akuo@bccrc.ca

Research Interests:

My research focuses on cancer genetics and epigenetics. In my project, I look for the relationship between histone modification and DNA methylation, one of the two main epigenetic events. Although the silencing of tumour suppressor genes is well documented, the epigenetic events that drive cancer progression have not been well identified. While integrating the mechanisms of DNA methylation and histone modifications, such research would shed light on how genes are deregulated during cancer development and could lead to the development of new targets for cancer treatment.

PUBLICATION:

Kuo ANC, Wilson IM, Vucic E, Lee EHL, Davies JJ, MacAulay C, Brown CJ, Lam WL. 'Comparative Cancer Epigenomics' in Comparative Genomics: Fundamental and Applied Perspectives (Brown JR, ed.), CRC Press / Taylor and Francis, LLC. Boca Raton, FLA. Published 2007.

AWARDS AND SCHOLARSHIP:

UBC University Graduate Fellowship

Natural Sciences and Engineering Research Council of Canada- Junior Award.

Best Student Abstract, 2006 World Microarray Congress.

INVITED TALKS:

Kuo A. (2007) Epigenetics: Chromatin and Histone Modification. 2007 Orientation of Cancer Genetics and Developmental Biology Department to Medical Oncology Residents. July 5, 2007

Kuo A. (2007) An Integrative Look at the Epigenome: DNA Methylation and Histone H3K9 Methylation. British Columbia Cancer Research Centre Trainee Seminar Series. April 12, 2007

Kuo ANC, Davies JJ, Wilson IM, Lam WL. (2006) High-resolution Analysis of Global Methylation Patterns in Lung Cancer. 2006 World Microarray Congress. (Best Student Abstract Award) March 24, 2006

Kuo ANC. (2006) Histone modification and application of ChIP-on-Chip assay. Canadian Institute of Health Research (CIHR) Molecular Pathology Training Program Array CGH Workshop. January 18. 2006

ABSTRACT AND PRESENTATIONS:

Kuo ANC, deLeeuw RJ, Chan WC, Gascoyne RD, Lam WL. (2008) Multi-dimensional study of the genetic, epigenetic, and gene expression of mantle cell lymphoma. 2008 World Microarray Congress. Vancouver BC.

Kuo ANC, Wilson IM, Coe BP, Chari R, Lam WL. (2008) Global DNA Methylation and Histone H3K9 Modifications Profiles of the Human HCC15 Cancer Genome. UBC Pathology Day. May 29th 2008. Abstract #28.

Kuo ANC, Wilson IM, Coe BP, Chari R, Lam WL. (2008) Global DNA Methylation and Histone H3K9 Modifications Profiles of the Human HCC15 Cancer Genome. American Association for Cancer Research Annual Meeting, San Diego CA. Abstract #6866

Kuo ANC, deLeeuw RJ, Chan WC, Gascoyne RD, Lam WL. (2007) Integrative Analysis of the Genome, Methylome, and Transcriptome of Mantle Cell Lymphoma. British Columbia Cancer Agency Annual Conference.

Kuo ANC, Wilson IM, Coe, BP, Chari R, Davies JJ, Lam WL. (2007) Integrative analysis of the genome and epigenome: DNA Copy Number Changes, Global DNA Methylation and Histone H3K9 Methylation in Lung Cancer. 2007 World Microarray Congress.

Kuo ANC, Wilson IM, Coe, BP, Chari R, Davies JJ, Lam WL. (2007) The interplay between the genome and the epigenome. University of British Columbia Pathology Day. Abstract # 25.

Davies JJ, Wilson IM, Kuo ANC, Lam WL (2006) Epigenomic variation in cancer. British Columbia Cancer Agency Annual Conference. 2006 British Columbia Cancer Conference Proceedings: 16.

Kuo ANC, Davies JJ, Wilson IM, Lam WL (2006) A whole genome approach to study histone H3K9 residue modificaions in human. British Columbia Cancer Agency Annual Conference. 2006 British Columbia Cancer Conference Proceedings: 29.

Kuo ANC, Davies J, Wilson IM, Lam WL (2006) A whole genome approach to study histone H3K9 residue modifications in the human genome. 2006 Genome BC Annual Meeting.

Kuo ANC, Davies JJ, Wilson IM, Lam WL (2006) A whole genome approach to study histone H3K9 residue modifications in the human genome. 2006 University of British Columbia Annual Pathology Day.

Kuo ANC, Davies JJ, Wilson IM, Chari R, Lam WL. (2006) Parallel Analysis of the Epigenome: DNA Methylation and Histone Modifications. 11th Annual Advancing Practice, Instruction and Innovation through Informatics Conference (APIII). Abstract # 116. Archives of Pathology and Laboratory Medicine.

Kuo ANC, Davies JJ, Wilson IM, Lam WL. (2006) A Whole Genome Approach to Study Histone H3K9 Residue Modifications in the Human Genome. University of British Columbia Pathology Day. Abstract #35.

Kuo ANC, Davies JJ, Wilson IM, Lam WL (2006) A whole genome approach to study histone H3K9 residue modifications in the human genome. 2006 Genome BC Annual Meeting.

Davies JJ, deLeeuw RJ, Kuo ANC, Lam WL (2006) Adaptation of a novel whole-genome epigenetic profiling technology for identifying genes disrupted in clinical mantle cell lymphoma. 2006 Genome BC Annual Meeting

Davies JJ, Kuo A, Wilson IM, Shadeo A, MacAulay C, Lam WL. (2006) Whole-genome Tiling Path Array CGH Analysis of DNA Methylation Levels in Breast Cancer Cells. 97th Annual American Association for Cancer Research (AACR). Abstract #2367.

Kuo ANC, Davies JJ, Wilson IM, Lam WL. (2006) High-resolution Analysis of Global Methylation Patterns in Lung Cancer. 2006 World Microarray Congress. (Best Student Abstract Award) [listed as above]

Kuo A, Davies JJ, Wilson IM, Vucic E, Lam WL. (2005) Detection of Known and Novel Imprinted Regions Throughout the Genome. British Columbia Cancer Agency Annual Conference.

Wilson IM, Davies JJ, Kuo ANC, Lam WL. (2005) High-throughput Epigenomic Analysis of CpG Islands. British Columbia Cancer Agency Annual Conference.

Kuo A, Coe BP, MacAulay C, Lam S, Lam WL. (2005) Novel Genomic Alterations in Small Cell Lung Cancer. Genome BC Annual Meeting.

Kuo A, Davies JJ, Wilson IM, Vucic E, Lam WL. (2005) Genome-wide Detection of Known and Novel Imprinted Regions. University of British Columbia Pathology Day. Abstract #15.

Wilson IM, Davies JJ, Kuo A, Lam WL. (2005) Construction of a High-Throughput Screen for Promoter CpG Island Hypermethylation. University of British Columbia Pathology Day. Abstract#52.

See Also:

• Jon Davies
• Ian Wilson
• Epigenomics