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In Press

1. Lo M, Ling V, Low C, Wang YZ, Gout PW. Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer Curr Oncol 2010 (In Press).
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2010

2. Dong X, Guan J, English J, Flint J, Yee J, Evans K, Murray N, MacAulay C, Ng R, Gout PW, Lam W, Laskin J, Ling V, Lam S, Wang YZ. Patient-derived first generation xenografts of non-small cell lung cancers: Promising tools for predicting drug responses for personalized chemotherapy Clin. Cancer Research 2010 (Epub February 23, 2010) (2010).
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3. McPherson S, Hussain S, Balanathan P, Hedwards S, Niranjan B, Grant M, Chandrasiri U, Toivanen U, Wang YZ, Taylor R, Risbridger G.. Estrogen receptor beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen-independent and TNFα-mediated. Proceedings of the National Academy of Science USA. (2010).
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2009

4. Chiu H, Yong TMK, Wang J, Wang Y, Vessella RL, Ueda T, Wang YZ, and Sadar MD. Induction of Neuronal Apoptosis Inhibitory Protein Expression in Response to Androgen Deprivation in Prostate Cancer. Cancer Lett. (Epub December 31, 2009). (2009).
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5. Gan L, Chen S, Wang Y, Watahiki A, Bohrer L, Sun Z, Wang YZ, Huang H. Inhibition of the Androgen Receptor as a Novel Mechanism of Taxol Chemotherapy in Prostate Cancer. Cancer Research 2009; 69:8386-94 (2009).
    [View Abstract - PubMed 19826044]  Request Paper

6. Guan J, Lo M, Dockery P, Mahon S, Karp C, Buckley A, Lam S, Gout PW, Wang YZ. The x_c^- cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: Use of sulfasalazine Cancer Chemotherapy and Pharmacology 2009;64:463-472. (2009).
    [View Abstract - PubMed 19104813]  Request Paper

7. Lo M, Wang YZ, Gout PW. Response to Savaskan NE et al. "The x_c^- Cystine/Glutamate Antiporter: A Potential Target for Therapy of Cancer and Other Diseases: Yet Another Cytotoxic Anticancer Approach?" J Cell Physiol 2009;220(2):533-534. (2009).
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8. Romanish MT, Nakamura H, Lai CB, Wang YZ, Mager DL. A novel protein isoform of the multicopy human NAIP gene derives from intragenic Alu SINE promoters. PLoS One. 2009 Jun 2;4(6):e5761. (2009).
    [View Abstract - PubMed 19488400]  Request Paper

2008

9. Al-Romaih K, Sadikovic B, Yoshimoto M, Wang YZ, Zielenska M, Squire JA. Decitabine induced demethylation of 5 CpG-island in GADD45A leads to apoptosis in osteosarcoma cells Neoplasia 10 p.471-480 (2008).
    [View Abstract - PubMed 18472964]  Request Paper

10. Lin D, Watahiki A, Bayani J, Zhang F, Liu L, Ling V, Sadar MD, English J, Fazli L, So A, Gout PW, Gleave M, Squire JA, Wang YZ. ASAP1, a Gene at 8q24, is Associated with Prostate Cancer Metastasis Cancer Research 68 p.4352-4359 (2008).
     [View Abstract - PubMed 18519696]  Request Paper

11. Lo M, Ling V, Wang YZ, Gout PW. The x_c^- cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance. British J. Cancer 99 p. 464-472 (2008).
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12. Lo M, Wang YZ, Gout, PW. The x_c^- Cystine/Glutamate Antiporter: a Potential Target for Therapy of Cancer and Other Diseases Journal of Cellular Physiology 215 p. 593-602 (2008).
     [View Abstract - PubMed 18181196]  Request Paper

13. Press JZ, Kenyon JA, Xue H, Miller MA, de Luca A, Miller DM, Huntsman DG, Gilks CB, McAlpine JN, Wang YZ. Xenografts of primary human gynecological tumors grown under the renal capsule of NOD/SCID mice show genetic stability during serial transplantation and respond to cytotoxic chemotherapy. Gyn. Oncol. 110 p.256-264 (2008).
     [View Abstract - PubMed 18547621]  Request Paper

14. Ricke WA, McPherson SJ, Cunha GR, Wang YZ, Risbridger GP. Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha-signaling The FASEB Journal 22, p. 1512-1520 (2008).
     [View Abstract - PubMed 18055862]  Request Paper

2007

15. Al-Romaih K, Somers GR, Bayani J, Hughes S, Prasad M, Cutz JC, Xue H, Zielenska M, Wang YZ, Squire JA. Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation Cancer Cell International 7:14:10 p.1186 (2007).
     [View Abstract - PubMed 17845729]  Request Paper

16. Doxsee D, Gout P, Kurita T, Lo M, Buckley A, Wang Y, Xue H, Karp C, Cutz JC, Cunha G, and Wang YZ. Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy. Prostate 67(2): 162-171 (2007).
     [View Abstract - PubMed 17075799]  Request Paper

17. Ogura Y, Ishii K, Kanda H, Kanai M, Arima K, Wang YZ, Sugimura Y. Bisphenol A induces permanent squamous change in mouseprostatic eqithelium. Differentiation 75 p. 745-756 (2007).
     [View Abstract - PubMed 17459086]  Request Paper

18. Ricke WA, Wang YZ, Cunha GR. Steroid hormones and carcinogenesis of the prostate: The role of estrogens. Differentiation 75: 871-882 (2007).
     [View Abstract - PubMed 17924963]  Request Paper

19. Verras M, Lee J, Xue H, Li TH, Wang YZ, Sun Z. The Androgen Receptor Negatively Regulates the Expression of c-Met, Implications for a Novel Mechanism of Prostate Cancer Progression Cancer Res. 67(3) : 967-975 (2007).
     [View Abstract - PubMed 17283128]  Request Paper

2006

20. Cutz JC, Guan J, Bayani J, Xue H, Sutcliffe M, English J, Flint J, LeRiche J, Yee J, Squire J, Gout PW, Lam S, Wang YZ. Establishment in Severe Combined Immunodeficiency Disease Mice of Subrenal Capsule Xenografts and Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression-Related Changes. Clin. Cancer Res. 12(13): 4043-4054 (2006).
     [View Abstract - PubMed 16818704]  Request Paper

21. Ricke WA, Ricke EA, Simko J, Wang YZ, Harward SW, and Cunha GR. Steroid Hormones Stimulate Human Prostate Cancer Progression and Metastasis. Int. J. Cancer 118(9) : 2123-2131 (2006).
     [View Abstract - PubMed 16331600]  Request Paper

22. Sobel RE, Wang YZ, Sadar MD. Molecular Ananlysis and Characterization of PrEC, Commercially Available Prostate Epithelial Cells. In Vitro Cellular and Developmental Biology Animal. 42:3339 (2006).
     [View Abstract - PubMed 16618209]  Request Paper

2005

23. Cunha GR, Place NJ, Baskin L, Conley A, Weldele M, Cunha TJ, Wang YZ, Cao M, Glickman SE. The Ontogeny of the Urogenital System of the Spotted Hyena. Biology of Reproduction 73 : 554-564 (2005).
     [View Abstract - PubMed 15917348]  Request Paper

24. Lee CH, Xue H, Sutcliffe M, Gout PW, Huntsman DG, Miller DM, Gilks CB, Wang YZ. Establishment of subrenal capsule xenografts of primary human ovarian tumors in SCID mice: potential models. Gynecol Oncol 96(1):48-55. (2005).
     [View Abstract - PubMed 15589579]  Request Paper

25. Wang Y, Xue H, Cutz JC, Bayani J, Mawji NR, Chen WG, Goetz LJ, Hayward SW, Sadar MD, Gilks CB, Gout PW, Squire JA, Cunha GR, Wang YZ. An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line. Lab Invest 85(11):1392-404. (2005).
     [View Abstract - PubMed 16155594]  Request Paper

26. Wang YZ, Revelo MP, Sudilovsky D, Chen WG, Goetz L, Xue H, Sadar M, Shappell SB, Cunha GR and Hayward SW. Development and characterization of efficient xenograft models for benign and malignant human prostate tissue. Prostate 64, 149-159 (2005).
     [View Abstract - PubMed 15678503]  Request Paper

2004

27. Cunha GR, Riche W, Thomson A, Marker PC, Risbridger G, Hayward SW, Wang YZ, Donjacour AA and Kurita T. Hormonal, Cellular, and Molecular Regulation of Normal and Neoplastic Prostatic Development. Journal of Steroid Biochemistry and Molecular Biology 92(4): 221-236 (2004).
     [View Abstract - PubMed 15663986]  Request Paper

2003

28. Cunha GR, Hayward SW, Wang YZ, and Ricke WA. Stromal micro-environment in carcinogenesis of the prostate. Int J Cancer. 107:1-10 (2003).
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29. Cunha GR, Wang YZ, Place NJ, Liu W, Baskin L, Glickman SE. Urogenital System of the Spotted Hyena (Crocuta crocuta Erxleben): A Functional Histological Study. J Morphology 256 (2): 205-18 (2003).
     [View Abstract - PubMed 12635111]  Request Paper

30. Rubenstein NM, Cunha GR, Wang YZ, Campbell KL, Conley AJ, Catania KC, Glickman SE and Place NJ. A peniform clitoris in New World moles with and without 'ovotestes'. Reproduction 126: 713-719 (2003).
     [View Abstract - PubMed 14748690]  Request Paper

31. Sharma M, Li X, Wang YZ, Zarnegar M, Huang CY, Palvimo JJ, Lam B, Sun Z. hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. EMBO 22 (22): 6101-6114 (2003).
     [View Abstract - PubMed 14609956]  Request Paper

32. Staack A, Kassis AP, Olshen A, Wang YZ, Wu D, Carroll PR, Grossfeld GD, Cunha GR, Hayward SW. Quantitation of apoptotic activity following castration in human prostatic tissue in vivo. Prostate 54: 212-219 (2003).
     [View Abstract - PubMed 12518326 ]  Request Paper

2002

33. Cunha GR, Hayward SW, Wang YZ. Role of stroma in carcinogenesis of the prostate Differentiation 70 (9-10): 473-85 (2002).
     [View Abstract - PubMed 12492490]  Request Paper

34. Day KC, McCabe MT, Zhao X, Wang YZ, Phillips J, Ried T, Davis JN, KuKuruga MA, Cunha GR, Hayward SW, Day ML. Homozygous disruption of the retinoblastoma gene promotes immortalization and alters cell cycle and growth kinetics, but does not alter prostatic differentiation and morphogenesis. J Biol Chem 277 (46): 44475-44484 (2002).
     [View Abstract - PubMed 12191999]  Request Paper

35. Kim MJ, Bhatia-Gaur R, Banach-Petrosky WA, Desai N, Wang YZ, Hayward SW, Cunha GR, Cardiff RD, Shen MM, Abate-Shen C. Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Research 62:2999-3004 (2002).
     [View Abstract - PubMed 12036903]  Request Paper

2001

36. Cunha GR, Wang YZ, Hayward SW, Risbridger GP. Estrogenic effects on prostatic differentiation and carcinogenesis. Reprod Fertil Dev 13:285-296 (2001).
     [View Abstract - PubMed 11800167]  Request Paper

37. Hayward SW, Wang YZ, Cao M, Hom YK, Zhang B, Grossfeld GD, Sudilovsky D, Cunha GR. Transformation In A Non-Tumorigenic Human Prostatic Epithelial Cell Line Cancer Res 61:8135-8142 (2001).
     [View Abstract - PubMed 11719442]  Request Paper

38. Kurita T, Wang YZ, Donjacour AA, Zhao C, Lydon JP, O'Malley BW, Isaacs JT, Dahiya R, Cunha G. Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system. Cell Death and Differentiation 8(2):192-200 (2001).
     [View Abstract - PubMed 11313721]  Request Paper

39. Phillips JL, Hayward SW, Wang YZ, Vasselli J, Pavlovich C, Padilla-Nash H, Pezullo JR, Ghadimi M, Grossfeld GD, Rivera A, Linehan WM, Cunha GR, Ried T. The Consequences of Chromosomal Aneuploidy on Gene Expression Profiles in a Cell Line Model for Prostate Carcinogenesis Cancer Res 61:8143-8149 (2001).
     [View Abstract - PubMed 11719443]  Request Paper

40. Risbridger G, Wang H, Young P, Kurita T, Wang YZ, Lubahn D, Gustafsson JA, Cunha G. Evidence that epithelial and mesenchymal estrogen receptor-alpha mediates effects of estrogen on prostatic epithelium. Dev Biol 229(2):432-42. (2001).
     [View Abstract - PubMed 11150243]  Request Paper

41. Settle S, Marker PC, Gurley K, Sinha A, Thacker A, Wang YZ, Higgins K, Cunha GR, Kingsley DM. The BMP family member GDF7 is required for seminal vesicle growth, branching morphogenesis, and cytodifferentiation. Develop Biol 234:138-150 (2001).
     [View Abstract - PubMed 11356025]  Request Paper

42. Wang YZ, Hayward SW, Cao M, Thayes KA, Cunha GR. Cell differentiation lineage in the prostate. Differentiation 68:270-279 (2001).
     [View Abstract - PubMed 11776479 ]  Request Paper

43. Wang YZ, Sudilovsky D, Zhang B, Haughney PC, Rosen MA, Wu DS, Cunha TW, Dahiya R, Cunha GR, Hayward SW. A Human Prostatic Epithelial Model of Hormonal Carcinogenesis. Cancer Res 61:6064-6072 (2001).
     [View Abstract - PubMed 11507055]  Request Paper

2000

44. Wang YZ, Hayward SW, Donjacour, AA, Young, P, Jacks T, Sage, J, Dahiya, R, Cardiff, R, Day, M, Cunha GR. Sex Hormone-induced Carcinogenesis in Rb-deficient Prostate Tissue. Cancer Res 60:6008-6017 (2000).
     [View Abstract - PubMed 11085521]  Request Paper

45. Wong YC, Wang YZ, Lee JS, Tam NN, Lee D. Changes in serum and tissue zinc levels in sex hormone-induced prostatic carcinogenesis in the noble rat. Tumour Biol 21(6):328-36. (2000).
     [View Abstract - PubMed 11006573]  Request Paper

1998

46. Wang, YZ and Wong, YC. Role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in the development of prostate cancer in the Noble rat: Evidence for stromal-epithelial interactions. Prostate 35:165-177 (1998).
     [View Abstract - PubMed 9582085]  Request Paper

47. Wong YC, Wang YZ, Tam NN. The prostate gland and prostate carcinogenesis. Ital J Anat Embryol 103(4 Suppl 1):237-52. (1998).
     [View Abstract - PubMed 11315954]  Request Paper

1997

48. Tam, NNC, Wang, YZ, Wong, YC. The influence of mesenchyme of neonatal seminal vesicle and embryonic urogenital sinus on the morphological and functional cytodifferentiation of Dunning prostatic adenocarcinoma: Roles of growth factors. Urol Oncol 3:85-93 (1997).
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49. Wang, YZ and Wong, YC. Oncogenes and tumor suppressor genes in prostate cancer: A review. Urol Oncol 3:41-46 (1997).
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In Press

1. Gleave M, Cox M, Wang Y. Z.. Cell biology of prostate cancer and molecular targets In Drug Management of Prostate Cancer, Humana Press (In Press).
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2. Ricke WA, Williams K, Palapattu G, Wang YZ, Cunha GR. Hormonal carcinogenesis: Roles of estrogens The Molecular Basis of Human Cancer, Vol. Part V, Humana Press (In Press).
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2006

3. Waterhouse DN, Gelmon KA, Klasa R, Chi K, Huntsman D, Ramsay E, Wasan E, Edwards L, Tucker C, Zastre J, Wang YZ, Yapp D, Dragowska V, Dunn S, Dedhar S, Bally MB. Development and assessment of conventional and targeted drug combinations for use in the treatment of aggresive breast cancers Current Cancer Drug Targets, 6, 455-489 (2006).
    [View Abstract - PubMed 17017873]  Request Paper

2005

4. Ricke WA, Wang YZ, Kurita T, Hayward SW, Cunha GR. Hormonal and stromal regulation of normal and neoplastic prostatic development. Developmental Biology of Neoplastic Growth, Alvaro, M-C. (Ed). Springer Verlag, New York, N.Y. pp. 183-215 (2005).
    [View Abstract - PubMed 17153485]  Request Paper

2003

5. Cunha GR, Hayward SW, Wang YZ, Ricke WA. Role of the stromal micro-environment in carcinogenesis of the prostate. In: Prostate and renal cancer, benign prostatic hyperplasia, erectile dysfunction and basic research: An update. Bangma CH and Newling DWW (eds), Parthenon Publishing Group, New York, pp. 155-171 (2003).
    [View Abstract - PubMed 12925950]  Request Paper

2002

6. Hayward SW, Wang YZ, Day ML. Rescue and Isolation of Rb-deficient Prostate Epithelium by Tissue Recombination. In: Cancer Cell Signaling: Methods and Protocols. (Terrian DM, ed) Methods in molecular Medicine, Humana Press, Totowa, NJ, Pp 17-34 (2002).
    [View Abstract - PubMed 12616709]  Request Paper

7. Wang YZ, Cunha GR, Hayward SW. In vitro and in vivo models of prostate cancer. American Cancer Society Atlas of Clinical Oncology. Carroll PR, Grossfeld GD eds. BC Decker Inc, Hamilton, London, pp 68-81 (2002).
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2000

8. Wong YC, Wang YZ. Growth factors and epithelial-stromal interactions in prostate cancer development. International Review of Cytology. Jeon KW ed, Academic Press, 199:65-116. (2000).
    [View Abstract - PubMed 10874577]  Request Paper