Dr. Sylvia Ng

 sng@bccrc.ca

• Senior Research Scientist
• Assistant Professor,  Pharmaceutical Sciences,  UBC

  View Publications

Department:	Advanced Therapeutics (@ the BCCRC since 2005)
Research Role:	Senior Scientist
Education:	PhD (Medical Biophysics), University of Toronto, 2002 MSc (Pharmacology and Therapeutics), UBC, 1998 BSc (Pharmacology and Therapeutics), UBC, 1996
Phone:	604-675-8027
Fax:	604-675-8183

Research Interests:

Pancreatic cancer; Drug resistance

Tumor-stromal interactions; Angiogenesis

Preclinical anti-cancer drug development

Research focus:

Pancreatic cancer has the worst survival rates of any cancer with a typical life expectancy of 3-6 months after diagnosis. This malignancy is extremely resistant to chemotherapy and radiotherapy. My research program is focused on the study of the molecular interactions between pancreatic cancer cells and stromal cells (namely, fibroblasts and endothelial cells). Our goals are to identify novel therapeutic targets and to develop more effective strategies using new drugs or combinations of existing drugs for the treatment of this devastating disease.

Current projects:

Cancer-Associated Fibroblasts and Drug Resistance
The predominant cell type in the tumor stroma is cancer-associated fibroblasts. We are currently investigating the role of these cells in mediating drug resistance in pancreatic cancer.

Preclinical Evaluation of Novel Agents for Cancer Therapy
My laboratory develops and utilizes multiple in vitro and in vivo pharmacodynamic assays to evaluate the therapeutic efficacy of new anticancer drugs (molecularly targeted and otherwise) for the treatment of pancreatic cancer.

For more information, please visit the website  British Columbia Pancreatic Cancer Research Net.

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