Conclusions

• As a group, the Z-scores of lesions classified as CIS by conventional histopathology were different from dysplasia and that dysplasia was distinct from normal.
• There was considerable overlap between the grades of dysplasia; hyperplasia and metaplasia also overlapped dysplasia.
• A better correlation was observed between the morphometric Z score and allelic loss and fluorescence imaging than with conventional histopathology.
• Morphometric chemoprevention results were more consistent than histopathological assessment.
• Morphometric measurements may be a good intermediate endpoint biomarker.

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