Recent Lam Lab Publications

2010

Chari R, Thu KL, Wilson IM, Lockwood WW, Lonergan KM, Coe BP, Malloff CA, Gazdar AF, Lam S, Garnis C, MacAulay CE, Alvarez CE, Lam WL (2010) Integrating the multiple dimensions of genomic and epigenomic lanscapes of cancer. Cancer and Metastasis Reviews 29: 73-93.

Lonergan, KM, Chari R, Coe BP, Wilson IM, Tsao MS, Ng RT, MacAulay C, Lam S, Lam WL (2010) Transcriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGE. PLoS ONE 5: e9162, 1-22.

Starczynowski D, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, Hirst M, Hogge D, Marra M, Wells R, Lam W, Humphries K, Karsan A (2009) Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nature Medicine 16: 49-58.

Thu KL, Pikor LA, Kennett JY, Alvarez CE, Lam WL (2010) Methylation analysis by DNA immunoprecipitation. Journal of Cellular Physiology 222: 522-31.

Gazdar AF, Girard L, Lockwood W, Lam W, Minna JD (2010) Lung cancer cell lines as tools for biomedical discovery and research. Journal of the National Cancer Institute. In press.

Dong X, Guan J, English JC, Flint J, Yee J, Evans K, Murray N, MacAulay C, Ng R, Gout PW, Lam WL, Laskin J, Ling V, Lam S, Wang YZ (2010) Patient-derived first generation xenografts of non-small cell lung cancers: Promising tools for predicting drug responses for personalized chemotherapy. Clinical Cancer Research. In press.

Vucic EA, Thu KL, Williams AC, Lam WL, Coe BP (2009) Copy number variations in the human genome and strategies for analysis. Methods in Molecular Biology. In press.

2009

Thu KL, Lam WL, Coe BP (2009) The emerging role of copy number variation in cancer. Cell Science 6: 98, 1-23.

Soh J*, Okumura N*, Lockwood WW, Yamamoto H, Shigematsu H, Zhang W, Chari R, Shames D, Tang X, MacAulay C, Varella-Garcia M, Vooder T, Wistuba II, Lam S, Brekken R, Toyooka S, Minna JD, Lam WL, Gazdar AF (2009) Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells. PLoS ONE 4: e7464, 1-13.

Tsui IFL, Poh CF, Garnis C, Rosin MP, Zhang L, Lam WL (2009) Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias. International Journal of Cancer 125: 2219-2228.

Garnis C, Chari R, Buys TPH, Zhang L, Ng RT, Rosin MP, Lam WL (2009) Genomic imbalances in precancerous tissues signal oral cancer risk. Molecular Cancer 8: 50, 1-7.

Astanehe A, Finkbeiner MR, Hojabrpour P, To K, Fotovati A, Shadeo A, Stratford AL, Lam WL, Berquin IM, Duronio V, Dunn SE (2009) The transcriptional induction of PIK3CA in tumor cells is dependent upon the oncoprotein Y-box binding protein-1 (YB-1). Oncogene 28: 2406-2418.

Vucic EA, Wilson IM, Campbell JM, Lam WL (2009) Methylation analysis by DNA immunoprecipitation (MeDIP). Methods in Molecular Biology 556: 141-153.

van Nederveen FH, Korpershoek E, deLeeuwRJ, Verhofstad AA, Lenders JW, Dinjens WN, Lam WL, de Krijger RR (2009) Array-CGH in sporadic benign pheochromocytomas. Endocrine Related Cancers 16: 505-513.

Coe BP, Lockwood WW, Chari R, Lam WL (2009) Comparative Genomic Hybridization on BAC Arrays. Methods in Molecular Biology 556: 7-19.

Ishkanian AI*, Malloff CA*, Meng A, Ho J, Albert M, Syed, A, van der Kwast T, Milosevic M, Lam WL, Bristow RG (2009) High-resolution array CGH identifies novel regions of genomic alteration in intermediate-risk prostate cancer. Prostate 69: 1091-1100.

Watson SK, Woolcock BW, Fee JN, Bainbridge TC, Webber D, Kinahan TJ, Lam WL, Vielkind JR (2009) Minimum altered regions in early prostate cancer progression identified by high resolution whole genome tiling path BAC array comparative hybridization. Prostate 69: 961-975.

Iqbal J, Kucuk C, deLeeuw RJ, Srivastava G, Tam W, Geng H, Klinkebiel D, Christman JK, Patel K, Cao K, Shen L, Dybkaer K, Tsui IFL, Ali H, Shimizu N, Au WY, Lam WL, Chan WC. (2009) Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia 23: 1139-1151.

Ma S, Chan YP, Woolcock B, Wong KY, Bainbridge T, Webber D, Guan X-Y, Lam W, Vielkind J, Chan KW (2009) DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer. International Journal of Cancer 124: 2323-2332.

Thu KL*, Vucic EA*, Kennett JY, Heryet C, Brown CJ, Lam WL, Wilson IM (2009) Methylated DNA Immunoprecipitation. Journal of Visualized Experiments 23. pii: 935. doi: 10.3791/935.

Gandhi JK, Zhang J, Xie Y, Shigematsu H, Soh J, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Varella-Garcia M, Minna JD, Gazdar AF (2009) Molecular changes in lung cancers and sensitivity to tyrosine kinase inhibitors. PLoS ONE 4: e4576, 1-11.

Buys TPH, Aviel-Ronen S, Waddell TK, Lam WL, Tsao MS (2009) Defining genomic alteration boundaries for a combined small cell and non-small cell lung carcinoma. Journal of Thoracic Oncology 4: 227-239.

Kubo T, Yamamoto H, Lockwood WW, Valencia I, Fujii T, Ouchida M, Soh J, Takigawa N, Kiura K, Shimizu K, Date H, Minna JD, Lam WL, Gazdar AF, Toyooka S (2009) MET gene amplification in lung cancers untreated with gefitinib. International Journal of Cancer 124: 1778-1784.

Finkbeiner MR, Astanehe A, To K, Fotovati A, Davies AH, Zhao Y, Jiang H, Stratford AL, Shadeo A, Boccaccio C, Comoglio P, Mertens PR, Eirew P, Raouf A, Eaves CJ, Dunn SE (2009) Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells. Oncogene 28: 1421-1431. [Shadeo′s Lam Lab publication]

Cheung KJ, Shah SP, Steidl C, Johnson N, Relander T, Telenius A, Lai B, Murphy KP, Lam W, Al-Tourah AJ, Connors JM, Ng RT, Gascoyne RD, Horsman DE (2009) Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances. Blood 113: 137-148.

2008

Chari R, Coe BP, Wedseltoft C, Benetti M, Wilson IM., Vucic EA., MacAulay C, Ng RT, Lam WL (2008) SIGMA2: A system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes. BMC Bioinformatics 9, 422: 1-12.

Lockwood WW, Chari R, Coe BP, Girard L, MacAulay C, Lam S, Gazdar AF, Minna JD, Lam WL (2008) DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers. Oncogene 27: 4615-4624.

Campbell JM*, Lockwood WW*, Buys TPH, Chari R, Coe BP, Lam S, Lam WL (2008) Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer. Genome 51: 1032-9.

Yamamoto H, Shigematsu H, Nomura M, Lockwood WW, Sato M, Okumura N, Soh J, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Date H, Lam WL, Minna JD, Gazdar AF (2008) PIK3CA mutations and gene copy number in human lung cancers. Cancer Research 68: 6913-6921.

Aviel-Ronen S, Coe BP, Lau SK, da Cunha Santos G, Zhu CQ, Strumpf D, Jurisica I, Lam WL, Tsao MS (2008) Genomic markers for malignant progression in pulmonary adenocarcinoma with bronchioloalveolar features. Proc. Natl. Acad. Sci. U.S.A. 105: 10155-10160.

Coe BP, Chari R, Lockwood WW, Lam WL (2008) Evolving strategies for global gene expression analysis of cancer. Journal of Cellular Physiology 217: 590-597.

Tsui IFL, Rosin MP, Zhang L, Ng RT, Lam WL (2008) Multiple aberrations of chromosome 3p detected in oral premalignant lesions. Cancer Prevention Research 1: 424-429.

Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A (2008) High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood. 112: 3412-3424.

Kennett JY, Watson SK, Saprunoff H, Heryet C, Lam WL (2008) Technical Demonstration of whole genome array comparative genomic. Journal of Visualized Experiments 18. [http://www.jove.com/index/Details.stp?ID=870, doi: 10.3791/870]

Chi B, DeLeeuw RJ, Coe BP, Ng RT, MacAulay C, Lam WL (2008) MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data. BMC Bioinformatics 9:243, 1-9.

Vucic EA, Brown CJ, Lam WL (2008) Epigenomics of cancer progression. Pharmacogenomics 9: 215-234.

Lee EHL*, Chari R*, Lam A, Ng RT, Yee J, English J, Evans KG, MacAulay C, Lam S, Lam WL (2008) Disruption of the non-canonical WNT pathway in lung squamous cell carcinoma. Clinical Medicine: Oncology 2: 169-179.

Li AH, Lam WL, Stokes RW (2008) Characterization of genes differentially expressed within macrophages by virulent and attenuated Mycobacterium tuberculosis identifies candidate genes involved in intracellular growth. Microbiology 154: 2291-2303.

Li AH, Lam WL, Stokes RW (2008) Bacterial artificial chromosome fingerprint arrays for the differentiation of transcriptomic differences in mycobacteria. Journal of Microbiological Methods 75: 416-424.

Gao K, Lockwood WW, Li J, Lam WL, Li G (2008) Gene candidates for acquired irinotecan resistance in melanoma cells. International Journal of Oncology 32:1343-1349.

Wang J-C, Coe BP, Lomax B, MacLeod PM, Parslow MI, Schein JE, Lam WL, Eydoux P (2008) Inverted duplication with terminal deletion of 5p with no cat-like. American Journal of Medical Genetics A. 146: 1173-1179.

Coe BP, Macaulay C, Lam WL, Ylstra B, Carvalho B, Meijer GA (2008) Comment re: A comparison of DNA copy number profiling platforms. Cancer Research 68: 4010.

Shadeo A, Chari R, Lonergan KM, Pusic A, Miller D, Ehlen T, Van Niekerk D, Matisic J, Richards-Kortum R, Follen M, Guillaud M, Lam WL*, MacAulay C* (2008) Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia. BMC Genomics 9: 64, 1-14.

Rosin MP, Poh CF, Elwood JM, Williams PM, Gallagher R, MacAulay C, Lam W, Auluck A, Zhang L, Hislop TG (2008) New hope for an oral cancer solution: Together we can make a difference. J Canadian Dental Association 74:261-266.

Fadlelmola FM, Zhou M, deLeeuw RJ, Dosanjh N, Harmer K, Huntsman D, Lam WL, Banerjee D (2008) Sub megabase resolution tiling (SMRT) array-based profiling reveals novel gains and losses of chromosomal regions in Hodgkin lymphoma and anaplastic large cell lymphoma cell lines. Molecular Cancer 7:2, 1-13.

Garnis C, Lam WL (2008) Oral Cancer. In Encyclopedia of Cancer. Second Edition (Manfred Schwab ed.) Springer. pp. 2183-2184.

Buys TPH, Lam WL (2008) Malignancy Associated Changes. In Encyclopedia of Cancer. Second Edition (Manfred Schwab ed.) Springer. pp. 1748-1749.

Buys TPH, Wilson IM, Coe BP, Lee EHL, Kennett JY, Lockwood WW, Tsui IFL, Shadeo A, Chari R, Garnis C, Lam WL (2007) Detailed comparisons of cancer genomes. In Comparative Genomics: Fundamental and Applied Perspectives. James R. Brown (ed.) CRC Press, Taylor and Francis Publisher. pp.245-259.

Kuo A, Wilson IM, Vucic E, Lee E, Davies JJ, MacAulay C, Brown C, Lam W (2007) Comparative cancer epigenomics. In Comparative Genomics: Fundamental and Applied Perspectives. James R. Brown (ed.) CRC Press, Taylor and Francis Publisher. pp. 261-279.

Buys TP, Wilson IM, Coe BP, Lockwood WW, Davies JJ, Chari R, DeLeeuw RJ, Shadeo A, MacAulay C, Lam WL. (2007) ″Key Features of BAC Array Production and Usage″• In DNA Microarrays (Methods Express Series, Schena M, ed), Scion Publishing, Ltd., Bloxham. pp.85-115.

Tucker CA, Kapanen AI, Chikh G, Hoffman BG, Kyle AH, Wilson IM, Masin D, Gascoyne RD, Bally M, Klasa RJ (2008) Silencing Bcl-2 in models of mantle cell lymphoma correlates with a loss in Cyclin D1a expression but not CyclinD1b and is associated with decreases in NFkappaB, p53, bax and p27 levels. Molecular Cancer Therapeutics 7:749-58. [Wilson’s Lam Lab publication]

2007

Mastracci TL, Boulos F, Andrulis IL, Lam WL (2007) Genomics and premalignant breast lesions: clues to the development and progression of lobular breast cancer. Breast Cancer Research 9:215, 1-9.

Tsui IFL, Chari R, Buys TPH, Lam WL (2007) Public databases and software for the pathway analysis of cancer genomes. Cancer Informatics 3: 389-407.

Kimm L*, DeLeeuw RJ*, Savage K, Rosenwald A, Campo E, Delabie J, Muller-Hermelink HK, Jaffe ES, Rimsza LM, Weisenburger DD, Chan WC, Staudt LM, Connors JM, Gascoyne RD, Lam WL (2007) Frequent occurrence of deletions in primary mediastinal B-cell lymphoma. Genes Chromosomes Cancer 46:1090-7.

Buys TPH, Chari R, Lee EHL, Zhang M, MacAulay C, Lam S, Lam WL, Ling V (2007) Genetic changes in the evolution of multi-drug resistance for cultured human ovarian cancer cells. Genes Chromosome Cancer 46:1069-79.

Chari R, Lonergan KM, MacAulay C, Ng R, Lam WL*, Lam S* (2007) Effect of active smoking on the bronchial epithelium transcriptome. BMC Genomics 8: 297, 1-13.

Shah SP, Lam WL, Ng RT, Murphy KP (2007) Modeling recurrent DNA copy number alterations in array CGH data. Bioinformatics 23: i450-i458.

Stratford AL, Habibi G, Astanehe A, Jiang H, Hu K, Park E, Shadeo A, Buys TP, Lam W, Pugh T, Marra M, Nielsen TO, Klinge U, Mertens PR, Aparicio S, Dunn SE (2007) Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer providing a potential target for therapy. Breast Cancer Research 9:R61, 1-14.

Robinson WP , Slee J, Smith N, Murch A, Watson S, Lam WL, McFadden DE (2007) Placental mesenchymal dysplasia associated with fetal overgrowth and mosaic deletion of the maternal copy of 11p15.5. American J Medical Genetics A 143:1752-9.

Wong KK, DeLeeuw RJ, Brown CJ, Lam WL (2007) Reply to: Copy number variations and human disease. American Journal of Human Genetics 81:415.

DeLeeuw RJ, Wong KK, Ng RT, Brown CJ, Lam WL (2007) Reply to: Numbers of CNVs and false negative rates will be underestimated if we do not account for the dependence between repeated experiments. American Journal of Human Genetics 81:420-1.

DeLeeuw RJ*, Zettl A*, Haralambieva E, Trottier M, Chari R, Ge Y, Gascoyne RD, Chott A, Muller-Hermelink H-K, Lam WL (2007) Whole genome analysis of enteropathy-type T-cell lymphoma reveals two distinct genetic signatures. Gastroenterology 132:1902-11.

Coe BP, Ylstra B, Carvalho B, Meijer GA, MacAulay C, Lam WL (2007) Resolving the resolution of array CGH. Genomics 89:647-53.

Shadeo A, Chari R, Vatcher G, Campbell J, Lonergan KM, Matisic J, Van NieKirk D, Ehlen T, Miller D, Follen M, Lam WL, MacAulay C (2007) Comprehensive serial analysis of gene expression of the cervical epithelium transcriptome. BMC Genomics 8: 142, 1-11.

Wong KK*, DeLeeuw RJ*, Dosanjh NS, Kimm LR, Cheng Z, Horsman DH, MacAulay C, Ng R, Brown CJ, Eichler EE, Lam WL (2007) A Comprehensive Analysis of Common Copy-Number Variations in the Human Genome. American Journal of Human Genetics 80: 91-104.  Link

Kneller JM, Ehlen T, Matisic JP, Miller D, Van Niekerk D, Lam WL, Marra M, Richards-Kortum R, Follen M, MacAulay C, Jones SJM (2007) Using LongSAGE to establish biomarkers of cervical cancer amenable to optical contrast agent labeling. Biomarker Insights 2: 447-461.

Thiberville C, Guillaud M, Lockwood WW, Lam WL, Follen M, MacAulay C (2007) Multi-scale systems biology applied to cervical inter-epithelial neoplasia. Gynaecologic Oncology 107: S72-82.

Renault N, Dyack S, Dobson MJ, Costa T, Lam WL, Greer WL (2007) Heritable skewed X-chromosome inactivation leads to haemophilia A expression in heterozygous females. European Journal of Human Genetics 15: 628-37.

Bretherick KL, Metzger DL, Chanione JP, Panagiotopoulos C, Watson SK, Lam WL, Fluker MR, Brown CJ, Robinson WP (2007) Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure. American Journal of Medical Genetics A 143: 945-951.

Watson SK, DeLeeuw RJ, Horsman DE, Squire JA, Lam WL (2007) Cytogenetically balanced translocations are associated with focal copy number alterations. Human Genetics 120: 795-805.

Lockwood WW, Coe BP, Williams AC, MacAulay C, Lam WL (2007) Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell lines. International Journal of Cancer 120: 436-43.

2006

Chari R, Lockwood WW, Coe BP, Chu A, Macey D, Thomson A, Davies JJ, MacAulay C, Lam WL (2006) SIGMA: a system for integrative genomic microarray analysis of cancer genomes. BMC Genomics 7, 324: 1-28.

Aviel-Ronen S, Zhu CQ, Coe BP, Liu N, Watson SK, Lam WL, Tsao MS (2006) Large Fragment Bst DNA Polymerase for Whole Genome Amplification of DNA from Formalin-Fixed Paraffin-Embedded Tissues. BMC Genomics 7, 312: 1-10.

Lonergan KM, Chari R, Deleeuw RJ, Shadeo A, Chi B, Tsao MS, Jones S, Marra M, Ling V, Ng R, MacAulay C, Lam S, Lam WL (2006) Identification of Novel Lung Genes in Bronchial Epithelium by Serial Analysis of Gene Expression. American Journal of Respiratory Cell Molecular Biology 35: 651-61.

Mastracci TL, Shadeo A, Colby SM, Tuck AB, O´Malley FP, Bull SB, Lam WL, Andrulis IL (2006) Genomic alterations in lobular neoplasia: A microarray comparative genomic hybridization signature for early neoplastic proliferationin the breast. Genes Chromosomes Cancer 45: 1007-17.

Shah SP, Xuan X, Deleeuw RJ, Khojasteh M, Lam WL, Ng R, Murphy KP (2006) Integrating copy number polymorphisms into array CGH analysis using a robust HMM. Bioinformatics 22: e431-9.

Coe BP*, Lockwood WW*, Girard L, Chari R, MacAulay C, Lam S, Gazdar AF, Minna JD, Lam WL (2006) Differential regulation of cell cycle pathways in small cell and non-small cell lung cancer. British Journal of Cancer 94:1927-35.

Chari R*, Lockwood WW*, Lam WL (2006) Bioinformatic applications for array comparative genomic hybridization data analysis and visualization. Cancer Informatics 2: 48-58. Link

Baldwin C, Garnis C, Zhang L, Rosin MP, Lam WL (2006). Response to: Genomic analysis of tumors by array comparative genomic hybridization: more is better. Cancer Research 66: 3955-3956.

Wilson IM, Davies JJ, Brown CJ, Weber M, Alveraz CE, MacAulay C, Schübeler D, Lam WL (2006) Epigenomics: mapping the methylome. Cell Cycle 5:155-8.

Shadeo A, Lam WL (2006) Comprehensive copy number profiles of breast cancer cell model genomes. Breast Cancer Research 8: R9, 1-14.

Lewis CM, Herbert BS, Bu D, Halloway S, Beck A, Shadeo A, Zhang C, Ashfaq R, Shay JW, Euhus DM (2006) Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier. Breast Cancer Res Treat. 99:103-15. [Shadeo´s Lam Lab publication]

Garnis C, Lockwood WW, Vucic E, Ge Y, Girard L, Minna JD, Gazdar AF, Lam S, MacAulay C, Lam WL (2006) Comparing canonical non-small cell lung squamous and adenocarcinoma model genomes. International Journal of Cancer 118: 1556-64.

Lockwood WW*, Chari R*, Chi B, Lam WL (2006) Recent advances in array comparative genomic hybridization technologies and their applications in human genetics. European Journal of Human Genetics 14:139-48.

Coe BP, Lee EHL, Chi B, Girard L, Minna JD, Gazdar AF, Lam S, MacAulay C, Lam WL (2006) Tiling genomic array profiling of small cell lung cancer cell lines identifies highly frequent copy number gains of MAD1L1. Genes Chromosomes Cancer 45: 11-19.

Khojasteh M, Coe B, Shah S, Ward RK, Lam WL, MacAulay C (2006) A novel algorithm for the analysis of array CGH data. Institute of Electrical and Electronics Engineers (IEEE) International Conference on Acoustics, Speech, and Signal Processing (ICASSP). Volume 2, 1020-23.

Aarts M, Dannenberg H, Deleeuw RJ, van Nederveen FH, Verhofstad AA, Lenders JW, Dinjens WN, Speel EJ, Lam WL, de Krijger RR (2006) Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p. Genes Chromosomes Cancer 45: 83-93.

2005

Weber M, Davies JJ, Wittig D, Haase M, Lam WL, Schübeler D (2005) Chromosome-wide and promoter-specific analyses reveal sites of differential DNA methylation in normal and transformed human cells. Nature Genetics 37: 853-62.

Baldwin C, Garnis C, Zhang L, Rosin MP, Lam WL (2005) Multiple microalterations detected at high frequency in oral cancer. Cancer Research 65: 7561-7.

Garnis C, Davies JJ, Buys TPH, Tsao M, Lam S, MacAulay C, Lam WL (2005) Chromosome 5p Aberrations and Glial Cell Line-Derived Neurotrophic Factor Activation Are Early Events In Lung Cancer. Oncogene 24: 4806-12.

Garnis C, Campbell J, Davies JJ, Lam S, MacAulay C, Lam WL. (2005) disruption of multiple developmental genes on chromosome 1p in lung tumorigenesis. Human Molecular Genetic 14: 475-82.

Khojasteh M, Lam WL, Ward RK, MacAulay C (2005) A stepwise framework for the normalization of Array CGH data. BMC Bioinformatics 6: 274, 1-15.

Prentice LM, Shadeo A, Lestou VS, Miller M, deLeeuw RJ, Makretsov N, Turbin D, Brown LA, Cheang MCU, Macpherson N, Yorida E, Bentley J, Chia S, Nielsen TO, C. Gilks B, Lam W, Huntsman DG (2005) NRG1 gene rearrangements in clinical breast cancer: identification of an adjacent novel amplicon associated with poor prognosis. Oncogene 24: 7281-89.

Zhang L, Williams M, Poh CF, Laronde D, Epstein JB, Durham S, Nakamura H, Berean K, Hovan A, Le ND, Greg Hislop G, Priddy R, Hay J, Lam WL, Rosin MP (2005) Toluidine blue staining identifies primary oral premalignant lesions with high molecular risk of progression. Cancer Research 65: 8017-21.

Rubio-Moscardo F, Blesa D, Mestre C, Siebert R, Balasas T, Benito A, Rosenwald A, Climent J, Martinez JI, Schilhabel M, Karran EL, Gesk S, Esteller M, deLeeuw R, Staudt LM, Fernandez-Luna JL, Pinkel D, Dyer MJ, Martinez-Climent JA (2005) Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes. Blood 106: 3214-22. [deLeeuw´s Lam Lab publication]

Davies JJ, Wilson I, Lam WL (2005) Array technologies and their applications to cancer genomes. Chromosome Research 13: 237-48.

Garnis C, Coe BP, MacAulay C, Lam WL (2005) High-resolution array CGH increases heterogeneity tolerance in the analysis of clinical samples. Genomics 85:790-3.

Garnis C, Zhang L, Rosin MP, Lam WL (2005) Alteration of AKAP220 an upstream component of the Rb pathway in oral carcinogenesis. International Journal of Cancer 116: 813-9.

Henderson LJ, Coe BP, Lee E, Girard L, Gazdar AF, Minna JD, Lam S, MacAulay C, Lam WL (2005) Genomic and gene expression profiling of minute alterations of chromosome arm 1p in small cell lung carcinoma cells. British Journal of Cancer 92: 1553-60.

Knezevich S, Ludkovski O, Salski C, Lestou V, Chhanabhai M, Lam W, Klasa R, Connors JM, Dyer MJS, Gascoyne RD, Horsman DE (2005) Concurrent translocation of BCL2 and MYC with a single immunoglobulin locus in high-grade B-cell lymphomas. Leukemia 19: 659-63.

Coe BP, Henderson LJ, Garnis C, Tsao-MS, Gazdar A, Minna J, Lam S, MacAulay C, Lam WL (2005) High resolution chromosome 5p array CGH analysis of small cell lung carcinoma cell lines. Genes Chromosomes Cancer 42: 308-13.

Lim G, Karaskova J, Beheshti B, Vukovic B, Bayani J, Selvarajah S, Watson SK, Lam WL, Zielenska M, Squire JA (2005) An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma. Genes Chromosomes Cancer 42: 392-403.

2004

Ishkanian AS, Malloff CA, Watson SK, DeLeeuw RJ, Chi B, Coe BP, Snijders A, Albertson DG, Pinkel D, Marra MA, Ling V, MacAulay, C, Lam WL (2004) A tiling resolution DNA microarray with complete coverage of the human genome. Nature Genetics 36: 299-303.

DeLeeuw RJ, Davies JJ, Bebb G, Gascoyne RD, Staudt LM, Martinez-Climent JA, Lam WL (2004) Whole genome array CGH profiling of mantle cell lymphoma model genomes. Human Molecular Genetics 13: 1827-37.

Garnis C, Buys TPH, Lam WL (2004) Genetic alteration and gene expression modulation during cancer progress. Molecular Cancer 3, 9: 1-23.

Garnis C, Coe BP, Zhang L, Rosin MP, Lam WL (2004) Overexpression of LRP12, a gene contained within an 8q22 amplicon identified by high resolution array CGH analysis of oral squamous cell carcinomas. Oncogene 23: 2582-86.

Krzywinski M, Bosdet I, Smailus D, Chiu R, Mathewson C, Wye N, Barber S, Brown-John M, Chan S, Chand S, Cloutier A, Girn N, Lee D, Masson A, Mayo M, Olson T, Pandoh P, Prabhu AL, Schoenmakers E, Tsai M, Albertson D, Lam W, Choy CO, Osoegawa K, Zhao S, de Jong PJ, Schein J, Jones S, Marra MA (2004) A set of BAC clones spanning the human genome. Nucleic Acids Research 32: 3651-60.

Chi B, DeLeeuw R, Coe B, MacAulay C, Lam WL (2004) SeeGH ‾ A software tool for the visualization of whole genome array CGH data. BMC Bioinformatics 5, 13: 1-6.

Garnis C, MacAulay C, Lam S, Lam W (2004) Genetic alteration on 8q distinct from MYC in bronchial carcinoma In situ lesions. Lung Cancer 44: 403-4.

Henderson LJ, Okamoto I, LestouVS, Ludkovski O, Robichaud M, Chhanabhai M, Gascoyne RD, KlasaR, ConnorsJM, Marra MA, Horsman DE, Lam WL (2004) Delineation of a Minimal Region of Deletion at 6q16.3 in Follicular Lymphoma and Construction of a Bacterial Artificial Chromosome Contig Spanning a 6-megabase Region of 6q16-q21. Genes Chromosomes Cancer 40: 60-65.

Garnis C, Coe BP, Ishkanian A, Zhang L, Rosin MP, Lam WL (2004) Novel regions of amplification on 8q distinct from the MYC locus and frequently altered in oral dysplasia and cancer. Genes Chromosomes Cancer 39: 93-8.

Watson SK, DeLeeuw RJ, Ishkanian AS, Malloff CA, Lam WL (2004) Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays. BMC Genomics 5, 6: 1-8.

MacAulay C, Lonergan K, Chi B, Zuyderduyn S, Shein J, Tsao M, LeRiche J, Jones S, Marra M, Lam S, Lam WL (2004) Serial analysis of gene expression profiles of developmental stages in non-small cell lung carcinoma. Chest 125 (5 Suppl):97S.

Garnis C, Coe B, Henderson LJ, Ishkanian A, Watson S, Marra M, Minna J, Lam S, MacAulay C, Lam W (2004) Construction and optimization of chromosome arm-specific comparative genomic hybridization arrays for identifying genetic alterations in preinvasive lung cancers. Chest 125 (5 Suppl):104S-5S.

Garnis C, Campbell J, Zhang L, Rosin MP, Lam WL (2004) OCGR Array, an oral cancer genomic regional array for comparative genomic hybridization analysis. Oral Oncology 40:511-9.

Neufeld JD, Yu Z, Lam W, Mohn WW (2004) SARST, Serial Analysis of Ribosomal Sequence Tags. In Molecular Microbial Ecology Manual, 2nd Ed. Kluwer, The Netherlands.

Neufeld JD, Yu Z, Lam W, Mohn WW (2004) Serial Analysis of Ribosomal Sequence Tags (SARST): a high-throughput method for profiling complex microbial communities. Enviromental Microbiology 6: 131-44.

2003

Garnis C, Baldwin C, Zhang L, Rosin MP, Lam WL (2003) Use of Complete Coverage Array CGH to Define Copy Number Alterations on Chromosome 3p in Oral Squamous Cell Carcinomas. Cancer Research 63: 8582-5.

Rosin MP, Lam WL, Zhang L (2003) Correspondence to: 3p14 and 9p21 loss is a simple tool for predicting second oral malignancy at previously treated oral cancer sites. Cancer Research 63: 5167-9.

Sokolov K, Aaron J, Hsu B, Nida D, Gillenwater A, Follen M, MacAulay C, Adler-Storthz K, Korgel B, Descour M, Pasqualini R, Arap W, Lam W, Richards-Kortum R (2003) Optical systems for in vivo molecular imaging of cancer. Technol Cancer Res Treat 2: 491-504.

Malloff CA, Dullaghan EM, I A, Stokes RW, Fernandez RC, Lam WL (2003) Two-dimensional DNA displays for comparisons of bacterial genomes. Biol. Proced. On. 53: 143-52.

Lestou VS, Ludkovski O′ Connors JM, Gascoyne RD, Lam WL, Horsman DE (2003) Characterization of the recurrent translocation t(1;1)(p36.3;q21.1-2) in non-Hodgkin′s lymphoma by multicolor banding and FISH analysis. Genes Chromosomes and Cancer 36: 375-81.

2002

Rosin MP, Lam WL, Poh C, Le ND, Li RJ, Zeng T, Priddy R, Zhang L (2002) 3p14 and 9p21 loss is a simple tool for predicting second oral malignancy at previously treated oral cancer sites. Cancer Research 62: 6447-50.
Lestou VS, Robichaud M, Chudoba I, O′Connell J, Maguire J, Sorensen PHB, Lam W, Horsman D (2002) Cryptic t(X;18) and ins(6;18) in a monophasic intraneural synovial sarcoma as characterized by mFISH and locus specific FISH analysis. Genes Chromosomes Cancer 138: 153-6.

Siwoski A, Ishkanian A, Garnis C, Zhang, L, Rosin MP, Lam, WL (2002) An Efficient method for the assessment of DNA quality of archival microdissected specimens. Modern Pathology 15: 889-92.

Malloff CA, Fernandez RC, Dullaghan EM, Stokes RW, Lam WL (2001) Two-dimensional display of respiratory pathogen genomes of high G + C DNA content. Gene 293: 205-11.

Oloumi A, Lam W, Banath JP, Olive PL (2002) Identification of genes differentially expressed in V79 cells grown as multicell spheroids. Int J Radiat Biol 78: 483-92.

Dullaghan EM, Malloff CA, Li AH, Lam WL, Stokes RW (2002) Two-dimensional bacterial genome display: a method for the genomic analysis of mycobacteria. Microbiology 148: 3111-7.

Zhang L, Epstein JB , Poh CF, Berean K, Lam WL, Rosin MP (2002) Comparison of HPV infection, p53 mutation and allelic losses in oral squamous cell carcinomas from transplant and non-transplant recipients. J Oral Path Med 31:134-41.

2001

Malloff CA, Fernandez RC, Lam WL (2001) Comaprative bacterial genomic hybridization. J Mol Biol 312: 1-5.

Zhang L, Cheung KJ, Lam WL, Cheng, X, Poh C, Priddy R, Epstein JB, Le ND, Rosin MP (2001) Increased genetic damage in oral leukoplakia from high-risk sites: potential impact on staging and clinical management. Cancer 91: 2148-55.

Zhang L, Poh C, Lam WL, Epstein JB, Cheng X, Zhang X, Priddy R, Lovas J, Le ND, Rosin MP (2001) Impact of localized treatment in reducing risk of progression of oral dysplasia: molecular evidence of incomplete resection. Oral Oncology 37: 505-12.

Poh CF, Zhang L, Lam WL, Zhang X, An D, Chau C, Priddy R, Epstein J, Rosin MP (2001) A high frequency of allelic loss in oral verrucous lesions may explain malignant risk. Laboratory Investigation 81: 629-34.

Rosin, MP, Cheng X, Poh C, Lam WL, Huang Y, Lovas J, Berean K, Epstein JB, Priddy R, Le ND and Zhang, L (2000) Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clinical Cancer Research 6: 357-62.

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