlation of LOH with Morphometric Index and Pathology Grade Moderate (4) and Severe (5) Dysplasia Only"

Site(#Cases)	LOH Status	Morphometric Index	Pathology Grade
9p(18)	-1 1	4.9 8	4.2 4.5
Rb(19)	-1 1	4.5 8.4	4.2 4.2
3p14.3(10)	-1 1	4.4 6.6	4.1 5
3p21-22(7)	-1 1	6.6 6.7	4.2 4
3p23-24(19)	-1 1	4.5 6.7	4.2 4.2
3p25(18)	-1 1	4.7 7.8	4.3 4.2

Figure 6: Morphometric Index Repeatability [View Image]

Figure 7: Morphometric Index: Before and After Chemoprevention Two Subjects: Site by Site Comparison [View Image]