Chad A. Malloff, B.Sc., M.Sc.

 camalloff@bccrc.ca

• Coordinator of Laboratory Operations
• Safety Officer

Department:	Cancer Genetics (@ the BCCRC since 1998)
Research Role:	Research Administration
Education:	B.Sc (Microbiology), UBC, 1997 M.Sc. (Pathology), UBC, 2002
Phone:	604-675-8000 ext.7707 or ext.7699

Research Interests:

Genetic alterations responsible for the development of cancer

Prostate Cancer

Mantle Cell Lymphoma

Pathogen Genomes

Bacterial Comparative Genomic Hybridization

Identification of genes involved in cancer progression and genes involved in bacterial pathogenesis. The majority of my work has dealt with the use of Two-dimensional DNA electrophoresis to compare large genomes. Along with my supervisor I have developed a Bacterial Comparative Genomic Hybridization (BCGH) method for the identification of acquired DNA in bacterial genomes. This technique has been applied to the identification of drug resistance both at the DNA and RNA level. Adaptations of this technique are also being used to look at mutations in specific cancer linked genes as well as whole-genome scanning of alterations in lung cancer.

Publications

Malloff CA, Fernandez RC, Lam WL (2001) Comaprative bacterial genomic hybridization. J Mol Biol. 312: 1-5.

Dullaghan EM, Malloff CA, Li AH, Lam WL, Stokes RW (2002) Two-dimensional bacterial genome display: a method for the genomic analysis of mycobacteria. Microbiology 148: 3111-7.

Malloff CA, Fernandez RC, Dullaghan EM, Stokes RW, Lam WL (2002) Two-dimensional display of respiratory pathogen genomes of high G + C DNA content. Gene 293: 205-11.

Malloff CA, Dullaghan EM, I A, Stokes RW, Fernandez RC, Lam WL (2003) Two-dimensional DNA displays for comparisons of bacterial genomes. Biol. Proced. On. 53: 143-52.

Watson SK, DeLeeuw RJ, Ishkanian AS, Malloff CA, Lam WL (2004) Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays. BMC Genomics 5, 6: 1-8.

Ishkanian AS, Malloff CA, Watson SK, DeLeeuw RJ, Chi B, Coe BP, Snijders A, Albertson DG, Pinkel D, Marra MA, Ling V, MacAulay, C, Lam WL (2004) A tiling resolution DNA microarray with complete coverage of the human genome. Nature Genetics 36: 299-303.

Ishkanian AI*, Malloff CA*, Meng A, Ho J, Albert M, Syed, A, van der Kwast T, Milosevic M, Lam WL, Bristow RG (2009) High-resolution array CGH identifies novel regions of genomic alteration in intermediate-risk prostate cancer. Prostate 69: 1091-1100.

 BCCRC | Cancer Genetics | Lam Lab | Lab Publications |

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