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In Press

1. Marotta A, Tan C, Gray V, Malik S, Gallinger S, Sanghera J, Owen D, Dedhar S, and Salh B. Dysregulation of Integrin-linked kinase (ILK) in colorectal carcinogenesis - Modulation by NSAIDS Oncogene (In Press).
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2005

2. Edwards LA, Thiessen B, Dragowska WH, Daynard T, Bally MB, Dedhar S. Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. Oncogene 24(22):3596-605. (2005).
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3. Filipenko NR, Attwell S, Roskelley C, Dedhar S. Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX. Oncogene . (2005).
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4. Hannigan G, Troussard AA, Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 5(1):51-63. (2005).
    [View Abstract - PubMed 15630415]  Request Paper

5. Qian Y, Zhong X, Flynn DC, Zheng JZ, Qiao M, Wu C, Dedhar S, Shi X, Jiang BH. ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene 24(19):3154-65. (2005).
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6. Sutherland BW, Kucab J, Wu J, Lee C, Cheang MC, Yorida E, Turbin D, Dedhar S, Nelson C, Pollak M, Leighton Grimes H, Miller K, Badve S, Huntsman D, Blake-Gilks C, Chen M, Pallen CJ, Dunn SE. Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. Oncogene 24(26):4281-92. (2005).
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2004

7. Barbera MJ, Puig I, Dominguez D, Julien-Grille S, Guaita-Esteruelas S, Peiro S, Baulida J, Franci C, Dedhar S, Larue L, Garcia de Herreros A. Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene 23(44):7345-54. (2004).
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8. Edwards LA, Shabbits JA, Bally M, Dedhar S. Integrin-linked kinase (ILK) in combination molecular targeting. Cancer Treat Res 119:59-75. (2004).
    [View Abstract - PubMed 15164873]  Request Paper

9. Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, Gerszten RE. Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol 24(18):8134-44. (2004).
    [View Abstract - PubMed 15340074]  Request Paper

10. McHardy LM, Sinotte R, Troussard A, Sheldon C, Church J, Williams DE, Andersen RJ, Dedhar S, Roberge M, Roskelley CD. The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange. Cancer Res 64(4):1468-74. (2004).
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11. Oloumi A, McPhee T, Dedhar S. Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochim Biophys Acta 1691(1):1-15. (2004).
     [View Abstract - PubMed 15053919]  Request Paper

12. Quelo I, Gauthier C, Hannigan GE, Dedhar S, St-Arnaud R. Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potency. J Biol Chem 279(42):43893-9. Epub 2004 Aug 6. (2004).
     [View Abstract - PubMed 15299025]  Request Paper

13. Tan C, Cruet-Hennequart S, Troussard A, Fazli L, Costello P, Sutton K, Wheeler J, Gleave M, Sanghera J, Dedhar S. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell 5(1):79-90. (2004).
     [View Abstract - PubMed 14749128]  Request Paper

14. Zhou FQ, Zhou J, Dedhar S, Wu YH, Snider WD. NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron 42(6):897-912. (2004).
     [View Abstract - PubMed 15207235]  Request Paper

2003

15. Attwell S, Mills J, Troussard A, Wu C, Dedhar S. Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Mol Biol Cell 14(12):4813-25. Epub 2003 Sep 5. (2003).
     [View Abstract - PubMed 12960424]  Request Paper

16. Cruet-Hennequart S, Maubant S, Luis J, Gauduchon P, Staedel C, Dedhar S. alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells. Oncogene 22(11):1688-702. (2003).
     [View Abstract - PubMed 12642872]  Request Paper

17. Marotta A, Parhar K, Owen D, Dedhar S, Salh B. Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. Br J Cancer 88(11):1755-62. (2003).
     [View Abstract - PubMed 12771992]  Request Paper

18. Mills J, Digicaylioglu M, Legg AT, Young CE, Young SS, Barr AM, Fletcher L, O'Connor TP, Dedhar S. Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowth. J Neurosci 23(5):1638-48. (2003).
     [View Abstract - PubMed 12629168]  Request Paper

19. Persad S, Dedhar S. The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metastasis Rev 22(4):375-84. (2003).
     [View Abstract - PubMed 12884912]  Request Paper

20. Terpstra L, Prud'homme J, Arabian A, Takeda S, Karsenty G, Dedhar S, St-Arnaud R. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol 162(1):139-48. Epub 2003 Jun 30. (2003).
     [View Abstract - PubMed 12835312]  Request Paper

21. Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem 278(25):22374-8. Epub 2003 Apr 8. (2003).
     [View Abstract - PubMed 12686550]  Request Paper

2002

22. Friedrich EB, Sinha S, Li L, Dedhar S, Force T, Rosenzweig A, Gerszten RE. Role of integrin-linked kinase in leukocyte recruitment. J Biol Chem 277(19):16371-5. Epub 2002 Feb 20. (2002).
     [View Abstract - PubMed 11856758]  Request Paper

23. Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem 277(42):39209-16. Epub 2002 Aug 2. (2002).
     [View Abstract - PubMed 12161443]  Request Paper

24. Tan C, Mui A, Dedhar S. Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-kappa B-dependent manner. J Biol Chem 277(5):3109-16. Epub 2001 Nov 27. (2002).
     [View Abstract - PubMed 11724787]  Request Paper

25. Yoganathan N, Yee A, Zhang Z, Leung D, Yan J, Fazli L, Kojic DL, Costello PC, Jabali M, Dedhar S, Sanghera J. Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties. Pharmacol Ther 93(2-3):233-42. (2002).
     [View Abstract - PubMed 12191615]  Request Paper

2001

26. Marotta A, Tan C, Gray V, Malik S, Gallinger S, Sanghera J, Dupuis B, Owen D, Dedhar S, Salh B. Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene 20(43):6250-7. (2001).
     [View Abstract - PubMed 11593435]  Request Paper

27. Mulholland DJ, Dedhar S, Vogl W. Rat seminiferous epithelium contains a unique junction (Ectoplasmic specialization with signaling properties of both cell/cell and cell/matrix junctions. Biology of Reproduction 64: 396-407 (2001).
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28. Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem 276(29):27462-9. (2001).
     [View Abstract - PubMed 11313365]  Request Paper

29. Persad S, Troussard AA, McPhee TR, Mulholland DJ, Dedhar S. Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J Cell Biol 153(6):1161-74. (2001).
     [View Abstract - PubMed 11402061]  Request Paper

30. Roskelley CD, Williams DE, McHardy LM, Leong KG, Troussard A, Karsan A, Andersen RJ, Dedhar S, Roberge M. Inhibition of tumor cell invasion and angiogenesis by motuporamines. Cancer Res 61(18):6788-94. (2001).
     [View Abstract - PubMed 11559552]  Request Paper

31. Roskelley CD, Williams DE, McHardy LM, Leong KG, Troussard A, Karsan A, Andersen RJ, Dedhar S, and Roberge M. Inhibition of tumour cell invasion and angiogenesis by motuporamines Cancer Res. 61: 6788-6794 (2001).
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32. Somasiri A, Howarth A, Goswami D, Dedhar S, Roskelley CD. Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells. J Cell Sci 114(Pt 6):1125-36. (2001).
     [View Abstract - PubMed 11228156]  Request Paper

33. Tan C, Costello P, Sanghera J, Dominguez D, Baulida J, de Herreros AG, Dedhar S. Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. Oncogene 20(1):133-40. (2001).
     [View Abstract - PubMed 11244511]  Request Paper

34. White DE, Cardiff RD, Dedhar S, Muller WJ. Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene 20(48):7064-72. (2001).
     [View Abstract - PubMed 11704830]  Request Paper

35. Wu C, Dedhar S. Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J Cell Biol 155(4):505-10. Epub 2001 Nov 5. (2001).
     [View Abstract - PubMed 11696562]  Request Paper

2000

36. Attwell S, Roskelley C, Dedhar S. The integrin-linked kinase (ILK) suppresses anoikis. Oncogene 19(33):3811-5. (2000).
     [View Abstract - PubMed 10949937]  Request Paper

37. Coppolino M, Dedhar S. Bi-directional signal transduction by Integrin Receptors Int. J. Biochem. and Cell Biol. 32: 171-188 (2000).
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38. D'Amico M, Hulit J, Amanatullah DF, Zafonte BT, Albanese C, Bouzahzah B, Fu M, Augenlicht LH, Donehower LA, Takemaru K, Moon RT, Davis R, Lisanti MP, Shtutman M, Zhurinsky J, Ben-Ze'ev A, Troussard AA, Dedhar S, Pestell RG. The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways. J Biol Chem 275(42):32649-57. (2000).
     [View Abstract - PubMed 10915780]  Request Paper

39. Dedhar S. Cell-substrate interactions and signalling through integrin-linked kinase (ILK). Curr. Opin. Cell Biol. (Cell Regulation) 12: 250-256 (2000).
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40. Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci U S A 97(7):3207-12. (2000).
     [View Abstract - PubMed 10716737]  Request Paper

41. Rauch F, Prud'homme J, Arabian A, Dedhar S, St-Arnaud R. Heart, brain, and body wall defects in mice lacking calreticulin. Exp Cell Res 256(1):105-11. (2000).
     [View Abstract - PubMed 10739657]  Request Paper

42. Troussard AA, Costello P, Yoganathan TN, Kumagai S, Roskelley CD, Dedhar S. The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene 19(48):5444-52. (2000).
     [View Abstract - PubMed 11114721]  Request Paper

43. Yoganathan TN, Costello P, Chen X, Jabali M, Yan J, Leung D, Zhang Z, Yee A, Dedhar S, Sangera J. Integrin linked kinase: a "hot" therapeutic target. Biochemical Pharmacol 60: 1115-1119 (2000).
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1999

44. Coppolino MG, Dedhar S. Ligand-specific, transient interaction between integrins and calreticulin during cell adhesion to extracellular matrix proteins is dependent upon phosphorylation/dephosphorylation events. Biochem J 340 ( Pt 1):41-50. (1999).
     [View Abstract - PubMed 10229657]  Request Paper

45. Dedhar S, Williams B, Hannigan G. Integrin linked kinase (ILK): a regulator of integrin and growth factor signalling. Trends Cell Biol. 9: 319-323 (1999).
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46. Novak A, Dedhar S. Signalling through β-catenin and LEF/TCF Cellular and Mol. Life Sci. 56: 523-537 (1999).
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47. Troussard AA, Tan C, Yoganathan TN, Dedhar S. Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner. Mol Cell Biol 19(11):7420-7. (1999).
     [View Abstract - PubMed 10523630]  Request Paper

1998

48. Coppolino M, Dedhar S. Molecules in Focus: Calreticulin. . Int. J. Biochem. and Cell Biol. 30: 553-558 (1998).
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49. Dedhar S. Integrins and signal transduction. Curr. Opin. Haematology 6: 37-43 (1998).
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50. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci U S A 95(19):11211-6. (1998).
     [View Abstract - PubMed 9736715]  Request Paper

51. Novak A, Hsu SC, Leung-Hagesteijn C, Radeva G, Papkoff J, Montesano R, Roskelley C, Grosschedl R, Dedhar S. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc Natl Acad Sci U S A 95(8):4374-9. (1998).
     [View Abstract - PubMed 9539744]  Request Paper

52. Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci U S A 95(25):14821-6. (1998).
     [View Abstract - PubMed 9843973]  Request Paper

53. Wu C, Keightley SY, Leung-Hagesteijn C, Radeva G, Coppolino M, Goicoechea S, McDonald JA, Dedhar S. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J Biol Chem 273(1):528-36. (1998).
     [View Abstract - PubMed 9417112]  Request Paper

1997

54. Coppolino MG, Woodside MJ, Demaurex N, Grinstein S, St-Arnaud R, Dedhar S. Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion. Nature 386(6627):843-7. (1997).
     [View Abstract - PubMed 9126744]  Request Paper

55. Hannigan GE, Bayani J, Weksberg R, Beatty B, Pandita A, Dedhar S, Squire J. Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15.5-p15.4. Genomics 42(1):177-9. (1997).
     [View Abstract - PubMed 9177792]  Request Paper

56. Hannigan GE, Dedhar S. Protein kinase mediators of integrin signal transduction. J Mol Med 75(1):35-44. (1997).
     [View Abstract - PubMed 9020382]  Request Paper

57. Radeva G, Petrocelli T, Behrend E, Leung-Hagesteijn C, Filmus J, Slingerland J, Dedhar S. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J Biol Chem 272(21):13937-44. (1997).
     [View Abstract - PubMed 9153256]  Request Paper

58. Shago M, Flock G, Leung Hagesteijn CY, Woodside M, Grinstein S, Giguere V, Dedhar S. Modulation of the retinoic acid and retinoid X receptor signaling pathways in P19 embryonal carcinoma cells by calreticulin. Exp Cell Res 230(1):50-60. (1997).
     [View Abstract - PubMed 9013706]  Request Paper

1996

59. Dedhar S, Hannigan GE. Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr Opin Cell Biol 8(5):657-69. (1996).
     [View Abstract - PubMed 8939656]  Request Paper

60. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 379(6560):91-6. (1996).
     [View Abstract - PubMed 8538749]  Request Paper

61. Kim YS, MacDonald PN, Dedhar S, Hruska KA. Association of 1 alpha,25-dihydroxyvitamin D3-occupied vitamin D receptors with cellular membrane acceptance sites. Endocrinology 137(9):3649-58. (1996).
     [View Abstract - PubMed 8756529]  Request Paper

62. St. Arnaud R, Candelieve GA, Dedhar S. New mechanisms of regulation of the genomic actions of Vitamin D in bone cells: Interaction of the Vitamin D receptor with non-classical response elements and with multifunctional protein, calreticulin. Frontiers in Bioscience 1: 176-187 (1996).
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1995

63. Coppolino M, Leung-Hagesteijn C, Dedhar S, Wilkins J. Inducible interaction of integrin α₂β₁ with calreticulin: Dependence on the activation-state of the integrin J. Biol. Chem. 270: 23132-23138 (1995).
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64. Coppolino M, Migliorini M, Argraves WS, Dedhar S. Identification of a novel form of the alpha 3 integrin subunit: covalent association with transferrin receptor. Biochem J 306 ( Pt 1):129-34. (1995).
     [View Abstract - PubMed 7864799]  Request Paper

65. Demetriou M, Nabi IR, Coppolino M, Dedhar S, Dennis JW. Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V. J Cell Biol 130(2):383-92. (1995).
     [View Abstract - PubMed 7615638]  Request Paper

66. Jewell K, Kapron-Bras C, Jeevaratnam P, Dedhar S. Stimulation of tyrosine phosphorylation of distinct proteins in response to antibody-mediated ligation and clustering of alpha 3 and alpha 6 integrins. J Cell Sci 108 ( Pt 3):1165-74. (1995).
     [View Abstract - PubMed 7622602]  Request Paper

67. St-Arnaud R, Prud'homme J, Leung-Hagesteijn C, Dedhar S. Constitutive expression of calreticulin in osteoblasts inhibits mineralization. J Cell Biol 131(5):1351-9. (1995).
     [View Abstract - PubMed 8522595]  Request Paper

1994

68. Dedhar S. Novel functions for calreticulin: interaction with integrins and modulation of gene expression? Trends Biochem Sci 19(7):269-71. (1994).
     [View Abstract - PubMed 8048166]  Request Paper

69. Dedhar S, Rennie PS, Shago M, Hagesteijn CY, Yang H, Filmus J, Hawley RG, Bruchovsky N, Cheng H, Matusik RJ, et al.. Inhibition of nuclear hormone receptor activity by calreticulin. Nature 367(6462):480-3. (1994).
     [View Abstract - PubMed 8107809]  Request Paper

70. Kruk PA, Uitto VJ, Firth JD, Dedhar S, Auersperg N. Reciprocal interactions between human ovarian surface epithelial cells and adjacent extracellular matrix. Exp Cell Res 215(1):97-108. (1994).
     [View Abstract - PubMed 7525326]  Request Paper

71. Leung-Hagesteijn CY, Milankov K, Michalak M, Wilkins J, Dedhar S. Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin alpha-subunit-binding protein. J Cell Sci 107 ( Pt 3):589-600. (1994).
     [View Abstract - PubMed 8006073]  Request Paper

72. Thacker JD, Dedhar S, Hogge DE. The effect of GM-CSF and G-CSF on the growth of human osteosarcoma cells in vitro and in vivo. Int J Cancer 56(2):236-43. (1994).
     [View Abstract - PubMed 7508889]  Request Paper

1993

73. Dedhar S, Gray V, Robertson K, Haqq C. Differential regulation of expression of specific integrin receptors by nerve growth factor and transforming growth factor β₁ during differentiation of human neuroblastoma cells Mol. Cell. Diff. 1: 1-20 (1993).
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74. Dedhar S, Saulnier R, Nagle R, Overall CM. Specific alterations in the expression of alpha 3 beta 1 and alpha 6 beta 4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected by in vitro invasion through reconstituted basement membrane. Clin Exp Metastasis 11(5):391-400. (1993).
     [View Abstract - PubMed 8375114]  Request Paper

75. Hughes DE, Salter DM, Dedhar S, Simpson R. Integrin expression in human bone. . J. Bone and Mineral Research, 8: 527-533 (1993).
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76. Kapron-Bras C, Fitz-Gibbon L, Jeevaratnam P, Wilkins J, Dedhar S. Stimulation of tyrosine phosphorylation and accumulation of GTP-bound p21ras upon antibody-mediated alpha 2 beta 1 integrin activation in T-lymphoblastic cells. J Biol Chem 268(28):20701-4. (1993).
     [View Abstract - PubMed 8407889]  Request Paper

77. McGlade J, Brunkhorst B, Anderson D, Mbamalu G, Settleman J, Dedhar S, Rozakis-Adcock M, Chen LB, Pawson T. The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J 12(8):3073-81. (1993).
     [View Abstract - PubMed 8344248]  Request Paper

1992

78. Dedhar S, Eaves C. Effects of hematopoietic growth factors on nonhematopoietic cells. Immunol Ser 57:601-14. (1992).
     [View Abstract - PubMed 1504149]  Request Paper

79. Dedhar S, Gray V, Robertson K, Saulnier R. Identification and characterization of a novel high-molecular-weight form of the integrin alpha 3 subunit. Exp Cell Res 203(1):270-5. (1992).
     [View Abstract - PubMed 1426047]  Request Paper

80. Dedhar S, Jewell K, Rojiani M, Gray V. The receptor for the basement membrane glycoprotein entactin is the integrin alpha 3/beta 1. J Biol Chem 267(26):18908-14. (1992).
     [View Abstract - PubMed 1527019]  Request Paper

81. Lang LM, Gailey C, Myrdal SE, Dedhar S, Auersperg N. Divergence in patterns of invasion among subpopulations derived from a human carcinoma clone: roles of intercellular contacts and of cell-substratum adhesion. Tumour Biol 13(5-6):364-77. (1992).
     [View Abstract - PubMed 1290033]  Request Paper

1991

82. Akiyama H, Kawamata T, Dedhar S, McGeer PL. Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue. J Neuroimmunol 32(1):19-28. (1991).
     [View Abstract - PubMed 1705945]  Request Paper

83. Dedhar S, Robertson K, Gray V. Induction of expression of the alpha v beta 1 and alpha v beta 3 integrin heterodimers during retinoic acid-induced neuronal differentiation of murine embryonal carcinoma cells. J Biol Chem 266(32):21846-52. (1991).
     [View Abstract - PubMed 1939209]  Request Paper

84. Finlay BB, Ruschkowski S, Dedhar S. Cytoskeletal rearrangements accompanying salmonella entry into epithelial cells. J Cell Sci 99 ( Pt 2):283-96. (1991).
     [View Abstract - PubMed 1909337]  Request Paper

85. Rojiani MV, Finlay BB, Gray V, Dedhar S. In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits. Biochemistry 30(41):9859-66. (1991).
     [View Abstract - PubMed 1911778]  Request Paper

1990

86. Dedhar S. Integrins and tumor invasion. Bioessays 12(12):583-90. (1990).
     [View Abstract - PubMed 2080913]  Request Paper

87. Dedhar S, Gray V. Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v. J Cell Biol 110(6):2185-93. (1990).
     [View Abstract - PubMed 1693626]  Request Paper

88. Dedhar S, Saulnier R. Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes. J Cell Biol 110(2):481-9. (1990).
     [View Abstract - PubMed 1688858]  Request Paper

89. Lemoine FM, Dedhar S, Lima GM, Eaves CJ. Transformation-associated alterations in interactions between pre-B cells and fibronectin. Blood 76(11):2311-20. (1990).
     [View Abstract - PubMed 2147863]  Request Paper

90. McGeer PL, Zhu SG, Dedhar S. Immunostaining of human brain capillaries by antibodies to very late antigens. J Neuroimmunol 26(3):213-8. (1990).
     [View Abstract - PubMed 1689743]  Request Paper

91. Sutherland H, Dougherty G, Dedhar S. Developmental biology and oncology. Two sides of the same coin? New Biologist 2(11): 970-973 (1990).
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1989

92. Dedhar S. Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. J Cell Physiol 138(2):291-9. (1989).
     [View Abstract - PubMed 2521862]  Request Paper

93. Dedhar S. Signal transduction via the beta 1 integrins is a required intermediate in interleukin-1 beta induction of alkaline phosphatase activity in human osteosarcoma cells. Exp Cell Res 183(1):207-14. (1989).
     [View Abstract - PubMed 2786815]  Request Paper

94. Dedhar S, Haqq C, Gray V. Specific overproduction of very late antigen 1 integrin in two human neuroblastoma cell lines selected for resistance to detachment by an Arg-Gly-Asp-containing synthetic peptide. J Biol Chem 264(9):4832-6. (1989).
     [View Abstract - PubMed 2784439]  Request Paper

95. Dedhar S, Mitchell MD, Pierschbacher MD. The osteoblast-like differentiated phenotype of a variant of MG-63 osteosarcoma cell line correlated with altered adhesive properties. Connect Tissue Res 20(1-4):49-61. (1989).
     [View Abstract - PubMed 2533054]  Request Paper

96. Klingemann HG, Dedhar S. Distribution of integrins on human peripheral blood mononuclear cells. Blood 74(4):1348-54. (1989).
     [View Abstract - PubMed 2475187]  Request Paper

1988

97. Dedhar S, Gaboury L, Galloway P, Eaves C. Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin. Proc Natl Acad Sci U S A 85(23):9253-7. (1988).
     [View Abstract - PubMed 3057504]  Request Paper

1987

98. Dedhar S, Argraves WS, Suzuki S, Ruoslahti E, Pierschbacher MD. Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp-containing peptide overproduce the fibronectin receptor. J Cell Biol 105(3):1175-82. (1987).
     [View Abstract - PubMed 2443508]  Request Paper

99. Dedhar S, Ruoslahti E, Pierschbacher MD. A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence. J Cell Biol 104(3):585-93. (1987).
     [View Abstract - PubMed 3469204]  Request Paper

1986

100. Dedhar S, Freisheim JH, Hynes JB, Goldie JH. Further studies on substituted quinazolines and triazines as inhibitors of a methotrexate-insensitive murine dihydrofolate reductase. Biochem Pharmacol 35(7):1143-7. (1986).
      [View Abstract - PubMed 3964294]  Request Paper

1985

101. Dedhar S, Goldie JH. Methotrexate-resistant human promyelocytic leukemia (HL-60) cells express a dihydrofolate reductase with altered properties associated with increased enzyme activity. Biochem Biophys Res Commun 129(2):536-45. (1985).
      [View Abstract - PubMed 3860203]  Request Paper

102. Dedhar S, Hartley D, Fitz-Gibbons D, Phillips G, Goldie JH. Heterogeneity in the specific activity and methotrexate sensitivity of dihydrofolate reductase from blast cells of acute myelogenous leukemia patients. J Clin Oncol 3(11):1545-52. (1985).
      [View Abstract - PubMed 3863895]  Request Paper

103. Dedhar S, Hartley D, Goldie JH. Increased dihydrofolate reductase activity in methotrexate-resistant human promyelocytic-leukaemia (HL-60) cells. Lack of correlation between increased activity and overproduction. Biochem J 225(3):609-17. (1985).
      [View Abstract - PubMed 3856428]  Request Paper

1983

104. Dedhar S, Freisheim JH, Hynes JB, Goldie JH. Inhibition of a methotrexate-insensitive dihydrofolate reductase from L5178Y cells by substituted triazines and quinazolines. Biochem Pharmacol 32(5):922-4. (1983).
      [View Abstract - PubMed 6838639]  Request Paper

105. Dedhar S, Goldie JH. Overproduction of two antigenically distinct forms of dihydrofolate reductase in a highly methotrexate-resistant mouse leukemia cell line. Cancer Res 43(10):4863-71. (1983).
      [View Abstract - PubMed 6192911]  Request Paper

1982

106. Hill BT, Dedhar S, Goldie JH. Preliminary communications. Biochem Pharmacol 31(2):263-6. (1982).
      [View Abstract - PubMed 6977363]  Request Paper

1981

107. Goldie JH, Dedhar S, Krystal G. Properties of a methotrexate-insensitive variant of dihydrofolate reductase derived from methotrexate-resistant L5178Y cells. J Biol Chem 256(22):11629-35. (1981).
      [View Abstract - PubMed 7298621]  Request Paper

1980

108. Goldie JH, Krystal G, Hartley D, Gudauskas GA, Dedhar S. A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells Eur. J. Cancer 16: 1539-1546 (1980).
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1978

109. Tidd DM, Dedhar S. Specific and sensitive combined high performance liquid chromatographic-flow fluorometric assay for intracellular 6-thioguanine nucleotide metabolites of 6-mercaptopurine and 6-thioguanine. J. Chromatography 145: 237-246 (1978).
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